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[Sudden deafness--on the age dependence of therapy results with reference to naftidrofuryl (Dusodril)].

The results of treatment of 100 patients with sudden sensorineural hearing loss were analysed in three age groups (under 30, 30-60, over 60 years). The basic therapy consisted of Dextran, Diazepam and Vitamins. One half of the patients in each age group was treated with Naftidrofuryl (Dusodril) too. Sudden hearing loss was more profound in the elderly patients than in the younger ones, and the hearing gain (%) decreased with increasing age. The absolute (dB) hearing gain was more or less independent of age and Dusodril, and for all patients averaged 21 dB. Only the hearing gain (%) of the 30-60 year old patients treated with Dusodril was significantly greater than that of the control group treated without Dusodril.

Adult↗

[Responses of auditory neurons of the medulla oblongata of the frog to presentation of tones with sinusoidal amplitude modulation].

The responses of single units in the medullary auditory regions of the frog Rana ridibunda to sinusoidally amplitude-modulated tones of characteristic frequencies were studied. The reproduction of the sound modulation in the discharge frequency of the units was determined from cycle histograms of the discharges locked to the modulation period. In dorsal nucleus units the amplitude modulation was preserved in the discharge modulation over a wide modulation frequency and sound intensity ranges. In many superior olivary neurons an enhancement of small amplitude changes within the range of modulation frequencies 70-150 Hz was observed. The reaction phase was linear-dependent on the modulation frequency. The best enhancement of amplitude changes took place for small modulation indices.

Animals↗

Handedness and dichotic listening to nonverbal features of speech.

The assumption that pitch and loudness are processed in the right hemisphere was tested by comparing left-handers' with right-handers' performance on pitch and loudness discrimination tasks. Four groups of left-handers (20 subjects in each group) were dichotically presented either with digits varying in pitch or loudness or with pure tones varying in pitch. The subjects identified the digits, or the pitch and loudness variations, from both ears. Confirming the assumption, the data showed that the left-handers, who had no ear preference on any of these tasks, differed significantly from the right-handers, who, preferring the right ear for digit identification, preferred the left ear for the discrimination of the nonverbal features (pitch and loudness) of these digits.

Functional Laterality↗

The perception of lexical tone in Mambila.

The issue of the perception of lexical tone has been addressed mainly through studies of Southeast Asian languages which feature phonological contour tones as well as level tones. Little attention has been paid to African languages which have, almost exclusively, only level tones. This paper examines tone perception in Mambila, a Benue-Congo language with four level lexical tones. A categorization experiment was run to determine some of the salient aspects of the perceptual nature of these tones. Since the four tones are well defined with respect to production, we sought to determine whether this characteristic carried over into perception, the expectation being that experimental stimuli, on the basis of pitch height alone, would fall into four reasonably well defined categories. Results showed interesting differences across the four tones, with indications that the two Mid tones, T2 and T3, are perceptually different than the High (T1) and Low (T4) tones. The experiment was run a second time, using a group of native English listeners, to assess to what extent results for the Mambila listeners were determined by the perceptual structure of the Mambila tone system. A Signal Detection analysis was used, which revealed important differences between the two groups of listeners. Results are discussed in light of what is known about universal tendencies of tone systems and the historical development of the Mambila system.

Adult↗

Effects of short-term endotracheal intubation on vocal function.

Transient voice change associated with endotracheal intubation has generally been attributed to vocal fold trauma. To assess the role of altered vocal fold function in transient voice change, a study was designed to evaluate the audioacoustic, endoscopic, and laryngostroboscopic characteristics of the postintubation voice. Vocal function of 10 patients undergoing short-term outpatient surgical procedures using general anesthesia and endotracheal intubation were studied preoperatively and postoperatively. A second group of 10 patients that did not have surgery or general anesthesia was used as an age-matched control. Fundamental frequency, frequency perturbation, electroglottography, endoscopy (including laryngeal stroboscopy), and subjective speech analysis by experienced listeners were used to assess vocal function. No consistent differences in fundamental frequency were observed, although patient-to-patient variation was marked. Statistically significant increases in cycle-to-cycle fundamental frequency variation (jitter) were found postoperatively in the majority of the postintubation patients (P less than 0.05). Electroglottography, laryngeal endoscopy, and stroboscopic laryngoscopy did not demonstrate consistent changes in glottic mucosal function. Listener judgments characterized the postintubation voice change by decreased intensity, increased roughness, and lowered affect without consistent changes in pitch. The perception of decreased affect in the voices (characterized by reduction in pitch variation, vocal stress, and increases in pause times) was a strong perceptual marker for change in the post-intubation voice. Objective measures of laryngeal function suggest that the glottic contribution to postintubation voice change is minimal and that this dysphonia is probably multifactorial.

Adolescent↗

Pitch ranking ability of cochlear implant recipients: a comparison of sound-processing strategies.

Pitch ranking of sung vowel stimuli, separated in fundamental frequency (F0) by half an octave, was measured with a group of eleven Nucleus 24 cochlear implant recipients using different sound coding strategies. In three consecutive studies, either two or three different sound coding strategies were compared to the Advanced Combinational Encoder (ACE) strategy. These strategies included Continuous Interleaved Sampling (CIS), Peak Derived Timing (PDT), Modulation Depth Enhancement (MDE), F0 Synchronized ACE (FOSync), and Multi-channel Envelope Modulation (MEM), the last four being experimental strategies. While pitch ranking results on average were poor compared to those expected for most normal hearing listeners, significantly higher scores were obtained using the MEM, MDE, and FOSync strategies compared to ACE. These strategies enhanced coding of temporal F0 cues by providing deeper modulation cues to F0 coincidentally in time across all activated electrodes. In the final study, speech recognition tests were also conducted using ACE, CIS, MDE, and MEM. Similar results among all strategies were obtained for word tests in quiet and between ACE and MEM for sentence tests in noise. These findings demonstrate that strategies such as MEM may aid perception of pitch and still adequately code segmental speech features as per existing coding strategies.

Acoustic Stimulation↗

Asymmetric performances in monaural localization of sound in space.

Ten subjects localized a 3.5-kHz high-pass noise originating in the median sagittal plane (MSP)--a plane along which location judgments are highly dependent on spectral cues. Three different experimental conditions were established: (1) binaural listening, (2) monaural listening with the left ear, and (3) monaural listening with the right ear. All subjects performed best when listening binaurally. In comparison with the right ear, location judgments of source elevation was significantly more accurate when listening with the left ear (P = 0.048). Also, perceived displacement from midline, a common occurrence when listening monaurally, was less when localizing with the left ear (P = 0.059). These data, in conjunction with the animal literature demonstrating that auditory cortex contralateral to the ear stimulated is essential for accurate localization, suggest that the right hemisphere is better in processing complex spectral information.

Acoustic Stimulation↗

Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of threshold tuning curves.

Tuning curves were obtained from 100 to 150 auditory-nerve fibers spanning the range of characteristic frequencies (CFs) in each of eight cases of permanent noise-induced and three cases of permanent kanamycin-induced threshold shift. In each ear, from one to six neurons were intracellularly labeled with horseradish peroxidase. Locating the labeled terminals in plastic-embedded surface preparations of the cochlea enabled us to accurately correlate particular tuning-curve abnormalities with the condition of the sensory cells generating them. The correlations between structural and functional changes suggest that a normal tuning-curve tip requires that the stereocilia on both the IHCs and OHCs (especially those from the first row) be normal. Selective damage to the OHCs is associated with elevation of the tips and hypersensitivity of the tuning-curve tails. This tuning-curve pattern also originates from cochlear regions at the basal border of hair cell lesions where the local hair cells (and their stereocilia) appear completely normal at the light-microscopic level. Total destruction of the OHCs in a region in which the IHCs appear normal (as can happen in cases of kanamycin poisoning) is associated with bowl-shaped tuning curves which appear to lack a tip. Combined damage to the IHCs and OHCs (as typically happens in cases of acoustic trauma) is invariably associated with elevation of both tips and tails on the tuning curve. A framework for the interpretation of the results is suggested in which the activity of the OHCs is transmitted via the tectorial membrane to the tall row of stereocilia on the IHCs.

Animals↗

The four factors leading to binaural masking-level differences.

A simple extension of the Webster-Jeffress model is presented together with its predictions for the effects of various stimulus parameters on the size of binaural masking-level differences (BMLDs). The four factors leading to BMLDs (just-noticeable differences (JNDs), temporal effects in simultaneous masking, binaural interaction, and temporal effects in non-simultaneous masking) are described, new measurements of the effect of signal duration on the detectability of interaural delay are presented, and the high degree of correlation between observers' sensitivity to changes in level and their sensitivity to changes in interaural delay is demonstrated. A number of examples illustrating where knowledge of JNDs for level and interaural delay and their joint dependence on certain stimulus parameters are sufficient to predict BMLDs are discussed.

Auditory Perception↗

Neurons in the cat's primary auditory cortex distinguished by their responses to tones and wide-spectrum noise.

In the cortex of barbiturate-anesthetized cats, area AI was identified by its tonotopic organization, and single neurons in that field were examined with regard to the shapes of their spike count-versus-intensity functions, the organization of their frequency-intensity response areas, and their responses to wide-spectrum noise, using calibrated sealed stimulating systems. Neurons whose pure tone rate intensity functions were monotonic in shape displayed V-shaped response areas that were open-ended at high tone intensities. In contrast, cells displaying nonmonotonic tone intensity functions tended to have circumscribed response areas; these cells were responsive to tones over limited ranges of both frequency and intensity. Monotonic neurons almost always responded to wide-spectrum noise stimuli, while nonmonotonic neurons often did not. The mean minimum latent period of monotonic cells (14.0 ms) was significantly shorter than that for nonmonotonic neurons (19.1 ms). For those cells that responded to both tones and noise, minimum latent periods for the two stimuli were similar or identical. Monotonic neurons tended to be horizontally segregated from nonmonotonic neurons across AI's middle cortical layers. The implications of these data for the nature of some neural mechanisms underlying the stimulus selectivity of cortical cells are discussed.

Anesthesia, General↗

Are we "experienced listeners"? A review of the musical capacities that do not depend on formal musical training.

The present paper reviews a set of studies designed to investigate different aspects of the capacity for processing Western music. This includes perceiving the relationships between a theme and its variations, perceiving musical tensions and relaxations, generating musical expectancies, integrating local structures in large-scale structures, learning new compositional systems and responding to music in an emotional (affective) way. The main focus of these studies was to evaluate the influence of intensive musical training on these capacities. The overall set of data highlights that some musical capacities are acquired through exposure to music without the help of explicit training. These capacities reach such a degree of sophistication that they enable untrained listeners to respond to music as "musically experienced listeners" do.

Auditory Perception↗

Auditory motion perception activates visual motion areas in early blind subjects.

We have previously shown that some visual motion areas can be specifically recruited by auditory motion processing in blindfolded sighted subjects [Poirier, C., Collignon, O., De Volder, A.G., Renier, L., Vanlierde, A., Tranduy, D., Scheiber, C., 2005. Specific activation of V5 brain area by auditory motion processing: an fMRI study. Brain Res. Cogn. Brain Res. 25, 650-658]. The present fMRI study investigated whether auditory motion processing may recruit the same brain areas in early blind subjects. The task consisted of simultaneously determining both the nature of a sound stimulus (pure tone or complex sound) and the presence or absence of its movement. When a movement was present, blind subjects had to identify its direction. Auditory motion processing, as compared to static sound processing, activated the brain network of auditory and visual motion processing classically observed in sighted subjects. Accordingly, brain areas previously considered as specific to visual motion processing could be specifically recruited in blind people by motion stimuli presented through the auditory modality. This indicates that the occipital cortex of blind people could be organized in a modular way, as in sighted people. The similarity of these results with those we previously observed in sighted subjects suggests that occipital recruitment in blind people could be mediated by the same anatomical connections as in sighted subjects.

Adolescent↗