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At least 721 records · Page 40Linked to original sources
PubMed1993

Changes in the peritoneum during the development of the testis, epididymis and ductus deferens in the pig.

The development of the peritoneal folds of the testis, epididymis and ductus deferens of the pig prior to testicular descent was studied in 18 to 82 days-old embryos/fetuses. The parietal attachment of the mesonephros, mesonephric and paramesonephric ducts and gubernaculum constituted the urogenital mesentery. This could be divided in a cranial and a caudal part. The first fixed the mesonephros and had a mesogonad as a secondary fold. The second had two branches, one laterally to the umbilical artery belonging to the gubernaculum (Plica gubernacularis) and the medial to the artery contained the meso- and paramesonephric ducts. The mesogonad was related caudally with Plica gubernacularis. The fold of the meso- and paramesonephric ducts could also be divided in two parts. The caudal was a primary component of the urogenital mesentery, while the cranial was first ventral and later lateral to the mesogonad (mesorchium) and appeared as a secondary fold of the urogenital mesentery (cranial part). A vascular fold contributed to separate the suspensory ligament of the testis from the developing mesorchium. The proposed meaning of the terms used might be useful for comparative studies.

Animals↗
PubMed2004

Morphologic changes of peritoneum and expression of VEGF in encapsulated peritoneal sclerosis rat models.

BACKGROUND: Simple sclerosis consisted of a thin layer of submesothelial sclerotic tissue in peritoneal dialysis patients. Encapsulated peritoneal sclerosis (EPS) was characterized by thick sclerotic tissue involving vascular alterations in peritoneal dialysis patients. The objective of the present study is to evaluate serial morphologic changes and expressions of angiogenic factors [i.e., vascular endothelial growth factor (VEGF), angiopietin-1 (Ang-1), and angiopoietin-2 (Ang-2)] in EPS rat models. METHODS: Twenty-four rats were given a daily intraperitoneal injection of chlorhexidine gluconate and ethanol dissolved in saline (CH). Nine rats were injected with CH and anti-VEGF neutralizing antibody simultaneously. Quantitative blood vessel evaluation was performed by staining for GS1-lectin. The mRNA expression of VEGF, Ang-1, Ang-2, and their receptors was evaluated by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining was performed in peritoneal vessels using anti-VEGF, Ang-1, and Ang-2 antibodies. Hematopoietic stem cells were detected using anti-CD34 antibody. RESULTS: The vessel area, diameter, and length gradually increased until day 21, and then decreased. VEGF and Ang-2 mRNA expressions gradually increased until day 35. In contrast, Ang-1 peaked at day 21 and then decreased significantly. VEGF blockade improved the experimental EPS. In immunohistochemistry, the vessels stained by VEGF and Ang-2 were detected in subfibrous layer. CD34-positive cells were markedly stained at day 21. CONCLUSION: Neoangiogenesis was observed in a rat model of experimental EPS. VEGF and angiopoietin/Tie system play an important role in the neoangiogenesis in this model. An analysis using this experimental rat model may elucidate the development of EPS in peritoneal dialysis patients.

Angiopoietin-1↗
PubMed1985

Penetration of sulbactam-ampicillin and clavulanic acid-amoxicillin into the pelvic peritoneum.

Sixteen patients were given single intravenous injections of ampicillin (0.5 g) with sulbactam (0.5 g), and 15 patients were given amoxicillin (1 g) with clavulanic acid (0.2 g) before elective laparoscopy. At 2 h after dosing, the concentrations of the four compounds in serum and in the peritoneal fluid from the Pouch of Douglas and the ratio of each combination reached levels shown to be effective for antimicrobial activity in vitro.

Adult↗