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At least 721 records · Page 40Linked to original sources
PubMed2000

[Lymphedema and lymphangioscintigraphy].

INTRODUCTION: The diagnoses of lymphoedema is generally based on clinical examination. Sometimes supplementary laboratory techniques are required. MATERIAL AND METHODS: A practical lymphangioscintigraphic method is described based on a survey of the literature and trial and error in a series of about 40 patients. The method gives an excellent picture of lymphatic pathology and the lymph stasis present in most lymphoedema patients. RESULTS: The use of the method in 48 patients is reported. An abnormal scintigraphic pattern was seen in 25 patients. In 20 cases with a well established clinical diagnose, the lymphangioscintigram was positive in 15 cases. INTERPRETATION: Lymphangioscintigraphy is a non-invasive method recommendable as first choice in supplementary examination of lymphoedema.

Adult↗
PubMed1976

Leucocyte ascorbic acid in abnormal leucocyte states.

Leucocyte ascorbic acid was estimated in patients with abnormal leucocyte states and other haematological disorders. Levels below the normal range were found in most cases of chronic myeloid leukaemia and chronic lymphatic leukaemia. Subnormal levels were found in more than a third of patients with acute leukaemias, lymphomas, glandular fever, myelofibrosis, and polycythaemia, and in the same proportion of patients receiving cytotoxic drugs, and also in those with a polymorph leucocytosis and those with purpura. Most patients with anaemia but a normal leucocyte count, and those with myelomatosis had normal levels. The majority of pregnant women tested had subnormal levels. In a wide variety of leucocyte disorders the leucocyte ascorbic acid may not be an accurate index of the body's Vitamin C status. The results also support the supposition that leucocyte ascorbic acid is mostly carried by normal mature polymorphs.

Ascorbic Acid↗
PubMed1978

Lymphangiographic changes after radiation therapy.

Lymphangiographic appearance following radiotherapy is described in 21 patients with pre- and posttherapy lymphangiograms. Following radiotherapy to normal lymphatics, decrease in nodal size and lymph vessel caliber is noted uniformly after 12 months. Before 12 months the development of these changes is variable and may not be seen, especially during the first several months. Following irradiation of abnormal lymph nodes, dilatation of the lymph vessels distal to the abnormal nodes may occur. These lymphangiographic findings can be related to histologic changes seen in lymph nodes after radiation therapy.

Adolescent↗
PubMed1979

The prognostic value of serum lysozyme activity in acute myelogenous leukemia.

Serum lysozyme activity was measured in samples from adult patients with acute leukemia, malignant tumors, and in normal adults. Twenty-eight adult patients with acute myelogenous leukemia (AML) had significantly elevated levels of lysozyme at diagnosis, and none of the adults fell within the normal range. Thirty-two patients with AML in complete remission had lysozyme levels comparable to normal adults, whereas patients with AML in relapse (eight cases) also had abnormally high levels of lysozyme activity. Ten patients with AML in remission and off therapy also had normal lysozyme levels. Three patients with acute lymphatic leukemia had normal lysozyme levels, while one child with monomyelocytic leukemia had substantially elevated lysozyme levels before treatment. It seems that in patients in remission and with normal blood values, the serum lysozyme activity is valuable for monitoring the remission.

Adult↗
PubMedDate not supplied

Colonoscopic indirect lymphangiography in a canine model.

Colorectal malignancies metastasize most frequently to mesenteric lymph nodes. Preoperative staging of these nodes by current modalities is problematic. This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic technique in a canine model. Ten mongrel dogs underwent endoscopic submucosal injection of Ethiodol at various sites in the transverse, descending, and rectosigmoid areas. Serial abdominal roentgenograms were obtained up to 2 weeks postinjection. In seven of the animals, demonstration of mesenteric nodal uptake corresponding to the area(s) of injection was radiographically documented. In the remaining animals (early in the series) nodal opacification was inadequate. This lack of nodal uptake appeared to be due to nonsubmucosal contrast injection. No complications were noted. Colonoscopic indirect lymphangiography appears to be a safe and potentially useful modality in the evaluation of mesocolonic lymph nodes. Further studies to refine this technique and investigate its potential to preoperatively delineate abnormal nodal architecture are warranted.

Animals↗
PubMed1964

ACUTE AND CHRONIC ENTEROTOXIN ENTERITIS.

1. Dogs develop severe gastrointestinal symptoms in response to intraintestinal administration of staphylococcal enterotoxin. These symptoms are salivation, vomiting, and diarrhea. 2. Staphylococcal enterotoxin induces acute enteritis marked by edema, hyperemia, round cell infiltration, mucosal exudation, and destruction of intestinal villi. 3. Prolonged administration of enterotoxin into the lumen of the intestine produced thickening of the entire bowel wall, edema, dilatation of the lymphatics, and exaggeration of submucous lymphoid nodules. The hypertrophy of the lymphoid nodules is visible, in the gross, as enlarged longitudinal mucosal ridges. This abnormality is arranged in skip areas, not dissimilar to those observed in human regional enteritis. 4. Chronic enterotoxin enteritis is associated with mesenteric lymph node hypertrophy. 5. The intestinal mucosa shows minute ulcerations, loss of villi, submucous fibrosis, and evidence of chronic inflammation.

Animals↗
PubMed1976

Immunoglobulin abnormalities in epileptic patients treated with diphenylhydantoin.

An immunologic study was made on 170 epileptic patients treated with antiepileptic drugs. The most noteworthy finding was that the serum IgA was decreased in 22 patients, and an IgA deficiency noticed in 12 of them. The blastic transformation rate of lymphocytes in PHA-containing cultures appeared low in seven out of 12 patients. Other findings included decreased serum IgM and IgG in some patients. These abnormalities were not encountered in epileptic patients taking no anti-epileptic drugs. Therefore, they could be considered as the side effects of antiepileptic drugs. In all patients manifesting these abnormalities, diphenylhydantoin was used in common. It was surmised that the above-mentioned immunologic abnormalities caused by anti-epileptic drugs, especially diphenylhydantoin, had resulted from disorders of the antibody producing organs in the bone marrow-thymus-lymphatic system.

Adolescent↗
PubMed1993

Case report: accessory lobe of the liver mimicking lesser omental lymphadenopathy.

An accessory lobe of the liver is an uncommon occurrence and often an incidental finding. We present the case of a middle-aged man whose upper abdominal pain was relieved following removal of an accessory lobe. His preoperative imaging had led us to believe that he had lesser omental lymphadenopathy. We draw attention to the fact that this congenital abnormality can cause diagnostic confusion.

Diagnosis, Differential↗
PubMed2004

Subacute cor pulmonale due to tumor embolism.

We describe a patient wih subacute cor pulmonale caused by tumor emboli in the lungs. A 64-year-old female suffering from a subacute progressive cough and shortness of breathing died of severe pulmonary hypertension seven days after admission. Neither chest CT scans nor lung perfusion scintigraphy showed any abnormal findings. Microscopic examination after an autopsy revealed diffuse intravascular tumor emboli occluding not only the small pulmonary arteries and arterioles, but also the lymphatic vessels, which were suggested to be metastases of a breast carcinoma resected five years previously. Thus, pulmonary tumor embolism should be considered in the differential diagnosis of primary pulmonary hypertension, particularly in patients with a past history of cancers.

Autopsy↗
PubMed2003

Cardiac effects of anthracycline treatment and their implications for aeromedical certification.

INTRODUCTION: In 1997 an autopsy on a professional pilot killed in an aircraft accident demonstrated myocardial fibrosis, thought to be the result of previous anthracycline treatment. The United Kingdom (UK) Civil Aviation Authority (CAA) was tasked with investigating the possible dangers to flight safety of treatment with this type of chemotherapy. METHODS: From CAA computer records of 18,319 professional license holders, 14 were identified as having received anthracycline treatment. These subjects underwent clinical cardiological examination, exercise and 24 h ambulatory electrocardiography, and echocardiography. Other studies were performed as needed. RESULTS: Of the 14 subjects, 9 demonstrated arrhythmias on ambulatory electrocardiography, including 4 with ventricular tachycardia and 5 with supraventricular tachycardia, a much higher incidence than expected. One pilot had evidence of left ventricular dysfunction and another developed symptomatic sinus arrest at first follow-up. Another died shortly after completing the investigations from acute lymphatic leukemia, probably a complication of his original chemotherapy for Hodgkin's disease. In this small cohort there seemed to be no correlation of abnormal findings with anthracycline dose nor with time since completion of treatment. CONCLUSIONS: The results presented strongly suggest the need for cardiological review of individuals who have received anthracycline treatment and who are seeking initial certification or recertification for professional aviation licensing.

Adult↗
PubMed1989

[Extra-pulmonary lymphangiomyomatosis presenting as an exudative enteropathy with a rapid fatal course].

We report a case of lymphangiomyomatosis (LAM) which occurred in a twenty six year old woman, presenting with protein losing enteropathy and pancreatic fibrosis due to lymphostasis. Despite having no pulmonary lesion, the patient died quickly. The proliferation of smooth muscle involved the mesenteric, peripancreatic lymphatic channels but also the submucosal lymphatic vessels of the duodenum. Only one other case of LAM presenting with protein losing enteropathy has been reported, in which there were no abnormalities in the intestinal tractus or in the pancreas.

Adult↗
PubMed1987

[Morphological aspects of inopportune fatty metamorphosis of the thymus].

Thymus glands from 43 early infants who died of asphyxia, birth injury and inflammatory diseases were studied morphologically. Unscheduled fatty metamorphosis (UFM) of the thymus was found in 32% of cases of inflammatory diseases. Lipid containing cells of the thymus are thymic macrophages in the state of irreversible lipoid dystrophy and death. Macrophagal enzymopathy with the disturbance of intracellular lipid digestion may account for it. Lipid dystrophy is also noted in some epithelial cells. It is shown that the accumulation of the lipids in thymic macrophages occurs not only in unscheduled fatty metamorphosis, but also during the accidental transformation of the thymus, thus the latter may be considered as a physiologic analogue of UFM. In case of UFM, however, this process acquires a pathologic character and results in macrophage death. Therefore, UFM may be considered as a variant of the accidental transformation abnormality of the thymus.

Fat Necrosis↗
PubMed1979

Lymphographic studies on protein-losing enteropathy.

Lymphographic studies were made on diseases of protein-losing in 19 cases, which include 9 cases of diseases of the digestive canal, 2 cases of constrictive pericarditis, and 8 cases of protein-losing enteropathy. Lymphographically in the diseases of the digestive canal no abnormal findings were detected, but in the constrictive pericarditis remarkable dilation and kinking of the thoracic duct with relatively poor congestion of the lumbar lymphatic vessels were observed. In the intestinal lymphangiectasia dysplasia of the lymphatics, passage disturbance of the thoracic duct with the congestive lumbar lymphatics, reflux to abdominal organs, oozing of contrast medium into the intestinal lumen were disclosed. Also experimentally lymphographic studies in thoracic duct-ligated dogs revealed the reflux to the mesenterial lymphatic system causing protein-losing into the intestine.

Animals↗
PubMed1992

Assessment of the cardiovascular and lymphatic systems.

Assessment of the cardiovascular and lymphatic systems first requires a complete signalment, history, and general physical examination. Further assessment of the cardiovascular system begins with evaluation of the cardiac borders through palpation and thoracic percussion. Complete cardiac auscultation requires careful evaluation of several parameters. The location, intensity, and character of normal heart sounds are first determined. This is followed by assessment of heart rate and rhythm. Finally, special attention should be placed on identifying abnormal heart sounds and describing them based on their location, intensity, duration, sound quality, and radiation. Assessment of the arterial, venous, and capillary systems provides additional information on the status of the cardiovascular system. Assessment of the lymphatic system primarily involves evaluation of external and palpable internal lymph nodes. Commonly palpable external lymph nodes include the intermandibular, parotid, retropharyngeal, superficial cervical, subiliac, mammary, and scrotal lymph nodes. Palpable internal abdominal lymph nodes include the iliofemoral lymph nodes and the iliosacral lymph center. Other lymph nodes that may be palpable include the renal, ruminal, and mesenteric lymph nodes. Lymph nodes should be evaluated for size, consistency, and tenderness.

Animals↗
PubMed2002

The influence of a restrictive atrial septal defect on pulmonary vascular morphology in patients with hypoplastic left heart syndrome.

Hypoplastic left heart syndrome (HLHS) with a restrictive atrial septal defect (ASD) is a form of congenital heart disease with considerable morbidity and mortality. This morphologic analysis assesses the pulmonary vasculature in this patient population. Pulmonary arteries, the persistence of high-resistance fetal arterioles, pulmonary veins, and lymphatics from multiple lung sections from each of five patients with HLHS and a restrictive ASD were compared to those of five patients with HLHS and nonrestrictive ASD. Lung sections from each patient were qualitatively graded in severity of pathology from 0 to 3 for each of the structures described previously, with the pathologist blinded to the status of the ASD. Patients with a restrictive ASD exhibited more significant pulmonary venous thickening and lymphatic dilatation (p = 0.02), with a tendency toward persistence of high-resistance fetal vessels (p = 0.2), compared to patients with a nonrestrictive ASD. These findings imply that patients with HLHS and a restrictive ASD possess pulmonary vascular abnormalities that place them at higher risk for the current surgical interventions available compared to patients with a nonrestrictive ASD.

Female↗