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PubMed1989

[The use of zaditen in the combined treatment of allergic skin diseases in children].

Zaditen combined with local therapy and a rational hygienic and dietetic regimen has been administered to 158 children suffering from neurodermatitis (n = 142), eczema (n = 13), and strophulus (n = 3). The treatment has been effective in 148 (93.7%) children. Clinical remission has been achieved in 35 (22.2%) children, a considerable improvement in 87 (55.0%), and an improvement in 26 (16.5%). In 10 (6.3%) children no improvement has been observed. The improvement has been developing within the first fortnight of the treatment, but the drug has been continued for another week or two to stabilize the therapeutic effect. A follow-up of 102 children, effectively treated with zaditen, for 1-12 mos has shown relapses in 72 (70.6%) children, of these 7 relapses of medium severity and 1 severe relapse. Zaditen has been well tolerated by the children.

Adolescent↗
PubMed1978

[Local reaction and neutralization test in smallpox vaccination after previous inoculation with MVA. Stickl's graduated vaccination (author's transl)].

Of 200 first inoculations and 8 revaccinations, the sera were examined for content of neutralizing vaccine antibodies 3 weeks after the MVA graduated inoculation. In spite of imponderables which affect the failure rate in the "clinical trial", a positive result was obtained on first vaccination in 85%. In vaccinated children with a negative neutralization test a distinct booster effect was obtained with a "main vaccination" after about six months. The same effect was seen with revaccinations. For the time being inadequately controlled cerebral convulsive diseases, severe endogenous eczema, neurodermatitis, acute allergies, malignancies, immunosuppressive therapy, cortisole and intensive antirheumatic therapy and acute and purulent diseases must be considered as contraindications.

Adult↗
PubMed1979

Changing trends in skin diseases at the University Clinic Hamburg.

The author reports about statistical analyses of the outpatients from the dermatological department of the University hospital Hamburg 1935-1966. It can be demonstrated in general a change of the frequency of some skin diseases e.g. a regression of bacterial diseases and scabies, a increase of mycoses and of neurodermatitis and of eczema.

Adolescent↗
PubMed1988

[New in vitro procedures in allergy diagnosis].

The diagnosis of IgE-mediated allergies is mainly based on anamnesis, skin test and antigen challenge. In some situations however, described in the text, skin test keeps in the background and serological antibody-identification becomes more and more important. This development is clearly illustrated by the example of patients suffering from neurodermatitis: since the introduction of appropriate screening-methods atopic organ manifestations of the patients are noticed significantly more often than before. All laboratory for the serological diagnoses of allergies, including completely new methods, are described and checked up for useful criteria of interpretation. For this purpose the statistical data of more than 20,000 persons, suffering from atopy were reviewed. Finally, both the variations of the IgE-level, including possible consequences, and the increased occurrence of cross-sensitivities between inhalational and ingestive antigens are discussed.

Antigens↗
PubMed1987

Psychosomatic aspects in dermatoses.

The purpose of this presentation is to offer a classification of psychocutaneous disease and to examinine factors which result in itching and scratching becoming chronic. Pruritus is a very common sensation in dermatoses. All forms of itching, whatever the cause, may be intensified by emotional stress. The patient sample of my own study consisted of seven diagnostic groups, giving a total of 99 patients. The dermatoses were: dermatitis herpetiformis, lichen ruber planus, chronic eczema, atopic eczema, neurodermatitis circumscripta, lichen corneus obtusus and pruritus psychogenes. The principal findings were as follows: 1. Many of the different mechanisms by which skin diseases became chronic had a psychological background. 2. Psychiatric disturbances were clearly more common than in the average population. Possibilities of psychiatric treatment were evaluated. The results confirm the hypothesis that in those skin diseases in which the disease mechanism is not yet sufficiently understood, psychosomatics is of considerable importance or offers an easier way to explain the mechanism.

Humans↗
PubMed1979

[Lichen striatus with nail involvement. Report of 4 cases and review of the 4 cases in the literature (author's transl)].

Four cases of lichen striatus (L.S.) with nail involvement were studied and the four cases published previously reviewed. There are several types of nail dystrophy: fraying, longitudinal ridging, splitting and shredding, onycholysis, and total nail loss. All of them are transient and can be explained by the pathologic changes observed, particulary the transitory disruption of the basal layer. Lichen striatus must be differentiated from systematized eruptions such as lichen planus (the simultaneous occurrence of L.S. and lichen planus is extremely rare and the resemblance of one dermatosis to the other can be so pronounced that a differential diagnosis is difficult) linear localized neurodermatitis, linear psoriasis (almost always associated with more typical lesions of psoriasis elsewhere on the body), linear keratosis follicularis (histologically typical of Darier's disease) and linear epidermal nevus which occasionaly does not appear at birth but later in life and may present nail involvement. In some cases, however, clinical similarity of the inflammatory linear verrucose epidermal nevus to lichen striatus is striking.

Adolescent↗
PubMed1977

Clinical results of photochemotherapy. The Cleveland Clinic experience.

PUVA therapy has proved to be beneficial for dermatologic conditions such as psoriasis, vitiligo, and mycosis fungoides. Attempts have been made to treat other diseases with the modality; five patients with pityriasis rubra pilaris were treated, with only a partial response noted in one. A poor to fair response was seen in treating a small group of patients with cystic acne, atopic dermatitis, and neurodermatitis. As might be expected, no response was seen in one patient with Darier's disease. At present, photochemotherapy must be viewed with cautious optimism. Strict adherence to a rational treatment approach and close longterm follow-up observations are essential for determining the safety of this modality.

Evaluation Studies as Topic↗
PubMed1982

Evaluation of a new halcinonide formulation in the treatment of common dermatoses.

An open evaluation of halcinonide 0.1 percent in a hydrophilic vanishing cream base was conducted in one hundred patients with common steroid-responsive dermatoses, including eczema, contact dermatitis, atopic dermatitis stasis dermatitis, and neurodermatitis. Patients applied the cream two or three times a day for two weeks (or less if the clinical response warranted earlier discontinuation). Follow-up assessments were made on days 4, 7, and 14 of the study. Ninety-eight percent of the patients showed some degree of improvement, and eighty-five percent had complete clearing or marked improvement. One patient had no response and one worsened. Seventy-seven percent of the patients who responded achieved their maximum response within the first week of treatment. One case of urticaria was the only side effect noted in this series. Ninety-six percent of the patients rated their acceptance of the new formulation as excellent or good.

Adolescent↗
PubMed1981

Efficacy of halcinonide cream, 0.1 percent, in the treatment of moderate and severe dermatoses.

The efficacy of halcinonide cream, 0.1 percent, was evaluated in 101 patients with moderate or severe dermatoses. Conditions of these patients included contact dermatitis, atopic dermatitis, nummular eczema, neurodermatitis, stasis dermatitis, dyshidrosis, and various combinations of these disorders. Halcinonide cream was prescribed twice or three times a day for three weeks, and patients were followed-up weekly during this period. Sixteen patients stopped treatment after two weeks because their lesions had cleared. By the end of three weeks, the condition in 46 of the patients had completely resolved, the condition in 39 showed marked improvement, the condition in 10 had improved moderately, the condition in 5 showed mild improvement, and the condition in 1 did not show any improvement. No local or systemic side effects were reported. We conclude that halcinonide cream is an effective and safe topical therapy in the short-term treatment of a variety of moderate to severe steroid-responsive dermatoses.

Administration, Topical↗
PubMed1981

[Interval treatment with local corticosteroids and bases].

Three therapy models under the application of fluocinolone acetonide 0.025% (Jellin) were compared with each other. Conventional therapy: application of Jellin ointment or cream alone, n = 24; daily interval therapy: alternating application (morning and evening) of Jellin ointment or cream and their bases, n = 26; weekly interval therapy: application of Jellin ointment or cream for 4 days followed by a 3-day application of the corresponding base, n = 21. 71 patients participated in the investigation. 21 suffered from psoriasis, 26 from chronic eczema and 24 from neurodermatitis. The duration of treatment was 2--3 weeks. The results show that the daily interval therapy is equivalent to the conventional mode of application and that both treatment methods were superior to the weekly interval therapy. Therapy was stopped in 2 patients of the weekly interval therapy-group and in one patient of the daily interval-group because of insufficient effect. Intolerance reactions were noticed in one patient of the conventional therapy group. The interval therapy leads--as expected--to a reduction of side reactions and to lessening of the corticosteroid amount applied.

Administration, Topical↗
PubMed1981

The use of megestrol acetate in some feline dermatological problems.

Twenty-one cats were treated with megestrol acetate because they were showing clinical signs associated with one of the following problems: eosinophilic ulcer, eosinophilic plaque, neurodermatitis, endocrine alopecia and miliary dermatitis. The dosage schedule was 5 mg orally per day per cat for seven days, then 5 mg every three days for 21 days. In all cats, we noted a good improvement of the lesions as soon as treatment was started. In 25% of the patients, one treatment schedule was sufficient to control the skin disease for at least 18 months. In the remaining 75%, two treatment schedules and/or a maintenance dosage had to be established.Side effects encountered were increased appetite, personality changes and depression.

Animals↗
PubMed1976

[Difluocortolone valerate: a new corticoid for topical use].

The clinical efficacy of diflucortolone valerate as a fatty ointment was investigated in 65 patients with very dry dermatoses. The results were very positive, being excellent in atopic eczema, neurodermatitis and atopic cheilitis. No side effects were observed.

Administration, Topical↗
PubMed1997

Dermatophagia: "wolf-biter".

Dermatophagia is a neurodermatitis akin to onychophagia, onychotillomania, trichotillomania, dermatothlasia, neurotic excoriations, and other conditions in which persons have a neurotic habit or compulsion to self-multilate their skin or its appendages. Dermatophagia is a habit or compulsion, consciously or subconsciously, to bite one's own skin. We believe "dermatophagia" is a more appropriate term for this disorder than the descriptive term "wolf-biter".

Bites and Stings↗
PubMed1997

[Genetic risk after high dose radioiodine therapy with regard to gonadal dose].

AIM: The genetic risk for the offspring of patients treated with high doses of radioiodine was to be assessed with special regard to the gonadal dose caused by diagnostic and therapeutic procedures. METHODS: 41 young females (aged between 19 and 39 years) and four young males (aged 26 to 36 years) treated with radioiodine because of a thyroid carcinoma were interviewed by use of a questionnaire. The course of pregnancy and birth history could be documented as well as the congenital and developmental conditions of 56 children. RESULTS: The amount of radioactivity applied for therapy and whole body scans ranged over 4.144 and 35.15 GBq 1-131; the individual gonadal dose was calculated based on the MIRD model and ranged over 0.2 and 2.2 Sv (0.51 Sv at a mean). The period of time between the last radioiodine application and confinement was at least 9 months, not exceeding 14 years. As to the course of pregnancy and birth two early abortions, one extrauterine gravidity and one premature birth due to an insufficiency of the placenta were stated. In one case a chromosomal translocation 7/14 occurred as a genetic defect which lead to an interruption. The children's development was unconspicuous except of two cases of neurodermatitis as well as multiple allergies and an early closure of the anterior fontanelle in one child each. CONCLUSION: Although the genetic risk is supposed to increase with the gonadal dose achieved (doubling dose 1 Sv) and the increased risk of any congenital anomaly was calculated as about 13% at a mean in our patients, the rate of genetic determined diseases was not elevated (1.8% or 1/57). Thus, no increase of genetic defects or congenital malformations was reported in a total of 408 children described in the literature and in our group.

Abortion, Spontaneous↗
PubMed1997

[Marginal keratitis in Behçet's disease].

One female patient in twenty-six years old, presents corneal marginal relapsed at the left eye, aphthae of inferior eyelid and aphthous stomatitis in episodically fits repeated at three-four weeks. Also she presents disorders of the intestinal transit and thrombosis of the right inferior limb, fragility of the vessels, thoracic neurodermatitis with presternal erythema; these phenomenon are improvement with cortico and immunomodulator therapy. On insist about present of the marginal, relapsed ulcus in Behçet disease.

Adult↗
PubMed1997

[Endophthalmitis after cataract surgery: long-term follow-up].

BACKGROUND: Endophthalmitis is a serious complication after cataract surgery. PATIENTS AND METHODS: Therefore, a retrospective study was performed by reviewing patient-records of all cases of end-ophthalmitis after catract surgery that were treated at the department of ophthalmology of the University Hospital in Mainz between January 1986 and December 1995. RESULTS: 44 eyes were treated for endophthalmitis. Of those, 38 had been referred. In 15 eyes cataract surgery was performed on an outpatient basis. In 20 cases the onset of end-ophthalmitis occurred within the first postoperative week. We isolated staphylococcus epidermidis (14), staphylococcus aureus (4), other gram-positive microorganisms (15), gram-negative bacteria (2) and candida (1). As risk factors we found a wound dehiscence (14), an intraoperative loss of vitreous (11), diabetes (11), skin-diseases like rosacea or neurodermatitis (6). In 36 cases a vitrectomy was performed. After a mean follow-up of 25 +/- 22 months 26 patients had a visual acuity of 0.05 or better. CONCLUSION: Gram-positive bacteria showed to be the most common causetive microorganisms. In a third of all cases the sample demonstrated no growth. More than 80% of the eyes were treated by vitrectomy. About 60% of the patients obtained a visual acuity of 0.05 or better.

Adult↗