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[Consciousness functions in psychoses. Concepts, empirism and hypotheses].

Schizophrenia may be described as a disease where speech, bodily language and social responsiveness are obvious expressions of a deteriorated ability to interact with the surroundings in a precise and relevant way. The lack of precision and relevance pertains to perception and recall as well as communication and action. The deficient potential for activation of the prefrontal cerebral cortex is a neurobiological correlate to the lesion of precise and relevant planning and expression. Impairment of formal thought and language in schizophrenia are suggested to result from a developmental disorder pertaining to language and concept formation (apperception). In reactive psychoses with dissociative disturbances of consciousness there is an inefficient capacity for adapting to external reality; thus relevant conscious planning and interaction with the outside world are impaired. Clinically a distractibility of a tematic nature ensues. Except for catastrophic events, psychotic reactions cannot be predicted from analysis of the actual experience--neither concerning the external nor the internal aspects of conscious awareness. Sometimes, however, previous events relating to the formation of the self may add explanatory value to the analysis of reactive psychosis. In some cases biological predisposition is the decisive determinant. The normal discrimination between sense-perception and imagination has a counterpart in the dichotomy of awareness of the outside world versus awareness of the self. The following are examples of psychotic experience where the normal ability for dichotomic discrimination may be damaged: Illusions of affect, hallucinations, Schneider's first rank symptoms, "Anwesenheit" and consciousness of time.(ABSTRACT TRUNCATED AT 250 WORDS)

Consciousness↗

Electroconvulsive therapy in patients with late-onset psychoses and structural brain changes.

The authors describe the brain magnetic resonance imaging results and the clinical courses of three patients with late-onset psychoses who were treated with electroconvulsive therapy (ECT). Consistent with previous work, preexisting structural brain changes were present in all three patients. The two patients with the more severe structural changes (lateral ventricular enlargement and large deep-white-matter hyperintensities) failed to respond to ECT. In addition, all three patients had caudate hyperintensities and developed a prolonged interictal ECT-induced delibrium. These observations are also consistent with previous studies that have reported that patients with caudate hyperintensities may be at an increased risk for developing an interictal delirum during a course of ECT.

Aged↗

[Schizophrenia, manic-depressive psychoses and "middle cases". A clinical and nosologic study with cluster analysis].

Having analyzed the main nosographies concerning the endogenous psychoses problem, the A. aim at obtaining a subdivision of the psychotic patients into classes based on the similarity shown by the same patients about symptoms found out by a transverse examination. For this purpose, 246 psychotic inpatients have been given PSE to evaluate the presence/absence of 18 symptoms considered discriminant to the clinical rating of the patients. Such data have been processed by a Cluster Analysis. We got 7 groups of probands that have stressed the relevant number of cases with a mixture of affective and schizophrenic symptoms. We suggest the use of a bidimensional model to get a proper fitting of psychotics with mixed symptomatology.

Adolescent↗

Ecclesiogenic neuroses and psychoses in adolescence. On the complicated detachment problems of adolescents from rigorously moralizing, Christian-religious movements.

In the child and adolescent psychiatric department of Bern University Clinic, between 1982 and 1986 42 adolescent male and female patients were admitted for in-patient treatment. 9 of them (21.4%) came from Christian-religious sects. This was all the more surprising as the proportion of marginal Christian-religious groups in the population was 1.4% in the population census in the canton Bern in December 1980. This noticeably over-proportional accumulation was taken as a reason for carrying out an analysis of the case histories. It was shown that the patients from the circles of Christian sects became either obsessive-compulsive neurotically, anorectically or psychotically ill in puberty and that a very strictly moralizing upbringing by the parents was present which led to an aggravation of the relation conflict with the parents in the detachment and separation-process in puberty. By means of three case reports the problem of ecclesiogenic neuroses and ecclesiogenic psychoses in adolescence was gone into and the conclusion was made that the religious conflicts must be given increased attention in the therapeutic dealings with the patients concerned with the inclusion of members of the family and also persons of reference outside the family.

Adolescent↗

[Delirious and hallucinatory disorders in late psychoses with the pattern of "home paranoia"].

Paranoid and hallucination syndromes were studied in 71 cases of senile non-dementia psychoses located at the patients' house. Two major variants were singled out: paranoid and hallucinatory (the latter subdivided into patterns with or without the persecution delusion, and physical affection delusion). Paranoid variant was shown to be based upon a special transformation of visual perception with formation of delusions of penetration of a "stranger" into the patients' home. Hallucinatory variants were based predominantly on primitive physically-straining hallucinations with protopathic meaning. As the paranoid syndrome increased in severity, the space of its projection onto housing place expanded. It is suggested that housing conditions themselves could influence the psychopathology of housing paranoid.

Aged↗

[Comparative evaluation of clinical and economic effectiveness of preventive therapy of affective and schizoaffective psychoses].

The authors provide the results of a comparative study into the action of different drug approaches to the prevention of relapses of affective and schizoaffective psychoses with the aid of multifactorial consideration of different clinical, economic and socioeconomic indicators characterizing the "benefits and losses" because of the use of carbamazepine and lithium carbonate. The comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients examined, with the preventive action of carbamazepine being more remarkable as regards the economic and clinical indicators.

Adult↗

[Karl Bonhoeffer and the concept of symptomatic psychoses].

Against the background of the lifetime of Karl Bonhoeffer, March 31, 1868 to December 4, 1948, and the eighty-year-old concept of symptomatic psychoses, a sketch of the latter is set out and its present significance in symptomatology and research followed up.

Germany↗

Late life psychoses.

The need for new diagnostic tools is illustrated in this discussion of elderly patients who develop psychoses secondary to organic brain syndromes.

Age Factors↗

[Comparative features of the preventive action of carbamazepine and lithium carbonate in affective and schizoaffective psychoses].

The preventive properties of carbamazepine were studied and compared to those of lithium carbonate in patients suffering from affective and schizoaffective psychoses. Thirty-nine patients were examined. Of these, 19 patients received preventive treatment with carbamazepine and 20 with lithium carbonate. As to the preventive efficacy of carbamazepine, it turned out superior to lithium carbonate in all respects, particularly in cases of the monopolar depressive type of illness. The data obtained made it possible to analyze the possibilities of overcoming disadvantages of the preventive therapy with lithium carbonate by means of the use of carbamazepine or combined treatment with both the drugs, which considerably widens the potentialities of the preventive therapy of recurrent affective diseases. The method for the preventive therapy with carbamazepine and combined treatment including the use of lithium carbonate and carbamazepine are described.

Adult↗

[The initial report of the surgical effect in chronic psychoses].

The report of the surgical curative effect in 37 cases of chronic and aggressive behaviour psychoses. The cerebral amygdaloid nucleus and the cinguli bundle were damaged in the part by the cerebral stereotaxic operation. Through we have been evaluated strictly and follow-up survey for 2 years, that shown 67% in the effective rate, the behaviour and hallucination were recovered especially. Select the operative target and some medicine administration in the period of postoperation about improve the curative effect are significant especially also.

Adult↗

The concept of basic symptoms in schizophrenic and schizoaffective psychoses.

This paper presents the psychiatric aspects of the concept of basic symptoms (BS), especially history, actual position and tendencies of development of the doctrine of BS, phenomenology and clinical picture of basic stages, the Bonn Scale for the assessment of dynamic and cognitive basic deficiencies (BSABS) and the importance of this concept for early diagnosis, therapy, prevention and rehabilitation. The patients experience and communicate the BS as deficiencies and are able to cope with, adapt and compensate for them. The BS were termed as basic symptoms because they represent the basis of the productive-psychotic symptomatology. Follow-up studies of cases with the suspicion diagnosis "prodrome of schizophrenia" based on BSABS rating, revealed that the subgroup passing over in schizophrenic psychoses after an average of 6.3 years showed significantly higher scores of cognitive BS at the time of index investigation. It now seems possible to impede increase of cognitive BS already present in prepsychotic prodromal states before reaching the threshold of transition into productive-psychotic symptomatology. Long-term development is more favorable if therapy commences as early as possible including the prepsychotic basic stages and also taking into consideration BS which were, until now, disregarded in DSM-III. Summarizing our findings of the last 30 years we suggest that the BS-concept may be an approach to overcome the dichotomy of negative and positive psychopathology in schizophrenia.

Cognition Disorders↗

[Schizophrenic puerperal psychoses. A psychodynamic approach].

The author describes the psychodynamics of schizophrenic childbirth psychoses and criticizes attempts to explain these on a one-sided somatogenic basis. Referring to ethnographic material on childbirth customs, he develops therapeutic approaches are intended to bring about a better social integration of the woman as well as a deflection from her uncontrollable aggression against the child.

Adult↗

[Genetico-demographic patterns of the prevalence of various forms of endogenous psychoses].

Prevalence rates (PRs) for EFP (schizophrenic, schizoaffective and affective psychoses), with allowance for proband sex and age-of-onset data were studied in a subdivided population from the North-East of the European Region of the USSR. The population includes three subpopulations: a small old religious semi-isolate of Russians ("Rs"), aboriginal Komi people ("Ks")--an ethnic community of Ugro-Finnish lineage, and a mixed group of migrants ("Ms") from various regions of the USSR. The latter is mainly an urban population, while the "Rs" and "Ks" are, on the whole, rural populations. The total PR for EFP was found to be 0.97% for the "Rs", 0.63% for the "Ks" and 0.35% for the "Ms", whereas PRs-0.85-1.15% in other parts of the USSR, mainly for "panmixed" populations in large towns. The lower PRs for EFP in the "Ms" is caused by a backmigration flow involving certain groups of patients; consequently, the mean liability for "Ms" offsprings (as a whole) should also be lower. On the other hand, the lower PRs for EFP in the "Ks" is caused by underpresentation of clinically mild cases of the mental disease (mainly, pseudoneurotic schizophrenia), especially among female patients, probably due to that the so affected persons are sufficiently adapted to the cultural traditions of this rural population. It was shown that in the "Rs" the total PR for "nuclear" and paranoid schizophrenia is 0.68% versus 0.25% in a "panmixed" population. The increase is most likely caused by the high inbreeding level in the "Rs" semi-isolate, and if this is correct, we may suppose that at least one or two recessive genes are involved in the liability to the most heavy forms of schizophrenia. On the other hand, in the "Ms" (as in other "panmixed" populations) positive assortative mating among hereditary-predisposed persons is a more significant factor influencing family transmission of EFP, since the correlation between probands and their spouses is rpp = 0.31 (p less than 0.001) in the "Ms", as compared to rpp = 0.19 (p less than 0.1) in the "Rs". Thus, our general conclusion is that neither the place of inhabitance nor the life mode are the causal factors for EFP, but rather some genetic factors, more accurately, certain sets of specific genes.

Affective Disorders, Psychotic↗

[Systems theory reflections on the treatment of the acute and post-acute stage of schizophrenic psychoses].

Biological, psychical and social phenomena of acute and postacute phase of schizophrenic psychoses are differentiated according to systems theory. During the acute phase the therapeutical interventions aim to stabilize mainly the biological and psychical sphere, whereas for the post-acute phase the emphasis lays on the psychical and social phenomena. This phase-oriented coupling between the therapist, the patient and his/her social network promotes a successive restructuring by generating consensual spheres, which help the patient and his/her social net to find new ways for autonomous development.

Acute Disease↗

[Coping and psychological compensation in patients with endogenous psychoses of schizophrenic origin].

For a long period of time, the coping and compensatory mechanisms that arise from the patients with schizophrenic psychoses themselves have been considered only to a small extent by the psychiatric research. On the basis of Huber's concept of basic symptoms, we extended the six categories of coping mechanisms which are described in the Bonn Scale for the Assessment of Basic Symptoms (BSABS) by three further categories. With ten schizophrenic patients - mostly in-patients - semistructured interviews concerning these categories were done. All patients were found to have coping and compensatory mechanisms, and as a contribution to recognize and describe these mechanisms, parts of the patients' remarks are quoted. This is a prerequisite for an operationalized recording on larger patient populations that will possibly also allow correlation-statistical conclusions.

Adaptation, Psychological↗

[Preliminary results of 99mTc-HMPAO-SPECT studies in endogenous psychoses].

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p less than 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

Adult↗

[Neuropeptides in the treatment of alcoholism and alcoholic psychoses].

The intranasal administration of the hypothalamic peptide hormones vasopressin and corticotropin was used in the therapy of alcohol abstinence syndrome, acute and chronic alcoholic psychoses and in the conditioned reflex therapy of alcoholism. The proposed methods of therapy were fairly effective and free of complications and marked side effects.

Administration, Intranasal↗