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Longitudinal follow-up of fitness during childhood: interaction with physical activity.

Health-related fitness values during childhood (from age 11 to 16 years) were analyzed in relation to changes in physical activity level. One hundred fifty-eight children were monitored over a 4-year period. Twice a year, they performed six physical fitness tests: standing broad jump, 10 x 5-meter shuttle run, sit-and-reach, handgrip, number of sit-ups in 30 s, and 20-m shuttle run. Height was measured four times per year to assess age at peak height velocity. Physical activity was assessed with a self-administered questionnaire at baseline and at the end of the follow-up. The physical activity level was defined by the frequency and the time spent in moderate-to-vigorous physical activities. Two groups were constituted: regularly active and sedentary. A multiple linear multilevel regression analysis was used to analyze the longitudinal relationships between changes in physical activity and physical fitness levels. Corrections were made for both time-dependent (time) and time-independent (sex) variables. Except for flexibility, boys' fitness performances increased more than that for the girls. Positive and significant (P < 0.05) regression coefficients were found with the regularly active for standing broad jump, 20-m shuttle run, number of sit-ups, 10 x 5-m shuttle run in both sexes, and for the girls' sit-and-reach performance. Increasing or decreasing physical activity level was not associated with changes in fitness performances over time, except for flexibility for the girls and the 20-m shuttle run for the boys. From childhood to adolescence, increasing physical activity is not sufficient to be more fit. The children who are stayed the most active were the fittest, particularly the girls. Am. J. Hum. Biol. 18:51-58, 2006. (c) 2005 Wiley-Liss, Inc.

Adolescent↗

Effect of Ca/P coating resorption and surgical fit on the bone/implant interface.

The effect of coating resorption on bone apposition and attachment strength to resorbable hydroxyapatite (HA), nonresorbable HA-coated, and uncoated rough titanium implants was evaluated in interference- and noninterference-fit (gap of 2-3 mm) surgical models 2, 4, and 12 weeks postoperatively. Interference and noninterference fits showed differences in bone bridging. Bone apposition was circumferential around the implants in noninterference fit. Significantly greater bone apposition was seen to nonresorbable HA-coated implants than uncoated and resorbable HA-coated implants at 4 and 12 weeks. Only resorbable HA coatings showed significantly lower bone apposition for noninterference versus interference fit and from 4-12 weeks. At 2 weeks, strengths of bone attachment to resorbable HA-coated implants were greater than the other implants, and decreased to lower values (not significant) than the nonresorbable HA-coated implants at 4 and 12 weeks. Differences in push-out shear strengths between interference- and noninterference-fit surgical models were significant for uncoated implants at 4 weeks, but not for HA-coated implants at any time period. Significant differences were seen between the three implant types only for the noninterference-fit model, where the HA-coated implants showed greater strengths than the uncoated implants (significant at 2 and 4 weeks). This study showed that presence of resorbable or nonresorbable HA coatings is beneficial when a gap of 2-3 mm is present between the implant and the bone. The resorbable HA-coated implants showed greatest strengths at the early time period. At later time periods, resorbable HA-coated implants showed lower bone apposition and attachment strengths than nonresorbable HA coatings.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium↗

Biological age versus physical fitness age in women.

The purpose of this study was to determine whether adult women who are in a state of high physical fitness are in a good state biologically, in terms of biological and physical fitness ages as estimated by statistical means. The subjects were 65 healthy Japanese women (aged 20-64 years). Biological and physical fitness ages were estimated from the data for 18 physiological function tests and 5 physical fitness tests, respectively, by a principal component model. The correlation coefficient between biological and physical fitness ages was 0.70 (P less than 0.01), which was generally regarded as a high correlation. Therefore, those who were in a state of high physical fitness were considered to be in good biological condition. This result is in good agreement with the results (r = 0.72) from adult men, on whom we reported previously. A statistical analysis to ascertain the relative importance of each contributory variable associated with the variance in biological age suggested that routine clinical evaluation of blood pressure and lipid metabolism might play an important role in determining not only the presence and severity of vascular disease but also the rate of biological aging in women.

Adult↗

The effects of acute phosphate supplementation in subjects of different aerobic fitness levels.

Six trained cyclists (high-fitness group) and six untrained individuals (low-fitness group), performed a 20-min cycle ergometer exercise test at 70% of maximum oxygen consumption (VO2max) followed by a 30-min rest period and then an incremental ride to exhaustion on two occasions, 1 week apart. Ninety minutes prior to exercise subjects consumed a drink containing either 22.2 g dibasic calcium phosphate (DCP; treatment) or calcium carbonate (placebo). Blood was drawn prior to drink ingestion, during submaximal exercise, during recovery and at exhaustion for determination of blood 2,3-DPG, blood ATP, plasma lactate, plasma phosphate, haemoglobin and haematocrit. Throughout exercise, cardiorespiratory variables [oxygen uptake (VO2), minute ventilation, (VE), respiratory exchange ratio, heart rate and oxygen pulse] were monitored, and ratings of perceived exertion obtained. Although there was a trend for the low-fitness group to have a higher plasma phosphate concentration prior to treatment ingestion, no treatment effects on plasma phosphate were noted at any sample time in either group. 2,3-DPG, VO2, oxygen pulse, VE, time to exhaustion and VO2max were significantly higher in the high-fitness group; however, no differences in these variables were observed as a result of phosphate ingestion. Plasma lactate was significantly lower in the high-fitness group during the submaximal exercise and the recovery period, but again phosphate ingestion had no effect. These results suggest that acute DCP supplementation is not effective as an ergogenic aid and that aerobic fitness level does not affect the response to phosphate supplementation.

2,3-Diphosphoglycerate↗

Improved physical fitness failed to alter the EEG patterns of sleep in young women.

We investigated the effect of a 12-week physical training programme on the sleep of nine unfit women. Data were collected at 0, 4, 8 and 12 weeks of the training programme. Changes in fitness were assessed by changes in maximal oxygen consumption (VO2max) and onset of blood lactate turn point (LTP). Lean body mass (LBM) was calculated from total body potassium measurements. The all-night sleep recordings were made following days during which the subjects carried out their normal daily routines and did no extra exercise. Although cardiorespiratory fitness improved significantly as indicated by an increase in both VO2max and LTP, there was no change in LBM. The improvement in cardiorespiratory fitness did not result in any changes in the sleep parameters measured. Other workers have reported an improvement in sleep quality in eight army recruits during their basic training. The male recruits showed improved cardiorespiratory fitness and an increase in muscle bulk. These results suggest that increased fitness only facilitates sleep when there is an associated increase in LBM. Alternatively it may be that the response of sleep to improved fitness is sex-linked.

Adult↗

Skeletal size and bone mineral content in Turner's syndrome: relation to karyotype, estrogen treatment, physical fitness, and bone turnover.

Bone mineral content (BMC), bone mineral density, and metacarpal dimensions were studied in 50 women with Turner's syndrome aged 21-45 years in relation to karyotype, estrogen treatment, physical fitness, and biochemical markers of bone turnover. No differences were found between the 25 women with karyotype 45.X and women with other karyotypes. Forty-six women had received estrogen. Significant partial correlations were found between bone mineral density of the forearm and duration of estrogen treatment and physical fitness. BMC of the lumbar spine corrected for vertebral height (BMC(C)spine) was directly correlated with duration of estrogen treatment and height, marginally correlated with physical fitness, and inversely correlated with age. Outer metacarpal width was positively correlated with duration of estrogen treatment, age at initiation of therapy, and body weight. The diameter of medullary space showed negative correlation with physical fitness and height, and positive correlation with age at initiation of estrogen treatment. Cortical thickness was positively correlated with duration of estrogen treatment, physical fitness, and height. No convincing effects of estrogen could be demonstrated in women below the age of 30. Above the age of 30, all bone mineral measurements were markedly elevated in women treated for longer than the average of this age group. BMC(C)spine was inversely correlated with biochemical markers of bone formation. Our results demonstrate that estrogen treatment and physical fitness are important determinants of bone mineral status in Turner's syndrome and add to the evidence that estrogen treatment increases BMC in Turner's syndrome.

Adult↗

Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus.

AIMS/HYPOTHESIS: Low cardiorespiratory fitness is a powerful and independent predictor of mortality in people with diabetes. Several studies have examined the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals. However, these studies had relatively small sample sizes and highly variable results. Therefore the aim of this study was to systematically review and quantify the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals. METHODS: MEDLINE, EMBASE, and four other databases were searched up to March 2002 for randomized, controlled trials evaluating effects of structured aerobic exercise interventions of 8 weeks or more on cardiorespiratory fitness in adults with Type 2 diabetes. Cardiorespiratory fitness was defined as maximal oxygen uptake (VO(2max)) during a maximal exercise test. RESULTS: Seven studies, presenting data for nine randomized trials comparing exercise and control groups (overall n=266), met the inclusion criteria. Mean exercise characteristics were as follows: 3.4 sessions per week, 49 min per session for 20 weeks. Exercise intensity ranged from 50% to 75% of VO(2max). There was an 11.8% increase in VO(2max) in the exercise group and a 1.0% decrease in the control group (post intervention standardized mean difference =0.53, p<0.003). Studies with higher exercise intensities tended to produce larger improvements in VO(2max). Exercise intensity predicted post-intervention weighted mean difference in HbA(1c) (r=-0.91, p=0.002) to a larger extent than did exercise volume (r=-0.46, p=0.26). CONCLUSIONS/INTERPRETATION: Regular exercise has a statistically and clinically significant effect on VO(2max) in Type 2 diabetic individuals. Higher intensity exercise could have additional benefits on cardiorespiratory fitness and HbA(1c).

Databases, Factual↗

Fitness versus longevity in age-structured population dynamics.

We examine the dynamics of an age-structured population model in which the life expectancy of an offspring may be mutated with respect to that of the parent. While the total population of the system always reaches a steady state, the fitness and age characteristics exhibit counter-intuitive behavior as a function of the mutational bias. By analytical and numerical study of the underlying rate equations, we show that if deleterious mutations are favored, the average fitness of the population reaches a steady state, while the average population age is a decreasing function of the average fitness. When advantageous mutations are favored, the average population fitness grows linearly with time t, while the average age is independent of the average fitness. For no mutational bias, the average fitness grows as t2/3.

Life Expectancy↗

A 15-year physical activity pattern is positively related to aerobic fitness in young males and females (13-27 years).

The purpose of this paper is to test the hypothesis that daily physical activity over a period of 15 years has been beneficial to aerobic fitness in young male and female participants (13-27 years) in the Amsterdam Growth and Health Longitudinal Study. Only subjects with the maximal data of six sets of measurements were included (83 male and 98 female participants). Daily physical activity was assessed using a standardized interview on activity and expressed as a weighted activity score. Aerobic fitness was assessed using a maximal running test on a treadmill and measuring the maximal oxygen uptake (VO2max) and the maximal slope of the track (Smax). To assess the longitudinal relationship between daily physical activity and aerobic fitness a real longitudinal analysis was carried out with generalized estimating equations, adjusting for differences in initial aerobic fitness at age 13, and for other lifestyle (dietary intake, smoking and alcohol consumption) and biological parameters (biological age, body fat, blood pressure and concentration of serum cholesterol). A significant relationship (P < 0.01) was observed between daily physical activity and both VO2max and Smax. It can be concluded that the development of aerobic fitness between the age of 13 and 27 years is independently and positively related to daily physical activity in this group of male and female participants in the study. The functional implications, however, are small: a relatively high increase in the weighted physical activity score of 30% over a period of 15 years results in a 2%-5% increase in aerobic fitness.

Adolescent↗

Fitness levels of Greek primary schoolchildren in relationship to overweight and obesity.

OBJECTIVES: The aim of the present cross-sectional study was to provide estimates for overweight and obesity in a sample of Greek schoolchildren and to determine their possible relation with selected motor and health-related fitness parameters. MATERIALS AND METHODS: The study sample consisted of 709 healthy children (328 girls, 381 boys, mean age = 8.9+/-1.6 years), living in the towns of Agios Stefanos (approximately 12,000 citizens) and Alexandroupolis (approximately 60,000 citizens), Greece. All pupils underwent anthropometric, motor and cardiovascular fitness assessments (Eurofit test battery). The body mass index (BMI) cut-off points adopted by the International Obesity Task Force were utilized for the assessment of overweight and obesity. RESULTS: 59.4% of the participants had a normal BMI, 25.8% were overweight and 14.8% were obese, without significant differences between genders. DISCUSSIONS: In general, the higher BMI categories were strongly associated with inferior performances in all fitness tests, except flexibility. This graded relationship was consistent for both boys and girls, although the statistical relationship between BMI categories and fitness performance varied by gender. CONCLUSIONS: In conclusion, the findings of the current study offer some support to the reported high prevalence of childhood obesity in Greece and suggest that overweight and obesity are limiting factors for fitness performance in primary schoolchildren. The present data suggest that interventions promoting children's health should, ideally, begin early in life and involve measures that simultaneously improve fitness and lower fatness.

Anthropometry↗

Real-time patient-specific finite element analysis of internal stresses in the soft tissues of a residual limb: a new tool for prosthetic fitting.

Fitting of a prosthetic socket is a critical stage in the process of rehabilitation of a trans-tibial amputation (TTA) patient, since a misfit may cause pressure ulcers or a deep tissue injury (DTI: necrosis of the muscle flap under intact skin) in the residual limb. To date, prosthetic fitting typically depends on the subjective skills of the prosthetist, and is not supported by biomedical instrumentation that allows evaluation of the quality of fitting. Specifically, no technology is presently available to provide real-time continuous information on the internal distribution of mechanical stresses in the residual limb during fitting of the prosthesis, or while using it and this severely limits patient evaluations. In this study, a simplified yet clinically oriented patient-specific finite element (FE) model of the residual limb was developed for real-time stress analysis. For this purpose we employed a custom-made FE code that continuously calculates internal stresses in the residual limb, based on boundary conditions acquired in real-time from force sensors, located at the limb-prosthesis interface. Validation of the modeling system was accomplished by means of a synthetic phantom of the residual limb, which allowed simultaneous measurements of interface pressures and internal stresses. Human studies were conducted subsequently in five TTA patients. The dimensions of bones and soft tissues were obtained from X-rays of the residual limb of each patient. An indentation test was performed in order to obtain the effective elastic modulus of the soft tissues of the residual limb. Seven force sensors were placed between the residual limb and the prosthetic liner, and subjects walked on a treadmill during analysis. Generally, stresses under the shinbones were approximately threefold higher than stresses at the soft tissues behind the bones. Usage of a thigh corset decreased the stresses in the residual limb during gait by approximately 80%. Also, the stresses calculated during the trial of a subject who complained about pain and discomfort were the highest, confirming that his socket was not adequately fitted. We conclude that real-time patient-specific FE analysis of internal stresses in deep soft tissues of the residual limb in TTA patients is feasible. This method is promising for improving the fitting of prostheses in the clinical setting and for protecting the residual limb from pressure ulcers and DTI.

Amputees↗

Role of physical fitness training in the fibrositis/fibromyalgia syndrome.

Cardiovascular fitness training has been suggested as a treatment for the fibrositis/fibromyalgia syndrome. Thirty-four patients with fibrositis/fibromyalgia who met Smythe's original criteria were randomly assigned to enter either a cardiovascular fitness training program or a program consisting only of flexibility exercises. Patients met in supervised groups three times weekly for a 20-week observation period. The cardiovascular fitness group underwent gradual heart rate-elevated training using a bicycle ergometer and achieved a 29.1 +/- 24.4 percent increase in peak work capacity at 170 beats per minute (PWC-170). Patients undergoing flexibility training had a net reduction in their PWC-170 scores of 4.3 +/- 9.4 percent. Patients in the cardiovascular fitness group had statistically significant improvements in the visual analogue pain scale of current pain intensity; total myalgic scores in which pain thresholds at five fibrositic tender points selected for acceptable intra-rater and inter-rater reliability were measured using a dolorimeter; percentage total body area affected as measured by self-administered pain diagrams; and patients' and physicians' global assessment scores. Psychologic profiles as measured by Symptom Checklist-90R also improved in the cardiovascular fitness group compared with the flexibility training group. It is concluded that cardiovascular fitness training is feasible in patients with fibrositis/fibromyalgia and that such training improves subjective measurements of pain-reporting behavior. A theoretic basis for improvements in pain measurement scales and psychologic profiles is discussed in light of recent literature.

Cardiovascular Physiological Phenomena↗

Physical activity, physical fitness, and psychological characteristics of medical students.

Exercise habits, cardiovascular fitness, and selected psychological characteristics were assessed in a sample of over 200 men and women at entrance to medical school. Fitness was measured with a step test, and other variables were measured with standardized questionnaires. Anger ('anger-in') showed the strongest negative correlation with both exercise and fitness. Anger suppression, Type A behavior, and daily stress showed significant negative correlations with both exercise and fitness variables, although the strengths of these associations were uniformly weak. Associations of exercise/fitness with depression and total anger inventory were nonsignificant. Few gender differences were found. Both exercise and fitness showed similar patterns of association with psychological variables. Both exercise and fitness were associated with a style of anger expression that has been found to be related to cardiovascular risk in other studies.

Adaptation, Psychological↗

Aerobic fitness and resting energy expenditure in young adult males.

Ambiguous findings have been reported in previous studies regarding the relationships among aerobic fitness, resting metabolic rate (RMR), and the thermic effect of a meal (TEM). We reexamined the association among these variables in young nonobese men who exhibited a wide range of aerobic fitness levels. RMR was measured after an overnight fast and TEM was assessed for three hours after ingestion of a liquid meal. Preprandial and postprandial plasma levels of insulin, glucose, and thyroid hormones (total T3 and T4) were measured. Daily energy intake was estimated from three-day food diaries, body composition from underwater weighing, and aerobic fitness from a test of VO2 max. Data were analyzed with linear and curvilinear regression analysis, as well as with ANOVA to test for differences among subjects classified by fitness level (ie, untrained, moderately, and highly trained). A significant correlation was found between RMR and VO2 max (r = .77, P less than .01). RMR adjusted for body weight and FFW was higher in highly trained men when compared to moderately and untrained individuals. However, a curvilinear relationship was found between TEM and VO2 max (P less than .05). Subjects who exhibited moderate levels of fitness showed the highest TEM, whereas a lower TEM was noted in untrained and highly trained men. These findings were observed in the absence of differences in plasma concentrations of total T3 and T4 among fitness levels. These findings suggest that highly trained men have a high RMR adjusted for their metabolic size.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Agreement of self-reported and physiologically estimated fitness status in a symptom-free population.

A population of 204 symptom-free clerical and white-collar employees who volunteered for a corporate-based health promotion program was studied to determine agreement between self-reported and physiologically determined fitness status. Physiologic fitness was estimated using exercise treadmill performance. There were statistically significant differences between self-reported and treadmill-estimated fitness status. The study population rated their fitness substantially higher than that estimated by treadmill performance. Self-reported fitness was found to be poorly correlated with physiologic fitness, indicating independent distributions. These relationships persisted across gender. The results question the use of self-reported estimates of physical health in health services research.

Adult↗

Physical fitness, physical activity, and cardiovascular disease risk factors in adolescents: the Oslo Youth Study.

Aerobic fitness, resting pulse rate, and self-reported physical activity were examined along with prevalence of cardiovascular disease risk factors in a population-based study of 413 boys and 372 girls, ages 10 to 14 years. Cardiovascular fitness (VO2 max) was predicted from heart rate measured during submaximal bicycle exercise. For both genders, fitness level was significantly and inversely related to body weight, body mass index [weight in kilos/(height in meters)2], triceps skinfold thickness, systolic and diastolic blood pressure, and pulse rate and positively related to high-density lipoprotein/total cholesterol ratio and physical activity. In addition, fitness level was positively related to high-density lipoprotein cholesterol and negatively related to triglycerides in females; it was also negatively related to height, total cholesterol, and hematocrit in males. Analyses of covariance, controlling for sexual maturity ratings, revealed that students in the lowest quartiles of VO2 max had significantly higher body mass index and triceps skinfold thickness than students in the higher quartiles. After adjustment for body mass index and sexual maturity ratings, blood pressure and pulse rate in both genders were significantly higher among students in the lower quartiles of VO2 max than among the groups who scored higher on the fitness test. Higher levels of VO2 max were also associated with a more favorable lipid profile in females. In gender-specific multiple regression analysis, triceps skinfold thickness was the strongest predictor of VO2 max, followed by pulse rate. Our study provides evidence that higher levels of fitness are associated with more favorable risk profiles in adolescents.

Adolescent↗

Fitness: a new look at an old term (measurements of human aerobic performance).

Despite the increased public interest in being fit, there is no universally accepted definition of "fitness." Various reports equate fitness to oxygen consumption with exercise. This genetically determined V02 maximum is the limiting factor in high-intensity, short duration maximal aerobic exercise. For the nonathelete, however, this capacity may not be an accurate assessment of fitness. Instead, the ability of this individual to do less vigorous work of greater duration may be the best estimate of his fitness. Energy expenditure, a requirement of work, is obtained from the metabolism of carbohydrates and lipids. A measure of the relative utilization of these substrates is the respiratory quotient (R.Q.). Initial phases of exercise depend primarily on carbohydrate metabolism which is reflected by an RQ of 1.0. As exercise continues, substrate utilization relies upon an increasing percentage of free fatty acid metabolism and the R.Q. will approach 0.7. As nonathletes are trained, there is more rapid shift to free fatty acid metabolism which is reflected by a lower R.Q. in the early phases of exercise. The serial measurement of R.Q. as an individual steadily exercises below his anaerobic threshold will reflect his ability to utilize lipids as an energy source. The greater the rate of change of R.Q. with time, the greater is his ability to metabolize lipids. Increased utilization of lipids during exercise indicates his augmented capacity to do submaximal long-duration work, therefore, fitness.

Cytochrome c Group↗

A quantitative in vitro assessment of fit and screw fixation on the stability of a cementless hemispherical acetabular component.

This investigation quantifies in vitro the effect of component fit, as well as the effect of adjuvant screw fixation, on the initial stability of cementless hemispherical titanium acetabular total hip arthroplasty components and assesses apposition of the acetabular components to bone. Six, fresh human hemipelvi (3 matched pairs) were harvested at autopsy. Titanium alloy acetabular components with a porous surface of commercially pure titanium fiber mesh (Harris Galante Porous acetabular components, Zimmer, Warsaw, IN) were used for implantation. Initially, each acetabulum was underreamed to achieve a 2 mm press-fit with the acetabular component. Pressure-sensitive film had been placed along the dome and medial wall at the bone-implant interface to assess the completeness of seating. After the implant was impacted into the acetabular cavity, relative motion between the implant and bone was measured during simulated single leg stance. Adjuvant fixation of the implant was then obtained with the insertion of four 6.5 mm cancellous screws. High-contrast roentgenograms of the specimens in multiple views were obtained after initial cup insertion and again after screw insertion. The stability of each implant under load was measured with four, three, two, one, and no screws in place. Further reaming of the bone was done to create a 1 mm press-fit. The sequence was then repeated. Further reaming was done to create an exact-fit and the sequence was repeated again. Under these conditions, 1 mm press-fit with or without screws provided the optimum combination of fit stability.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗