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At least 721 records · Page 40Linked to original sources
PubMed2004

Phase II study of low-dose topotecan in myelodysplastic syndromes: a Hoosier Oncology Group (HOG) study.

Topotecan has demonstrable activity in high-risk MDS and CMMoL. However, the significant toxicity of topotecan administered at a dose of 2mg/m2 i.v. daily for 5 days as a continuous infusion limits its use in older patients. Therefore, we studied topotecan 1.5mg/m2 per day i.v. over 2 h for three consecutive days in 20 patients with high-risk MDS (12 RAEB; 4 RAEB-T; 4 CMMoL). Cycles were given every 4-6 weeks. Fifteen patients were evaluable for response. Only one patient achieved a durable complete remission (CR). There were three deaths within the first cycle of therapy. Severe myelosuppression was the most common toxicity. Grades 3-4 infections were documented in four patients. We conclude that topotecan administered at this dose and schedule has no clinically significant activity.

Aged↗
PubMed2002

Carboplatin plus paclitaxel and sequential radiation followed by consolidation carboplatin and paclitaxel in patients with previously untreated locally advanced NSCLC. A Hoosier Oncology Group (HOG) phase II study.

Chemoradiation is standard treatment for patients with unresectable locally advanced non-small cell lung cancer (NSCLC). However, local and distant relapse rates remain high. It has been postulated that the addition of consolidation chemotherapy might further decrease the systemic relapse rate. We performed this phase II study to evaluate the toxicities and activity of two cycles of paclitaxel and carboplatin administered prior to and following thoracic radiation in patients with locally advanced, inoperable NSCLC. From April to December 1997, 25 patients were entered on study. Twenty-three patients were eligible and received paclitaxel 225 mg/m(2) intravenously over 3 h followed by carboplatin at an AUC (6) on days 1 and 22. Radiation consisted of 60 Gy given over 6 weeks beginning on day 43. Patients with non-progressive disease received two additional cycles of consolidation carboplatin and paclitaxel. Four of 23 patients progressed during induction chemotherapy. There were seven PR's and 11 had SD after induction chemotherapy. Following radiation, the response changed to 11 PR, four SD, and three had progressive disease. Of the 15 patients eligible to receive consolidation chemotherapy, three were excluded due to a poor performance status. Twelve patients were treated with consolidation chemotherapy with further improvement in two patients (SD to PR, PR to CR). All 12 patients who received consolidation chemotherapy developed grade 3 or 4 neutropenia, including three patients with neutropenic fever. The overall response rate was 52.1%. The median survival, 1-, and 2-year survival was 10.5 months, 45, and 17%, respectively. In conclusion, consolidation chemotherapy was associated with significant hematologic toxicity without an obvious improvement in survival in comparison to other studies utilizing chemoradiation alone.

Adult↗
PubMed1981

The dynamics of experimental bacterial infections in muscles of mice and the influence of hog gastric mucin.

NMRI-mice were infected in the posterior of the thigh muscles of the right hind leg by injecting one of two isogenic strains of E. coli, one of which was passaged from mouse to mouse for 20 years [mouse-pathogenic (MP) strain], whereas the other was transferred on agar slants only for the same period of time (lab strain). Both strains cause persistent infections only if given as undiluted overnight culture, the MP-strain seeming slightly more virulent. Injection of lower numbers of bacteria results in a corresponding decrease of bacterial cell counts in the animals' thighs. The elimination of the bacteria seems to be all the more rapid the smaller the inoculum. If the infection was administered in mucin suspension, the MP-strain multiplies in the host tissue to a greater degree than the lab strain, irrespectively of the dose injected. The number of cells per muscle reaches a maximum level of about 10(9) even after injecting 10(2) cells of the MP-strain in mucin. To reach the same level, 10(5) cells of the lab strain are needed. Four days after infection, the bacteria start to die off in those animals originally receiving the lower infection doses. Possible reasons are discussed.

Animals↗
PubMed1981

[Effect of the addition of hog pancreatic colipase on the permeability to glucose and the phase transition of phosphatidyl choline liposomes].

An interaction between porcine pancreatic coli-pase and lecithin liposomes is demonstrated by gel filtration assays. The extent of the colipase penetration into the phospholipid bilayer was assessed by permeability and calorimetry studies carried out on the liposome colipase complex. The addition of colipase to liposomes induces a three fold increase in the permeability to [6-H3] glucose. This result reflects a perturbation in the bilayer which may be the consequence of the colipase interaction. The phase transition temperature is not modified by the added colipase. This observation suggests that the perturbation brought by the protein does not affect the acyl chain packing of the bulk lipid. On the other hand the enthalpy of transition (delta H) is decreased from 8.9 to 7.8 kcal/mole by the addition of colipase to the lipid. This could be explained by the interaction of the colipase with neighbouring acyl chains which do not participate in the cooperative melting of the bulk lipid. In agreement with previous spectrophotometric observations, the present results are indicative of hydrophobic interactions between colipase and bilayer hydrocarbon chains.

Animals↗
PubMed1985

In vitro study of the biological activity of RNAs after incubation of hog liver, heart and brain tissue at room temperature.

The biological activity of RNA, isolated from tissue which was incubated for 1, 3, or 6 hours at room temperature (simulation of post-mortem conditions), was preserved. However, the different organs used differ from each other. When liver is used, qualitative differences in the in vitro translation products are observed, after one hour incubation at room temperature, whereas when heart and brain are used these differences are not observed. We have also shown that relatively small amounts of post-mortem tissue is sufficient for RNA extraction. When using frozen tissue it is absolutely necessary to add RNase inhibitors during thawing to reduce the loss of biological activity.

Animals↗
PubMed1997

Ascaris suum prevalence and intensity: an abattoir survey of market hogs in Saskatchewan.

Two surveys examining the prevalence and intensity of Ascaris suum were conducted at a Saskatchewan abattoir. In the first, 2500 livers from market weight animals were examined and scored for lesions consistent with ascarid migration. Forty-four percent displayed some degree of scarring with approximately 8% being severely damaged. In the second, both livers and intestinal contents from 500 market weight animals were examined. Seventeen percent were infected with intestinal A. suum (mean of 2.5 parasites per infected pig) and 50% had liver lesions typical of ascarid larval migration. Fifty-three percent of the animals in the second survey had some evidence of ascarid infection (adult parasites, hepatic lesions or both). The results are compared with those from a similar survey conducted in the late 1970s at the same abattoir as well as with surveys conducted elsewhere in Canada and in the UK.

Abattoirs↗