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At least 721 records · Page 40Linked to original sources
PubMed1989

Sclerosing stromal tumor of the ovary. Immunohistochemical and electron-microscopic demonstration of smooth-muscle differentiation.

Two cases of sclerosing stromal tumor of the ovary (SST) are described. Immunohistochemical analysis of SSTs was performed using formalin-fixed and paraffin-embedded materials in comparison with thecofibromas and normal ovaries. The existence of desmin- and smooth-muscle actin-positive isolated spindle cells in SSTs and also in cortical stroma of the normal ovary was characteristically demonstrated, whereas such smooth-muscle-like cells were absent from six thecofibromas. Immunohistochemistry of desmin and smooth-muscle actin is useful in distinguishing SST from thecofibroma. Ultrastructural study further evidenced the presence of smooth-muscle-like cells in SSTs. In addition, we histochemically demonstrated heterogeneous cellular components in SSTs, including fibroblastic, thecalike, smooth muscle and endothelial cells. Hence, it is suggested that SST is derived from pluripotent immature stromal cells of the ovarian cortex.

Actins↗
PubMed1989

Thecal metaplasia in the adrenal gland of a man with acquired bilateral testicular atrophy.

Thecal metaplasia of the adrenal was observed as an incidental autopsy finding in a 77-year-old man with acquired bilateral testicular atrophy, probably secondary to previous bilateral inguinal herniorrhaphy. The metaplastic focus was composed of interlacing bundles of spindle cells attached to the adrenal capsule, strongly resembling ovarian theca. A related finding was hyperplasia of the anterior pituitary, involving particularly the basophils. We believe that the acquired gonadal failure of this man may have led to increased activity of the pituitary gonadotropes. Blastema cells outside of the testes with the ability to form gonadal stroma, such as cells of the adrenal capsule, were thereby stimulated to undergo metaplasia, giving rise to ovarian theca. Similar thecal metaplasia has been described previously in the adrenals of postmenopausal women. Whether the metaplastic foci are capable of hormone production is not known. Since this patient had an occult prostatic carcinoma at autopsy, potential hormone production by such metaplastic gonadal stroma is clinically relevant.

Adrenal Cortex↗
PubMed1989

Hilus cell tumor of the ovary. A clinicopathological analysis of 12 Reinke crystal-positive and nine crystal-negative cases.

The clinical and pathological features of 12 Reinke crystal-positive and nine probable (crystal-negative) hilus cell tumors of the ovary were reviewed. The patients' ages ranged from 32 to 82 years. The initial manifestation was androgenic in 62% of the cases. The levels of testosterone were high (200-2,400 ng/dl) even though the tumors had a mean diameter of only 2.1 cm. All the tumors were centered in the hilus of the ovary, extending for varying distances into the ovarian stroma. They were composed of polyhedral to rounded cells with generally abundant eosinophilic cytoplasm and often showed a perivascular aggregation of nuclei with avascular pooling of cytoplasm or hyalinization of stroma. Fibrinoid changes in the vessels of the tumors were frequently noted. None of the 10 patients for whom follow-up data of 1-17 years were available died of tumor; virilizing symptoms regressed but did not completely disappear in five of the 10 patients after the removal of the tumor.

Adult↗
PubMed1987

Recurrent androgenicity in pregnancy: a case report and literature review.

A case of recurrent androgenicity associated with pregnancy is described. The patient is a 32-year-old black woman with hirsutism and irregular menses who developed elevated androgen levels in the male range during a pregnancy, with remission after delivery. A recurrence of the elevated androgen levels was noted during a subsequent pregnancy, again with remission after a termination. We have analyzed the possible etiologic mechanisms underlying this condition and reviewed the literature of similar cases.

Adult↗
PubMed1987

[The hormonal state of pregnancy: modification of cortisol and testosterone].

The pattern of cortisol and testosterone levels during the normal pregnancy was investigated by measuring these hormones in the same 19 healthy pregnant women at 11th to 19th, 24th to 29th and 34th to 39th week post amenorrhea. We noted the well-known increase in total plasma cortisol and testosterone, due to the elevated concentration of their transport protein, i.e., Corticosteroid Binding Globulin (CBG) and Testosterone Estradiol Binding Globulin (TeBG), consecutive to the increase in plasma oestrogens. Morning (8h) and evening salivary cortisol (20 h) values, which are a good reflect of free plasma cortisol, were found increased since the second trimester of pregnancy, with a conserved circadian cycle. 24 h urinary free cortisol was slightly increased since the first trimester, yet remaining within the normal range; in the late pregnancy it reached sometimes higher levels. "Vesperal" urinary cortisol measured on a collected urine sample between 20 h and 24 h was higher in pregnant women since the beginning of pregnancy as compared to that of non pregnant women. Levels of salivary free testosterone measured in a few patients appeared similar to that of non-pregnant controls. We also report the data obtained in two pregnant women with Cushing's syndrome due to an adrenocortical carcinoma which showed a strong elevation of urinary and salivary free cortisol while a pregnant woman with a luteoma had a lower level as compared to normal pregnant. Moreover these three patients had a marked increase in free salivary testosterone opposite to normal pregnant women.

Adenoma↗
PubMed1987

Mouse ovarian tumors--a review including classification and induction of neoplastic lesions and description of several previously unreported types.

The purpose of this study is to review the pertinent literature on the incidence, methods of induction and pathogenesis of ovarian tumors of mice. Strains of mice with a high incidence of spontaneously occurring granulosa cell tumors (gct) and tubular adenomas (ta) are the C3HeB/Fe and C3HeB/De; strain HAN:NMRI developed Sertoli cell tumors and (DBA x Ce)F1 hybrids had a high incidence gct. Ninety-five percent of hybrid (C57BL/6J x C3H/HeJ)F1 WxWv mice which lack germ cells develop complex tubular adenomas. Strain LT, in which a high percentage of ovarian ova develop parthenogenetically, develops has a high incidence of teratomas. The use of hormones, castration and transplantation of the ovaries in a number of inbred strains results in a high incidence of ovarian tumors; in strain Maf/Sp gct and luteomas were induced in 82%. Irradiation with gamma rays produced a similar incidence of ovarian tumors in (C57L x A)F1 hybrids. The chemical inducing the highest incidence (92%) of ovarian tumors of mice is 9,10 Dimethyl 1,2 benzanthracene (DMBA). Recently, 4-Vinylcyclohexene was shown to induce a high incidence of ovarian tumors. A number of rare ovarian tumors were reported. Described are five androblastomas composed of either Leydig or Sertoli cells or a combination of the two cell types and a single undifferentiated androblastoma. Seven teratomas were described, three of which contained large amounts of neural tissue; another was classified as a teratoma with a parieto-visceral yolk-sac carcinoma component.

Adenoma↗
PubMed1987

Bilateral ovarian thecosis and virilization in pregnancy. A case report.

Virilization is usually associated with amenorrhea, infertility and ovarian stromal lesions. Paradoxically, however, it may also be seen in pregnancy; this type of virilization is rare and accompanies ovarian thecosis. Thecosis, also known as thecomatosis and stromal thecosis, is a complex assortment of types of ovarian stromal proliferation associated with various types and amounts of hormonal activity. A patient had progressive virilization that began about seven years after menarche. Nonetheless, she had six pregnancies and bore five normal living children. Her last child, a female, was not affected by the high maternal testosterone levels. The patient's virilization was associated with an ovarian stromal hyperplasia classified as combined thecosis. In this case, as in some others, there was reason to suspect a genetic basis for such progressive virilization with retained fertility; an analysis of it provides insight into the complex nature of ovarian stromal hyperplasia and hormonal activity.

Adult↗
PubMed1988

[Differential diagnosis of malignant forms of hormonally-active tumors of the ovary].

Case histories of 427 patients with main histotypes of hormone-producing tumors of the ovaries (201--theca-cell, 177--granulosa-cell, 28--mixed theca-granulosa-cell and 21--virilizing) were analyzed. The problem of differential diagnosis of malignant forms of these tumors by methods of clinical examination was studied. Major statistically significant clinical signs of malignancy of hormone-producing tumors of the ovaries--extension of abdomen and abdominal pain, relatively short duration of case history, bilateral lesions, large size of sessile tuberculous tumors, high level of ascites, especially hemorrhagic one, and comparatively young age of patients--were established.

Adenoma↗
PubMed1988

Sclerosing stromal tumour of the ovary. Ultrastructural study.

Two typical cases of sclerosing stromal tumours of the ovary are studied ultrastructurally, and the findings are correlated with the clinical data. One of the cases, with predominantly fibroblastic morphology, was asymptomatic. The second case, rich in cells with steroid-secreting features, had polymenorrhoea disappearing after removal of the tumour. The Authors suggest that clinical symptoms of sclerosing stromal tumour of the ovary depend from the degree of differentiation reached by the tumour cells.

Adult↗
PubMed1985

[Treatment results of patients with granulosa and theca cell tumors and their mixed forms].

Clinical and pathological dates of 28 patients with granulosa- and thecacelltumors and mixed granulosatheca tumors were analysed. The present therapeutical possibilities, clinical courses and the survival rate (63.6%) are described. The treatment of granulosa tumors and mixed granulosathecatumors first of all consists in hysterectomy with salpingo-oophorectomy with following irradiation. Conservative surgical therapy is only practised on young women wanting a baby later on. The connection of hormonal active ovarian tumors and the various alterations of endometrium is pointed out. An endometrial carcinoma was diagnosed only in one case.

Castration↗
PubMed1985

[Luteinized cystic hyperplasia of the ovaries in normal pregnancy. Diagnostic and nosological problems].

The authors report a new case of luteinized hyperplastic cystic ovary in a pregnancy that was in every other respect normal. This syndrome of ovarian hyperstimulation is most often found in patients suffering from trophoblastic diseases or following iatrogenic accidents. It is exceptionally rare in a non-molar pregnancy. The comparison with the other form of ovarian hyperactivity that gives rise to a luteoma of pregnancy emphasizes the questions that have to be answered of the hormonal mechanism leading to maternal and fetal virilisation that complicate these two pseudo-tumours and how they are handed on from one generation to the other, and what the mechanisms is of placental HCG in this abnormal condition.

Adult↗
PubMed1985

[Patterns in the metastasis of malignant ovarian tumors based on autopsy data].

The results of post-mortem examination of 532 cases of ovarian malignancies are presented. A certain pattern of metastatic spread was established. Tumors most frequently disseminated into the parietal and visceral peritoneum (93.9%), greater omentum (73.6), lymph nodes (48.2), pleura (31.5) and liver (25.4%). Implantation was shown to be the most common mode of spread. Lymphogenous and hematogenous metastases were of low clinical significance since they did not develop so fast as implantation metastases did which advanced rapidly and determined the clinical course.

Carcinoma↗