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At least 721 records · Page 40Linked to original sources
PubMed1988

Surgical management of head and neck cancer.

The management of advanced carcinoma of the head and neck excluding thyroid carcinoma requires a combination of operation and radiation therapy to give the patient the best chance of cure. It is not appropriate to try to extirpate advanced squamous cell carcinoma by operation alone. There is evidence that postoperative radiation therapy is more effective in local regional control at least in certain sites than preoperative radiation therapy and there is better patient acceptance of the treatment plan in which the radiation therapy is administered after the operation.

Carcinoma, Squamous Cell↗
PubMed1977

[Risk evaluation of neoplasms relevant to jaw surgery].

The authors evaluate the risks of tumours and growth processes in the maxillofacial region. The tumours and growth processes in question are so-called semi-malignant tumours with tendency to locally limited infiltration, intra-epithelial carcinomata, precanceroses with abnormal epithelial growth and usually benign tumours with increased risk of degeneration. The clinicopathologica characteristics of these neoplasms are discussed, and recommendations for discriminating therapy are given. The clinician should use, by early detection and treatment, the primarily lower riskiness of these processes for the complete healing of patients affected with these diseases.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Results of immediate reconstruction following surgery for advanced cases of cancer of the cheek, jaw and lip.

Results of immediate reconstruction of the defects resulting from excision of cancer of the cheek, lower jaw, upper jaw and lip in 13 patients using temporal island, deltopectoral and cervicoacromial flaps have been described. The surgical techniques have been outlined. Previous radiotherapy is not a contraindication for primary excisional and reconstructive procedures although the incidence of postoperative gangrene of the flap was greater in these cases.

Adult↗
PubMedDate not supplied

Anesthetic management of a patient with Kasabach-Merritt syndrome.

Kasabach-Merritt syndrome presents various problems for anesthetic management, which include thrombocytopenia, bleeding tendency, and problems arising from the hemangioma mass itself. A 20-month-old female was scheduled for cryosurgery of a hemangioma on the face. Massive bleeding from the tumor was easily induced even by slight contact. The hematologic examination revealed a low platelet count and anemia. Anesthesia was induced carefully by applying an adult anesthetic mask to avoid the large tumor mass on the face and maintained with halothane and nitrous oxide/oxygen. Additional doses of prednisolone were administered before and during anesthesia to compensate for possible adrenal insufficiency due to steroid therapy which she had been receiving. Neither excessive bleeding nor any other particular complications occurred during anesthesia and surgery, and the postoperative course was also uneventful.

Anesthesia, Dental↗
PubMed1986

[Tobacco and dermatologic lesions].

The authors consider the clinical pathologic aspects of the skin and mucosa in chronic smokers. This features are not exclusively found in these impatiens, but in spite of no specificity the authors mention the significance of this pathology with special reference to oral cancer.

Humans↗
PubMed1986

[Role of radiation therapy in the multi-modal treatment of head and neck cancer--with special emphasis on oral and maxillary sinus cancer].

The role of radiation therapy as part of the multi-modal treatment of head and neck cancer appeared to be important with respect to functional and cosmetic morbidity. As for oral cancer, the value of brachytherapy was excellent in cases of localized disease. As far as the latter technique was applicable, patients with tongue cancer at T1, T2 and T3 could be treated by radiation as the initial choice unless palpable neck node metastasis was present. In contrast, cure of the lesion would not be expected from external irradiation alone even when combined with chemotherapy. Accordingly, in such advanced cases, salvage surgery should be applied with or without radiation and/or chemotherapy. As for maxillary cancer, the introduction of "trimodal therapy" has improved the local control rate only to a slight degree. After the application of conservative surgery followed by conventional trimodal combination therapy, local control and five-year survival rates have been improved markedly.

Brachytherapy↗
PubMed1986

[Multidisciplinary treatment of cancer of the maxilla and the oral cavity].

A study was performed involving patients with cancer of the maxilla (N = 70), the oral tongue (N = 56), the lower gum (N = 30), the oral floor (N = 22), the upper gum (N = 11), the hard palate (N = 10) and the cheek (N = 11) to evaluate how far the long-term survival rate could be improved with a combination of Linac X-ray irradiation (6000 rads/30 d), chemotherapy (5-FU), and radical surgery followed by primary reconstruction. The results of the above therapy were analysed. The 5-year crude and relative survival rates for maxillary cancer were 64.2% and 72.1% respectively. For T4 squamous cell carcinoma, the crude 5-year survival rate was 63%. While the 5-year actual survival rate for all cases of tongue cancer was 80.6%, the 5-year survival rate of T2N0M0 cases in which prophylactic neck dissection was not performed routinely, was 71.4%. The 5-year survival rates for cancers of the lower gum, the oral floor, the upper gum, the hard palate and the cheek were 79.2%, 68.8%, 70.7%, 62.2% and 90.9% respectively. By combined therapy, it was possible to obtain high local control of the tumor. The most common cause of therapeutic failure was distant metastasis which was seen frequently in N1-3 cases and cases with undifferentiated or poorly differentiated carcinoma. In our present trial therapy, further combination of nonspecific immunotherapy and chemotherapy consisting chiefly of CDDP has been incorporated to control microscopic distant metastasis in these high-risk cases.

Adenocarcinoma↗
PubMed1986

[Verrucous carcinoma and carcinoma cuniculatum--forms of squamous cell carcinoma?].

The morphology of verrucous carcinoma (Ackerman tumor) and carcinoma cuniculatum is described and the problems of diagnosis and classification are discussed on the basis of the relevant literature. Both lesions are closely related aggressive proliferations of squamous epithelium of the skin and mucous membranes. Verrucous carcinoma exhibits an exophytic as well as endophytic growth pattern on a broad front; dissociated invasive growth, however, is usually absent. Carcinoma cuniculatum is similar; however, conspicuous deep duct-like formations and keratin-filled sinuses are formed. Clinically, these tumors appear to be malignant. Histological evaluation often results in the tumors being underestimated and a false diagnosis of a benign papillomatous lesion or pseudoepitheliomatous hyperplasia being made. The necessity is stressed of a thorough histological investigation of the tumors in multiple sections and of a search for dissociated invasive growth. It is suggested that cases without this feature should not be termed carcinoma but should rather be given a more descriptive diagnosis such as verrucous hyperplasia or proliferation. Cases with clear invasive growth should be classified as papillary squamous cell carcinomas (grade I). A detailed characterization should be given in addition. Although both tumors show features of viral lesions, it has so far not been possible to demonstrate viruses by electron microscopy or structural antigens of human papilloma viruses (HPV). Both clinical picture and histology must be taken into consideration when diagnosing these two tumors ("clinicopathologic entity"). Close cooperation between the clinician and the pathologist is desirable for individual assessment of these lesions as regards classification and therapy.

Carcinoma, Papillary↗
PubMed1986

[Determination of sialic acid in cancer of the upper aero-digestive tract].

The determination of serum lipid sialic acid (LSA) in subjects with laryngeal and oral cavity carcinomas demonstrated an important correlation between the presence of carcinoma and tumor marker elevation. 90% of positivity has been found in 60 cases of laryngeal carcinoma; 100%, on the contrary in 19 cases of oral cavity. The authors affirm the importance of LSA as a tumor marker, in particularly in monitoring patients submitted to surgical excision.

Humans↗