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PubMed1979

Cell-mediated lympholysis by human maternal and neonatal lymphocytes: mother's reactivity against neonatal cells and vice versa.

Maternal reactivity in cell-mediated lympholysis (CML) against cells from her own child is, in average, half of the maternal reactivity against unrelated adult cells. This finding remains the same when cells from a newborn or from an older child are used, suggesting that the reduced maternal reactivity is based rather on the one haplotype identity between the mother and child than on the occurrence of specific maternal tolerance. Consistently, CML-capacity of the child, directed against cells of own mother, is half of the control values, again independently of the child's age.

Adolescent↗
PubMed1991

[Biological specificity of the neonate and infant heart, with reference to selenium and glutathione peroxidase--the study to clarify the cause of vulnerability of neonate and infant heart].

Selenium (Se) is known to be an integral part in glutathione peroxidase (GSHPx). There are some reports serum Se levels are lower in infants than in adults and GSHPx activity is parallel to Se levels. There may be reasons why myocardial reperfusion injury occurs more easily in infants than in adults by reperfusion of ischemic myocardium. Serum and myocardial Se levels and GSHPx activity in experimental rats were measured to clarify the vulnerability of infant heart. Wistar rats were divided into three groups. First, infant rats 8-12 days after birth (infant rats), second, adult rats fed Se-deficient diet for two months (Se-deficient rats), and third, adult rats fed normal diet for two months (control rats). Serum Se levels, serum GSHPx activity and myocardial GSHPx activity in both infant and Se-deficient rats were significantly lower than that in control rats (p less than 0.01). However myocardial Se levels in infant rats were significantly higher than that in both Se-deficient and control rats (p less than 0.01). The lipid peroxide levels in heart mitochondria of Se-deficient rats were significantly higher than that in control rats (p less than 0.01). These results suggest that in infant heart Se does not manifest an effective function for a integral part of GSHPx despite its high level, its reason is not clear, and this phenomenon generates more oxygen-derived free radicals after reoxygeneration of the ischemic myocardium.

Animals↗
PubMed1989

[Neonatal Steinert's disease. Comments on a case and determination of the pregnancy aspects which are predictive of neonatal death].

The authors report a case of antenatal diagnosis which is original in that a maternal illness was discovered that had not been thought of until then. Steinert's myotonic dystrophy can show up in two types after birth, a congenital type and a lethal type. The antenatal diagnosis at present consists in a combination of hydramnios and lack of fetal movements on ultrasound. The obstetrical complications are the threat of premature labour and, often, breech presentation. The method of delivery will depend on how severely the fetus is affected; which is worked out by looking for features of poor prognosis. In the future it will be possible to make an antenatal diagnosis by villus biopsy with the discovery of the responsible gene.

Adult↗