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PubMed1992

On the theory of partially inbreeding finite populations. III. Fixation probabilities under partial selfing when heterozygotes are intermediate in viability.

In a previous paper by the senior author, an approximation to the probability of survival was given for a mutant, which is originally present in a single heterozygote, in a population that reproduces partly by selfing and partly by random mating. The population was assumed to be very large, but the result obtained is general with regard to the level of dominance in viability. In this paper two errors which were made in that earlier work are corrected. A general approximate expression is then derived for the probability that an allele A is fixed in a partially self fertilizing population of size N, if its initial frequency is p, selection is weak and heterozygotes with the allele are exactly intermediate in viability compared with genotypes AA and AA. A rigorous proof is given for a special case that is a generalization of the classical binomial sampling model. In this case, but not in general, the approximate fixation probability is independent of the probability of reproduction by selfing. Some implications are discussed.

Alleles↗
PubMed1993

F statistics in Drosophila buzzatii: selection, population size and inbreeding.

Drosophila buzzatii is confined to reproducing in a well defined patchy environment consisting of rotting cactus cladodes which are ephemeral, permitting at most three generations. Flies emerging from such rots were used to estimate the additive genetic variance within rots and the genetic variance between rots for body size and also were electrophoresed to determine their genotypes at six polymorphic loci. F statistics were estimated from body size and allozyme data. The FST derived from body size was significantly larger than the allozyme FST. It is proposed this is due to selective differentiation of body size. The allozyme FST is used to estimate effective population size: 10 < N < 50. It is suggested that the regularly observed positive FIS's could be due to partial sib mating, S. If so, the estimated lower bound is S = 0.258. Experiments are identified which could support or contradict these interpretations.

Animals↗