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PubMed1975

Early intrauterine development: I. The rate of growth of Caucasian embryos and fetuses between the 6th and 20th weeks of gestation.

Liberalization of abortion laws in various countries and states of Europe and America has offered an opportunity for the study of the correlations between menstrual age and the rate of bodily development of human embryos and fetuses. In several institutions where local bylaws mandated the consent of the patients requesting therapeutic abortion to pathological investigation of the products of conception, various parameters of growth were measured systematically. These included crown-rump and foot lengths and body weight. The analysis of the data indicated that in the embryosic stages of development the rate of growth is substantially slower than it had been assumed previously. In the more advanced fetal stages of development the findings supported the validity of the long-established standard of Streeter. Since the current study has been based on apparently normal gestations of healthy women, whereas earlier data had rested, to a great extent, on spontaneously aborted and extopic embryon and fetuses, it seems evident that pathological specimens are not suitable for the purpose of establishing reliable standards of normal intrauterine growth rate. The present data support the suggestion, based on various experimental and clinical observations, that pathological gestations often result from abnormal ovulations that occur at times other than the mid-cycle and that such conceptions are frequently followed by a bleeding episode that simulates menstruation. It is likely that the inclusion of a high number of such cases biased the results of earlier investigations concerning embryonic growth rate on account of the frequent incidence of erroneous menstrual histories. The material available did not permit the extension of the investigation beyond the 20th week of gestation. It appears, however, that the average growth rate in the mid-trimester may be slower than the data adopted by the American Academy of Pediatrics would indicate. The possible causes of some phenomena observed in the course of the investigation, such as unexplained scatter of growth-rate patterns at all developmental stages and discrepancies among various literary data, have been discussed in some detail. While a tentative attempt has been made to correlate the investigated parameters of fetal growth with biparietal diameters of the head, a measurement accessible to direct assessment by sonography during pregnancy, the necessity of improving these standards through a prospective study has been emphasized.

Abortion, Therapeutic↗
PubMed1993

Fetotoxic and teratogenic potential of substituted phenylurea herbicide, isoproturon, in rats.

Effect of isoproturon (0.225, 0.45 and 0.90 g/kg/day) administered (po) from day 6 through 15 of gestation was studied on pregnant rats and their offsprings. There were no distinct clinical signs other than dose-related depression and drowsiness of pregnant rats. None of the animals died due to toxicity of isoproturon. At higher doses, decreased maternal body weight was observed during the advanced stage of pregnancy. The litter size, fetal weight and crown-rump and transumbilical lengths were decreased. There was increase in fetal resorption frequency and the number of fetuses with stunted growth. The compound had no effect on fetal sex ratio. No major visceral and skeletal malformations were observed. The study indicates fetotoxic potential of the compound.

Abnormalities, Drug-Induced↗
PubMed1993

Steroid metabolism in the cortex and the medulla of the early fetal bovine ovary.

Suspensions of cells obtained from the cortex and the medulla of the ovary of early bovine fetuses of 4-10 cm in crown-rump (C-R) length were used for studies of the metabolism of radiolabeled exogenous steroid precursors. Tritiated dehydroepiandrosterone, androstenedione, and testosterone were employed as precursors and their metabolic products were evaluated after separation by thin-layer chromatography. The extent of conversion of tritiated dehydroepiandrosterone to androstenedione was higher in cells from medulla than in those from the cortex. Androstenedione was metabolized mainly to estrone, and the percent of transformation was similar in the cortex and the medulla, but the rate of formation of 17 beta-estradiol was higher in the medulla than in the cortex. Furthermore, cells obtained from the cortex and the medulla aromatized testosterone to 17 beta-estradiol at a similar rate. In all cases, the percent of transformation was higher in ovaries from fetuses of 4.0 cm in C-R length than those from fetuses of 9.0-10.0 cm in C-R length. These data suggest that, in the bovine fetal ovary, the activity of 3 beta-hydroxysteroid dehydrogenase/isomerase and 17 beta-hydroxysteroid dehydrogenase predominates in the medulla, whereas aromatase activity is similar in the cortex and the medulla of the early fetal bovine ovary.

Androstenedione↗
PubMed1995

Androstenedione metabolism in the indifferent stage of bovine gonad development.

Suspensions of cells obtained from genital ridges and gonads of bovine embryos of 1.0-3.4 cm in crown-rump (C-R) length were used for studies of the metabolism of radiolabeled exogenous steroid precursor. Tritiated androstenedione was employed as precursor and the final products of their metabolism were evaluated after separation by thin-layer chromatography. Genetic sex was determined by the karyotype of hepatocytes from the same embryos. The extent of conversion of tritiated androstenedione was higher in cells from male embryos than cells from female embryos. Furthermore, androstenedione was metabolized mainly to testosterone in male embryos. By contrast, cells obtained from female embryos transformed androstenedione to estrone and 17 beta-estradiol. The onset of this activity was observed at 1.8 cm in C-R length in males and at 2.2 cm in C-R length in females. In all cases, after the onset, the metabolic activity increased in relation to the age of the embryos. These data show that in the bovine embryo gonad, the activity of aromatase and 17 beta-hydroxysteroid dehydrogenase are present when the morphological differentiation of the gonadal sex has not yet been established.

Androstenedione↗
PubMed1996

Anastomosis between both hypoglossal nerves in a 30 mm human embryo.

In this paper we present the first description of an anastomosis between both hypoglossal nerves during the embryonic period, a very uncommon anatomical variation. This was observed in a 30 mm crown-rump (C-R) length human embryo (Carnegie stage 23) from the Bellaterra Collection (Prof. Doménech Mateu), stained for nerve fibers. The anastomosis consisted of a large diameter trunk (36.7 microns) situated in front of and slightly below the hyoid cartilage, and clearly distinguishable from the anastomosis found in adults, which has a very fine diameter and is located in the suprahyoid region.

Embryo, Mammalian↗
PubMed1978

Development of the omasum in sheep.

Data are presented on the histogenesis of the omasal mucosa in sheep from the 2.5 cm crown-rump (c-r) length fetus to the adult. 11 stages of fetal development, and 4 post-natal stages, were studies. The distribution of glycogen in the omasal epithelium was also studied. During fetal life the omasal epithelium was initially stratified cuboidal in type, but the superficial layers of cells became flattened in later stages of gestation. This epithelium became extremely thick by the late stages of fetal life, reaching a maximum of 358 micron, and consisting of greater than 20 layers of cells, in the 45 cm c-r fetus (approximatelay 140 days). After birth the epithelium became markedly reduced in thickness, being approximately 77 micron in the adult, and had differentiated into a cornified stratified squamous epithelium of the adult type by 12 weeks after birth. Glycogen was extremely abundant in the omasal epithelium of the 2.5 cm fetus, and declined gradually thereafter to be almost completely absent in post-natal specimens. 4 orders of laminae were present in the adult omasum, distributed in the seqeunce 1-4-3-4-2-4-3-4-1. The 1st order was already present in fetuses of 2.5 cm c-r length, with the 2nd, 3rd and 4th appearing by the 3.5, 5.5 and 11.0 cm stages, respectively. Initial stages in the development of conical papillae were first seen in 15.0 cm fetuses, but the development of these papillae was not completed until after birth.

Age Factors↗
PubMed1993

Neonatal treatment of male monkeys with a gonadotropin-releasing hormone agonist alters differentiation of central nervous system centers that regulate sexual and skeletal development.

Male rhesus monkeys treated continuously with a GnRH agonist for the first 4 months of postnatal life exhibited a delay in the onset of puberty and an attenuated peripubertal rise in testosterone (T) secretion. The objectives of the current study were to determine whether these effects on sexual development were permanent and whether the hypothalamic-pituitary-testicular axis was functioning normally in these animals as adults. Neonatal GnRH agonist treatment delays but does not permanently block sexual maturation in male monkeys. Treated animals that did not show a pubertal rise in serum T during the breeding season of their 4th year exhibited a seasonal but subnormal elevation of serum T during the subsequent breeding season. Growth of the skeleton was diminished as evidenced by shorter adult crown-rump, tibia, and femur length and reduced bone mineral density of the humerus and lumbar spine. The magnitude of the serum LH and T response to iv pulses of GnRH [50 ng/kg body weight (BW)] and naloxone (1 mg/kg BW) did not differ between control and treated animals during the nonbreeding or breeding season at 6 yr of age. Conversely, treated animals showed a subnormal serum LH and T response to N-methyl-D,L-aspartic acid (5 mg/kg BW iv) during the nonbreeding season. These data suggest that adult monkeys treated neonatally with a GnRH agonist exhibit subnormal sensitivity of the central nervous system to one or more excitatory amino acids (e.g. aspartate or glutamate). Thus, abolishing neonatal activation of the pituitary-testicular axis with a GnRH agonist may permanently alter differentiation of central nervous system centers that are either involved in GnRH secretion or govern this process.

Animals↗
PubMed1988

[Reproduction studies of carboplatin (II)--Intravenous administration to rats during the period of fetal organogenesis].

Carboplatin, an oncostatic drug, was administered intravenously to pregnant Crj: CD (Sprague-Dawley) rats from day 7 through 17 of gestation at dose levels of 1, 2 and 4 mg/kg/day. The summarized results obtained are as follows: 1. Carboplatin 4 mg/kg suppressed the maternal body weight gains from day 13 through 20 of gestation. 2. Uterine weights were reduced in F0 dams at term at carboplatin 4 mg/kg. 3. Carboplatin 4 mg/kg brought the inhibition of fetal growth accompanied by the lowered values in fetal weights, crown-rump distances and tail lengths. Furthermore, the elevated incidences of unossified 5th and 6th sternum , as well as retarded ossification of sacrococcygeal vertebrae were also noted in this dose level. 4. The birth rate was reduced in neonates (F1) at carboplatin 4 mg/kg. 5. Body weight gains in male F1 rats were suppressed at carboplatin 4 mg/kg from 4 to 8 weeks of age. 6. Carboplatin 4 mg/kg decreased the brain weights on an absolute basis in female F1 rats, but failed to affect their postnatal differentiations, early behavioral developments, learning ability, motor activity or emotional development. 7. Reproductive ability in F1 rats of both sexes were not affected by carboplatin. 8. Influences on prenatal development were not apparently observed for F2 fetuses derived from F1 rats whose dams had ever received carboplatin during the organogenetic period. Based on these results, the no-effect dose level of carboplatin under the present experimental condition was estimated to be 2 mg/kg/day against dams and their offspring.

Animals↗
PubMed1990

[Reproductive and developmental toxicity studies of buspirone hydrochloride (I)--Oral administration to rats during the period of fetal organogenesis].

Buspirone hydrochloride (buspirone), an anxiolytic drug, was administered orally to pregnant Crj: CD (Sprague-Dawley) rats from day 7 through 17 of gestation at dose levels of 2, 12 and 75 mg/kg/day. The summarized results obtained are as follows: 1. Decreased activity was observed for F0 dams at buspirone 75 mg/kg. Further, the suppression of maternal body weight gains accompanied by the reduction of food consumption was shown during the administration period at the same dose level. 2. Liver weights were increased in F0 dams at term at buspirone 12 mg/kg and higher. Besides, brain, pituitary, adrenal and ovarian weights were increased in F0 dams at term at buspirone 75 mg/kg. 3. Buspirone 75 mg/kg brought the inhibition of fetal growth followed by the lowered values in fetal weights, crown-rump distances and tail lengths. Furthermore, the elevated incidence of skeletal abnormalities such as nodular and wavy ribs and unossified 5th and 6th sternum , as well as retarded ossification of cervical vertebrae, forelimbs and hindlimbs were also noted in this dose level. Also, the retarded ossification was observed at 12 mg/kg. 4. Buspirone failed to affect the parturition of F0 dams. 5. Buspirone did not function the viability of newborns (F1), and postnatal differentiations, learning ability, motility, motor activity or emotional development in F1 animals. 6. Body weight gains were depressed in female F1 rats from 4 to 9 weeks of age and food consumption was decreased in male F1 rats from 6 to 8 weeks of age at buspirone 75 mg/kg. 7. Buspirone 75 mg/kg produced suppressions of brain weights at 10 weeks of age in male and female F1 rats and lung weights at weaning in male F1 rats. Spleen weights were increased in female F1 rats at 10 weeks of age at the same dose level. However, buspirone failed to affect their reproductive ability. 8. F2 neonates derived from F1 rats whose dams had ever received buspirone during the period of fetal organogenesis showed no changes in observation items at birth. Based on these results, the no-effect dose level of oral buspirone under the present experimental condition was estimated to be 2 mg/kg/day against dams and their offspring.

Abnormalities, Drug-Induced↗
PubMed1994

[Reproductive and developmental toxicity studies of paclitaxel. (I)--Intravenous administration to rats prior to and in the early stages of pregnancy].

Paclitaxel, an antineoplastic agent, was administered intravenously to Crj: CD (SD) rats daily at dose levels of 0 (saline and vehicle), 0.1, 0.3 and 1.0 mg/kg for 63 days prior to mating and during the mating period in males, and for 14 days prior to mating and during the mating period as well as day 0 to day 7 of gestation in females. Results were as follows: 1. Body weight gains were shown a tendency to hasten in vehicle-treated male rats associated with the increased food consumption. However, the vehicle-treated group had no effect in the other parameters that were measured in this study when compared to the saline-treated group. 2. 1.0 mg/kg paclitaxel caused suppression of the body weight gains accompanied by the decreased food consumption in either male or female rats. 3. Adrenal and ovarian weights were decreased in 1.0 mg/kg dams at term. 4. The fertility indices in both sexes of 1.0 mg/kg were lower than the saline-treated group. However, the copulation indices in both sexes in 1.0 mg/kg rats were comparable to those of the saline-treated group. 5. Decreases in the number of corpora lutea, implantations and live fetuses or increases in the number of empty implantation sites and total embryo-fetal deaths were observed in 1.0 mg/kg dams. However, the fetal weights, crown-rump distances and tail lengths in live fetuses were not affected by paclitaxel treatment. Based on the reproductive and developmental indices, the no toxic-effect dose level of paclitaxel is 0.3 mg/kg/day for parent animals and their fetuses.

Adrenal Glands↗
PubMed1983

The effects of low dosages of trichloroethylene on chick development.

This study reports the effects of low dosages of trichloroethylene (TCE) (1-25 mumol/egg) on chick development when embryos were exposed directly to TCE on days 1 and 2 and examined at day 14 of embryogenesis. The results indicate that in terms of embryotoxicity, growth defects and morphological anomalies, the treated embryos differed significantly from the controls. The low doses of TCE tested produced 50% mortalities. Survivors in all instances exhibited these developmental defects: evisceration; subcutaneous edema; light pigmentation of the epidermis; beak malformations; club foot and patchy feathering. The incidence of these malformations varied depending on the day of exposure to TCE except for embryos treated with 1 mumol. Irrespective of the day of injection or concentration, the highest proportion of malformations were those of light pigmentation and edema. Neither controls (uninjected embryos, O) nor sham controls (mineral oil injected embryos OMO) exhibited any malformations. Differences in measurements of crown-rump (CR), leg, wing, toe and beak lengths between treated embryos and controls were significant at the P less than 0.05 level of confidence. However, there was no significant difference between the weights of livers of treated embryos and controls nor was any pathology noted for the livers. The embryotoxicity of TCE is described by comparing the average percentage of deaths caused by all concentrations of TCE injected on both days 1 and 2 of embryogenesis. For TCE injected embryos this average was 2.5 times higher than the average for sham controls and 6 times higher than for uninjected controls.

Abnormalities, Drug-Induced↗
PubMed1979

Foot length--a new and potentially useful measurement in the neonate.

The foot length, occipito-frontal head circumference (OFC), crown-rump, and crown-heel length (CHL) of 123 neonates of gestational ages 26-42 weeks, were measured between 12 hours and 5 days. A gauge, designed and constructed at St Mary's Hospital, Manchester, was used to measure foot length. In term babies (37-42 weeks) who were of weights appropriate for gestational age (AGA) the scatter about the mean of foot length measurements was small (coefficient of variation = 4.5%) compared with birthweight (coefficient of variation = 12.0%). The wide range of foot length measurements in babies of different gestational ages prevented maturity being accurately estimated. The mean birthweight of term light-for-dates (LFD) babies was 30.9% lower than term AGA babies, whereas the mean foot length, OFC, and body length of LFD babies was reduced by only 4.2-8.8%. There was a positive linear correlation between foot length and other indices of body size in LFD and AGA babies of all gestational ages. However, in premature babies (less than 37 weeks) the correlation between foot length and birthweight (r = 0.95) and foot length and CHL (r = 0.96) was pronounced. The 95% confidence limits of the regression lines were +/- 327 g and +/- 2.3 cm respectively. Birthweight and CHL of premature babies can therefore be estimated from a measurement of foot length that is performed simply and rapidly. Measurements of foot length are valuable in premature babies who are too ill at birth for conventional anthropometric measurements to be made, and in whom such measurements cannot be carried out subsequently because of the encumbrance of the incubator and intensive care apparatus. Drug dosages and intravenous fluid requirements based on body weight or surface area can be indirectly calculated from a measurement of foot length.

Anthropometry↗
PubMed1987

[Arterial and neural pedicles of the anorectal region in the human embryo and fetus. Inductor role in normal and pathological development].

To gain a better understanding of the development of ano-rectal malformations, a study of the arterial supply of the ano-rectal region was made in 26 human embryos and fetuses. The development of the ano-rectum was studied in 20 embryos, varying in length from 3 mm to 40 mm (Crown-Rump: 22-60 days), and 6 using Born's method reconstruction; 10 fetuses aged from 3 to 7-8 months were used for a topographic study of the ano-rectal region. 40 fetuses, the majority frozen after expulsion were injected immediately. The fetuses obtained were of ages corresponding to 12-39 weeks of amenorrhea. A staged histologic study after selective micropaque injections of the inferior mesenteric artery was carried out to demonstrate the arterial parietal distribution in the ano-rectum. Smith silver impregnation method, emphasizes the connections between the rectal arteries and extrinsic and intrinsic nerves. The subdivision of the cloaca is constituted by the folding of the ano-rectal and uro-genital parts and by the thickening of the dorsal cloacal epithelium, explained perhaps by the precocious development of arterial supply. The superior rectal artery is predominant and supplies the whole of the anorectum, eventually penetrating the wall of the anal canal. The well-developed median sacral artery is surrounded by a nervous tissue which reaches the M. Levator Ani. The sympathetic nerve fibers follow the arteries until the submucous layer. The development of the intramural plexus of the rectum is independent of the arterial supply.(ABSTRACT TRUNCATED AT 250 WORDS)

Anal Canal↗
PubMedDate not supplied

Growth of the body in early fetuses studied by multivariate analysis.

The growth of the body was studied in 30 human fetuses ranged from 10 to 22 weeks of gestation. The fetuses were fixed by immersion in 4 percent formaldehyde and the following dimensions were studied: a) lengths: arm, forearm, hand, thigh, leg, foot and crown-rump (sitting height), b) perimeters: head, thorax and abdomen. A covariance matrix was calculated from natural logarithms of all measurements. The relative growth of these measurement was computed by multivariate allometry using a principal components analysis (PCA). All characters were positively correlated with the first principal component which accounted for 94.65 per cent of the total variance. Considering the different measurements in the sequence of the increasing growth rates no one was considered to increase in isometric relationship. PCA showed that the following measurements grew with negative allometry: head perimeter, C-R length, thoracic perimeter, length of the forearm and abdominal perimeter. On the other hand, the following lengths grew with positive allometry: hand, foot, thigh, arm and leg. In conclusion, during the first two trimesters of prenatal life the growth of the body is allometrical. Limbs increase with greater growth rates than the perimeters of the body cavities.

Body Height↗
PubMed1987

Temporal relationship between fetal bovine skeletal growth and circulating hormonal levels.

Skeletal growth and serum hormonal levels in bovine fetuses were studied cross-sectionally from late first trimester to late third trimester of gestation (corresponding approximately to 75-275 days of age, and a crown-rump (CR) 5-105 cm/in size). Measurements of tibial and femoral lengths showed that bone growth proceeds at a 30% faster rate in fetuses of 50-105 cm CR, coincident with the appearance and exponential growth (y = 0.000207 e 0.12522 x; y, dried weights of ossification in grams and x, CR in cm) of a secondary center of ossification in the epiphysis. During this period there is an increase in the proportion of [3H]-thymidine-labeled nuclei (measured by autoradiography) in the proliferative zone of the epiphyseal growth plate and a progressive hypertrophy of chondrocytes in the epiphysis; in serum there is a rise in alkaline phosphatase activity, a rise in the calcium, and a decrease in the phosphorus concentrations. Cellularity (nuclei/area) and the proportion of [3H]-thymidine labeled nuclei in epiphyseal cartilage decline during the period of 15-105 cm CR, except at 25-45 cm CR when both parameters of chondrocyte growth have transiently stabilized. [35S]-Sulfate and [3H]-proline incorporation (cpm/100 micrograms DNA) in epiphyseal cartilage also decline initially during 10-25 cm CR, then attain a stable level during 25-50 cm CR; subsequently, [35S]-sulfate incorporation gradually increases and [3H]-proline incorporation remains at a constant level. The proportion of [3H]-thymidine-labeled nuclei in the epiphyseal growth plate also declines in early gestation, then becomes stabilized at 20-50 cm CR. The whole growth plate thickness varies during gestation and is maximal during 20-50 cm CR. The proliferative zone attains maximal thickness at 20-50 cm CR while the hypertrophied and degenerative zone has maximal thickness at 40-80 cm CR. Gestational changes of hormone levels were quantitated in fetal serum. Glucocorticoids and thyroxine were measured by radioimmunoassay; somatomedinlike bioactivity was measured as the capacity of a serum sample to stimulate [3H]-thymidine incorporation in chondrocytes compared to that of a control serum. Temporally related to the changes occurring in the skeletal tissues, there is a high serum level of glucocorticoids at 10-20 cm CR when the cartilaginous activities are declining, a peak level of serum somatomedinlike bioactivity at 20-50 cm CR when cartilage growth and metabolism become stabilized, and a rise of thyroxine level after 45 cm CR during which time there is an increasing rate of bone formation.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1975

[Normal prenatal growth of the golden hamster (author's transl)].

In the golden hamster (Mesocricetus auratus) the gestation period and the loculus size of the gravid uterus from day 6 to day 15.5 (parturition) of gestation as well as the weight, width (umbilcus-black) and lenght (crown-rump) of the embryos from day 9 to the parturition were measured. The results obtained were as follows: 1. The gestation period of the golden hamster was 15 days and 15 +/- 3 hours post coitum. 2. The average values of the length (in the direction of uterine long axis) and width (mesome-trial-antimesometrial axis) in the loculus of the gravid uterus were 0.39 cm and 0.56 cm at 6 days, and 2.42 cm and 1.74 cm at 15.5 days (partiurition), respectively. 3. The average values of the crown-rump measurements, width (umblicus-back) and weight in the hamster embryos were 0.42 cm, 0.24 cm and 0.026 g at 9 days, and 2.40 cm, 1.39 cm and 2.272 g at 15.5 days (parturition), respectively. 4. The loculus size of the gravid uterus, the crown-rump measurements and width (umblicus-back) of the embryos in the period from day 13 to day 14 of gestation were markedly increased in comparison with any other period, and the weight increase of the embryos occurred rapidly from day 13 of gestation. 5. The shape of the loculus during the gestation was ovoid (mesometrial-antimesometrial axis) until the end of 10 days converged to the spherical form and thereafter changed gradually to the ovoid from in the direction of uterine long axis contraly to the previous days.

Animals↗
PubMed1991

Brief communication: Morphometric data for adult lion-tailed macaques (Macaca silenus).

Basic morphometric data were collected from 22 adult lion-tailed macaques (M. silenus) of both sexes. M. silenus is a rare primate species from which adequate morphometric data have not heretofore been available for comparative purposes. Data collected include measures of gross body size (weight; crown-rump and rump-heel length), and for males, measures of secondary sexual characteristics (canine tooth and testes size). Degree of sexual dimorphism was marked, with males significantly larger and heavier than females. The three body size measures were correlated for males but not for females. There was substantial variation among individual males in secondary sex characteristics measurements. The data indicate than lion-tailed macaque morphometrics are consonant with the general pattern of positive allometry for body size and sexual dimorphism characteristic of the primate order.

Animals↗
PubMed1986

Growth patterns of rat body, brain, and cerebellum in fetal alcohol syndrome.

Pregnant Sprague-Dawley rats were offered protein- and vitamin-enriched, nutritionally balanced, liquid ethanol diet, providing 35% of calories as ethanol, beginning on day 6 of gestation. Control animals were pair-fed identical liquid diet except that maltose-dextrins were substituted for ethanol. At birth the pups of both ethanol exposed and pair-fed mothers were surrogate-fostered by normal dams. Plasma concentrations of ethanol and thyroxine were determined in dams of experimental and control groups. Thyroxine concentrations were significantly reduced in ethanol-fed dams compared with pair-fed. Pups of both groups were killed at 0-1, 5, 7, 10, 14, 21, 28, 35, and 42 postnatal days. The crown-rump, crown-tail lengths, and weights of body, brain, and cerebellum were significantly reduced in ethanol-exposed pups compared with controls at all time sequences studied.

Animals↗