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Interocular transfer of learned pattern discrimination tasks in chimpanzees with sectioned optic chiasma is dependent on the forebrain commissures. This function is sustained by the splenium and the anterior commissure, the former pathway being the more capable.
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There is growing consensus that the U.S. health care system is not producing value relative to the resources invested. Unwarranted variation exists in quality and outcomes of care and underutilization of both evidence-based medicine and evidence-management practices. To address these issues, this article calls for a broad-based social science approach focused on obtaining a greater understanding of change at the individual, group, organizational, and environmental levels as they influence each other. Specific examples and questions for research are suggested with regard to the redesign of care systems, enhancing learning and transferring knowledge, and creating effective financial incentives. The specific measurement, analysis, and study design issues involved in under-taking such a research agenda are discussed.
BACKGROUND: The spread of OXA-48-like carbapenemases represents a major public health challenge. Although previous studies have investigated OXA-48-like carbapenemases risk factors, nosocomial dissemination, and plasmid dynamics, an integrated plasmid-centered framework combining complete plasmid mining, transmission-unit analysis, phylogenetic reconstruction, and machine learning-based risk assessment remains limited. METHODS: We systematically collected 747 complete plasmid sequences carrying blaOXA-48-like genes from the NCBI database, establishing the largest collections of complete plasmid sequences to date. Using an integrative framework of population genomics, phylogenetic dating, and machine learning, this study aimed to characterize the dissemination patterns, plasmid replicon diversity, transmission units, mobile genetic elements, co-resistance profiles, and risk classification of these plasmid. RESULTS: Plasmids carrying blaOXA-48-like genes were detected across 50 countries on six continents, with blaOXA-48 predominating in Europe, blaOXA-181 in South Asia, and blaOXA-232 largely in Asia. IncL and ColKP3/IncX3 replicons, together with Tn1999.2 and other MGEs, were central drivers of plasmid maintenance and spread. Sixteen transmission units were defined, with AA068_Cluster3 estimated to have originated in the Netherlands around 2005 before expanding to Europe, the Middle East, Asia, and North America. Co-resistance analyses revealed frequent modules involving aminoglycoside and quinolone resistance, with qnrS1 and aph(3'')-Ib most prevalent. Notably, high-risk transposon structures were often identified in non-clinical environments, underscoring their cross-ecological transmission potential. Machine learning-based classification models showed good internal performance for predefined composite-risk categories, with plasmid mobility, clinical/non-clinical source composition, and host background contributing to the classification results. CONCLUSIONS: This study provides a large-scale plasmid-centered genomic analysis of publicly available complete plasmid sequences carrying blaOXA-48-like genes, integrating transmission-unit inference, phylogeographic reconstruction, mobile genetic element and co-resistance profiling, and composite genomic risk stratification. This gene-centered framework may support future One Health-oriented antimicrobial resistance surveillance and prioritization of plasmids with higher dissemination and resistance potential.
Music performance requires that musicians represent many different kinds of sequence structure: musicians must remember which pitch to produce, when to produce it, and how to produce it (with what movements). The time course of item retrieval and movement preparation processes during music performance are considered. Serially ordered stage models of retrieval, in which item retrieval ends before movement preparation begins, are compared with interactive cascade models, in which the time course of both processes overlap, permitting interaction. Evidence from transfer of learning paradigms, production errors, and anticipatory movements, as measured in motion capture, are described. This early evidence suggests different time courses for item retrieval (slower, earlier) than for movement preparation (faster, later) with significant temporal overlap during music performance.
While the ability to analyze polarized light is widespread among animals, its contribution to form vision has not yet been documented. We tested the hypothesis that polarization vision can be used for object discrimination, by training octopuses to distinguish between targets on the basis of the presence or absence of a pattern produced by a 90 degrees polarization contrast within the target. Octopuses recognized a 90 degrees contrast pattern within a single target, when presented either on a horizontal/vertical axis or on a 45 degrees/135 degrees axis. They were able to transfer their learning to new situations and to detect a polarization contrast when the orientations of the e-vector of light passing through the target center and background differed by as little as 20 degrees. Polarization vision may provide information similar to that available from color vision and thus serve to enhance the detection and recognition of objects.
The present study examined two approaches to teaching social behaviors to 3 developmentally disabled youths in work contexts. In one approach, a problem-solving procedure was learned and transferred to different materials. Conversational probes monitored interactions between disabled employees and their co-workers and customers. A multiple baseline design demonstrated that the training produced generalization and maintenance of the targeted social behaviors to the work settings: A second approach based on a role-playing intervention produced no substantial generalization in the work setting. A social validation questionnaire administered to co-workers supported the efficacy of the problem-solving training procedure. The efficacy of social problem-solving training was discussed in terms of sufficient exemplars, common stimuli, and self-mediations.
The definition of an operant as a response class each of whose members possesses the property upon which reinforcement is contingent is not broad enough to cover the units that are supposed in Skinner's accounts of extinction, superstition, and transfer of learning. A broader definition is suggested. Finally, properties defining operants are discussed.
This study examined the conditions under which conditional stimulus control by the sample stimuli in three-key matching-to-sample paradigms would generalize across the different possible sample locations. In Experiments 1 and 2, the samples appeared on the left and right side keys during initial training and then on the center key during testing. Transfer of pigeons' matching performances to the center-key samples was evident after both identity and symbolic matching training. In Experiment 3, pigeons trained on symbolic matching with two side-key samples or with a side-key and a center-key sample generally transferred their learned matching performances to those samples when they subsequently appeared in the remaining (novel) location. These results indicate that, when two-choice conditional discriminations are learned with more than one sample location, the visual characteristics of the sample per se predominantly come to control the pigeons' comparison choices. This finding encourages the use of the multiple-location training procedure as a way of reducing control by location, thus providing a more discriminating test of symmetry in animals.
The transformation of functions refers to the untrained acquisition of stimulus functions among members of stimulus equivalence classes or relational frames. Although it is widely assumed that contextual control over the transformation of fuctions must exist, this has not yet been conclusively demonstrated in laboratory studies. Four experiments are reported in which (a) stimulus equivalence classes were established, (b) a conditional stimulus function was trained for one member of each of the classes, and (c) multiple-exemplar procedures were used to train and test for contextual control over the transformation of the stimulus function within the classes and to assess whether it generalized to new equivalence classes. Although a significant amount of training was required, the procedures ultimately resulted in the contextual control of function transformation for 9 of 10 participants and generalized contextual control for 4 of 5 participants.
Using a simulation game designed to teach children to obey certain traffic safety rules, an experimental study was conducted with 136 five-year-old children in four Quebec schools. Within each classroom, subjects were randomly divided into four groups: three intervention groups and one control group. Each of the experimental groups was subjected to a different intervention with outcome measured using three instruments related to attitudes, behavior, and transfer of learning of pedestrian traffic safety. Results suggest that simulation games including role-playing/group dynamics and modeling/training can change attitudes and modify behavior in the area of pedestrian traffic safety in children of this age.
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Explore the source record for details and available documents.
``Single-cell and spatial atlases describe the healthy and diseased liver at high resolution, including lobular hepatocyte zonation, fibrotic macrophage-stellate niches, cholangiocyte reactions, immune remodeling, and hepatocellular carcinoma ecosystems. These maps show where cell states occur but do not, by themselves, predict whether liver injury will progress or how the liver will respond to an untested drug, toxicant, or genetic perturbation. In this review, we organize current approaches toward an AI Virtual Cell (AIVC) for the liver into three complementary modeling routes. Generative models represent cell states, dynamics and transport models infer state transitions, and pretrained or foundation models test whether learned representations transfer across donors, etiologies, disease stages, and platforms. Perturbation-response prediction serves as a cross-cutting assessment of whether these layers can predict responses to untested genetic, chemical, inflammatory, or metabolic interventions. Available evidence can be categorized as direct liver validation, liver-included benchmarks, general single-cell evidence, and conceptual applications. Published models demonstrate individual components, including atlas integration, inferred trajectories, transferable representations, and retrospective response programs. However, these models do not constitute a prospectively validated liver simulator. At minimum, evaluation should include donor-, etiology-, stage-, platform-, and perturbation-level hold-outs. Model performance should be reported using response direction, recovery of differentially expressed genes and rare states, and calibrated uncertainty. Claims about tissue- or function-level prediction additionally require independent spatial, histologic, metabolic, and functional readouts. Near-term use should prioritize experiment selection and hypothesis generation, whereas clinical decision support remains a longer-term objective.
INTRODUCTION: There is a critical shortage of specialty rheumatology services in Canada. The impact is felt more in rural and northern regions than on urban areas of the country. In response to the need, this study was conducted to compare the satisfaction of referring physicians with rheumatology services through conventional visiting specialty clinics; email consults and regularly scheduled videoconference. METHODS: Three rural communities of similar size and availability of physician services were assigned to one of the following means of providing outreach rheumatology services: visiting rheumatologist clinics, email access to rheumatologist and scheduled videoconference consults. A case based pre/post test, and post satisfaction questionnaire were administered to the primary care physicians in these communities. Patient outcomes, and physician ability and confidence in managing specific arthritis problems, were measured. RESULTS: Physicians responded positively to all methods of rheumatology service provision. The videoconference group were the most positive. The reasons were: immediate feedback to referring physician and patient, effective case based learning and transfer of knowledge, and improved accessibility. CONCLUSION: Videoconference is preferred to visiting clinics and email as a method for rheumatology services to rural/northern communities. It is cost effective and there is knowledge transfer between the rheumatologist and the referring physicians.
Information learned in one situation often fails to transfer to a similarly structured situation. However, prior findings suggest that comparing two or more instances that embody the same principle can promote abstraction of a schema that can be transferred to new situations. In two lines of research, we examined the effects of analogical encoding on knowledge transfer in negotiation situations. In Experiment 1, undergraduates were more likely to propose optimal negotiation strategies and less likely to propose compromises (a suboptimal strategy) when they received analogy training. In Experiment 2, graduate management students who drew an analogy from two cases were nearly three times more likely to incorporate the strategy from the training cases into their negotiations than were students given the same cases separately. For both novices and experienced participants, the comparison process can be an efficient means of abstracting principles for later application.
This article describes the blood clotting disorder of hemophilia, including its transmission, incidence, and physical and psychosocial effects. The epidemiology of persons with both hemophilia and HIV are discussed, as well as HIV's rapid spread due to contaminated blood products and the mechanisms commonly used to cope with HIV infection. Specific suggestions on occupational therapy intervention are provided, including helping clients learn to cope with HIV by transferring skills previously learned for coping with hemophilia; teaching stress reduction, anger management, communication, and energy conservation skills; educating families and helping them set appropriate goals; designing adaptive systems for dealing with neurological deficits; and designing exercise programs.