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Biophysical injury mechanisms in electrical shock trauma.

Electrical shock trauma tends to produce a very complex pattern of injury, mainly because of the multiple modes of frequency-dependent tissue-field interactions. Historically, Joule heating was thought to be the only cause of electrical injuries to tissue by commercial-frequency electrical shocks. In the last 15 years, biomedical engineering research has improved the understanding of the underlying biophysical injury mechanisms. Besides thermal burns secondary to Joule heating, permeabilization of cell membranes and direct electroconformational denaturation of macromolecules such as proteins have also been identified as tissue-damage mechanisms. This review summarizes the physics of tissue injury caused by contact with commercial-frequency power lines, as well as exposure to lightning and radio frequency (RF), microwave, and ionizing radiation. In addition, we describe the anatomic patterns of the resultant tissue injury from these modes of electromagnetic exposures.

Animals↗

Geophysical variables and behavior: LXXXVIII. Atmospheric electromagnetism: the possible disturbing influence of natural sferics on ESP.

Sferics are electromagnetic impulses generated by electrical discharges during thunderstorms (lightning). One category is comprised of very low frequency electromagnetic waves, traveling over distances up to a thousand kilometers. Sferics have been shown to affect biological responses such as pain syndromes, reaction times, and power in the alpha band of the EEG. In the present study, in which 100 subjects took part, sferics have been studied in their relation to performance on a forced-choice extrasensory perception (ESP) task and to several secondary variables. The general finding is a negative correlation between ESP performance and sferics activity around the time of the session, most notably 24-48 hours prior to the session. Secondary variables appear to modulate this correlation, as has been found in previous research on sferics: the correlation tended to be stronger for persons who scored lower on Neuroticism and higher on the Openness scale of a Five-Factor Personality Questionnaire.

Adolescent↗

Electrical injury from Tasering and miscarriage.

A case report is presented of a woman who was "Tasered" by law enforcement personnel while 12 weeks pregnant. The Taser (Thomas A. Swift's Electric Rifle) is an electronic immobilization and defense weapon that has been commercially available since 1974. The Taser was developed as an alternative to the .38 special handgun. The patient was hit with Taser probes in the abdomen and the leg. She began to spontaneously miscarry 7 days later and received a dilatation and currettage procedure 14 days later for incomplete abortion. The world's literature on electrical and lightning injury to pregnant women is reviewed, and the mechanism of action of Taser injury is discussed. As use of the Taser becomes more common, obstetrical clinicians may encounter complications from the Taser more often.

Abortion, Spontaneous↗

Headache and sferics.

Many patients with migraine believe weather is a trigger for their headaches. The objective of this study was to determine if very low frequency sferics, pulse-shaped electromagnetic fields originating from atmospheric discharges (lightning), are precipitating factors. The occurrence of sferics impulses is characterized by a daily, as well as an annual, periodicity and is thought to be associated with various pathological processes. The diaries of 37 women suffering from migraine and tension-type headaches were analyzed over a period of 6 months and correlated with daily sferics activity and other weather phenomena in the area of Giessen, Germany. From October through December (autumn), sferics activity was correlated with the occurrence of migraine (r = 0.33, P<.01); however, there was no correlation in July and August (summer), when the thunderstorm activity had been very intense. In summer, tension-type headaches were associated with other weather parameters such as temperature (r = 0.36, P<.01) and vapor pressure (r = 0.27, P<.05).

Adult↗

Responding to summer emergencies.

Summer's arrival ushers in health hazards ranging from bee stings to lightning strikes. This article discusses preventive measures and provides first aid and ongoing care instructions for common summertime emergencies.

Bites and Stings↗

The neurological complications of electrical injury: a nursing case management perspective.

High-energy electrical injury, whether from lightning strike or electrical shock, occurs primarily in the workplace. Neurological dysfunction can be a devastating complication of electrical injury. A review of the literature was undertaken to develop a better understanding of the epidemiology, mechanisms of injury and neuropathology associated with this type of injury. The numerous challenges inherent in the management of these complex cases were illustrated by three case studies.

Accidents, Occupational↗

[Electrical injuries in childhood (author's transl)].

11 children were admitted with electrical injuries to the Department of Paediatrics, University of Graz, over the 10-year period 1965 to 1974. The electricity was of low voltage in the case of 9 of these children, who were injured whilst playing with plug sockets of defective cables and of high voltage in 4 case. 1 child was stuck by lightning. Cessation of respiration occurred in 4 of the patients and was successfully counteracted in all cases by prompt mouth-to-mouth breathing. 7 children were still shocked on admission. All children showed the characteristic skin lesions of electrical injury (current marks of linear, round or spidery form). The boy injured by high voltage electricity received extensive burns, in addition. The modes of electrical injury in childhood, the various forms of the resultant lesions, especially of the skin and the treatment of electrical burns are discussed.

Adolescent↗

Electrocution: a review of 155 cases with emphasis on human factors.

A review of 155 cases of electrocution were investigated to determine the role of human factors, such as carelessness and intoxication, as contributions. The cases were retrieved by computer coding from the repository of the Armed Forces Institute of Pathology, covering the period 1955-1988. The cases are predominantly of military origin. Cases were divided into low-voltage electrocution (N = 47), high-voltage electrocution (N = 79), lightning strikes (N = 16), and unclassified (N = 13). For each group, data is presented on the circumstances of the incident and the pathologic findings. Blatant carelessness, misuse or improper maintenance of equipment, and intoxication are analyzed as contributory factors.

Accidents, Home↗

Protracted Lhermitte's sign following head and neck irradiation.

Lhermitte's sign is a rare complication of head and neck irradiation involving the delivery of dose to the cervical spinal cord. Although uncommon, symptoms of lightning-like electric sensations spreading into both arms, down the dorsal spine, and into both legs on neck flexion following head and neck irradiation, causes great concern in both the patient and the physician. This spontaneously reversible phenomenon is important for the otolaryngologist and radiation oncologist to recognize and discuss. A particularly severe and protracted case of Lhermitte's sign involving a patient recently completing a radical course of radiation for nasopharyngeal carcinoma is described in detail, including a review of the literature surrounding the cause and management of this condition.

Carcinoma, Squamous Cell↗

Advances in the genetics of progressive myoclonus epilepsy.

The genetic progressive myoclonus epilepsies (PMEs) are clinically characterized by the triad of stimulus sensitive myoclonus (segmental lightning like muscular jerks), epilepsy (grand mal and absences) and progressive neurologic deterioration (dementia, ataxia, and various neurologic signs depending on the cause). Etiologically heterogenous, PMEs are rare and mostly autosomal recessive disorders, with the exception of autosomal dominant dentatorubral-pallidoluysian atrophy and mitochondrial encephalomyopathy with ragged red fibers (MERRF). In the last five years, specific mutations have been defined in Lafora disease (gene for laforin or dual specificity phosphatase in 6q24), Unverricht-Lundborg disease (cystatin B in 21q22.3), Jansky-Bielschowsky ceroid lipofuscinoses (CLN2 gene for tripeptidyl peptidase 1 in 11q15), Finnish variant of late infantile ceroid lipofuscinoses (CLN5 gene in 13q21-32 encodes 407 amino acids with two transmembrane helices of unknown function), juvenile ceroid lipofuscinoses or Batten disease (CLN3 gene in 16p encodes 438 amino acid protein of unknown function), a subtype of Batten disease and infantile ceroid lipofuscinoses of the Haltia-Santavuori type (both are caused by mutations in palmitoyl-protein thiosterase gene at 1p32), dentadorubropallidoluysian atrophy (CAG repeats in a gene in 12p13.31) and the mitochondrial syndrome MERRF (tRNA Lys mutation in mitochondrial DNA). In this review, we cover mainly these rapid advances.

Cystatin B↗

Sharing open secrets in training future generations of clinical psychologists.

Commentary writers vary in their agreement with the ideas presented in the C.R. Snyder and T.R. Elliott lead article (this issue, PP. 1033-1054), but they share the view that clinical-counseling psychology already is in the midst of an evolution. There are two general camps to such commentaries. First, there are those who caution us to move slowly and carefully as we respond to the change-inducing forces. Second, there are those who see this time as one in which we should make bold moves in our field in response to the societal forces that we are encountering. We suggest that the lightning rod for potential changes in the field of clinical-counseling psychology must be a shared emphasis on our scientific heritage.

Behavior Therapy↗

Atmospherically relevant ion chemistry of ozone and its cation.

The importance of ionic processes that occur in terrestrial, planetary, and stellar atmospheres is receiving increasing recognition. Actually, ions play important, often crucial, roles in a variety of atmospheric processes throughout the universe, and a strong link with the neutral chemistry is also apparent. In the terrestrial atmosphere, the ionic reactions are most relevant in those transient and fleeting events, e.g., lightning, coronas (in thunderstorm clouds and along power lines), where the local ion density is much higher than in unperturbed air, and the chemical systems are typically far from equilibrium. In such cases, ozone, a key molecule for the terrestrial atmosphere, is also present in high local concentrations; it is formed from O(2) by the same transient event. Accordingly, this review provides a survey of the positive ion chemistry of ozone with several of the most important "atmospheric" species: the reactions, the products, and the importance of the examined processes are discussed also in the light of the local thermodynamic disequilibrium (LTD) approach to the chemistry of transient atmospheric events. In all such studies, mass spectrometry is traditionally, and remains today, the experimental technique of choice. The novel application of mass spectrometry to the study of neutral species (NRMS), highly successful for the preparation and positive detection of long-sought, otherwise inaccessible, short-lived neutrals, makes mass spectrometry the most powerful tool now available for the study of the species and processes that are relevant to atmospheric chemistry. Selected examples of the interlink between the neutral and the ionic chemistry are also illustrated.

Air Ionization↗

Essential myoclonus and myoclonic dystonia.

This review explores the history and use of the terms essential myoclonus and myoclonic dystonia. In addition, the review proposes that hereditary essential myoclonus and dominantly inherited myoclonic dystonia, with lightning jerks and dramatic response to alcohol, are the same disease, although proof of this hypothesis must come from ongoing genetic studies.

Alcohol Drinking↗

Linkage studies in alcohol-responsive myoclonic dystonia.

A large German family with "myoclonic dystonia with lightning jerks responsive to alcohol" was identified. Eleven affected pedigree members and six obligate gene carriers from five generations were identified. A description of one branch of this pedigree was published in 1964. Our examination 30 years after the initial report confirms the clinical syndrome of a nonprogressive movement disorder characterized by myoclonic jerks affecting the proximal muscles and the muscles of the trunk, accompanied by mild dystonic features in some affected family members. Segregation analysis favors autosomal dominant inheritance with high, but incomplete, penetrance in males and much lower penetrance in females. Linkage analysis was performed using simple sequence repeat polymorphisms (CA repeats) closely associated with or spanning the chromosomal regions containing 15 candidate genes: the gene for early-onset generalized torsion dystonia, DYT1 (chromosome 9q34); the genes for subunits alpha 2, beta 1, and gamma 1 (chromosome 4p12-4q13); for alpha 1, alpha 6, beta 2, and gamma 2 (chromosome 5q31.1-5q31.3); for alpha 4, alpha 5, beta 3, and gamma 3 (chromosome 15q11-15q13); for rho 1 and rho 2 (chromosome 6q14-6q21) of the gamma-aminobutyric acid A receptor; and for the alpha subunit of the glycine receptor (chromosome 5q31). By a combination of pairwise and multipoint linkage analysis, it could be excluded that any of these candidate gene-bearing chromosomal regions contain the disease gene in this family. We also excluded major portions of three chromosomal regions syntenic with mouse chromosome 3, which carries the murine beta subunit of the glycine receptor.

Adolescent↗

Cine spiral imaging.

Interleaved spiral scanning of k-space is an efficient and fast method for imaging dynamic processes. In this article, a cine version of interleaved spiral imaging is presented. The method is shown to overcome the "lightning-flash" artifacts of the conventional triggered (gated) method. Compared with the segmented k-space 2DFT method, it achieves better temporal resolution in a comparable or shorter scan time. Preliminary human studies show that the method is a promising tool for imaging dynamic processes.

Humans↗

Childhood leukemia following phototherapy for neonatal hyperbilirubinemia (Denmark).

To test the hypothesis that exposure to high intensity lightning (around 400 nanometers) in neonatal nurseries increases the incidence of childhood leukemia, over 55,120 newborn children treated with phototherapy for hyperbilirubinemia were identified from the Danish Hospital Discharge Register for 1977-89. Linkage of the roster with the national cancer registry through 1991 revealed 87 childhood cancers, whereas 85 were expected from the rates for the general population. The incidence of leukemia in 34 children was not unusual (standardized incidence ratio [SIR] = 1.2, 95 percent confidence interval [CI] = 0.8-1.7). Subgroup analyses revealed no remarkable patterns for any category of leukemia subtype, gender, or age at diagnosis. We conclude that whole-body exposure to phototherapy (420-470 nm) shortly after birth is not a significant risk factor for childhood leukemia.

Adolescent↗

Electrical cataract and optic neuropathy.

We report on a 20 year old male, who developed mature cataract (Electrical Cataract) on both eyes after a severe electric shock from high voltage. Both of his hands and the left foot had to be amputated, because of the severe injury. Although electrical cataract due to high voltage or lightning is rare, they may still occur after industrial or home electric accidents. Even if extracapsular cataract extraction with intraocular lens implantation is successfully performed, the final visual acuity will depend on other ocular damage due to the electric current.

Adult↗

Organic synthesis by quench reactions.

The effects of chemical quench reactions on the formation of organic compounds at a water surface under simulated primordial earth conditions were investigated for the study of chemical evolution. A mixture of gaseous methane and ammonia over a water surface was exposed to an arc discharge between an electrode and the water surface. This discharge served as a source of dissociated, ionized and excited atomic and molecular species. Various organic molecules were formed in the gaseous, aqueous, and solid states by a subsequent quenching of these reactive species on the water surface. The effects of these water-surface quench reactions were assessed by comparing the amounts of synthesized molecules to the amounts which formed during the discharge of an arc above the water level. The results showed that: (1) the water-surface quench reaction permitted faster rates of formation of an insoluble solid and (2) the quench discharge yielded twice as much amino acids and 17 times more insoluble solids by weight than the other discharge. The highest yield of amino acids with the quench reaction was 9 x 10-7 molecules per erg of input energy. These observations indicate that quench reactions on the oceans, rain, and clouds that would have followed excitation by lightning and shock waves may have played an important role in the prebiotic milieu. Furthermore, the possibility exists that quench reactions can be exploited for the synthesis of organic compounds on a larger scale from simple starting materials.

Amino Acids↗