Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Tooth Eruption”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 721 records · Page 40Linked to original sources
PubMed1995

Immunolocalization of interleukin-1 alpha in rat mandibular molars and its enhancement after in vivo injection of epidermal growth factor.

Immunolocalization of interleukin-1 alpha in the first mandibular molars of rats from day 0-12 postnatally showed that the protein was localized in the epithelial stellate reticulum adjacent to the dental follicle. Staining of the stellate reticulum was most prominent in the early days postnatally and was absent by postnatal day 11. Injection of epidermal growth factor into rats at day 0 greatly increased the intensity of the staining for interleukin-1 alpha in the stellate reticulum. Epidermal growth factor (EGF) enhanced the gene expression of interleukin-1 alpha in stellate reticulum cells in vitro, and this study suggests there is enhanced translation of interleukin-1 alpha messenger RNA in the stellate reticulum following EGF injection. In turn, the interleukin-1 alpha may exert its effect on the dental follicle cells adjacent to the stellate reticulum because EGF also enhanced expression of the interleukin-1 receptor type I messenger RNA in cultured dental follicle cells as well as enhancing its expression in vivo. In view of the fact that injection of EGF will stimulate precocious eruption of teeth, its stimulus of interleukin-1 alpha synthesis in the stellate reticulum may be the mechanism by which EGF initiates a cascade of molecular events to signal the onset of tooth eruption.

Animals↗
PubMedDate not supplied

[Relationship among the eruption of the first temporal teeths, the breast feeding duration and the anthropometric development in the first two years of life].

BACKGROUND: The anthropometric development in the first two years of life can be influenced by diverse factors, being analyzed in this study the implication of the primary tooth eruption and the breast feeding duration in this development. METHODS: Longitudinal study. 141 healthy children participated (67 boys and 74 girls), being analyzed the association among the duration of breast feeding, the number of teeth present at the 6, 7, 9 and 12 months, the anthropometrics parameters weight, height and body mass index (BMI) to the birth, 1-7, 9, 12, 15, 18 and 24 months and the growth rate. RESULTS: The weight and height at the birth or the duration of breast feeding didn't associate significantly with the weight and height at the 2 years or the number of teeth at 6,7,9 or 12 months, but the women with more weight (r = 0,366) and height (r = 0,377) at month of life have a bigger number of teeth at 9 months (p = 0,001). In both sexes, the number of teeth at the 9 months are associated significantly with the weight (boys r = 0,328, p = 0,01; girls r = 0,307, p = 0,011) and height (r = 0,352 boys and girls p = 0,005) at two years. CONCLUSIONS: In healthy children the duration of maternal nursing doesn't influence in the degree of anthropometric development reached at 2 years, but yes makes it the number of teeth present at 9 months, result that suggests that the eruption dental early could suppose an evolutive advantage.

Body Size↗
PubMed2002

Dento-skeletal adaptation after bite-raising in growing rats with different masticatory muscle capacities.

The aim of this study was to analyse the effects of normal and hypofunctional masticatory muscles on dento-skeletal adaptation to posterior bite blocks in growing rats. Fifty-two young male rats were divided into two groups, fed a hard and soft diet, respectively, to develop different functional capacities in the masticatory muscles. Bone markers were inserted in the mandible on day 0. After two weeks, an appliance that raised the bite by 2 mm was inserted in half of each group. Lateral radiographs were taken on day 0, 14, 28, and 42 of the experiment. Images of the mandible were superimposed on the bone markers. Differences in cephalometric measurements were analysed by two-way ANOVA. The reduced muscle capacity resulted in an upward growth of the snout and a shorter mandibular ramus with less bone apposition on its lower border. Bite blocks induced a more upward growth of the snout and a shorter mandibular ramus, and inhibited the eruption of the upper molars and intruded the lower molars. The rats with weaker masticatory muscles had less inhibitory effect of the posterior bite blocks on upper molar eruption and showed different bone apposition in the ramus, especially during the first two weeks. In conclusion, masticatory muscle capacity seems to influence the effect of the posterior bite blocks on both tooth eruption and skeletal adaptation. The results suggest that the characteristics of the masticatory muscles should be taken into account when predicting the efficiency of a functional appliance.

Adaptation, Physiological↗
PubMed1992

Isolation of granule proteins from cells of the dental follicle and stellate reticulum of rat mandibular molars.

The presence of a dental follicle is required for eruption of teeth of limited eruption but it is uncertain if any molecules indigenous to the follicle regulate this eruption. However, electron-dense granules of unknown composition and function are present in the fibroblasts of the dental follicle of rat molars, as well as the adjacent stellate reticulum, before and during tooth eruption. Here the granules have been isolated; two proteins, of 167 and 200 kDa, have been determined by biochemical and immunological methods to be major components of the granules.

Animals↗
PubMed1976

Orthodontically induced eruption of the permanent canine combined with alveolar cleft osteoplasty: a new procedure illustrated by a case with stereophotogrammetric reconstructions.

A new technique is suggested which will allow secondary bone grafting to be carried out at approximately 10 years of age when some potential of active tooth eruption and maxillary alveolar growth remains. Surgery is followed during the healing phase by orthodontic traction of the unerupted canine through the bone graft. This allows the reconstruction of the dental arch, while the bone graft is maintained by the osteogenic influence of the canine root. The technique is detailed and illustrated and a case report presented. A stereophotogrammetric reconstruction demonstrates the improvement in integumental contour following the technique described.

Activator Appliances↗
PubMed2004

[Time of permanent teeth eruption in schoolchildren of Saint-Petersburg].

The terms of permanent teeth eruption were analyzed in 909 children (permanent residents of St. Petersburg) aged 7-15 years. The study showed that all groups of permanent teeth, except the first molars, erupted on the mandible earlier than on the maxilla. In girls only canines and second molars erupted earlier than in boys. There was virtually no sex-specific difference in the terms of eruption of both premolars, and the terms of the end of eruption of both groups of canines were virtually the same in boys and girls. Twenty-one children lacked some of permanent teeth by 15 years (the age considered as the upper threshold level for the end of normal tooth eruption). The most frequent teeth that failed to erupt in time were the upper lateral canines (33.3% of all teeth which failed to erupt by the age of 15 years), lower central canines and upper first premolars and molars (12.8% each).

Adolescent↗
PubMedDate not supplied

[The morphological changes in the periodontal tissues of outbred white rats during ontogeny].

Morphologic studies, carried out by three methods, by van Gieson's, Schmorl's methods, and with the use of 0.1% solution of safranin T, have revealed heretofore unknown structures lying beyond the tooth rudiment of white noninbred rats and disappearing in the course of ontogenesis. The mechanism of the formation of autonomic circulation of the dental follicle, unrelated to the animal body, has been shown. Dental follicular tissues were found grown together with the gingival epithelium and they ruptured during tooth eruption.

Aging↗
PubMed1996

Mesial migration of lower molars in relation to facial growth and eruption.

Mesial migration of teeth in the buccal segments is a well recognised phenomenon in the human dentition. Its aetiology is not fully understood. It has been suggested that it is, to some extent, dependent on growth changes in the lower face. The purpose of this investigation was to examine mesial movement of first molars in the intact lower arch in relation to the amount and direction of facial growth and eruption of teeth. Mesial migration of lower first molars between 13 and 18 years was measured on 60 degrees cephalograms of 22 males and 29 females with intact lower arches. Correlation analyses were used to examine the relation between mesial migration and tooth eruption, growth changes in mandibular length and anterior face height and direction of growth. There was, on average, forward movement of first molars of 2.0-3.0 mm and eruption of 2.0-4.0 mm. No relation was found between forward movement of first molars and their eruption or the amount and direction of facial growth.

Adolescent↗
PubMed1975

A new method for assessment of dental maturity using the individual curve of number of erupted permanent teeth.

A new method for the evaluation of dental age in healthy children, using the curve of the total number of erupted permanent teeth, is presented. The method is based on the observation that the curves of the total number of teeth erupted are parallel and similar in shape in different individuals provided that logarithms are used for both age and number of erupted teeth. The chronological age for a specific reference point on the eruption curve was determined graphically in individual subjects. At this age each child has reached the same degree of dental maturity. A group of 133 healthy boys and 137 girls was examined annually for seven years. The mean age at the reference point of the tooth eruption curve was 8.75 years for the boys and 8.44 years for the girls.

Age Determination by Teeth↗
PubMed1994

Dental abnormalities in the osteopetrotic rat mutation microphthalmia blanc.

Dental manifestations of the mild, transient osteopetrosis in the rat mutation microphthalmia blanc (mib) were examined. Eruption of all teeth was delayed in mib rats compared to normal littermates. The delays ranged from 5 days for incisors to 3 and 2 days for the first and second molars. Normal rats had straight incisors in the sagittal plane that exhibited signs of wear, but in mib littermates the incisors were maloccluded, distorted, and showed no signs of wear. Radiographic and histological examination of the dentition of 1- and 4-week-old rats revealed that the apical end of incisors in mib rats failed to extend posteriorly to the third molar region as in normal siblings, but ended at the first molar. Histological examination of longitudinal sections of mandibles through the incisors of neonatal normal and mib rats showed that in 1-day-old mutants the incisor was closely surrounded by alveolar bone to which it was ankylosed. The incisor body in mib rats was also malformed, with an indented apical end. This ankylosis was temporary, being resolved by 3 days. These findings show that neonatal reductions in bone resorption cause incisor defects and delay the eruption of all teeth in mib rats. The malocclusion and distortion of incisors of mib rats are likely caused by temporary ankylosis of incisor matrices to alveolar bone. Taken together, these findings illustrate the concept that bone resorption is an essential and rate-limiting element of tooth eruption.

Animals↗
PubMed1977

Role of attrition and occlusal contact in the physiology of the rat incisor: XL Kinetics of inner enamel epithelium during severely impeded eruption.

Under conditions of high impediment, the rate of eruption of the rat incisor decreases considerably as does the rate of cell production of the inner enamel epithelium (IEE). The latter is acomplished by a decrease in the size of the proliferative compartment and an increase in the generation time. A linear relation exists between IEE cell production and tooth eruption, and cell production can be estimated from eruption measurements.

Animals↗
PubMed2006

Runx2 and dental development.

The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for the initial commitment of mesenchymal cells to the osteoblastic lineage and also controls the proliferation, differentiation, and maintenance of these cells. Control is complex, with involvement of a multitude of factors, thereby regulating the expression and activity of this gene both temporally and spatially. The use of multiple promoters and alternative splicing of exons further extends its diversity of actions. RUNX2 is also essential for the later stages of tooth formation, is intimately involved in the development of calcified tooth tissue, and exerts an influence on proliferation of the dental lamina. Furthermore, RUNX2 regulates the alveolar remodelling process essential for tooth eruption and may play a role in the maintenance of the periodontal ligament. In this article, the structure of Runx2 is described. The control and function of the gene and its product are discussed, with special reference to developing tooth tissues, in an attempt to elucidate the role of this gene in the development of the teeth and supporting structures.

Ameloblasts↗
PubMed2003

Dental age and dental health determined longitudinally from patient records in three towns in Finland.

The aims of this study were to test the suitability of normal dental records in determining the eruption times of teeth and to compare the retrospective longitudinal DMF values with the statistical cross-sectional means. Patient records for two cohorts (1970 and 1980) were collected from three Finnish towns. The study population comprised 1910 children. The eruption times of the permanent teeth, DMFT and DMFS curves (excluding F due to fractures and M due to orthodontic reasons) were investigated for the year of examination in different study locations. The cross-sectional DMF values were compared to longitudinally calculated data. Tooth eruption was earlier in girls than in boys. However, girls did not have significantly higher DMF values than boys. In all towns, dental health was significantly better in the 1980 cohort than in the 1970 cohort. Comparison of the cross-sectional DMF values in the municipal health center statistics showed that the mean statistics gave considerably higher values than the measured values did after 15 years of age. The inconsistency between measured longitudinal DMF values and the cross-sectional statistical DMF values indicates the importance of creating computer programs for analyzing data longitudinally from normal dental records.

Adolescent↗
PubMed1984

A nonhuman primate model of risk for deviant development.

Delayed development and permanent retardation can result from genetic, prenatal, perinatal, and postnatal factors often acting through complex interactions. For human subjects experimental study of such developmental systems is often impossible due to confounding of variables and ethical considerations. One alternative is to study an animal model. A nonhuman primate model for studying genetic, physiological, and psychosocial processes producing delayed development was described in this paper. The model focuses on parental risk for poor reproductive outcomes using pigtailed monkey (Macaca nemestrina) subjects. In initial experiments subjects were offspring from high- and low-risk breeders who were nursery-reared with no postnatal contact with their parents. Results showed that both maternal and paternal factors are associated with delayed development in systems ranging from tooth eruption to concept learning ability.

Animals↗
PubMed1989

Follicular cysts of mandibular third molar teeth: radiological evaluation of enlargement.

To test the hypothesis that follicular (dentigerous) cyst enlargement arises from impeded tooth eruption, data from standardized Orthopantomographs of 30 uninfected, wholly intracortical cysts associated with mandibular third molar teeth were analysed. Cyst areas were measured with a computer-aided image analyser (Magiscan 2, Joyce Loebl, Gateshead, UK). Two size categories, small and large, each comprising 15 cases, were distinguished. These were correlated with the radiographic variables of cyst relationships to tooth crown, and angulation and nature of impaction of associated tooth. Cyst enlargement is most active in the third and fourth decades of life. Smaller cysts were associated with teeth impacted against adjacent tooth or bone, whereas larger cysts developed predominantly from horizontally angulated teeth intruded endosteally. These findings lend support to the haemodynamic concept of follicular cyst enlargement linked with dysfunctional eruptive forces.

Adult↗
PubMed1993

An immunohistochemical study examining the role of collagen type VI in the rodent periodontal ligament.

The distribution of collagen types I and VI has been examined in the periodontal ligaments of rat incisor and molar teeth using cryosections and immunohistochemical staining procedures. The stain for collagen type I was uniform in all the ligaments examined. Uniform staining for collagen type VI was evident only in the ligament of the fully erupted molars, and the stain was absent from the mid-zone of the ligaments of the erupting molars and incisors. The staining pattern of the collagen type VI antibodies is consistent with previous reports which have suggested that the removal of collagen type VI precedes the degradation of major banded collagen fibrils in remodelling connective tissues. The removal of collagen type VI from the mid-zone of the incisor ligament may precede the remodelling events which facilitate tooth eruption.

Animals↗
PubMed1998

In vivo effect of interleukin-1 alpha on colony-stimulating factor-1 gene expression in the dental follicle of the rat molar.

Interleukin-1 alpha (IL-1 alpha) acts in vitro to enhance the gene expression of colony-stimulating factor-1 (CSF-1) of dental follicle cells. Because the dental follicle is required for tooth eruption and because CSF-1 appears to be a key molecule in initiating eruption, it was the aim of this study to determine if IL-1 alpha could enhance the expression of the CSF-1 gene in the dental follicle in vivo. To determine this, rats were injected with IL-1 alpha at different ages postnatally and the total RNA was isolated from the dental follicles of the first mandibular molars. Reverse transcription-polymerase chain reaction showed that IL-1 alpha enhanced the expression of CSF-1 in the follicle. Thus, IL-1 alpha may play a part in the cascade of molecular signals that initiate eruption by its effect upon the CSF-1 gene.

Animals↗