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Burn and scald injuries.

Burns are one of the most harmful physical and psychological traumas. Infection is the major cause of morbidity and mortality in burns. Infections acquired from hospital or from the patient's own endogenous flora have a significant prevalence after burns. Pseudomonas aeruginosa and Staphylococcus aureus are the most frequent colonizing agents whereas group A beta-haemolytic streptococci are the most virulent bacteria. Anaerobic bacteria and fungi are also prevalent. Viral infection is less frequent. Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients.

Anti-Infective Agents, Local↗
PubMed1990

[A rat model for the study of Pseudomonas aeruginosa enterogenous infection after severe scald].

Eighty eight healthy Wistar rats were used in this study. Pseudomonas aeruginosa (serotype IX, labelled with fluorescein isothiocyanate) were fed in suspension (10(9)/ml, 1ml/100g body weight) following a 25-28% full-thickness burn created on the back of animals. The animals were sacrificed at eight different time phases from 1-72 hours after burns. The labelled bacteria were traced in internal organs, the quantitative bacterial cultures of visceral tissues and blood cultures were performed coincidently. The results showed that the labelled bacteria introduced into GI tract could be demonstrated from the internal organs and blood circulation.

Animals↗