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[Herbicides and neoplasms of the hemolymphopoietic system].

The study is a population-based case-control study on hematolymphopoietic tumors, conducted in west Liguria with high prevalence of exposure to chemicals suspected (about 10%) of increasing the risk of leukaemias or lymphomas and multiple myeloma (pesticides). Cases and control were identified and confirmed during the period 1/1/1990 through 31/12/1993. Cases are identified through periodic contacts with the Pathology, or Hematology or other relevant Department of the Hospitals of west Liguria and Genoa town or University of Genoa where patients living in these area are referred for hematolymphopoietic malignancies. Controls are a random sample of the general population living in each area (using the demographic health archives). The range of the age is 20-74. After identification each case or control is contacted to have his consent to the interview near the home. Informations collected using a most completed questionnaire regard drinking and smoking habit, the addresses and the conditions of the homes where spending the life, particularly hobbies about exposure of pesticides and/or solvents, more important pathological events on the life and the occupational exposure. Actually we are in the phase of identification of cases and controls.

Adult↗

[Hepatotoxic occupational risk factors].

In this review the authors present a synthetic and critical analysis of the most recent epidemiological, clinical and experimental studies on the main risk factors thought to cause occupational liver diseases. The aim was to list the main occupational hepatotoxic substances in order to enable the earliest identification of possible occupational liver pathologies and the application of suitable means of prevention in the workplace. The following data emerge from a critical analysis of the studies reported. The list of potentially hepatotoxic substances is certainly very long and reliable evidence of specific toxicity only exists for some; many of these substances are used not only in the professional world, but often outside the workplace. The main route through which lesions occur is by inhalation and, in the case of many substances, also through the skin. In clinical terms, occupational liver pathologies may take an acute, subacute or chronic form, often with comparable symptoms to those found following non-occupational exposure. No particular histological features can be seen, nor are there specific diagnostic means to evaluate individual chemical substances. With regard to the data reported, the authors reach a few conclusions: when formulating an etiological diagnosis of occupational toxic hepatopathy, it is important to bear several aspects in mind such as the characteristics of the workplace (type of activity performed, products handled, working conditions, etc.), lifestyle (hobbies, use of drugs, etc.), varying individual susceptibility; each of these factors contributes to the onset of morbid conditions whose target is the liver.

Chemical and Drug Induced Liver Injury↗

Chronic sorrow in persons with Parkinson's and their spouses.

Chronic sorrow is the grief experienced from continual loss during the trajectory of an illness or disability. The presence and nature of chronic sorrow were determined in a sample of six persons with Parkinson's disease and four of their spouse caregivers using the Burke NCRCS Questionnaire. Four of the afflicted individuals and two of the spouse caregivers reported symptoms of chronic sorrow that for half of them were more intense than at the time of diagnosis. Respondents used extensive problem-solving and emotive coping strategies to handle their sorrow. Most of the respondents described themselves within the context of the illness and the care required. Losses triggering their sorrow included loss of future plans, restricted social life, and inability to travel and participate in hobbies. Support from others was restricted mainly to physicians at the time of diagnosis and close family. Supportive nursing interventions for their grief are indicated.

Adaptation, Psychological↗

Life-style, aging and work ability among active Finnish workers in 1981-1992.

OBJECTIVES: Life-style is an important factor in explaining the changes in health and well-being in old age. In this study life-style was defined according to Abel's definition as combining life chances and life conduct. The main question concerned the change in life-style components and work ability over a 11-year period. METHODS: The study population comprised workers who responded to a questionnaire in both 1981 and 1992 and were still working in 1992 (N = 924). The changes in the dimensions of life-style (hobbies, living habits, life satisfaction) were tested with Pearson's chi-square test. The associations between life-style, work ability, and health were analyzed by correspondence analysis. RESULTS: Physical activity was the life-style factor that showed a major change; it increased among both genders. All other leisure-time activities decreased during the follow-up. The women's satisfaction with their life situation increased, but the men were less satisfied at the end of the study. Work ability, as measured with the work ability index, was a crucial factor in these changes. If the work ability remained good, the respondents were also more active and more satisfied with their life. This effect of work ability was strong, especially with respect to the men's satisfaction with their life situation. CONCLUSIONS: Life-style, work ability, and perceived health are highly associated, and studying them separately may give a simplistic view of the interaction between aging and work. In the future, more comprehensive approaches should be applied.

Adult↗

[Late diabetic sequelae].

Diabetic patients are exposed to higher risk of morbidity and mortality. However, it is difficult to define this in advance and to predict the degree of inability for work. The risk is depending on type of diabetes, age of manifestation, age of the patient course and duration of the disease and mainly from glycemic control. Educational programs may markedly ameliorate the overall situation and decrease of risk of late complications which may threat kidney, eyes, nerves and the cardiovascular system. However, it is an erroneus notion that most diabetics may be crippled by complications of their disease which may result in unwarranted bias against them in both work and leisure activities. Most diabetics may undertake any occupation or hobby, of course with some exceptions when hypoglycemia due to insulin or hypoglycemic agents represents risk for themselves and other persons. Those patients may not serve as pilots and cannot hold public service vehicle driving licences. They should not take over the supervision in power-stations etc. Ordinary driving licences can be held by diabetic patients if on insulin or not, provided that they are otherwise physically fit and do not suffer from blackouts. From many studies it is known that the rate of accidents is not higher with respect to diabetic patients than in the normal population. Life assurance premiums are often raised by amounts which depend on the result of a medical examination but it is very important that the judgement is not made on the basis of a single checkup at a given time. To get information about the presence or development of late complications which have a very broad spectrum it is necessary to have insight into the course of the metabolic disorder and the tendency of worsening or amelioration.

Cause of Death↗

[Exercises that should be prescribed for heart patients].

The goal of cardiac rehabilitation is to assist the patient in regaining, as close as possible, normal functioning. Participation in an exercise program is one way to achieve this objective. Exercise improves not only the physiologic state of the patient, but also produces many psychosocial benefits. However, exercise prescription is different for cardiac patients, according to the factors associated with the type of cardiac pathology and the surgical intervention. The goal of this article is to inform and guide the nurse in prescribing exercise for cardiac patients. A case study of a patient with cardiac pathologies such as angina, myocardial infarction, and congestive heart failure is presented. The nurse will learn how to prescribe the appropriate types of activities as well as the intensity, duration and frequency of the training sessions. The nurse will also be able to recommend appropriate physical activities for phase II of cardiac rehabilitation, a phase embracing the time from hospital discharge through the following three months. Finally, a list of activities and hobbies, with various energy costs, is presented.

Exercise Therapy↗

[Quality of life in chronic renal insufficiency: the effect of disease development and various method of therapy].

The aim of the study was to evaluate the impact of development and way of treatment of chronic renal failure on patient's life style. Health related quality of life aspects were studied in 47 persons (26 males and 21 females), age range from 21 to 76 years. They were classified in six groups: early (clearance of creatinine more than 50 ml/min-2 males, 3 females, age 25-65), overt (clearance of creatinine between 20 and 50 ml/min-4 males, 5 females, age 28-67) and final (clearance of creatinine less than 20 ml/min-6 males, 4 females, age 27-76) stage of the disease, on haemodialysis (6 males, 4 females, age 21-67), treated with recombinant human erythropoietin and haemodialysis (4 males, 4 females, age 30-65), and after transplantation (4 males, 1 females, age 28-57). Life style has been determined by an original questionnaire consisting of 37 questions divided in five groups: personal data, socio-demographic characteristics, health status, personal life and subjective evaluation of patient's current status. Sixteen life quality variables were investigated: marital status, family relations, working status, working ability, sleep, physical activities, appetite, wound healing, hobby, sports, friendships, sexual activity, mood, travelling, housework and happiness. The results have shown that the progression of the disease has negative influence on all life functions, with statistically significant differences between the early and overt stage patients concerning physical activities, appetite, travelling and sexual activity. Significant improvements were demonstrated in social activities and working ability after transplantation compared with patients in end-stage renal disease and those undergoing haemodialysis, while haemodialysis showed positive influence only on appetite. Combination of haemodialysis and erythropoietin treatment demonstrated significant improvements in working ability, appetite, travelling, wound healing and physical abilities compared with all other patients, suggesting benefits of this treatment.

Adult↗

[Health conditions and life styles of residential elderly. Part 1. Characteristics and factors related to being healthy elderly persons from a survey of health life style].

A survey was conducted in a highland community of Gifu prefecture on 815 residential elderly persons, over 65 years old, utilizing self-administered questionnaires to study the degree of association between life style factors and health conditions. A total of 718 valid participants (90.6% of the total) were analyzed and cross-examined by applying Breslow's seven health factors, daily behavior factors, physical health consciousness, social mobility factors (13 behavior factors which were determined by the Institute of the Elderly) to determine associations with respondents health conditions. Of the participants, 310 were male and 408 were female with mean ages of 73.8 +/- 6.9 years old and 74.0 +/- 6.9 respectively. The survey results indicated that there were no prominent gender differences over the mobility rate and physical health consciousness among participants. However, it was also found that in the male participants the per person prevalence of past history of illness was higher than in females. In the daily activity analysis, female participants indicated a higher prevalence of difficulty in walking and balance maintenance while ascending and descending stairs. In the general daily activity analysis, male participants had a higher requirement for an aide. In social mobility, male participants recorded a high degree of self-reliance by being physically, socially, and intellectually active and the female participants by fulfilling their social responsibilities. Breslow's seven health indicators were applied and their evaluation points were calculated as 3.9 +/- 1.7 for male participants and 3.5 +/- 1.8 for female participants which showed a significantly higher score for the male participants. The survey also indicated that factors which increase the Breslow score for males, were having a spouse, hobbies, a satisfactory life, a habit of exercising, and non-smoking which in females an appropriate sleeping habit (not less than 7 hours), and working, were the positively related factors.

Activities of Daily Living↗

[Microenvironmental lead poisoning].

Authors describe two cases of lead poisoning of unusual origin. A 43 year old male patient bought some waste metal in order to build a fence around his new house for saving money. He removed the old corroded coat of paint using a grinder without any protection. Consequently, he had got grave lead intoxication with colic and anemia. Another 34 year old unemployed male person moulded leaded chessmen in his own kitchen. This activity resulted in serious intoxication of the patient and highly increased lead absorption of the family members. In addition to the exploration of professional exposure the authors stress also the significance of the clearing up of occasional lead-related hobbies and home activities in case of lead intoxication of unknown origin.

Adult↗

Contact dermatitis caused by sesquiterpene lactones.

BACKGROUND: Compositae dermatitis involves workers such as gardeners, florists, and farmers, and less commonly people not employed in occupations at risk. OBJECTIVE: To report a case of contact sensitization caused by Compositae, the source of sensitization being both pesticides and plants. METHODS: A 65-year-old man, whose hobby was gardening, was affected by a chronic eczema of the face and the hands for 6 months that reoccurred after using fertilizers and handling plants. Patch tests with the International Contact Dermatitis Research Group standard series, the plants series and pesticides series (Hermal Trolab) were performed. RESULTS: We found the following positive reactions at day 2 and day 3: sesquiterpene lactone mix, 0.1% in petrolatum; arnica tincture, 20% in petrolatum; pyrethrum, 2% in petrolatum; captafol, 0.1% in petrolatum. CONCLUSION: Pyrethrum and its derivatives are made from Compositae plants; the arnica tincture is obtained from Arnica montana, which is also a member of the Compositae family. In our patient, the clinical manifestations were certainly caused by the exposure to sesquiterpene lactones, confirmed by the positive patch test to sesquiterpene lactone mix.

Aged↗

[Prevalence of diagnosing extrinsic allergic alveolitis in Poland in the years 1990-1994].

Poland is the country, where almost 40% of population inhabit rural areas. So EAA may be an important health problem. The aim of the study was to assess incidence of EAA in different districts in Poland. We asked hospitals to send us lists of patients with diagnosis of EAA established in the period of 1990-1994. In some hospitals we collected information by ourselves. This way, we have got data concerning patients with EAA. The highest prevalence of EAA 1.5-7.0/100,000 population was observed in eastern and south-western regions of Poland. Eastern Poland is rural area with small not specialised farms and possible high exposure to EAA antigens. In south-western Poland (Silesia) keeping pigeons is a very popular hobby, which may explain high incidence of EAA.

Adult↗

[Self-efficacy and related factors related in Parkinson's disease patients].

This study was designed to assess self-efficacy and the factors leading to higher self-efficacy in Parkinson's disease patients, as measured by General Self-Efficacy Scale (GSES). Questionnaires were mailed to patients with Parkinson's disease in Tokyo. This study surveyed 73 male and 70 female patients. Approximately 66.5% of the patients fell into the low self-efficacy group. Data was divided into 3 groups (high, moderate and low) and evaluated statistically. Approximately 66.5% of the patients fell into the low self-efficacy group. Patients in the high self-efficacy group exhibited the following features: Males: 1) The male patients in the high self-efficacy group tended to belong to more groups and had less trouble than any other groups in coping with their daily lives; 2) they generally had people to turn to for mental support outside their families, and for their daily life inside or outside their families; 3) they also felt confident that they had sufficient understanding of better life styles and how to exercise. Females: 1) The female patients in the high self-efficacy group tended to go out more often than any other groups and had places to go where they could practice hobbies and exercise; 2) they generally had people outside their families to turn to for mental support; 3) their subjective symptoms, such as freezing and dysarthria, tend to be less acute than in the moderate or low self-efficacy patients. 4) had les trouble than any other groups in coping with their housing accommodations; 5) they also felt confident that they understood how to exercise. In order to increase self-efficacy among Parkinson's disease patients, this study suggests that support, both social and psychological, and providing health education, are important.

Aged↗

[Factors affecting active-life orientation among the elderly in a community in Japan and its relationship to social activities].

We surveyed a stratified random sample of 205 person from 45,500 residents, aged 65 years or older, in a city of Japan using an interview schedule including scales of active-life orientation, social activities and other covariates. A total of 157 (77%) participated in the study. The main results were as follows: 1) Significantly higher scores of active-life orientation were observed in those who currently worked, than in those who did not work in males and females (p < 0.05). In males, scores of active-life orientation were significantly higher in those who had hobbies than in those who did not (p < 0.05); in those who traveled during the past year than in those who did not (p < 0.05). 2) In multiple linear regression analysis, PGC scale scores positively and significantly correlated with score of active orientation in males and females (p < 0.05). Age negatively correlated with the scores in males. Scores of affiliation orientation positively correlated with scores of active orientation, and satisfaction with available social support negatively correlated with the scores in females (p < 0.05).

Aged↗

Uses of mushrooms by Finns and Karelians.

Finns have adopted two traditions of mushroom use: one, the old Roman tradition, came through France and Sweden to the educated, mostly Swedish speaking people of southwest Finland; the other came from the east via Karelia and was adopted by ordinary country folk. This eastern tradition is still maintained among the Karelinas living in Tver government in Russia. Even the use of Amanita muscaria for killing flies is still utilized there. The western tradition favoured chanterelles and Boletus edulis, the eastern acrid milk caps, the Lactarius species. During the famines in the 1860's and after the World War II the government authorities tried to promote the use of wild mushrooms, but the real impulse to a more versatile mushroom use was initiated after the war when 400,000 evacuees from that part of Karelia conquered by the Soviet Union were resettled among farming families all over Finland. In 1969 the National Board of Forestry began to train mushroom advisors, a programme which still continues. In 1981 Finland passed a statute on edible mushrooms and drew up a list of commercial species. Even today the largest percentage of marketed mushrooms comes from Eastern Finland and the Lactarius tivialis species sells best. Gyromitra esculenta, the false morel is considered a delicacy. Today picking mushrooms is a passionate hobby for many Finns.

Basidiomycota↗

[Environmental factors possibly associated with onset of senile dementia].

Factors associated with senile dementia have not been clarified, and factors, especially those in the living environment which seem to have a close link to the dementia need to be analysed. We conducted a case-control study targeting patients within the jurisdiction of Nagahama Public Health Center in Shiga and Hikone city, who are diagnosed to have senile dementia of the Vascular type, senile dementia of the Alzheimer type, and senile dementia of the Mixed type, and compared them to age matched controls. The outcome of the study by Matched pair analysis (McNemar's test) before the onset of the senile dementia were as follows. 1 The factors related to senile dementia of the vascular type were: Previous histories (Matched Odds Ratio (MOR): 8.0 p < 0.05), disturbance of the lower limbs (MOR = 8.0 p < 0.05). Environmental factors were: strong preference for sweets (MOR = 8.0 p < 0.05 female), smoking (MOR = 3.7 p < 0.10), lower utilization of health care (MOR = 3.3 p < 0.10), such as periodic medical check (MOR = 0/6 p < 0.10), sleep (MOR = 0/5 p < 0.10), less commitment to hobbies (MOR = 2.6 p < 0.10), such as handicrafts (MOR = 0/5 p < 0.10) etc, less intercourse with relatives (MOR = 0/9 p < 0.01), not living together with children's family (MOR = 0.20 p < 0.05 female), and death (MOR = 8/0 p < 0.05) or hospitalization (MOR = 9.0 p < 0.05) of a family member. 2 The factors related to senile dementia of the Alzheimer type and the Mixed type were: some previous histories (MOR = 8.0 p < 0.05), less disturbance of gait (MOR = 0/5 p < 0.10). Environmental factors were: lower utilization of health care, such as periodic medical check (MOR = 0.18 p < 0.05), and lower participation in exercise (MOR = 0/5 p < 0.10) etc, less association with neighbors (MOR = 0.11 p < 0.05), less participation in community activities (MOR = 0.11 p < 0.05), not living together with children's family (MOR = 0/8 p < 0.05), relocation (MOR = 5/0 p < 0.10) and retirement (MOR = 5/0 p < 0.10).

Aged↗

Lenticular acral keratosis in washerwomen.

BACKGROUND: In 1952, a Brazilian dermatologist, Oswaldo Costa, described a dermatosis characterized by accentuation of the cutaneous folds on the knuckles of both hands and small horny papules on the thenar eminences, posterior surface of the wrists, and the interdigital space between thumb and index finger; he called this entity acrokeratoelastoidosis. Other similar entities, such as focal acral hyperkeratosis and marginal keratoelastoidosis, have been described. The features of the different types of lenticular acral keratosis are discussed. MATERIALS AND METHODS: Fifteen patients with lenticular acral keratosis and five controls were studied clinically and pathologically. The skin biopsies were processed for light and transmission electron microscopy. The clinical data were reviewed, and the following variables were recorded: age, sex, distribution and morphology of the lesions, history of exposure to sunlight and objective evidence of photodamage, familial incidence, occupation and hobbies, time of evolution, and response to previous treatments. The results were compared with samples taken at autopsy from five women without dermatoses. RESULTS: All patients were women, with flat, keratotic papules located on the transition between the dorsal and volar surfaces of the fingers and hands. Histologically, there was an increased amount of elastic fibers, which were coarse and tortuous, and appeared to be interrupted in some areas. In contrast, there were sparse, thin fibers in the mid and deep dermis in the skin of controls. Transmission electron microscopy of these papules showed enlarged, thickened elastic fibers, with deposits of electron-dense, coarse clumps. CONCLUSIONS: Our cases do not seem to correspond to any of the three entities which are manifested clinically by acral keratotic plaques. All of these women washed clothes by hand on a stone washboard for many hours every day. As there is no clinical or histologic evidence of actinic damage, chronic trauma seems to be the cause of the dermatosis in this type of patient. We propose the term "occupational lenticular acral keratosis" for our cases.

Acrodermatitis↗

[The use of an enzyme-kinetic-method for bacteriological examinations of heavy polluted surface waters (author's transl)].

The greatest fraction of nutrients dissolved in water are organic substances which are decomposed, transformed and mineralized by heterotrophic microorganisms. For this reason, investigations concerning energy transfer in an aquatic ecosystem, or practical examinations of the pollution load of surface waters, cannot be set up when based exclusively on more or less good counts of microorganisms of the production or destruction group. Above all, it is important for heterotrophic bacteria that productivity parameters for these numerical estimations are also provided. PARSON and STRICKLAND were successful in measuring the uptake of organic material in waters with uptake-kinetic methods; HOBBIE and WRIGHT developed a method for measuring the uptake of marked test-substrates in certain concentration ranges. As a result, for these substrates it was possible to measure the turnover in natural populations. Consequently, after frequent improvement of the technique in determining the decomposition rates of individual organic substrates, a way was found not only to determine static descriptions of an aquatic biotope, but also to make possible a dynamic description of nutrient transfers. The kinetic parameters computed from these measurements are: the maximum uptake velocity (Vmax), the turnover velocity (Tt) and the transport constant (Kt) (Michaelis Constant). The maximum uptake velocity of a substrate can be regarded as the "heterotrophic capacity" of the biotope for this substrate. One restriction is, however, that only quickly assimilatable substrates can be used, as for example hexoses, organic acids, amino acids, etc. Since this technique was tested practically only in oligotrophic waters, this study undertakes to investigate its applicability in polluted biotopes and to answer the question whether a decomposition gradient is reflected in the kinetic data. A small eutrophic lake in the eastern section of the Holstein Lake District (350 ha, 9.5 m mean water depth) was chosen as the test biotope. Emptying into the lake was the runoff of a biological water treatment plant with 12,000 population equivalents and without notable business and industry. In a rectangular investigation area at first with 30 sampling stations positioned close to the outlet of the water treatment plant into the lake, kinetic tests were carried out in 48 hour intervals and then compared with bacteriological, chemical and meteorological sample results taken at the same time. Two typical result-blocks are illustrated (Fig. 1-4, 5-8). The first shows four successive test days with periodically strong wind and light to fairly strong but short periods of precipitation. The second block illustrates conditions during a following period of fair weather with only very light wind intensities. The corresponding conditions of the stratification of the drainage water in the investigation area are illustrated by the distribution of coliform organisms. In two other tables the kinetic parameters and individual, dominant data are contrasted numerically...

Bacteria↗

[Evaluation of factors associated with well-being of elderly in an aged society by analytic hierarchy process analysis].

In the coming aged society in Japan, where about one quarter of the citizens will be aged 65 or more, the social policy concerning the well-being of the elderly will become very important for the local government. In this analysis, the authors evaluated the importance of future social programs on this subject using the Analytic Hierarchy Process (AHP) technique in a community of Fukuoka prefecture. Fifty-three participants in this study regarded six keywords as important for the well being of the elderly in the coming aged society in the following order: health, family hobby life-long education, friends community, economic conditions, and social participation. Considering the contribution to each of the six keywords, composite priorities among the four programs were determined by the AHP technique to be in the following order: assistance for the social autonomy of the elderly, health promotion programs, development of welfare services, and development of medical services. These results indicate that for Japan to achieve a comfortable aged society, a democratic government made possible by autonomous individual citizen is desirable, with wide participation of individual in services provided by autonomous local governments that incorporate the structured elements shown to be important in this study.

Aged↗