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At least 721 records · Page 40Linked to original sources
PubMed2003

Iridium-192 implantation for T1 and T2a carcinoma of the tongue and floor of mouth: retrospective study of the results of treatment at the Royal Berkshire Hospital.

Carcinomas of the tongue and floor of mouth are relatively rare tumours, which may be treated using several modalities. We reviewed the results of iridium wire implants performed at the Royal Berkshire Hospital between 1994 and 2000. 24 patients had iridium wire implants as primary treatment for tongue and floor of mouth cancers. Four patients were treated after excision biopsy with close or involved margins. One patient was treated for a recurrence after surgery. The median age at treatment was 61 years. There were 18 men and 11 women. 21 patients had tumours of the tongue and eight of the floor of mouth. 13 had T1 tumours and 11 had T2a tumours. The median follow up was 42 months. The primary tumour was controlled in 22 of the 29 patients by the implant alone. Of the seven patients with local recurrence four were successfully salvaged with surgery. The acturarial 2 year survival rates were: overall survival 81%, disease specific survival 91%, local recurrence free survival 85% and nodal relapse free survival 76%. The recorded complication rate was low, one patient developing radionecrosis of the mandible at 7 years post implant. We believe these results show that brachytherapy remains a treatment option for patients with early tongue carcinoma with a high rate of local control and low toxicity.

Adult↗
PubMed1986

Compression plates in the treatment of advanced anterior floor of mouth carcinoma.

Advanced anterior floor of mouth squamous cell carcinoma has been traditionally treated with wide excision in conjunction with mandibulectomy and radical neck dissection. This has resulted in significant mandibulofacial defects with functional and cosmetic significance. Efforts at primary reconstruction in the past using bone grafts, osteomyocutaneous flaps, and other methods have yielded unsatisfactory results. A history of prior irradiation has made this problem even more refractory. We present a series of 11 patients who underwent composite resection for advanced anterior floor of mouth carcinoma (T2-T4), with primary reconstruction using a dynamic compression plating system in conjunction with local and regional tissue flaps. The clinical courses, complications, and surgical techniques are discussed. The issues of reconstruction at primary treatment, irradiation with a metal plate in the field, and the early restoration of oral function are addressed. Experience in this series shows that compression plates can be an effective method of primary reconstruction for advanced anterior floor of mouth lesions.

Adult↗
PubMed1986

Mouth protectors and oral trauma: a study of adolescent football players.

A total of 754 junior high school and high school football players from the Birmingham, AL, area were studied to determine the extent of sports-related oral trauma among players. More than half the oral injuries and more than a third of the concussions were reported in sports other than football. Basketball and baseball players had a high prevalence of hard tissue oral trauma with virtually none of the players wearing mouth protectors. The results of this study indicate that current mouth protector designs are helpful in preventing hard tissue trauma, yet additional soft tissue protection is indicated in football mouth protector design.

Adolescent↗
PubMed1998

Mouthguards. Protection for the mouth in rugby union.

The mouthguard is a resilient device or appliance which is placed inside the mouth to protect against injuries to the teeth, lacerations to the mouth and fractures and dislocations of the jaw. There is clear support in the scientific literature for the use of mouthguards in contact sports such as rugby. Moreover, there is evidence that mouthguards are effective in protecting against concussion and injuries to the cervical spine. There is a high level of acceptance of mouthguards by players and an increasing number are regularly wearing mouthguards. This is especially true among the elite players, but acceptance and wearing rates are moderately high among club players as well. There is strong support among players and researchers for mouthguard wearing to be made compulsory. It is generally recommended that: (i) mouthguards be worn during both practice sessions and games; (ii) the habit of wearing a mouthguard begins at an early age; (iii) mouthguards be regularly replaced while children are still growing; and (iv) adult players replace their mouthguards at least every 2 years. The selection of a mouthguard will depend on a number of factors including the age of the individual, effectiveness and cost. The type I (stock), or 'off-the-shelf', mouthguards are considered inferior when compared with the other available types, and their use is discouraged. Type II (mouth-formed) mouthguards come in 2 forms, the shell-liner version and the popular thermoplastic 'boil and bite' version. While the effectiveness of the shell-liner mouthguard was examined in one experimental study, no such research has been reported for the thermoplastic mouthguard. Type III (custom-fabricated) mouthguards are recommended for players playing in the more vulnerable positions and in the higher grades. Most experimental studies in which the effectiveness of mouthguards has been demonstrated have involved type III mouthguards.

Adolescent↗
PubMed1993

Cystic masses in the floor of the mouth: value of MR imaging in planning surgery.

OBJECTIVE: The purpose of this study was to determine the value of preoperative MR imaging for planning the best surgical approach for excising cystic masses in the floor of the mouth. In addition, different sequences and slice orientations were compared in order to develop a standard MR examination technique for this purpose. SUBJECTS AND METHODS: Eleven patients with cystic masses in the floor of the mouth were prospectively examined with MR imaging after palpation and sonography. The imaging protocol included T1- and T2-weighted spin-echo sequences, both unenhanced and contrast enhanced. The exact topographic relationship of these cysts to the surrounding muscles and the value of different MR techniques were analyzed. RESULTS: The mylohyoid muscle, which serves as a key structure in determining the exact position of a cystic mass, was visualized in all cases. T2-weighted images facilitated the primary diagnosis of cystic lesions, whereas T1-weighted images allowed the best visualization of anatomic details. Use of gadopentetate dimeglumine did not provide significant diagnostic information. Coronal and axial slices provided the best visualization of the topographic relationship of cyst and muscles. Sagittal slices were helpful only for midline lesions. In two cases, the choice between the intraoral and the cervical surgical approach was altered by MR imaging findings. CONCLUSION: MR imaging facilitates exact visualization of the location and extent of cystic lesions in the floor of the mouth and is useful for determining their relationship to the surrounding muscles. We conclude that MR imaging is an important adjunct to palpation and sonography in planning the best surgical approach.

Adult↗
PubMed2002

Use of a portable real-time reverse transcriptase-polymerase chain reaction assay for rapid detection of foot-and-mouth disease virus.

OBJECTIVE: To evaluate a portable real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay designed to detect all 7 viral serotypes of foot-and-mouth disease virus (FMDV). DESIGN: Laboratory and animal studies. STUDY POPULATION: Viruses grown in tissue culture and animals experimentally infected with FMDV. PROCEDURE: 1 steer, pig, and sheep were infected with serotype O FMDV. Twenty-four hours later, animals were placed in separate rooms that contained 4 FMDV-free, healthy animals of the same species. Oral and nasal swab specimens, oropharyngeal specimens obtained with a probang, and blood samples were obtained at frequent intervals, and animals were observed for fever and clinical signs of foot-and-mouth disease (FMD). Samples from animals and tissue cultures were assayed for infectious virus and viral RNA. RESULTS: The assay detected viral RNA representing all 7 FMDV serotypes grown in tissue culture but did not amplify a panel of selected viruses that included those that cause vesicular diseases similar to FMD; thus, the assay had a specificity of 100%, depending on the panel selected. The assay also met or exceeded sensitivity of viral culture on samples from experimentally infected animals. In many instances, the assay detected viral RNA in the mouth and nose 24 to 96 hours before the onset of clinical disease. CONCLUSIONS AND CLINICAL RELEVANCE: The assay reagents are produced in a vitrified form, which permits storage and transportation at ambient temperatures. The test can be performed in 2 hours or less on a portable instrument, thus providing a rapid, portable, sensitive, and specific method for detection of FMDV.

Animals↗
PubMed1999

MR imaging of squamous cell carcinoma of the floor of the mouth. Appearance of the sublingual and submandibular glands.

PURPOSE: To determine the diagnostic value of MR imaging for tumors of the floor of the mouth and the effects of the tumors on the sublingual and submandibular glands. MATERIAL AND METHODS: Thirty-seven patients with proven squamous cell carcinoma of the floor of the mouth underwent MR imaging, including unenhanced T1-weighted, T2-weighted, dynamic, and contrast-enhanced T1-weighted images. The appearance of the tumor and the sublingual and submandibular glands was assessed qualitatively and quantitatively. RESULTS: All tumors demonstrated replacement of the normal signal intensity in the adjacent sublingual gland. Twenty-one patients (57%) had abnormal signal intensity of the submandibular gland without tumor invasion, presumably secondary to submandibular duct obstruction by the tumor. Unenhanced T1-weighted images provided high contrast between tumor and sublingual gland. Tumors limited within the gland were well detected on unenhanced T1-weighted images. Large tumors extending beyond the gland were well delineated on dynamic images, but no better than on T2-weighted images. CONCLUSION: At MR imaging for tumor of the floor of the mouth, one must carefully evaluate the appearance of the sublingual and submandibular glands. Contrast-enhanced studies are unnecessary when the tumor is limited within the sublingual gland on precontrast MR images.

Adult↗
PubMed2005

Absence of antibodies to foot-and-mouth disease virus in free-ranging roe deer from selected areas of Germany (2001-2002).

Blood samples (n = 223) of free-ranging roe deer (Capreolus capreolus) were collected from selected hunting grounds in Germany between October 2001 and October 2002. Samples originated from Lower Saxony (n = 43) and North-Rhine Westphalia (n = 108) within a 20-km area ("cordon") cordoned off along the border of The Netherlands. This is adjacent to the area of a foot-and-mouth disease outbreak that occurred between 21 March and 22 April 2001 in The Netherlands. Negative control samples were taken from northern Germany (Schleswig-Holstein, n = 72). Two different enzyme-linked immunosorbent assays (ELISAs) were used for the detection of antibodies against foot-and-mouth disease virus (FMDV) serotype O strain Manisa. To confirm ELISA-positive results, a virus neutralization test was performed. All samples tested negative for antibodies against FMDV. These results suggest that FMDV was not transmitted to free-ranging roe deer living in parts of Germany adjacent to the area affected by the 2001 foot-and-mouth disease outbreak in The Netherlands.

Animals↗
PubMed2000

[Mouth opening in patients with systemic sclerosis: base analysis and during follow-up].

BACKGROUND: A large number of orofacial abnormalities have been described in patients with Systemic Sclerosis (SSc) but no data are reported on the correlation with different subgroups of patients on the efficacy of different therapies. METHODS: In the present study mouth opening was retrospectively evaluated in 40 patients with SSc in whom measurement of interlabial distance was taken at the first clinical control and during follow-up. The data confirmed that the mouth opening is significantly decreased in patients with SSc independently from sclerosis subgroup, age or disease duration. RESULTS: Follow-up (8 +/- 8.3 years) showed a different behaviour of the parameter: in 12 patients (group I) no variation in mouth opening was detected, in 18 patients (group II) a decrease and in 10 patients (group III) an increase was observed. CONCLUSIONS: The only difference between the three groups was the treatment received: 80% of the patients of group III (p < 0.01) have been treated with cyclophosphamide (CF). Our data further support the efficacy of treatment with CF in patients with SSc.

Adult↗
PubMedDate not supplied

Clinical evaluation of hard tissue proliferations in the mouth.

OBJECTIVES: This work shows the results of a study of the proliferation of bone tissue in the mouth. DESIGN OF THE STUDY: It was carried out on a sample of 530 persons who were natives of Central American countries, 179 males and 154 females, evaluating the rate of appearance of these formations depending on age, sex, racial group, and their location within the jaw. RESULTS: It was observed that 38% of the total sample showed hard tissue proliferation in the mouth. Of these cases, 158 (80%) were located in the superior maxilla and 48 (20%) of the cases in the jaw. Of which, 52 were men (25%) and 154 women (75%). This proliferation has greater incidence in the black race, in university students and liberal professions. The most frequent are torus palatinus and bilateral torus mandibularis. CONCLUSIONS: The Central American population shows a high incidence of hard tissue proliferations in the mouth; a radiological study is sufficient for their detection.

Adolescent↗
PubMed2002

[Full mouth one stage disinfection of the oropharynx. A new treatment strategy for periodontitis].

Most periodontal pathogens colonise different niches such as the oral mucosa, tongue, saliva, periodontal pockets, all hard intra-oral surfaces and the tonsils. Since intra-oral translocation of these pathogens between these niches is possible, a 'one stage' disinfection of the whole mouth in one or two consecutive days as treatment strategy for periodontal infections must be considered. A one stage full-mouth disinfection is achieved by a scaling and root planing of all periodontal pockets within 24 hours, in combination with a chlorhexidine application in all niches (subgingival irrigation, mouth wash, brushing of the tongue, and spray for the pharynx). As such, reinfection by bacteria of recently instrumented sites is inhibited. This approach results in significant additional clinical and microbiological results compared to the classical approach (scaling and rootplaning per quadrant with several days or weeks between each session).

Dental Plaque↗
PubMed2002

[Rule of lymph node metastasis in the cancer of mouth floor and its treatment].

BACKGROUND & OBJECTIVE: There was little report on the rule of lymph node metastasis in the cancer of mouth floor. The aim of this study was to investigate the rule of lymph node metastasis and investigate the reasonable treatment. METHODS: A total of 79 cases with squamous carcinoma of mouth floor were included into this study retrospectively. The distributive difference of clinical and pathological positive lymph node was compared. The recurrent rate of the patients who were performed with radical neck dissection and supra-half-neck dissection in clinical positive lymph node group were compared with the recurrent rate of the patients who were preformed with radical neck dissection, supra-half-neck dissection, submandibular triangle dissection, and clinical observational group. RESULTS: Clinical and pathological positive lymph node was found mainly in II region (61.8% and 40.0%, respectively), secondly in I and/or III region, and rarely in IV, V, and VI region. In clinical positive lymph node group, the recurrent rate of the patients who performed with radical cervical neck dissection was lower than supra-half-neck dissection, but without statistical significance (chi 2 = 3.403, P = 0.065). In clinical cervical negative lymph node group, the recurrent rates of the patients performed with supra-half-neck, submandibular triangle dissection, and in clinical observational group were 11.1% (1/9), 40.0% (2/5), and 23.5% (4/17), without statistical significance (chi 2 = 1.554, P = 0.46). CONCLUSION: Lymph node metastasis of cancer of floor of mouth mainly distributes in I, II, III region; The patients with negative cervical lymph node should be performed lymph node dissection in I, II, III region (supra-half-neck).

Adult↗
PubMed2003

[Cyst of the floor of the mouth causing respiratory obstruction. Report of one case].

Three major groups of lesions can cause swelling in the floor of the mouth: infectious, neoplastic, and cystic. We present the case of a patient with inflammatory cyst in the floor of the mouth that reached, in a little while, huge dimensions. Needle aspiration of the lesion caused an infectious process that enlarged the cyst and led to progressive difficulties in breathing. Treatment was by emergency tracheostomy and enucleation of the lesion using an intraoral approach. The enucleation was performed through a mucosal incision along the midline of the floor of the mouth, starting just behind the lingual fold, and extending along the ventral surface of the tongue.

Aged↗
PubMed2004

[Clinic significance of morphometric study on squamous cell carcinoma of floor of mouth].

OBJECTIVE: The purpose of this study was to investigate the role of cell morphometric factor (FC) and the average density of light in squamous cell carcinomas at the floor of mouth by immunohistochemical method (SABC). METHODS: The slices made from the paraffin specimens of 28 patients with squamous cell carcinomas at the floor of mouth were stained by the immunohistochemical technique with monoclonal antibody CK10 and CK14. In these stained slices the FC parameters and the average density of light were measured by using an image analysis system. RESULTS: In primitive tumors, the FC parameters and the average density of light were significantly different between positive and negative lymph nodes metastasis or between different pathological grades (P < 0.05 or < 0.001). The significance was not existed among clinical stages (P > 0.05). The difference of FC expressed in positive and negative lymph nodes metastasis were significant (P < 0.05 or < 0.001). CONCLUSION: The cell morphometric factor (FC) parameters and the average density of light of CK10 and CK14 could be used as a biological guideline to evaluate the clinically infiltrative and metastasic potential of squamous cell carcinoma at the floor of mouth.

Adult↗
PubMed2005

[Burning mouth].

Various conditions of the oral mucosa can give rise to a burning sensation. Candidosis, geographic tongue (erythema migrans), mucocutaneous conditions and stomatitis can all cause mouth burns with visible changes to the oral mucosa. The so-called 'burning-mouth syndrome' (BMS) is a fairly rare but extremely unpleasant condition characterised by a bilateral burning sensation of the oral mucosa in the absence of clinically visible mucosal changes. Frequently-associated symptoms include dry mouth and loss or change of taste. The aetiology is unknown, even though most of the literature focuses on the role of a possible underlying psychogenic disorder. Several mucosal disorders can cause symptoms similar to BMS. Therefore, careful oral examination is required before establishing the diagnosis of BMS. Additional laboratory tests or a specialist examination rarely yield abnormal findings of relevance. Reassurance and understanding are important keywords in the management of patients suffering from BMS. Unless clearly indicated dental or medical treatment should be avoided, even if the patient insists on it, since such treatment is rarely effective.

Antidepressive Agents↗
PubMed2005

[Cyst and pseudocyst lesions of the floor of the mouth with submental affectation].

There are several lesions which can present as a cyst or pseudocyst of the floor of the mouth with submental repercussion. The aim of this paper is to review the diagnosis methods which can help us to differentiate these lesions such as the surgical peculiarities of every tumour. We are reporting two cases of cystic/pseudocystic lesions of the floor of the mouth with submental repercussion. Both of them were epidermoid cysts. Ranulas, lipomas and lymphangiomas should be considered in the differential diagnosis. Imaging diagnosis, fine needle aspiration and adequate treatment in all of the tumours are reviewed. Both cases were operated via intraoral. They are now free of disease after at least one year. Differential diagnosis of cystic lesions of the floor of the mouth is important because the recommended surgery technique is not exactly the same in all of them. The firmness of the wall of dermoid cysts let their exeresis via intraoral even when they are of a big size. Exeresis of sublingual gland is recommended by most authors to treat ranulas, although it is followed by an important percentage of morbidity.

Adult↗
PubMed2006

[Role of various etiologic factors in the development of burning mouth syndrome].

Burning mouth syndrome (BMS) has been comparatively recently isolated as the separate nosologic diagnosis. This disease is characterized by the feeling of burning, dryness, numbness, pricking and seldom by pain in the tongue or mouth cavity area (palate, lips, alveoli) without any changes in mucous membrane. Absence of visible causes of the disease complicates its treatment and makes the patients to address the physicians of various profiles, often without any result. All the above stated made the authors to define the etiologic factors of various clinical versions of BMS and to carry out their differential diagnostics along with the development of pathogenetic therapy of BMS. 30 women of 40 to 70 year of age were examined. According to the anamnesis, BMS was developing gradually and in most cases it was associated with the aggravation of the existing disease (hypertension, diabetes mellitus, aggravation of climacteric state) or with deterioration of psycho-emotional sphere due to conflicting situation. The carried out studies enabled the authors to select and divide patients with BMS into groups according to clinical values and the etiologic factors. In most cases diverse clinical versions of the burning mouth syndrome are cause-and-effect expressions of various somatic diseases, the timely determination and adequate therapy of which give the best results in the struggle against BMS.

Adult↗
PubMed1990

[Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth].

The results of radiation therapy were compared in 217 patients at advanced stages of cancer of the tongue (131) and fundus of the mouth (86) using split courses of conventional (SCF) and dynamic fractionation (SDF) and SDF combined with metronidazole. Dose-effect curves were evaluated by probit-analysis. SCF at a total focal dose increased from 64-76 up to 78-82 Gy did not improve therapeutic results. The predicted limits of efficacy were higher in SDF as compared to SCF. The most effective was the use of SDF in combination with metronidazole (one year after therapy discontinuation 52% of patients with cancer of the tongue and 36% of patients with cancer of the fundus of the mouth were alive). In a total focal dose increased up to 68-72 Gy a rise of efficacy in T3 was 11% for cancer of the tongue and 18% for cancer of the fundus of the mouth. This method permits the evaluation not only of the predicted limits of efficacy but also of a probable rate of improvement in a raised TFD.

Carcinoma, Squamous Cell↗