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PubMed2003

[The effect of retabolil and support loads on atrophied muscles in suspended rats].

In experiments with rats histological and morphometric methods were employed to study effects of anabolic steroid rhetabolil and a combination of rhetabolil with predetermined support loads on development of atrophy in m. soleus and m. gastrocnemius. Muscular atrophy was provoked by tail suspension of rats for a period of 30 days. Rhetabolil was injected once a week I/M at a total dose of 10 mg per 100 g of the body mass. The experiment showed that this dose of rhetabolil had no effect on atrophy development; neither it amplified the favorable effect of support loads observed in earlier experiments with injection of small doses of rhetabolil. A supposition was made that the anti-atrophy effects of rhetabolil combined with the support loads are dose dependent. It was concluded that large doses of rhetabolil do not activate anabolic processes in the load-deprived muscles.

Anabolic Agents↗

PubMed2003

[The use of large doses of retabolil and support loads for prevention of osteopenia in male rats during suspension].

The histological and histomorphometric techniques were used to evaluate effects of anabolic steroid rhetabolil and graded support loads on the osteopenia progress in suspended rats. Thirty-day head-down tail suspension was found to inhibit body mass gain, induce a moderate stress reaction, dampen the longitudinal bone growth and provoke osteopenia in the spongy metaphysis of rats' tibiae. Rhetabolil injection at a total dose of 10 mg per 100 g of the body mass (a large dose) prevented tibial osteopenia, and yet it hampered bone growth in length. Daily 3-hr. support loads also inhibited osteopenia in the suspended rats, especially when combined with the rhetabolil injections. The unfavorable side-effect of the dose was virtually complete thymus aplasia in all animals. Hence, large rhetabolil doses as a means against osteopenia in the inadequately loaded locomotor system should be given with great care and require further investigations.

Anabolic Agents↗

PubMed2003

ATP and LPL histochemical activity of rat cardiomyocytes and adipocytes treated with androgenic anabolic steroids.

AIM: To study the effect of short-term and long-term treatment with retabolil, an androgenic anabolic steroid, on the activity of the enzymes ATP and LPL in rat cardiomyocytes and adipocytes. MATERIAL AND METHODS: Six male Wistar rats (mean weight 195-200 g.) were given retabolil 50 mg/kg once subcutaneously, another six were treated with retabolil at the same dose subcutaneously once a week for 6 weeks and another six were used as controls treating them with physiological saline in the same way. After six weeks the animals were sacrificed. Fragments of the left ventricle of the heart and of the subcutaneous tissue from the gluteal region were resected and enzyme-histochemical reactions for ATP and LPL were performed on fresh cryostat sections. RESULTS: The cardiomyocytes of the rats treated only once with retabolil showed no changes in the ATP and LPL activity in comparison with the controls. In the rats given a long-term treatment with retabolil, the enzyme-histochemical reaction for ATP was better expressed while that for LPL was weak. The subcutaneous adipose tissue of the long-term retabolil-treated animals contained some adipocytes that expressed positive LPL and ATP activity. CONCLUSIONS: Our data suggest that androgenic anabolic steroids exert an effect on the activity of the enzymes ATP and LPL in rat cardiomyocytes and adipocytes which depends on the duration of treatment.

Adenosine Triphosphate↗

PubMed1992

[The zona reticularis and the regulation of its activity under stress exposures].

A single stress effect activated the fascicular zone whereas repeated stress effects activated both the fascicular and the reticular zones in male rats. Therefore, these zones seem to have different modes of regulation despite the fact that their common basic regulating agent is ACTH. A new scheme of regulation of the reticular zone in repeated stress effects, has been presented.

Anabolic Agents↗

PubMed1961