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At least 721 records · Page 40Linked to original sources
PubMed1986

New primary malignant melanoma, epidermotropism and Indian-file arrangement of metastatic tumor cells in a case with intransit metastases of acral type of malignant melanoma.

Multiple malignant melanocytic lesions developed on a localized area of the thigh in an 80-year-old woman 3 years after excision of a primary malignant melanoma on the left second toe and dissection of left inguinal lymph nodes. Biopsy specimens obtained from 2 small pigmented macules revealed the histologic features of new primary lesions, simulating that of the primary lesion on the toe; no tumor cells were found within vessel lumina. A brown-black papule neighboring one of the macules histologically resembled compound type of melanocytic nevus, but the tumor cells compressed thinned epidermis with focal epidermotropism. Other papules, whose color ranged from light brown to reddish brown, showed metastatic tumor cells only in the dermis. In 3 of them, individual tumor cells were lined up along the collagen bundles, showing an 'Indian-file' arrangement. Such a combination of various histologic features in a case of intransit metastases of acral type of melanoma has not been reported in the literature.

Aged↗
PubMed2000

Basic knowledge of Internet in forensic medicine: logging on, fetching files and information.

The Internet stands at the forefront of telecommunications in medicine, including forensic medicine, since information technology (IT) has been able to revolutionize medical and scientific practices. Today, forensic physicians and professionals need to be familiar with the use of computers and the key applications of information technology: multimedia and the Internet. From the office, the forensic physician can communicate with other physicians by means of e-mail, take part in discussion groups, obtain information on meetings and get information from public libraries and various databases by means of file transfer protocol. The search among the huge amount of information is facilitated by the 'click and play' use of the Internet, by its increased ease and availability of access and by faster communications to an increasing number of accessible technical, scientific and biomedical resources. Therefore, it is useful to introduce some of the most frequent concepts encountered when exploring the Internet, to give simple references for any forensic physician exploring the Internet and to present typical Internet aspects by illustrations saved from worldwide websites and linked to the accompanying text. Some of the main forensic websites and basic Internet procedures are described, explaining how to search and exchange information in the domain of forensic medicine and sciences. Search engines and search procedures on the worldwide web are briefly explained. The aim of this paper is to give forensic physicians, scientists and law professionals some basic tools and references to access the vast possibilities of the Internet.

Forensic Medicine↗
PubMed1990

Observer variation in mammary thermography: results of a teaching file test carried out in four different centers.

To evaluate observer variation in mammary thermography, a teaching file test of 159 thermographies was worked out by 4 senology centers. The evaluation of accuracy and the K index of variability demonstrated a significant variability among centers. The reliability of thermography in senology seems to be too poor for it to be able to direct any therapeutic decision, either diagnostic or prognostic.

Breast Neoplasms↗
PubMed1978

Primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog. A report of 16 cases from the files of the AFIP.

Sixteen cases of primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog were reviewed from the files of the Armed Forces Institute of Pathology (AFIP). The mean age of affected dogs was 9.5 years. The presenting clinical signs were epistaxis, nasal discharge or facial swelling. Eleven of the affected dogs were purebred. Three of these were Collies and two German Shepherds. The nasal cavity was involved most often. All neoplasms were malignant (11 carcinomas and five sarcomas), and there was invasion of the adjacent bony structures in most dogs. Tumors were classified according to prominent cell type and degree of differentiation into respiratory epithelial carcinoma (four), adenocarcinoma (one), squamous cell carcinoma (one), mucoepidermoid carcinoma (two), undifferentiated carcinoma (three), chondrosarcoma (three) and undifferentiated sarcoma (two).

Adenocarcinoma↗
PubMed2002

ORFer--retrieval of protein sequences and open reading frames from GenBank and storage into relational databases or text files.

BACKGROUND: Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite of the cloning and recombinant expression of these proteins. RESULTS: A Java program was developed for retrieval of protein and nucleic acid sequences and annotations from NCBI GenBank, using the XML sequence format. Annotations retrieved by ORFer include sequence name, organism and also the completeness of the sequence. The program has a graphical user interface, although it can be used in a non-interactive mode. For protein sequences, the program also extracts the open reading frame sequence, if available, and checks its correct translation. ORFer accepts user input in the form of single or lists of GenBank GI identifiers or accession numbers. It can be used to extract complete sets of open reading frames and protein sequences from any kind of GenBank sequence entry, including complete genomes or chromosomes. Sequences are either stored with their features in a relational database or can be exported as text files in Fasta or tabulator delimited format. The ORFer program is freely available at http://www.proteinstrukturfabrik.de/orfer. CONCLUSION: The ORFer program allows for fast retrieval of DNA sequences, protein sequences and their open reading frames and sequence annotations from GenBank. Furthermore, storage of sequences and features in a relational database is supported. Such a database can supplement a laboratory information system (LIMS) with appropriate sequence information.

Animals↗
PubMed2004

pdb-care (PDB carbohydrate residue check): a program to support annotation of complex carbohydrate structures in PDB files.

BACKGROUND: Carbohydrates are involved in a variety of fundamental biological processes and pathological situations. They therefore have a large pharmaceutical and diagnostic potential. Knowledge of the 3D structure of glycans is a prerequisite for a complete understanding of their biological functions. The largest source of biomolecular 3D structures is the Protein Data Bank. However, about 30% of all 1663 PDB entries (version September 2003) containing carbohydrates comprise errors in glycan description. Unfortunately, no software is currently available which aligns the 3D information with the reported assignments. It is the aim of this work to fill this gap. RESULTS: The pdb-care program http://www.glycosciences.de/tools/pdb-care/ is able to identify and assign carbohydrate structures using only atom types and their 3D atom coordinates given in PDB-files. Looking up a translation table where systematic names and the respective PDB residue codes are listed, both assignments are compared and inconsistencies are reported. Additionally, the reliability of reported and calculated connectivities for molecules listed within the HETATOM records is checked and unusual values are reported. CONCLUSION: Frequent use of pdb-care will help to improve the quality of carbohydrate data contained in the PDB. Automatic assignment of carbohydrate structures contained in PDB entries will enable the cross-linking of glycobiology resources with genomic and proteomic data collections.

Carbohydrate Conformation↗
PubMed1991

Effects of right ventricular pacing rate on the pattern of left ventricular contraction and filing as assessed by radionuclide ventriculography.

Changes in the pattern of the global left ventricular (LV) time-activity curve with increasing pacing rates were evaluated using radionuclide ventriculography in 15 patients with chronically implanted right ventricular VVI pacemakers. The variables obtained were correlated with the conventional systolic time intervals recorded immediately after radionuclide ventriculography in 8 of the 15 patients. Increasing the pacing rate from 50 to 110 beats per minute (bpm) altered the pattern and timing of LV contraction and filling dramatically. It produced progressive delay and reduction of LV contraction, thus shortening the LV diastolic filling time, and sometimes resulting in LV filing even during early systole. Despite these profound alterations, relative cardiac output increased progressively, peaking at a pacing rate of 110 bpm in most patients. In paced patients, filling parameters and diastolic timing intervals require careful attention, since they may be difficult to determine from the altered LV time-activity curve at higher pacing rates.

Aged↗
PubMed1993

Religious homogamy and marital duration among those who file for divorce in California, 1966-1971.

The hypothesis that having a common religion is associated with more stable marriages is tested using California data on divorce for the period 1966-1971. The results confirm the hypothesis, and the authors note that "religious homogamy among Jewish couples is associated with longer [marriage] duration than any other group. Couples who report no religious affiliation appear to be at greatest risk of early filing for divorce. The religious groupings include the Jewish, the Conservative Protestant, the Liberal Protestant, the Roman Catholic and those with no religious affiliation."

Americas↗
PubMed1987

Wife's employment status and marital duration in a population filing for divorce.

This study analyzes data from a 2% random sample of all couples who filed for divorce/dissolution in California in each of the 6 years, 1966-1971, in order to examine the relationship between wife's employment status and marital duration to separation. Using exchange theory, anomie theory, and role conflict as basic theoretical perspectives, the elaboration analysis of the zero order relationship is discussed vis a vis the findings that housewives are likely to be married longer before separation than employed wives, except when they marry very young. The analysis shows the enhancement of our zero order relationship for housewives marrying in their 20's, having an education of high school or above, and having been previously married. Furthermore, a causal linkage is posited between wife's employment status, presence of children, and marital duration to separation, which shows the zero order relationship to be non-spurious through the interpretation that occurred when controlling on presence of children.

Black or African American↗
PubMed1980

The anticurvature filing method to prepare the curved root canal.

The anticurvature filing method maintains the integrity of canal walls at their thin portion and reduces the possibility of root perforation or stripping. With this method, the dental practitioner maintains digital control over the endodontic instrument, and the preparation of the curved canal is eased.

Dental Instruments↗
PubMed1990

A method of macro-auditing and assessing the preventability of infant mortality using large volume computerized files.

We present a method for auditing and evaluating infant mortality with the aid of a preventability grading system, based on national computerized files of livebirths and infant deaths. Diagnostic categories and specific causes of deaths were classified into one of the following three preventability grades: Preventable (P), Possibly Preventable (PP) and Non Preventable (NP). This classification was then applied to two different scales: Preventability of Condition (PC) and Preventability of Death (PD) from which a third scale--Preventability of Mortality (PM)--was derived. The method was then applied to matched records of 39,786 livebirth and 452 infant death certificates between 1977 and 1984, in a semi-urban region in Israel encompassing 220,000 inhabitants. Comparison of mortality rates, according to the proposed preventability scores, demonstrated that higher infant mortality rate in non-Jewish population, or in Jewish mothers with a lower educational, was present only in the preventable categories (P or PP), while death rates due to non preventable causes were identical for all groups. The suggested macro-auditing method facilitates the assessment of large scale infant mortality rates in terms of preventability.

Congenital Abnormalities↗
PubMed2005

Reductive denitrification of nitrate by scrap iron filings.

Reduction of nitrate by zero-valent iron is a highly exergonic reaction that has long been known to occur. Use of scrap iron filings (SIF) as the PRB (Permeable Reactive Barrier) material can be used to recycle certain by-products, and identify cheaper replacements for expensive conventional PRB materials, especially pure metallic iron. The feasibility of reductive denitrification of nitrate by SIF was studied by batch experiments. Operational parameters such as pH value, SIF dosage and initial concentration of nitrate were investigated. The removal efficiency of nitrate reached 80% under the conditions of pH of 2.5, nitrate initial concentration of 45 mg/L and SIF dosage of 100 g/L within 4 h. Results indicated that nitrate removal is inversely related to pH. Low pH value condition favors for the nitrate transformation. Different from the results of others who studied nitrate reduction using iron powder, we found that there was a lag time before nitrate reduction occurs, even at low pH. Finally, the possible mechanism of nitrate reduction by Fe0 is discussed.

Computer Simulation↗
PubMed1980

The quality and completeness of birthweight and gestational age data in computerized birth files.

Computerized birth files compiled by the State of North Carolina for the years 1975-1977 were analyzed for omissions and inaccuracies. A wide range in the per cent missing values was found for different data items, from essentially none missing (birthweight, sex, race) to about 20 per cent missing (gestational age, paternal social data). Recorded birthweight showed the expected skewing from a normal distribution. The only demonstrable inaccuracy was in the form of digit preference, probably causing errors of +/- 1 oz (28.3 g). Reported gestational ages were more suspect, falling outside the range of biologically plausible gestation length in 2.8 per cent of cases. An additional 1.5 per cent of gestational ages were found to be misdated by four to 20 weeks based on the observed bimodal weight distributions among births of the same reported gestational age. Hospitals of various sizes and administrative affiliations submitted records with missing or inaccurate gestational age data with roughly equal frequency. These records were found to come from a socio-demographically high-risk subpopulation. The implications of elimination of incomplete or erroneous birth record data in perinatal epidemiologic research are discussed.

Adult↗
PubMed2004

Improving patient care: the use of a digital teaching file to enhance clinicians' access to the intellectual capital of interdepartmental conferences.

OBJECTIVE: We describe a simple method for creating teaching cases from clinical data, radiologic images, surgical images, and images from pathologic slides that are presented at tumor board conferences. CONCLUSION: The resulting interdisciplinary case files are of educational value both during and after conference presentations and can be used by clinicians to gather appropriate historical, laboratory, imaging, surgical, and pathologic data on their patients. This system improves the efficiency and accuracy in gathering patient histories when care is transferred among clinics, the emergency department, and wards.

Access to Information↗
PubMed2005

A solution for transferring 35-mm slide collections into a digital teaching-file database system.

OBJECTIVE: Our objective was to develop a convenient yet comprehensive process for transferring 35-mm radiology slides into a digital teaching-file system capable of delivering online educational content and serving also as a general-purpose digital media repository. CONCLUSION: We believe this approach provides a feasible solution for converting radiologists' educational 35-mm slides into well-organized, high-quality digital media suitable for both online education and speaker-led presentations.

Computer-Assisted Instruction↗
PubMed1979

Rheumatoid arthritis in a Norwegian community (Jondal). A study based on the local doctor's file.

This study of rheumatoid arthritis has been made in Jondal, Norway, on 803 persons between the ages of 16 and 75 years. Patients suspected of suffering from joint disease other than traumatic lesions were selected from the general practitioner's file, and further information on these patients was obtained from the local hospital and from personal interviews. It was found that 0.5% of the men and 1.2% of the women suffered from rheumatoid arthritis. Six persons (0.7%) fulfilled the ARA criteria for classical and definite rheumatoid arthritis, one fulfilled four criteria (probable RA). However, only 0.4% of the investigated population had more severe disease.

Adolescent↗
PubMedDate not supplied

Experience of transferring an integrated hospital-administration system from a CODASYL data-base to a standard MUMPS file structure.

University College Hospital, a teaching hospital situated in Central London, has been using computers since 1964. Development of an integrated on-line hospital administration computer system was started in 1974. By mid 1977, the components of the system which had been implemented included a patient Master Index, Registration of new patients, Waiting Lists, Bed State, Out-patient Appointments, X-ray, Microbiology and Disease Index. The system was implemented using the Rank Xerox Data Systems (CODASYL based data-base management software, with the majority of applications running on a terminal network supported by transaction processing programs. The experience gained during three years of using such a system is reviewed, with particular emphasis on the ways in which the system matched up in practice to the expected benefits of data-base management facilities. In early 1977, it was decided to replace the Rank Xerox mainframe with a minicomputer which was considered to be a more cost-effective solution to the hospital's computing requirements. The machine selected a PDP 11-70, is running the Digital Equipment Corporation's implementation of Standard MUMPS, an interpretive language developed in a hospital environment, with its own file management software. The decisions which were made in redesigning the existing computer systems for the new machine are discussed. The progress made to date in the transfer of applications from the mainframe to the mini is reviewed, and some of the features of the software available on each machine and its suitability for the implementation of on-line data management and retrieval systems are compared.

Computers↗
PubMed2006

The use of digital video recorders (DVRs) for capturing digital video files for use in both The Observer and Ethovision.

Before switching a laboratory from analog to digital, for the recording of video files for use in Noldus software such as Ethovision and The Observer, researchers need to proceed with caution. There are obvious advantages in moving to digital recording for behavioral work, including increased storage capacity; no requirement to purchase video tapes; immediate search by date, time, or event; digital images are of higher quality; ability to view study sites remotely by Internet connection; and "smart" features, such as motion detection. But before you throw away your time-lapse video recorders, time code generators, and video multiplexors, there are some important cautions to take account of. Some research groups have bought digital surveillance systems on the assumption that they work with Ethovision and The Observer, only to be disappointed. The vast majority of systems depend on proprietary compression software that must then be converted to work properly in Ethovision or The Observer.

Animals↗