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PubMedDate not supplied

Estrogen for dementia-related aggression in elderly men.

OBJECTIVE: To report the use of conjugated estrogens for aggression in two elderly men with dementia and to review the available literature relating to estrogen use for aggression in the elderly. CASE SUMMARIES: Case 1. A 78-year-old white man had probable Alzheimer dementia and aggression (verbal and physical) that was nonresponsive to antipsychotic, antidepressant, and mood stabilizer therapy. However, conjugated estrogens 1.875 mg/d reduced his physical aggression, as evidenced by a 75% decline in aggressive episodes, per 24-hour nursing reports and progress notes. Case 2. A 78-year-old African-American man with vascular dementia, physical aggression, and sexual inappropriateness was unsuccessfully managed with several antipsychotic and benzodiazepine trials. He did, however, exhibit a decline in physical and sexual aggression by 80%, as well as a 55% reduction in sexual comments, after daily treatment with conjugated estrogens 0.625 mg. Estrogen was well tolerated by both patients. DATA SOURCES: MEDLINE (January 1966-May 1998) and PsychLit (January 1974-May 1998) database searches were performed to identify case reports, letters, or clinical trials discussing estrogen use in aggressive elderly patients. CONCLUSIONS: As with previous reports, these cases suggest that conjugated estrogens may be used to reduce physical and sexual aggression associated with dementia in elderly men. Additional study is needed to determine the exact role of this alternative pharmacologic intervention.

Aged↗
PubMed2006

Quantitative genomics of aggressive behavior in Drosophila melanogaster.

Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in modulating aggressive behavior is well characterized, other genetic mechanisms affecting this complex behavior remain elusive. Here, we developed an assay to rapidly quantify aggressive behavior in Drosophila melanogaster, and generated replicate selection lines with divergent levels of aggression. The realized heritability of aggressive behavior was approximately 0.10, and the phenotypic response to selection specifically affected aggression. We used whole-genome expression analysis to identify 1,539 probe sets with different expression levels between the selection lines when pooled across replicates, at a false discovery rate of 0.001. We quantified the aggressive behavior of 19 mutations in candidate genes that were generated in a common co-isogenic background, and identified 15 novel genes affecting aggressive behavior. Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits.

Aggression↗
PubMed1998

Cognitive functioning and the inhibition of alcohol-induced aggression.

OBJECTIVE: A highly replicable research finding is that alcohol intoxication tends to induce aggressive responding. Recent research investigating the role of cognitive function in this relationship has shown that individuals who perform poorly on certain cognitive tasks have difficulty responding to contingencies to inhibit aggression, while high performers do not. High performers, however, do show increased aggression while intoxicated. This study investigated whether subjects with above average cognitive functioning would, when intoxicated, inhibit aggression in order to attain monetary reward. METHOD: Men (N = 43), aged 18-30, selected on the basis of high performance on a neuropsychological test putatively assessing function of dorsolateral prefrontal cortex, the spatial conditional associative learning task, participated in a modified version of the Taylor Aggression Task. Half the subjects were acutely alcohol intoxicated, the other half were sober. Furthermore, half the subjects in each of these groups received contingent monetary reward for choosing lower shocks. Aggression was defined as shock intensity delivered to a sham opponent. RESULTS: Contrary to the hypothesis, intoxicated subjects, even though significantly impaired cognitively relative to their nonintoxicated peers (F = 4.29, 1/41 df, p < .05), appeared to have no difficulty inhibiting their aggression in order to gain monetary reward. That is, there was no difference between intoxicated and nonintoxicated subjects on the dependent variable, shock intensity, when contingent money was available (F = .01, 1/20 df, p = .935). CONCLUSION: This finding provides further evidence that alcohol-induced aggression is not a uniform phenomenon, and it suggests a neuropsychological mechanism that may mediate the relationship. It may be that individuals with above average cognitive abilities retain sufficient residual functioning to inhibit aggressive responding, even when acutely alcohol intoxicated.

Adult↗
PubMed2005

A further examination of gender differences in alcohol-related aggression.

OBJECTIVE: The purpose of this investigation was to replicate and extend findings from a previous study on the acute effects of alcohol on aggressive behavior in men and women in a laboratory setting. METHOD: Subjects were 234 (111 men and 123 women) healthy social drinkers between 21 and 35 years of age. They were randomly assigned to either an alcohol or a placebo group. Aggression was measured using a modified version of the Taylor Aggression Paradigm, in which electric shocks are received from and administered to a fictitious opponent during a supposed competitive interpersonal task. Aggression was operationalized as the intensity and duration of shocks that subjects administered to their "opponent." RESULTS: Provocation was a stronger elicitor of aggression than either gender or alcohol. Overall, alcohol increased aggression for men but not for women. CONCLUSIONS: In conjunction with other laboratory investigations on alcohol-related aggression, this study suggests that alcohol increases aggression for men but not for women. This finding may be due to gender-related differences in liability thresholds for aggression as well as discrepancies in how men and women respond to different forms of provocation.

Adult↗
PubMed2005

Maternal aggression in Wistar rats: effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum.

The objective of the present study was to assess the role of the 5-HT2A/2C receptor at two specific brain sites, i.e., the dorsal periaqueductal gray matter (DPAG) and the medial septal (MS) area, in maternal aggressive behavior after the microinjection of either a 5-HT2A/2C receptor agonist or antagonist. Female Wistar rats were microinjected on the 7th postpartum day with the selective agonist alpha-methyl-5-hydroxytryptamine maleate (5-HT2A/2C) or the antagonist 5-HT2A/2C, ketanserin. The agonist was injected into the DPAG at 0.2 (N = 9), 0.5 (N = 10), and 1.0 microg/0.2 microl (N = 9), and the antagonist was injected at 1.0 microg/0.2 microl (N = 9). The agonist was injected into the medial septal area (MS) at 0.2 (N = 9), 0.5 (N = 7), and 1.0 microg/0.2 microl (N = 6) and the antagonist was injected at 1.0 microg/0.2 microl (N = 5). For the control, saline was injected into the DPAG (N = 7) and the MS (N = 12). Both areas are related to aggressive behavior and contain a high density of 5-HT receptors. Non-aggressive behaviors such as horizontal locomotion (walking) and social investigation and aggressive behaviors such as lateral threat (aggressive posture), attacks (frontal and lateral), and biting the intruder were analyzed when a male intruder was placed into the female resident's cage. For each brain area studied, the frequency of the behaviors was compared among the various treatments by analysis of variance. The results showed a decrease in maternal aggressive behavior (number of bites directed at the intruder) after microinjection of the agonist at 0.2 and 1.0 microg/0.2 microl (1.6 +/- 0.7 and 0.9 +/- 0.3) into the DPAG compared to the saline group (5.5 +/- 1.1). There was no dose-response relationship with the agonist. The present findings suggest that the 5-HT2A/2C receptor agonist has an inhibitory effect on maternal aggressive behavior when microinjected into the DPAG and no effect when microinjected into the MS. Ketanserin (1.0 microg/0.2 microl) decreased locomotion when microinjected into the DPAG and MS, but did not affect aggressive behavior. We interpret these findings as evidence for a specific role of 5-HT2A/2C receptors in the DPAG in the inhibition of female aggressive behavior, dissociated from those on motor activity.

Aggression↗
PubMed2004

Association between overt and relational aggression and psychosocial adjustment in undergraduate college students.

This study examined the relations between overt and relational aggression, social anxiety, loneliness, depressive symptoms, and alcohol and drug use in a sample of 287 undergraduate college students. Consistent with prior work, men reported engaging in more overt aggression than women. Contrary to our predictions, men also reported engaging in more relational aggression than women. Results also indicated that overt and relational aggression were positively associated with social anxiety, loneliness, depressive symptoms, alcohol use, and drug use for the overall sample. Hierarchical regression analyses showed positive relations between overt aggression and alcohol use for men and no relations between relational aggression and any psychosocial adjustment index. For women, overt aggression uniquely predicted social anxiety, loneliness, and depressive symptoms, whereas relational aggression uniquely predicted social anxiety, loneliness, depression, and alcohol and drug problems. Implications of these findings are discussed in terms of the role of peer aggression in students' psychosocial adjustment.

Adaptation, Psychological↗
PubMed2003

Factors associated with aggression between pairs of domestic ferrets.

OBJECTIVE: To identify factors (eg, familiarity, sex, neutering status, and time of year) associated with aggression between domestic ferrets and test a method for reducing aggression when introducing ferrets. DESIGN: Prospective trial. ANIMALS: 56 healthy domestic ferrets. PROCEDURE: To identify variables associated with aggression, pairs were placed in an enclosed area and observed. To test whether increasing familiarity would decrease aggression when introducing ferrets, pairs of ferrets were housed in separate cages next to each other or in separate rooms for 2 weeks prior to introduction. RESULTS: 49 of 82 pairs of strangers fought, but 31 cage mate pairs did not. Time of year had no apparent effect. Pairs consisting of 2 neutered females or 2 sexually intact males were significantly more likely to fight than were pairs consisting of a neutered female and a sexually intact male. Pairs caged next to each other for 2 weeks prior to introduction were no less likely to fight than were control pairs. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that familiarity, sex, and neutering status are important determinants of aggression between ferrets. If unfamiliar neutered ferrets are introduced, then pairing 2 males or a male and female would likely result in the lowest levels of aggression. However, neutered females and sexually intact males are not indiscriminately aggressive, as a neutered female can be paired with a sexually intact male without resulting in aggression. Caging ferrets next to each other for 2 weeks does not decrease aggression when the ferrets are introduced.

Aggression↗
PubMed1989

A new approach to explain aggression.

Two separate experiments are reported. They show the methodological difficulties and subsequent conceptual complications in Berkowitz's modified frustration-aggression theory and Zillman's theory of aggression. There was a marginally significant difference in the verbal measure of aggression favouring subjects aroused by frustration over subjects aroused by exercise, but not on the behavioral measure of aggression. Exp. II was conducted to test an alternative hypothesis, deduced from Fraisse's theory of emotion, which states that subjects respond more aggressively when confronted with unexpected than with expected annoyance. All six measures of aggression confirmed the hypothesis. The results of these two experiments indicate conceptual and methodological difficulties inherent in Berkowitz's modified frustration-aggression theory and Zillman's theory of aggression; they also suggest that Fraisse's theory of emotion presents a better model of aggression.

Adult↗
PubMed1988

Aggressive behavior of sows at parturition.

Sows, especially primiparous, may show aggressive behavior at parturition against their own piglets, resulting in wounding or death of the piglets. Frequency, environmental influences and heritability of aggressive behavior were studied in two data sets. The first (923 first litters) was collected at an experimental farm and the other (925 first litters) came from a pig breeding organization. Frequency of aggressiveness ranged, depending on its definition, from 7 to 12%. Fixed effects of year, season and feeding level of the gilt during the rearing period did not affect the frequency of aggressiveness. A regression of aggression on postpartum sow weight was found, suggesting that low weight at first farrowing might predispose sows to aggressive behavior. Coefficients for backfat and litter size were positive but nonsignificant. Heritability of aggressiveness on the underlying normal scale, estimated from the paternal half-sib component of variance, averaged .12 for the first data set, and .25 for data set II. Estimates from daughter-dam regression were .49 and .87 for the two data sets, respectively. A simulation study indicated that this difference might be due to maternal effects. A simple application would be to select boars and gilts from non-aggressive sows only. Response to selection would be rather slow if the frequency of aggressive behavior is low. At frequencies that are too high from an economic point of view, estimation of breeding values, combining own performance and(or) data from relatives, is required.

Aggression↗
PubMed1995

Aggressivity among sons of substance-abusing fathers: association with psychiatric disorder in the father and son, paternal personality, pubertal development, and socioeconomic status.

An association between childhood aggression and risk for subsequent development of a substance abuse disorder is now well-accepted. In order to better understand the relationship between the presence of paternal substance abuse and aggression among their offspring, 10-12 year old sons of fathers with (n = 34) and without (n = 39) a history of a substance abuse disorder were contrasted on demographics, aggressivity, biological indices of reproductive maturation, and the presence of psychiatric diagnoses. In addition, personality factors, the potential for physical abuse, and psychiatric diagnoses were also ascertained among their fathers. Sons of substance-abusing fathers were found to be significantly more aggressive than sons of nonsubstance abusers. However, they also differed from comparison boys on the basis of SES and school grade attained, as well as the proportion with specific psychiatric disorders. Substance-abusing fathers differed from nonsubstance-abusing men in terms of personality factors and the presence of specific psychiatric disorders, including antisocial personality. They also showed significantly higher child abuse potential scores. A multiple regression analysis of factors contributing to aggression in the boys revealed that a paternal personality factor characterized by stress reactivity, alienation, and aggression was the most robust contributor to aggression among the boys. The boys' diagnoses of attention deficit disorder, oppositional defiant disorder, and lower household socioeconomic status were also significant predictors of aggressivity. Contrary to expectations, paternal, psychiatric diagnoses, substance abuse status, and potential for physical abuse were noncontributory. The results suggest potential mechanisms by which both aggression and risk for substance abuse may be transmitted from father to son.

Aggression↗
PubMedDate not supplied

Congruence between aggressive behavior and type of intervention as rated by nursing personnel.

In this pilot study, nursing staff matched three levels of intervention (verbal, chemical, and physical) with 84 aggressive behaviors. It was a preliminary step in the development of a theoretical framework regarding how nurses select interventions for aggressive patients. Specifically, it was an attempt to address the following: Do nurses intervene with aggressive behaviors based on learned stereotypes or do nurses perceive behavior as aggressive because there is consistency in the behavior and level of aggression? All 442 members of the nursing staff were invited to participate in the study; and 211 (48%) responded. Factor analyses were conducted on responses to the behaviors of subjects matched with each intervention. The same three factors were identified for verbal and chemical intervention: behaviors that are precursors to an actual aggressive episode, aggressive behaviors directed inwardly, and aggressive behaviors directed outwardly. The last two behaviors were also identified for physical intervention. The results suggest that the nursing staff did differentiate among behaviors reflecting differing levels of aggression and that they were not responding in a stereotypical manner.

Adult↗
PubMed1997

Physical aggressive resident behavior during hygienic care.

Management of aggressive behavior has been identified as a concern for nursing staff who provide institutional care for cognitively impaired elderly. The Omnibus Reconciliation Act (OBRA '87) mandates a trial reduction in the use of chemical and physical restraints, and the development of nursing interventions for the management of behavioral disorders of institutionalized cognitively impaired elderly. Most skilled nursing facilities, however, are limited in their ability to provide environmental and behavioral programs to manage aggressive patient behavior. For the purposes of this study, physically aggressive behavior was identified as threatened or actual aggressive patient contact which has taken place between a patient and a member of the nursing staff. This study explored the nursing staff's responses to patient physical aggression and the effects that physical aggression had on them and on nursing practice from the perspective of the nursing staff. Nursing staff employed on one Dementia Special Care Unit (DSCU) were invited to participate. Interviews with nursing staff were analyzed using qualitative descriptive methods described by Miles and Huberman (1994). Nursing staff reported that they were subjected to aggressive patient behaviors ranging from verbal threats to actual physical violence. Nursing staff reported that showering a resident was the activity of daily living most likely to provoke patient to staff physical aggression. The findings revealed geropsychiatric nursing practices for the management of physically aggressive residents, and offered recommendations for improving the safety of nursing staff and residents on a secured DSCU.

Adult↗
PubMed2004

Aggression toward staff by nursing home residents: findings from a grounded theory study.

Aggressive behaviors by nursing home residents are common and can result in injury to both staff and residents. In addition, such aggressive behavior may lead to resident abuse by staff. This article describes a grounded theory study of nursing home staff response to aggressive residents and explores the problem of aggressive behaviors by nursing home residents, the conditions and context of aggression, and strategies staff use to prevent and manage aggression. To effectively deal with resident aggression, staff must become proactive, which involves three dynamic and interactive processes: practicing vigilance, intuiting, and strategizing. This article details these processes as well as the strategies staff use to deal with aggressive behaviors and makes specific recommendations for handling aggression toward staff.

Aged↗
PubMed2006

A pilot study on differences in aggression in New York City and Madrid, Spain, and their possible impact on suicidal behavior.

OBJECTIVE: Published results from a U.S. study of depressed suicide attempters and a Madrid, Spain, study including all consecutively admitted suicide attempters suggested that aggression scores were higher in U.S. attempters. This observation led us to compare depressed attempters and controls from both suicide research centers and explore whether New York City (NYC) patients carry out suicidal acts of greater lethality than patients in Madrid. The study goals were (1) to compare aggression scores in attempters and healthy volunteers between the 2 cities and (2) to determine whether higher aggression scores are associated with greater medical lethality of suicide attempts. METHOD: The respective samples from NYC and Madrid included attempters with a DSM-IV diagnosis of major depressive disorder (N = 117 and N = 133) and healthy controls (N = 90 and N = 317). Aggression scores, measured by the Brown-Goodwin Scale, in attempters and healthy volunteers from both sites were compared using an analysis of variance model. The relationship between lethality of suicidal acts and aggression scores in attempters was assessed using logistic regression analyses. NYC subjects were recruited from 1998 to 2001, and Madrid subjects were selected from consecutive admissions in 1999. RESULTS: Depressed suicide attempters from NYC made attempts of greater lethality and reported more lifetime aggressive behavior than depressed attempters in Madrid. NYC healthy volunteers also reported more aggression than their Madrid counterparts. CONCLUSIONS: This pilot study suggests that the greater lethality of suicidal behavior in NYC compared to Madrid is related to higher aggression levels, although the data have limitations. Cross-cultural studies are needed to verify whether aggression and higher lethality suicide attempts share a common diathesis explaining the higher suicide rates in NYC.

Adult↗
PubMed1990

[The influence of perceived mother model attitudes on children's aggressive or prosocial behavior].

The present experiment was to examine the influence of perceived attitudes of mother models on preschool children's aggressive or prosocial behavior. Based on the score of CCP (children's cognition of parents) Test, sixty four-year-olds were selected and then modeling sessions were administered to them. Their mothers and kindergarten teachers were asked to answer a questionnaire on aggression and altruism of children in daily life situations. Mothers were also required to make self-ratings on their aggression, altruism and rearing attitudes. The following results were obtained. Boys who perceived being rejected by their mothers displayed less imitative aggressive behaviors than other boys and they showed significantly more extrapunitive responses in the P-F Study. No relationships were found between children's modeling behaviors and their aggression or altruism. Children's aggression at kindergarten correlated positively with their aggression at home and with their mother's aggression. It was noteworthy that girl's altruism at kindergarten correlated positively with their mother's rejection, control, and aggression.

Adult↗
PubMed1975

[Origins and consequences of aggression in Etroplus maculatus (Cichlidae, Pisces). The problem of drive].

Increased aggressive activity between male and female in isolated pairs of Etroplus maculatus has hitherto been explained either by the drive hypothesis or by the external stimulus hypothesis. In an attempt to investigate these two hypotheses the partners of 48 pairs were separated and their aggressiveness towards their mirrored images and their non-aggressive activities were recorded the following day and again 4 days later after 180 brief presentations of an adjacent compartment. For both sexes aggressiveness was lowered if this compartement was empty (isolation) and heightened if it held the original mate. Females also reacted more aggressively on seeing conspecific strangers of both sexes. There was no significant alteration of non-aggressive activities in any of the series. The increase of aggressiveness caused by the presence of the mate was normally offset by various investigated mechanisms preventing its eruption against the partner. Attacks only occurred if the equilibrium between aggressiveness and inhibition was disturbed. All results and those of other authors are discussed; it is concluded that the behaviour of E. maculatus can be better explained in terms of external stimulation than in terms of an endogenous production of aggressive drive energy.

Aggression↗
PubMedDate not supplied

Update on the biological treatment of aggression.

This review is focused on aggressive behavior in adult patients with major mental disorders. Aggression, agitation, and hostility are defined. The roles of intramuscular forms of ziprasidone and olanzapine in the treatment of acute agitation and aggression are discussed. We review general considerations pertaining to persistent aggression in inpatients and outpatients, including comorbidity of major mental disorders with substance use disorders and personality disorders. The role of clozapine as an antiaggressive agent is well established, particularly in inpatients. Evidence also exists for the efficacy of risperidone, olanzapine, quetiapine, and aripiprazole. Anticonvulsants and lithium are widely used with the intent to control aggression, but their efficacy lacks strong evidential support. Benzodiazepines have a role in controlling acute agitation, but their long-term use for persistent aggression is not recommended. There is evidence for antiaggressive effects of SSRIs and hormonal agents with antiandrogenic properties. Beta-adrenergic blockers and electroconvulstive treatment are rarely used in clinical practice to control aggression, but they may be effective. The heterogeneity of aggressive behavior is a challenge for developing rational treatments. Emerging genetic findings hold a promise of future treatments of aggressive behavior developed on the basis of individual patients' genotypes.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[The neurochemical control of aggression and submission].

Neurochemical mechanisms of agonistic behaviour in different models of aggression are discussed. The effects of aggression and submission experience in 10 mice intermale confrontations under conditions of sensory contact on the levels of brain neurotransmitters and their metabolites were investigated in 7 brain areas. The values obtained in aggressive and control, or submissive and control, animals were compared. In this comparison neurochemical alterations specific for aggressive or submissive behaviours, or nonspecific became apparent. The long experience of victories leads to activation of dopaminergic system through DA catabolism which leads to DOPAC formation. The long experience of defeats increases the 5HT metabolism and decreases NA level in some brain areas. The dopaminergic system of Nucleus accumbens and midbrain are nonspecifically activated in both aggressive and submissive animals. The investigation of values obtained in animals with conversion of behavioural type (after defeat of previously aggressive animals and/or display of aggressive reaction by previously submissive mice) allowed to find many significant differences between aggressive, submissive and "converted" males; in particular the amygdala is the site of opposite changes in 5HT system during inversion of aggressive or submissive behaviours. The above data evidence for the specific role of transmitter systems and brain structures in maintaining or inversion of different types of agonistic behaviour.

Aggression↗