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Results for “Intestinal Neoplasms”

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PubMed1979

[Transplantable carcinoma of the large intestine in BD IX rats: a new model for study of metastatic dissemination and experimental therapeutics].

Using cells in culture of a large intestine carcinoma by the rat BD IX, the authors have produced 5 experimental models of metastases: subcutane, of the lung, the liver and the peritoneum. These metastases have the same properties as the primitive tumor. These four models have the originality to be metastases of a large intestine carcinoma chemically induced in the rat representing situations frequently encountered in human cancerology in the case of generalised cancer. These models allow immunotherapy, immunoprophylaxis, chimotherapy, angiotherapy and biochemical studies and to test the effects of certain substances such as the anticoagulants.

Animals↗
PubMed1979

Hyperplasia and neoplasia of the intestinal tract.

Measurements of RNA and DNA in the rat have been used to identify mucosal hyperplasia in the remaining gut within 48 h of partial intestinal loss. Structural adaptation of the ileum is still present 3 months after jejunal resection, whereas transection of the bowel produces merely transient hyperplasia. A humoral factor can be transmitted between rats linked in vascular parabiosis that is capable of stimulating intestinal cell proliferation. Humoral agents may also explain reduced adaptation of the distal bowel after jejunal bypass as opposed to equivalent resection. Although bile can initiate prompt ileal hyperplasia, the additional presence of pancreatic juice is needed to prolong this effect. Adaptation is controlled by luminal and systemic factors that are closely interlinked. Experimental intestinal carcinogenesis is promoted by proximal enterectomy.

Adaptation, Physiological↗