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At least 721 records · Page 40Linked to original sources
PubMed2006

Differential involvement of the endocannabinoid system in short- and long-term expression of incentive learning supported by nicotine in rats.

RATIONALE: We previously reported that the CB1 cannabinoid receptor antagonist, rimonabant, impaired the acquisition and the short-term (24 h), but not long-term (3 weeks), expression of conditioned place preference (CPP) induced by nicotine in rats. OBJECTIVE: To assess the time interval of efficacy of a single pretest injection of rimonabant to abolish nicotine-CPP, and the effects of chronic CB1 receptor blockade on long-term expression of nicotine-CPP. MATERIALS AND METHODS: Wistar rats were conditioned to nicotine (0.06 mg/kg, subcutaneous) using an unbiased one-compartment procedure. Two test sessions were conducted 24 h (without injection) and 1, 2, or 3 weeks later. Rimonabant (3 mg/kg, intraperitoneal) or vehicle was administered daily between the two test sessions. In addition, the CB1-stimulated [(35)S]GTP-gamma-S binding was assessed in rats from the 3-week experiment. RESULTS: The capacity of a single injection of rimonabant (3 mg/kg, 30 min pretest) to block the expression of nicotine-CPP disappeared within 1 week after conditioning. Daily administrations of rimonabant for 6, 13, or 20 days post-acquisition did not impair nicotine-CPP but allowed an additional pretest injection of rimonabant to retain its capacity to abolish long-term expression of nicotine-CPP. The CB1 receptor-mediated G-protein signaling was not altered in various brain areas of rats given rimonabant for 3 weeks. CONCLUSIONS: The endocannabinoid system is essential to the expression of nicotine-CPP during less than 1 week after conditioning but not later. However, endocannabinoid-dependent mechanisms are critically involved in the development of the neuroadaptive changes responsible for the shift from CB1-dependent to CB1-independent expression of nicotine incentive learning.

Animals↗
PubMed2006

Incentive for a shift from modern scientific medicine to integrative medicine.

Medicine has been evaluated in recent years both quantitatively and qualitatively. Contemporary medicine has been assumed to be conceptually based on modern science. However, there is a problem that quantity and quality are hard to evaluate using only scientific parameters. It is, therefore, the aim of this article to emphasize that the quantity and quality of medicine need to be evaluated not only from the standpoint of modern scientific medicine but also in terms of integrative medicine. Integrative medicine is postulated to be comprehensive in its fundamental doctrine, emphasizing a holistic approach including technical, artistic, social, religious, philosophical, and ethical elements. However, in evaluating carefully and seriously actual performance, it was noted that contemporary medicine has been giving greater emphasis to aspects of integrative medicine where increasing concern is paid to patients' personal preferences, as indicated by their quality of life. An incentive for a shift from exclusively scientific to integrative medicine, which started as early as the 1970s, is revival emotion toward a prime modality of medicine.

Complementary Therapies↗
PubMed2005

Medical errors: getting the incentives right.

This work examines the role of penalties as providers of incentives to prevent medical errors and ensure that such incidents, once they occur, become common knowledge. It is shown that a scheme with two penalties (accountability and non-report) induces the first-best solution. However, this scheme does not necessarily imply a punitive environment, but may, under given circumstances, yield insignificant and even negative penalties. Alternative sanction systems, such as voluntary reporting and immunity, are found to have less desirable properties. An exception is confidentiality (anonymity) which turns out to be an optimal scheme. Finally, the examination of various penalty restrictions (scope and scale) shows that such barriers may promote both tougher and softer sanction schemes.

Confidentiality↗
PubMed1977

A cortical evoked potential that reflects the conditioned, positive incentive value of the stimulus. II. Drive motivation (hunger).

It was shown that the late negative wave evoked in squirrel monkey cortex by tone cues signalling the availability of reward was smaller when the animal did not respond to the cue and often disappeared if the animal ignored many cues in succession. It decreased in amplitude as a test session progressed, and the rate of this decrease increased if the rate of reinforcement was increased. In some animals the size of the evoked wave was smaller if the animal was not fasted before a test session. In some animals the average size of a significant positive correlation with the number of cues responded to and a negative correlation with the animal's average reaction time. It is concluded that the evoked wave is probably a reflection of the conditioned incentive value of the cue.

Animals↗
PubMed1977

A cortical evoked potential that reflects the conditioned, positive incentive value of the stimulus. III. Manipulative motivation and the value of the reward.

Changing animals from a schedule on which they had to bar-press after a tone cue to get a food pellet, to a schedule on which the food pellet was presented automatically after the tone cue and the manipulandum was not available, had no effect on the latency, amplitude, or shape of the M-wave evoked by the tone cue. The amplitude of the evoked wave did, however, decrease more rapidly, as a test session progressed, with the latter schedule than with the former schedule. Failure to fast animals before test sessions markedly reduced the amplitude of the M-wave. Variation in the type of food pellet used caused marked variations in the amplitude of the evoked response. In all cases, there was a high degree of correlation between M-wave amplitude and a behavioral indication of the animal's interest in the reward. It was concluded that the M-wave reflects the conditioned incentive value of the cue, or in other words, the level of interest of the animal in the reward.

Animals↗
PubMed1979

Dissociation of a visual discrimination task into incentive, location and response habits.

Rats previously trained to run from a start box, through a choice chamber, approach and displace a white card rather than a black card and enter a goal box in order to avoid footshock sustained damage to either the medial thalamus, occipital cortex or rostral caudoputamen. The retention test disclosed that the avoidance response was abolished by thalamic lesions, the visual discrimination response was abolished by occipital lesions and the card displacement response was abolished by caudatal lesions. These data demonstrate that this visual discrimination task can be fractionated into a least three discrete habits: One is related to the initiation of the response leading to the reward (incentive habit), the second is related to the location of the correct pathway to the reward (location habit) and the third is related to the response necessary to gain access to the reward (response habit).

Animals↗
PubMed1983

Incentive relativity effects reduced by exogenous insulin.

In two experiments rats shifted from 32% to 4% sucrose consumed less of the 4% than rats maintained on the 4% solution. This negative contrast effect was eliminated if the rats were injected with insulin (5.4 U/kg) on the shift day. This insulin dose reduced blood glucose levels to less than 50% of control levels, but the brief access period to 4% sucrose just before blood sampling reliably increased blood glucose levels. The results were discussed in terms of the effects of deprivation conditions on incentive relativity.

Animals↗
PubMed1996

Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood.

Early social experience has profound effects on a wide spectrum of behaviors and neurochemical correlates in the rat. Repeated separation of rat pups from their dam during the early neonatal period causes acute perturbation of neuroendocrine and physiological status. The chronic sequelae of repeated separations have not been studied as extensively as the acute responses. Altered social experience at a later developmental stage, postweaning isolation rearing, is known to induce enduring changes in the behavioral responses to reward and reward-related stimuli in maturity. We have evaluated the influence of repeated early maternal separation on the responses to both primary and conditioned incentives in mature rats. Separated animals showed enhanced weight gain, a blunted locomotor response to a novel environment and a blunting of the response to both negative and positive contrast effects. Female separated animals, but not males, exhibited a profound attenuation of the acquisition of a conditioned anticipatory locomotor response to the presentation of food. These data are discussed with respect to the putative involvement of ventral striatal dopamine systems in reward mechanisms and the potential utility of early maternal separation as an animal model of depression.

Animals↗
PubMed1991

A 5-year evaluation of a smoking cessation incentive program for chemical employees.

BACKGROUND: This 5-year study of the Dow Chemical Texas Operations 1984-1985 Smoking Cessation Incentive Program (SCIP) evaluated the smoking habits of 1,097 participants and 1,174 nonparticipants. RESULTS: We observed, via questionnaire and saliva cotinine data, that participants were 2.3 times more likely to be long-term (greater than or equal to 5 years) nonusers of tobacco than nonparticipants (10.2% vs 4.4%, P less than or equal to 0.01). However, smoking cessation rates for 3-4 years, 1-2 years, and less than 1 year were similar for participants who remained smokers at the conclusion of SCIP and nonparticipants. Age and the interaction between the management job category and having quit smoking for at least 30 days sometime prior to the worksite program were important predictors of smoking cessation among participants. Thirty-six percent of the participants who were considered exsmokers of 6 months duration at the conclusion of the program in 1985 remained long-term quitters 5 years later. Stress and enjoyment of smoking were the two most important reasons provided by participants for recidivism. CONCLUSIONS: The results of this 5-year evaluation demonstrate the heterogeneity of employee participation and success with a worksite smoking cessation program.

Absenteeism↗
PubMed1993

Two types of motivation revealed by ibotenic acid nucleus accumbens lesions: dissociation of food carrying and hoarding and the role of primary and incentive motivation.

Rats with dopamine-depleting lesions of the nucleus accumbens (NAcc) no longer carry food and leave it in a refuge (carry-to-leave or hoard). The present study replicates this finding and extends it to rats with ibotenic acid lesions. The same rats, however, were found to carry food to a refuge to eat it (carry-to-eat). Thus, within a test session, control rats would first carry food to eat it, and when sated, carry the remaining food to leave it in the refuge. NAcc food-deprived rats carried food to eat it but when sated engaged mainly in exploratory behavior. When carrying-to-eat, NAcc rats modulated responses normally to food size and eating time, their movement speed and motor patterns were normal, and their eating times were normal. Nevertheless, they were slower to return for food after eating, and they did not show normal slowing of eating times with successively presented food pellets. The failure of NAcc rats to carry-to-leave when sated was not related to general inactivity. In activity tests, they were as active in the light, more active in the dark, and did not differ from control rats under amphetamine (1.25 and 2.5 mg/kg). Their impairments were also not related to damage to other forebrain related structures, as they displayed normal neocortical and hippocampal atropine-sensitive and atropine-resistant electroencephalograms (EEG). The finding that NAcc rats carry-to-eat when hungry but do not carry-to-leave when sated suggests two separate conclusions. First, food carrying can be dissociated into two separate actions with respect to neural control, carrying-to-eat and carrying-to-leave. Second, the selective involvement of the NAcc in only carrying-to-leave suggests that it is associated with recruiting actions in response to the secondary incentive features of food but is not required for behaviors associated with food consumption. Other structures are presumably activated by the primary drive-reducing features of food. The results are discussed in relation to two-factor theories of motivation.

Animals↗
PubMed1984

Considering the effects of financial incentives and professional ethics on 'appropriate' medical care.

This manuscript presents a model of an 'ethical' physician's allocation of time and income between work and leisure activities for various remuneration types and income levels. The physician is 'ethical' because, ceteris paribus, he prefers to provide that amount of medical care which he believes to be in the patient's best interests. Remuneration systems include fixed, time-based and output-based incomes. Only output-based income provides the physician with incentives which may (if the physician density and medical care price are sufficiently high) generate more-than-'appropriate' care per patient. Fixed and time-based incomes necessarily lead the physician to provide less-than-'appropriate' care.

Ethics, Medical↗
PubMed1993

Economic incentives, health status and health services utilisation.

The impact on utilisation of differential public entitlements to free health services is analysed, using data for a large sample of Irish households. GP visiting rates are seen to be significantly higher for those on low incomes whose costs are covered by the State than for those who pay for such care, having controlled for other characteristics including health status. The importance of taking differences in health status into account in attempting to distinguish the effects of economic incentives is shown both for GP visits and hospital stays.

Adolescent↗
PubMed1996

Gene patents--a time to balance access and incentives.

The issue of patents on inventions of genomic research is the subject of intense debate. The exchange of scientific information and access to new technologies are critical to biomedical research. Similarly, strong patent laws are necessary to encourage innovation. Thus, it is time to balance access and incentive. Patents claiming genes with purely speculative utilities should not be issued, and they possibly limit research. Reasonable access to properly patented genes should be provided for research, and exclusive positions maintained for commercial utilities. This will promote ready access to genomic information and fundamental technologies, while optimizing the discovery and disclosure of basic advances in biomedical research.

Biotechnology↗
PubMed1993

Hispanic Americans and the state mental hospitals in Texas: ethnic parity as a latent function of a fiscal incentive policy.

This paper examines patterns of utilization of the state mental hospitals in Texas by Hispanics compared to Anglos over a 5-year period from FY 1984 to FY 1988. Historically, Hispanics have been underrepresented in public mental health client populations in the United States. In the mid-1980s in Texas, the ethnic gap in use of psychiatric facilities was expected to widen as Hispanic population growth outpaced the capacity of the public system to provide accessible mental health services for persons with serious and persistent psychiatric illnesses. But in the inpatient sector, the gap narrowed significantly in the second half of the decade, due to a policy-driven sharp reduction in the overall census of the state mental hospitals. A fiscal incentive program to stimulate the development of community-based mental health services had a markedly different effect on subsequent inpatient utilization by Anglos compared to Hispanics, most notably in counties that were less urban and less affluent and counties with a relatively high proportion of Hispanic residents. The context and mixed implications of these developments are explored.

Adolescent↗
PubMed1992

The effect on response rates of offering a small incentive with a mailed questionnaire.

To determine whether response rates to a mailed questionnaire sent to population control subjects could be increased through offer of a small incentive, half of the control subjects (n = 477) in a case-control study of renal cell carcinoma were randomly selected to receive a contact letter offering a lottery ticket if a completed questionnaire was returned; the remaining subjects (n = 477) received the same letter but with no mention of a lottery ticket. Overall response rates did not differ between the two groups (72.6% versus 74.4%), although a higher percentage of those offered a lottery ticket responded without follow-up (24.4% versus 18.5%). Binomial regression modeling of the effect of the lottery ticket offer, sex, age, and percent of urban dwellers on response indicated a significant effect only for percent of urban dwellers, the rate of response increasing with a decreasing percentage of urban dwellers. The effect of sex was of borderline significance (P = 0.05), with females having the higher rate of response.

Adult↗
PubMed2006

TuBaFrost 4: access rules and incentives for a European tumour bank.

When designing infrastructure for a networked virtual tumour bank (samples remain at the collector institutes and sample data are collected in a searchable central database), it is apparent that this can only function properly after developing an adequate set of rules for use and access. These rules must include sufficient incentives for the tissue sample collectors to remain active within the network and maintain sufficient sample levels in the local bank. These requirements resulted in a key TuBaFrost rule, stating that the custodianship of the samples remains under the authority of the local collector. As a consequence, the samples and the decision to issue the samples to a requestor are not transferred to a large organisation but instead remain with the collector, thus allowing autonomous negotiation between collector and requestor, potential co-authorship in publications or compensation for collection and processing costs. Furthermore, it realises a streamlined cost effective network, ensuring tissue visibility and accessibility thereby improving the availability of large amounts of samples of highly specific or rare tumour types as well as providing contact opportunities for collaboration between scientists with cutting edge technology and tissue collectors. With this general purpose in mind, the rules and responsibilities for collectors, requestors and central office were generated.

Europe↗
PubMed2005

Financial incentives for disease management programmes and integrated care in German social health insurance.

As a result of recent health care reforms sickness funds and health care providers in German social health insurance face increased financial incentives for implementing disease management and integrated care. Sickness funds receive higher payments form the risk adjustment system if they set up certified disease management programmes and induce patients to enrol. If health care providers establish integrated care projects they are able to receive extra-budgetary funding. As a consequence, the number of certified disease management programmes and the number of integrated care contracts is increasing rapidly. However, contracts about disease management programmes between sickness funds and health care providers are highly standardized. The overall share of health care expenses spent on integrated care still is very low. Existing integrated care is mostly initiated by hospitals, is based on only one indication and is not fully integrated. However, opportunity to invest in integrated care may open up innovative processes, which generate considerable productivity gains. What is more, integrated care may serve as gateway for the introduction of more widespread selective contracting.

Adolescent↗
PubMed2006

Incentives to improve farm management: EMS, supply-chains and civil society.

This paper focuses on impediments to environmentally sound management practices and how these might be overcome, with an emphasis on the role of environmental management systems, supply chains and civil society. It argues that: Farmers are under increased pressure to cut costs and improve production but with little opportunity to increase prices. Commonly short-term economic interest has damaging environmental implications. Current government policy, in Australia and in many other jurisdictions, relies heavily on voluntary arrangements, education and information, as the main policy instruments through which to persuade farmers to adopt better environmental farm management - e.g. the recent push to encourage the use of voluntary environmental management systems. However, there is good evidence to suggest that these can only make a valuable contribution when combined with a range of other policy instruments, including positive and negative incentives, intervention by third parties and in some cases, an underpinning of regulation. Arguably, what is needed is a strategy that builds on the strengths of voluntary environmental management arrangements while compensating for their weaknesses by combining them with other, complementary policy instruments. If so, we must engage with a range of questions that have not so far figured substantially in the policy debate. Although the principal focus has been on the role of government in bringing about on-farm change in management practices, supply chain pressure (at least in respect of agricultural chemicals and practices which threaten food safety) and civil society action are also potentially powerful mechanisms for bringing about change. Government can and should play a role in harnessing such forces in the interests of improved environmental on-farm practices.

Agriculture↗