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[Ethnic factors and their relation to the pathogenesis and geography of multiple sclerosis].

Epidemiological and immunogenetic studies made in patients with multiple sclerosis (MS), carried out for the first time in Uzbekistan, demonstrated the varying disease incidence in 4 populations: Uzbek, Tadjik, Russian and Tatar. In Uzbeks and Russians, a significant relationship was established between MS and antigen HLA-B7 carriership. A correlation was noted between the low incidence of MS among Uzbeks (0.8:100,000) and the higher among Russians (11.5:100,000) and the low prevalence of antigen HLA-B7 in the Uzbek and the higher one in the Russian population. It has been shown that the use of the medico-geographic mapping to specify the nature of MS is ineffective without regard to ethnic factors.

Asian People↗

The geography of trust.

Leaders who rely forever on the same internal advisers, entrusting them with issues of ever greater sensitivity and consequence, run the risk of being sold short and possibly betrayed. Alternatively, lone-wolf leaders who trust no one may make enormous, yet preventable, mistakes when trying to sort through difficult decisions. A sophisticated understanding of trust can protect leaders from both fates. During the past decade, author and consultant Saj-nicole Joni studied leadership in more than 150 European and North American companies. Her research reveals three fundamental types of trustpersonal trust, expertise trust, and structural trust. Executives may persevere in relationships that are based on personal trust, no matter how exalted their leadership roles become. But such relationships are unlikely to remain static. They also probably won't provide the kinds of deep, often specialized knowledge leaders need. In circumstances where advisers' competence matters as much as their character, expertise trust--reliance on an adviser's ability in a specific subject--enters the picture. In organizations, leaders develop expertise trust by working closely with people who consistently demonstrate their mastery of particular subjects or processes. Structural trust refers to how roles and ambitions influence advisers' perspectives and candor. It shifts constantly as people rise through organizations. High-level structural trust can provide leaders with pure insight and information--but advisers in positions of the highest structural trust generally reside outside organizations. These advisers provide leaders with insights that their organizations cannot. High-performing leaders' most enduring--and most valuable--relationships are characterized by enormous levels of all three kinds of trust.

Administrative Personnel↗

Substance use, social networks, and the geography of urban adolescents.

This article demonstrates a research strategy and prevention methodology for substance using urban youth that incorporates individual, social, and geographical parameters to systematically understand the ecology of risk and protection for urban youth. The primary goal of this study was to describe and analyze substance using and nonusing urban adolescents' social networks; risky and protective settings where they socialize; and the relationship to health outcomes such as substance use, depression, and stress. Geographic Information Systems (GIS) derived spatial relationships and analyses between the specific locations where the teens are active, their subjective ratings of these locations, and objective environmental risk data. These social network and GIS data were merged to form a detailed description and analysis of the social ecology of urban adolescent substance use. A case study was constructed to illustrate the methodology of creating a three-dimentional ecological profile that helps explain these relationships and provides preventive applications. Linear distances were computed between the homes of the users and the risky and safe places that they identified. On average, the distance between users' homes and their identified safe places was three times the distance between their homes and their identified risky places. This study provides support for understanding urban adolescent substance use through the detailed and multiple dimensional analysis of teens' social ecologies.

Adolescent↗

Racial disparities in cardiac care: geography matters.

Racial disparities in health care have been well-documented, although the reasons for many of these disparities remain obscure. An intriguing possibility is that geographic factors--the places where certain groups live or obtain health care--contribute to racial disparities, especially in the use of new medical technologies. This Issue Brief examines racial disparities in the use of life-saving cardiac procedures and mortality after cardiac arrest, and considers how geographic differences in health care affect these disparities.

Aged↗

[Geography of endobronchial pathology in the Astrakhan Region during anthropogenic burden of the region].

Bronchoscopy was made in 2264 patients with tuberculosis (1998-2003). The development included 1274 patients with endobronchial pathology that was divided into 3 groups: 1) nonspecific endoronchitis; 2) tuberculous bronchial lesions (+ cicatricial stenoses); and 3) benign and malignant bronchial tumors. In the Astrakhan Region, endobronchial pathology is nonuniformly distributed, its greater proportion being observed in the southeastern and south-western areas of the region. Endoronchitis holds the lead (74%), next are bronchial tuberculosis (19%) and tumors (7%). There is an association of endobronchial pathology with atmospheric discharges of noxious substances exceeding the maximally allowable concentrations. Moreover, a correlation analysis revealed a close relationship of endobronchitis to bronchial tuberculosis and a tumorous process.

Bronchial Diseases↗

The geography of mammalian speciation: mixed signals from phylogenies and range maps.

The importance of geographic isolation in speciation has been debated since the 19th century. Since the beginning of the 20th century, the consensus has been that most speciation involves divergence in allopatry. This consensus was based largely on decades of observations by naturalists and verbal arguments against speciation without isolation. Recent attempts to quantify the importance of allopatric versus sympatric speciation using comparative methods called "age-range correlation" (ARC) suggest that allopatric speciation is more common than sympatric speciation. However, very few taxa have been studied and there are concerns about the adequacy of the methods. We propose methodological improvements including changes in the way overlap between clades is quantified and Monte Carlo methods to test the null hypothesis of no relationship between phylogenetic relatedness and geographic range overlap. We analyze 14 clades of mammals, chosen because of the availability of data and the consensus among mammalogists that speciation is routinely allopatric. Although data from a few clades clearly indicate allopatric speciation, divergence with gene flow is plausible in others and many results are inconclusive. The relative rarity of significant correlations between phylogenetic distance and range overlap may have three distinct causes: (1) post-speciation range changes, (2) relative rarity of range overlap, and (3) a mixture of geographic modes of speciation. Our results support skepticism about ARC's power for inferring the biogeography of speciation. Yet, even if few clades provide clear signals, meta-analytic approaches such as ARC may set bounds on the prevalence of alternative modes of speciation.

Animals↗

Chinese in west Malaysia: the geography of beta thalassaemia mutations.

The overseas Chinese in West Malaysia are almost exclusively from the south-eastern provinces of China-Kwangtung, Fukien, and Kwangsi. To institute a comprehensive thalassaemia control programme for this region we have characterised the beta thalassaemia mutations in 16 Chinese patients from West Malaysia: 4 beta thalassaemia mutations were seen: a) an A----G substitution in the TATA box [-28 base pairs (bp)], an A----T substitution in codon 17 [17 A----T], c) a 4 base pairs - TCTT deletion in codon 41-42 [frameshift mutation (FSC 41-42)], and d) a C----T substitution at the second intervening sequence (IVS 11) position 654. Similar mutations have been described in patients from the south-eastern provinces of China. The delineation of the specific mutations present will enable effective prenatal diagnosis for beta thalassaemia of ethnic Chinese in West Malaysia to be instituted.

Adolescent↗