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Results for “Retinal Vasculitis”

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At least 721 records · Page 40Linked to original sources
PubMed1985

Fluorescein angiography in inflammation of the peripheral fundus: involvement of the choroid and retina. II.

Fluorescein angiographies were performed in 65 patients with peripheral uveitis. 34 subjects (52%) showed pathologic dye transit of the peripheral choroid. Fluorographic evidence of retinal involvement was high (91%), preferentially consisting in leakages from capillaries and venules. Fluorescein angiography was able to detect minute lesions and corresponded with the activity of the inflammation.

Choroiditis↗
PubMed1999

Atypical Wegener's granulomatosis with positive cytoplasmic antineutrophil cytoplasmic antibodies, ophthalmologic manifestations, and slowly progressive renal failure without respiratory tract involvement.

A 68-year-old woman had microscopic hematuria and proteinuria since the age of 50. She also had hearing impairment, arthralgia, retinal embolism, peripheral arterial occlusion of the right foot and chronic renal failure during the course. At the age of 68, she had progressive renal failure and nephrotic syndrome with high titers of serum cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA). No evidence of respiratory tract involvement was found. Methylprednisolone pulse therapy and low dose cyclophosphamide therapy ameliorated the renal failure and reduced the serum c-ANCA level. She, however, died on July 19, 1998 due to pulmonary fungal and pneumocystis carinii infection.

Aged↗
PubMed1989

Biochemical analysis of serum proteins from Eales' patients.

In the present study attempt has been made to identify the possible factor(s) which are responsible for Eales' disease. The serum of Eales' patients and that of age and sex matched healthy controls did not differ in their total protein concentration. Sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) analysis did not reveal any difference between the two groups. However, analysis of the serum samples with isoelectric focusing showed the presence of two unique proteins with pI of 5.5 and 5.9 in Eales' patients. Further two dimensional SDS-PAGE analysis indicated the presence of a distinct protein spot with a pI of 5.9 and a molecular weight around 23 KD in the serum of Eales' patients. This 23 KD protein has been partially purified and found to be anionic in nature. Antisera to this partially purified protein have been raised and tested. The implication of this finding is discussed in relation to the aetiology of Eales' disease.

Adult↗
PubMed1991

Idiotypic characterisation of monoclonal antibodies with restricted epitope specificity for retinal S-antigen.

This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-related anti-idiotypes prepared against each of the monoclonal antibodies recognised common idiotypes only amongst those monoclonal antibodies which reacted with the same epitope on S-antigen. Two of the three idiotypes were detected in the sera of BALB/c mice but not in two strains of rat immunised with xenogeneic S-antigen and none could be detected in the sera of patients with anti-photoreceptor autoantibodies. Our results demonstrate that the idiotypes of murine monoclonal antibodies to retinal S-antigen exhibit restricted epitope specificity but are species-restricted and imply that the S-antigen lacks a dominant antigenic epitope.

Antibodies, Monoclonal↗
PubMed2000

[Birdshot retinochoroidopathy].

Birdshot retinochoriodopathy is a bilateral posterior uveitis seen in adults over 45 years of age. The uveitis is associated with moderate vitreal inflammation, vasculides of large vessels, chronic papillitis and the yellow birdshot spots typical of the disease. The disease shows tight linkages with HLA A29 carried by more than 90% of the patients. The visual prognosis depends on the development of complications of the chronic ocular inflammation, particularly crystoid macular edema. These complications lead to lowered visual acuity which becomes a major handicap. Long-term local or general corticosteroid therapy is required and leads to cortico-dependence. An immunosuppressor (cyclosporinA) may be associated. As these treatments cause major morbidity, intravenous immunoglobulins offer a less toxic therapeutic approach. Intravenous immunoglobulins can reduce inflammatory phenomena, providing an interesting alternative for the treatment of birdshot retinochoroidopathy.

Adrenal Cortex Hormones↗
PubMed1975

Subretinal cysticercosis.

Subretinal cysticercosis was discovered in two South African Bantu-speaking blacks. A 50-year-old man had a live, mobile, subretinal cyst, 0.3 mm in diameter, at the macular of his only eye, causing retinal edema and superficial and deep hemorrhage. A 25-year-old woman had a 6-mm wide, live, mobile cyst at the posterior pole of her right eye, surrounded by retinal edema, hemorrhage, and vasculitis involving the disk. This cyst was removed intact, after division of the lateral rectus muscle and maximum rotation of the eye. Massive vitreous hemorrhage occurred despite diathermy application, and vision was lost. Localization and incision of the sclera were difficult; in retrospect, a lateral orbitotomy would have been advisable. Histology of the cyst showed typical features of the larva of Taenia solium-a single scolex with suckers and hooks-gland-shaped folds in the neck and membrane of the cyst wall.

Adult↗
PubMed2002

Eales' disease with neurological manifestations.

Eales' disease is a primary retinal perivasculitis of an undetermined etiology seen predominantly in the Indian subcontinent. However, neurological involvement is rare. We report here a patient of retinal perivasculitis with neurological dysfunction. Our patient is a 39 years male who developed acute diminished vision right eye in March 99, which progressed for four days and remained static. In April 99 he developed acute diminished vision left eye, which progressed to near total blindness in 48 hours. He was undergoing ophthalmic evaluation. Fourty five days later he developed incoordination and weakness left half of body. The examination revealed bilateral retinal perivasculitis with pyramidal signs and left sided cerebellar signs. Investigations revealed an ESR of 40 mm at the end of first hour. His CT head revealed bilateral basal ganglionic infarcts. MRI head revealed enhancing lesions both basal ganglia and right parietal region. Cerebrospinal fluid examination showed xanthochromic fluid with markedly elevated protein and lymphocytic pleocytosis. His workup for connective tissue disorders was negative. He was put on ATT with steroids. Eales' disease is presumed allergy to tuberculoprotein. A trial of ATT with steroids has been tried with varying results. Our patient had bilateral retinal perivasculitis and neurological dysfunction. He had lymphocytic pleocytosis with markedly elevated protein in the CSF.

Adult↗
PubMed2003

Frosted branch angiitis in two Chinese young girls.

We examined 2 relatively healthy young girls who presented with acute red eyes and blurred vision. Each patient developed thick, inflammatory infiltrates surrounding the retinal vessels creating the appearance of frosted tree branches in both eyes. Marked inflammatory reactions with cells and flare were noted in anterior chambers. One patient even had hypopyon in both eyes. Initial visual acuity ranged from 6/6.7 to 6/60. Both patients showed rapid improvement with systemic and/or topical corticosteroid therapy, and all of the affected eyes regained a visual acuity of 6/6. The clinical appearances and courses of these two patients matched the condition previously described in Japan and labeled frosted branch angiitis. Before this article, there was only one case reported in Taiwan.

Adrenal Cortex Hormones↗
PubMed1992

A case of frosted-branch retinal angiitis in a child.

We report the case of a patient with frosted-branch angiitis of the retina in a 3-year-old girl. She had acute visual disturbances OU, and we observed iritis, retinal edema, and retinal angiitis. Retinal angiitis showed the same condition as previously described, the so-called acute frosted retinal periphlebitis accompanied with vascular sheathing. Her eyes improved rapidly after administration of an oral corticosteroid, and during the ensuing four months, she had no recurrences.

Child, Preschool↗
PubMed1989

Behçet's disease.

Explore the source record for details and available documents.

Behcet Syndrome↗
PubMed1989

Immunological status of patients of Eales' disease.

To test the hypothesis that altered immune reactivity to an extraneous agent might lead to primary retinal perivasculitis, a study was undertaken to determine the serum immunoglobulin levels, T lymphocyte subsets, antibody responses to BCG and 'S' antigen, and lymphoproliferative response to mitogens. No difference was observed in these parameters between patients and controls. Both Mantoux positive and negative conditions existed in patients with Eales' disease. Mantoux positive patients showed a higher level of lymphoproliferative response in vitro to PPD than Mantoux positive controls, indicating the presence of two populations among Eales' patients.

Adolescent↗
PubMed1988

Acute frosted retinal periphlebitis.

We examined three previously healthy young patients who suffered acute visual loss associated with diffuse bilateral retinal periphlebitis. Each patient developed thick, inflammatory infiltrates surrounding all of the retinal veins, creating the appearance of frosted tree branches. Initial visual acuities ranged from 20/20 to hand motions (median, counting fingers). All patients showed rapid improvement after starting oral corticosteroid therapy, and all but one of the six affected eyes regained a visual acuity of 20/20. The clinical appearance and course of these patients matched those of a condition previously described in Japan and labeled frosted branch angiitis. The term "acute frosted retinal periphlebitis" seems to describe more accurately the clinical findings.

Acute Disease↗
PubMed1985

[Ocular cysticercosis. Apropos of a clinical case of presumed ocular cysticercosis].

The study of a case of ocular cysticercosis and its angiographic analysis enables the authors to formulate some hypothesis regarding the pathogenesis of the retinal lesions. In particular the presence of a bilateral gravitational retinal epitheliopathy contrasting with the unilateral localisation of the parasite, associated to vascular alterations, suggests that the presence of the cysticercus at subretinal level may trigger an autoimmune process mainly directed against the photoreceptors. A similar process to the one experimentally observed in monkeys after S retinal antigen immunisation can be imagined.

Antigens↗