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At least 721 records · Page 40Linked to original sources
PubMed1991

T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor.

A transcriptionally active open reading frame (T2) from Shope Fibroma Virus was recently shown to have striking sequence homology with members of a new superfamily of cell surface proteins, including a receptor for human tumor necrosis factor. Here we report that recombinant T2 protein expressed in COS cells is a soluble, secreted glycoprotein which specifically binds human TNF alpha and beta, and inhibits binding of these cytokines to native TNF receptors on cells. T2 binding of TNF is not inhibited by nerve growth factor, although the nerve growth factor receptor is also a member of the same family, nor by nine other recombinant cytokines. Further, the repeating domain structure of T2 most closely resembles that of the type I TNF receptor (p75) and is significantly different from other family members, including the type II TNF receptor (p55). Since T2 possesses a leader sequence but lacks a transmembrane domain, these results confirm the original suggestion (1) that T2 represents a soluble form of the type I TNF receptor which is secreted from virally infected cells, and whose function is to immunosuppress the host by abrogating the potentially destructive effects of TNF. This is the first such virally-encoded soluble cytokine receptor to be identified, and may represent a more general mechanism by which viruses subvert the host immune system.

Amino Acid Sequence↗
PubMed1986

Recurrent pleural fibroma.

Pleural fibromata are rare tumours. We report a case of histologically proven pleural fibroma with later recurrence following resection. The case emphasizes the need for long-term review of patients with pleural fibromata.

Female↗
PubMed1976

Ossifying Fibroma-one disease or six? An analysis of 39 fibro-osseous lesions of the jaws.

Thirty-nine cases of benign fibro-osseous lesions of the jaws of which ten cases were reported as central ossifying fibromata are reviewed. Such lesions usually present in young adults with the exception of classical fibrous dysplasia which is normally first diagnosed in the second decade of life. All the lesions appear to be more common in females and with the exception of the peripheral ossifying fibroma show a prediliction for the mandible. It is argued that as there is no absolute histological distinction between bone and cementum and as cementum-like areas of calcification are seen in fibro-osseous lesions of all membrane bones the distinction between ossifying and cementifying lesions should be discontinued. It is also suggested that the benign fibro-osseous jaw lesions may represent different stages in the evolution of a single disease process.

Adult↗
PubMed1983

Congenital cardiac fibroma associated with fetal arrhythmia.

A congenital cardiac fibroma presented itself, antenatally by bursts of extrasystoles which were detected by the cardiotocograph during labor. Congenital cardiac tumors are extremely rare. The symptomatology of such tumors consists mainly of hemodynamic disturbances and various arrhythmias. Most of the reported cases were diagnosed in neonates or infants, usually in autopsies, none were diagnosed in utero. It seems logical to assume that some of the arrhythmias may have been present but not diagnosed antepartum. To the best of our knowledge the association of congenital cardiac tumor and fetal arrhythmia (FA) has not been reported yet.

Adult↗
PubMed1990

Ovarian fibroma--clinical and histopathological characteristics.

Twenty-three cases of ovarian fibroma, comprising 3% of all benign tumors seen over a 20-year period, were analyzed. It was unilateral in all cases affecting more commonly the left ovary (70%). Whilst a majority of cases (77%) were encountered in the reproductive age group, the tumor was rare before the second decade. Only in 13% of cases was ascitis clinically detectable. This was not influenced by the size and weight (average of 9.3 x 10.8 x 11.1 cm and 959 g, respectively) of the tumors; a smooth-surfaced tumor was, however, associated with a greater amount of peritoneal fluid. Varying degrees of calcification in some tumors are detectable on ultrasonography and occasionally on abdominal radiography. The classical Meig's Syndrome was seldom encountered. The histopathological features, diagnostic problems and management are discussed.

Adult↗
PubMed1983

Fibroma in a Nine-banded armadillo (Dasypus novemcinctus).

An adult male Nine-banded armadillo (Dasypus nonemcintus) had a large tumour between the first and second phalanges of the right fore-foot. The tumour was of dermal origin, consisted of dense interlacing bundles of collagen, and contained numerous fibroblasts with elongate nuclei and sparse cytoplasm. Mitotic figures were not observed, there was no evidence of lipid accumulation, and there was no metastasis to regional lymph nodes or other tissues. Electron microscopy showed that the major cells of the tumour were fibroblasts. These did not contain nuclear or cytoplasmic inclusions but had dense bodies in the nucleus and there was a conspicuous absence of lysosomes. This lesion was considered to be a benign fibroma of undetermined aetiology.

Animals↗
PubMed1977

Desmoplastic fibroma of bone. A case in the mandible.

A case of desmoplastic fibroma of the mandible in a 25-year-old white man, expanding from the first molar to the ramus, is presented. This is a rare primary central neoplasm. It grows expansively and may destroy the cortex. Few cases in the mandible have been reported. Its diagnosis is important because the experience reported by different authors has shown the tendency for recurrence when treatment consists of less than radical resection.

Adult↗
PubMed1984

Fibrous defect (nonossifying fibroma) of the mandible.

Two cases of fibrous defect (nonossifying fibroma) of the mandible are presented. Each case occurred in the mandibular ramus of an 11-year-old girl. The usual fibrous defect of bone is an intraosseous fibrous, nonneoplastic, reactive lesion which appears as a well-delineated defect in the metaphysis of long bones. This report reviews the literature, histopathology, and classification of the fibrous defect of bone.

Child↗
PubMed1985

Radiographic characteristics of central ossifying fibroma.

Sixty-four instances of histologically documented ossifying and/or cementifying fibromas were evaluated. Adequate radiographs were available in 43 of the cases. Most of these benign fibro-osseous neoplasms occurred in women, with a predilection for the third and fourth decades. Six distinct radiographic patterns could be identified: (1) radiolucent, superimposed over teeth or residing in edentulous regions (28%); (2) radiolucent with opaque foci, lying in edentulous areas or superimposed over teeth (42%); (3) radiolucent, interposed between contiguous teeth (5%); (4) radiolucent with opaque foci, interposed between contiguous teeth (9%); (5) multilocular expansile (7%); and (6) aggressively expansile with opacification (9%). All lesions exhibited well-defined margins. Root resorption was a feature in 11% of the sample, and root divergence occurred in 17% of the cases.

Adult↗
PubMed1987

The histomorphologic spectrum of peripheral ossifying fibroma.

A series of 207 cases of peripheral ossifying fibroma was analyzed both clinically and histologically. Almost 60% of the lesions occurred in the maxilla, and in both jaws more than 50% occurred in the incisor-cuspid region. The lesion was most common in the second decade. Females were affected more frequently than males; the ratio was 1.7:1. The recurrence rate--16%--was relatively high. Histologically, in 66% of the cases the surface epithelium was ulcerated and in the remainder it was intact. The ulcerated lesions were composed of highly cellular fibroblastic connective tissue, whereas in the nonulcerated lesions part of the tissue was more collagenized. Both types contained mineralized products in the form of bone, cementum-like material, and/or a dystrophic type of calcification. The dystrophic calcification was most prevalent in the ulcerated lesions. The mean duration at time of excision for the ulcerated lesions was 5.6 months and for the nonulcerated lesions was 24 months. It is proposed that the ulcerated and nonulcerated lesions represent a spectrum of one lesion with different stages of maturation.

Adolescent↗
PubMed1987

Early aggressive cemento-ossifying fibroma: a diagnostic and treatment dilemma.

A case involving a 22-year-old male patient with early aggressive cemento-ossifying fibroma in the mandible is discussed. The historical difficulty in categorizing fibro-osseous lesions is reviewed, and the importance of clinical, radiographic, and surgical findings to the ultimate diagnosis and correct treatment of these lesions is emphasized.

Adult↗
PubMed1989

Bilateral ossifying fibroma of the maxillary sinus.

A case involving a 35-year-old man with massive, bilateral, slow-growing ossifying fibromas in the maxillary sinuses resulting in facial deformity and orbital compression is discussed. The historical difficulty in categorizing fibro-osseous lesions and the importance of clinical, radiographic, and surgical findings relating to the proper diagnosis and treatment are reviewed. The use of the CT scan to delineate the extent of the pathologic lesion is demonstrated.

Adult↗
PubMed1983

Extrachromosomal deer fibromavirus DNA in deer fibromas and virus-transformed mouse cells.

The non-virus-producing fibromatous portions of five deer fibromas were examined for deer fibromavirus (DFV) DNA sequences. Liquid-phase hybridization revealed 100 to 330 copies per cell of the virus genome. Southern blot analysis of undigested deer tumor DNA preparations indicated that most of the DFV DNA was present as monomeric, unintegrated genomes; however, restriction enzyme digestion patterns suggest a small population of resistant DFV sequences. DFV DNA was also present in virus-transformed NIH/3T3 mouse cells as multiple, extrachromosomal genomes.

Animals↗
PubMed1985

Molecular characterization of two strains of Shope fibroma virus.

An isolate of Shope fibroma virus (SFV), designated Indiana (SFV-I), was previously described to be tumorigenic in vivo as SFV, cytocidal in vitro as the orthopoxviruses (vaccinia, rabbitpox, etc.), and to share antigenic determinants with SFV and vaccinia. The genetic relatedness of SFV-I to SFV and vaccinia was studied by means of Southern blotting and hybridization. The results indicated that SFV-I shares extensive DNA homology with vaccinia, but few common sequences with SFV. By contrast, SFV and vaccinia show no sequence homology. These findings suggest that SFV-I is an orthopoxvirus which carries some genetic information from the leporipoxviruses. Recombinants between two genera of poxviruses have not been reported before.

Animals↗
PubMed1985

Characterization, molecular cloning, and physical mapping of the Shope fibroma virus genome.

Five strains of Shope fibroma virus (SFV), a strain of rabbit myxoma virus, and a strain of vaccinia virus were compared by restriction endonuclease digestion of their viral DNAs. Restriction digest patterns revealed that SFV and rabbit myxoma, both members of the Leporipoxvirus genus, were distinct from vaccinia, an Orthopoxvirus. All strains of SFV examined had a high degree of nucleotide sequence homology as shown by conservation of restriction sites within their genomes. However, restriction patterns of SFV and myxoma were quite different from one another suggesting that the genomes from these two viruses of the Leporipoxvirus genus do not share a large, highly conserved region of homology as do the viruses belonging to the Orthopoxvirus genus. Restriction mapping identified inverted terminal repeats of approximately 12 kb in length. Restriction fragments representing all but 400 bp of the termini were cloned in plasmid vectors.

Animals↗
PubMed1985

Tumorigenic poxviruses: genomic organization of malignant rabbit virus, a recombinant between Shope fibroma virus and myxoma virus.

The genome of malignant rabbit virus (MRV), a newly discovered tumorigenic poxvirus of rabbits, has been analyzed using cloned DNA probes from Shope fibroma virus (SFV) and myxoma virus. Under high stringency conditions for Southern blotting such that SFV probes do not cross-hybridize with myxoma virus DNA, it is demonstrated that greater than 90% of the MRV genome has been derived from myxoma virus, and that approximately 10 kb of SFV-derived sequences have substituted for a similar amount of myxoma sequences. Mapping of the MRV genome indicates that the SFV sequences are present in two regions of the genome, one in each copy of the MRV terminal inverted repeat sequence. Furthermore, fine mapping studies of the integration sites for SFV into the myxoma background show that these SFV sequences are not symmetrical with respect to the left and right genomic termini. At the left end, 4 kb of SFV-derived DNA maps between 6 and 10 kb from the terminus, while at the right end about 5.5 kb of SFV sequences are found to extend at least 1 kb further toward the unique internal sequences. Based on this asymmetrical bipartite distribution of SFV sequences in MRV, a two-stage model to rationalize the origin of MRV is proposed. This model postulates an initial recombination event similar to gene conversion between myxoma and SFV at the right terminus of myxoma, followed by an incomplete transposition of only part of these SFV sequences to the left terminus.

Animals↗
PubMed1987

Tumorigenic poxviruses: genomic organization and DNA sequence of the telomeric region of the Shope fibroma virus genome.

Shope fibroma virus (SFV), a tumorigenic poxvirus, has a 160-kb linear double-stranded DNA genome and possesses terminal inverted repeats (TIRs) of 12.4 kb. The DNA sequence of the terminal 5.5 kb of the viral genome is presented and together with previously published sequences completes the entire sequence of the SFV TIR. The terminal 400-bp region contains no major open reading frames (ORFs) but does possess five related imperfect palindromes. The remaining 5.1 kb of the sequence contains seven tightly clustered and tandemly oriented ORFs, four larger than 100 amino acids in length (T1, T2, T4, and T5) and three smaller ORFs (T3A, T3B, and T3C). All are transcribed toward the viral hairpin and almost all possess the consensus sequence TTTTTNT near their 3' ends which has been implicated for the transcription termination of vaccinia virus early genes. Searches of the published DNA database revealed no sequences with significant homology with this region of the SFV genome but when the protein database was searched with the translation products of ORFs T1-T5 it was found that the N-terminus of the putative T4 polypeptide is closely related to the signal sequence of the hemagglutinin precursor from influenza A virus, suggesting that the T4 polypeptide may be secreted from SFV-infected cells. Examination of other SFV ORFs shows that T1 and T2 also possess signal-like hydrophobic amino acid stretches close to their N-termini. The protein database search also revealed that the putative T2 protein has significant homology to the insulin family of polypeptides. In terms of sequence repetitions, seven tandemly repeated copies of the hexanucleotide ATTGTT and three flanking regions of dyad symmetry were detected, all in ORF T3C. A search for palindromic sequences also revealed two clusters, one in ORF T3A/B and a second in ORF T2. ORF T2 harbors five short sequence domains, each of which consists of a 6-bp short palindrome and a 10- to 18-bp larger palindrome. The significance of these palindromic domains in this ORF is unclear but the coincidence of the end of one larger palindrome with the end of the translated protein sequence that has homology with the B chain of insulin suggests that the palindromes may divide the T2 protein into several functional units. The salient organizational features of the complete SFV TIR are also discussed in light of what is known about other poxviral TIRs.

Amino Acid Sequence↗