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Endotracheal tube obstruction during stereotactic craniotomy.

The authors present a case of endotracheal tube (ETT) obstruction during stereotactic computer-assisted volumetric resection of an enlarging left thalamic mass in a prone patient. The head was fixed in a stereotactic COMPASS head frame and the patient positioned on transverse hip and shoulder rolls. The prone position was achieved with attention given to ensure an adequate distance between the sternum and mentum. At the time of dural incision, the patient's peak airway pressure and end-tidal CO2 tension increased markedly whereas the O2 saturation remained stable at 99%. It immediately became clear that the patient's torso had moved cephalad resulting in ETT obstruction, despite the continued integrity of head fixation. We emphasize the need for proper and safe patient positioning, the placement of a bite block between the molar teeth, and particularly in obese patients, the need to tape the patient's torso securely to the operating room table. In addition, it may be necessary to place the operating room table in reverse Trendelenberg position to prevent cephalad movement of the torso. This case represents an unusual mechanism of ETT obstruction, as normally the latter is caused by flexion of the head rather than by cephalad movement of the torso.

Adult↗

Craniotomy performed with LMA: a case report.

Since its introduction into clinical practice in 1988, the laryngeal mask airway (LMA) has been used as an alternative device to achieve and maintain control of the airway during anesthetics. The LMA has been used primarily in patients undergoing peripheral procedures in the supine position. The authors describe its use in an open intracranial neurosurgical procedure for a patient with a space occupying lesion. To our knowledge, this is the first such description in the literature.

Adolescent↗

Anesthetic considerations in a patient with severe aortic stenosis for craniotomy.

Severe aortic stenosis can pose a serious hazard for noncardiac surgery as patients with this condition have a high risk for developing perioperative cardiac complications. We describe the anesthetic management of a patient with a malignant brain tumor who was found to have severe aortic stenosis during preanesthetic evaluation. She underwent palliative balloon aortic valvuloplasty prior to surgery, and this combined with appropriate monitoring and drug therapy resulted in a satisfactory outcome. Adverse intraoperative events like hypotension and left ventricular failure occurred; however, these events were transient and responded to treatment.

Anesthesia↗

Inhalational or intravenous anesthetics for craniotomies? Pro inhalational.

PURPOSE OF REVIEW: In neurosurgery, anesthesiologists and surgeons focus on the same target - the brain. The nature of anesthetics is to interact with brain physiology, leading to favorable and adverse effects. Research in neuroanesthesia over the last three decades has been dedicated to identifying the optimal anesthetic agent to maintain coupling between cerebral blood flow and metabolism, keep cerebrovascular autoregulation intact, and not increase cerebral blood volume and intracranial pressure. RECENT FINDINGS: Sevoflurane is less vasoactive than halothane, enflurane, isoflurane, or desflurane. The context sensitive half-life is short and similar to that of desflurane, which translates into fast on and offset. Compared with propofol, sevoflurane decreases cerebral blood flow to a lesser extent, while cerebral metabolism is suppressed to the same degree. Sevoflurane does not increase intracranial pressure, while propofol decreases intracranial pressure. SUMMARY: In neurosurgical patients with normal intracranial pressure, sevoflurane might be a good alternative to propofol. In patients with reduced intracranial elastance, caused by space occupying lesions, with elevated intracranial pressure or complex surgical approaches, propofol should remain first choice.

Anesthesia Recovery Period↗

A comparison of the 2% and 1% formulations of propofol during anaesthesia for craniotomy.

This study investigated the pharmacodynamic and pharmacokinetic equivalence of 1% and 2% propofol emulsions when used for total intravenous anaesthesia for intracranial surgery. The same infusion rate (6.7 mg.kg-1 x h-1) of the two preparations was administered. Induction doses, recovery times, and haemodynamic profiles were identical. Similar propofol concentration profiles were produced and total body clearance of propofol was identical. Both preparations were associated with a similar incidence of injection pain but neither resulted in venous thrombosis or thrombophlebitis at 24 h. Plasma triglyceride concentrations were significantly higher with the 1% solution, but there were no differences in cholesterol concentrations. The 1% and 2% emulsions appeared to be pharmacologically equivalent with similar minor effects on arterial blood pressure and heart rate. Two percent propofol may be preferable to the 1% solution for maintenance of anaesthesia in patients in whom a large lipid load might be considered undesirable.

Adolescent↗

Minimum cerebral blood flow and metabolism during craniotomy. Effect of thiopental loading.

Cerebral blood flow and metabolism were measured repeatedly during surgery for cerebral tumours by a modification of the classical Kety & Schmidt method using 133Xe infusion intravenously. Our standard procedure for neuroanaesthesia (pentobarbitone-fentanyl induction, halothane-nitrous oxide maintenance) reduced blood flow from 47.1 to 24.2 ml X 100 g X ml-1 and metabolism from 3.30 to 1.83 ml O2 X 100 g-1 X ml-1. PaCO2 was reduced by hyperventilation from 5.3 to 3.6 kPa. Additional thiopental loading and maintenance using 4 + 4 mg X kg-1 (n = 5) or 8 + 8 mg X kg-1 (n = 5) reduced cerebral metabolism by an additional 15% (P less than 0.01) and blood flow by 16.5% (P less than 0.01), while mean arterial blood pressure fell from 11.0 to 9.9 kPa (P less than 0.05). PaCO2 remained unchanged. This additional reduction in cerebral metabolism and blood flow is small, but we nevertheless conclude that it may well be of clinical interest to the problem of protecting the brain in case of episodes of focal cerebral ischaemia which may arise peroperatively during intracranial surgery.

Adult↗

Changes in CMRO2, EEG and concentration of etomidate in serum and brain tissue during craniotomy with continuous etomidate supplemented with N2O and fentanyl.

Fourteen patients with supratentorial cerebral tumours were anaesthetized with continuous etomidate infusion (30 or 60 micrograms kg-1 min-1) supplemented with N2O 67% and fentanyl. Peroperatively cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were measured twice by the Kety and Schmidt method. Simultaneously with the CBF measurements, blood for serum etomidate was sampled and EEG was recorded in 2-min periods in 12 patients. In 10 patients a brain biopsy for etomidate was taken peroperatively and correlated with the other data. The results indicate a dose-dependant increase in serum etomidate and brain tissue etomidate, a decrease in CMRO2 and suppression of EEG activity. In individual studies an increase in serum etomidate or a decrease in CMRO2 correlated to a suppression of the EEG activity, and vice versa. However, the wide variations in these relationships within and between patients make any conclusion regarding CMRO2 impossible from the EEG recording, infusion rate of etomidate or serum concentration of etomidate.

Adult↗

Effect of alfentanil on intracranial pressure during propofol-fentanyl anesthesia for craniotomy. A randomized prospective dose-response study.

BACKGROUND: The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results. METHODS: Thirty-one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus-dose of alfentanil 10 (group 1), 20 (group 2), or 30 microg kg(-1) (group 3) was administered followed by an infusion of 10, 20, or 30 microg.kg(-1).h(-1) to patients in groups 1, 2, and 3, respectively. A control group received no alfentanil. Subdural ICP, mean arterial blood pressure (MAP), and cerebral perfusion pressure (CPP) were monitored and arterial and jugular bulb blood were sampled before and every minute for 5 min after the bolus administration of alfentanil and again after 5 min of hyperventilation to be able to calculate cerebral arterio-venous oxygen content difference (AVDO2) and carbon dioxide reactivity (CO2-reactivity). RESULTS: No changes in subdural ICP or AVDO2 from alfentanil in the study period were observed within the groups. However, alfentanil decreased MAP and CPP. The maximum CPP decrease (mean value of each group) was 4 mmHg, 8 mmHg, and 18 mmHg in groups 1, 2, and 3, respectively. There was no difference between groups as regards the CO2-reactivity. CONCLUSION: We conclude that administration of alfentanil to propofol-fentanyl anesthetized patients with supratentorial cerebral tumors decreases MAP and CPP in a dose-related way, but does not influence subdural ICP, AVDO2 or the CO2-reactivity.

Adolescent↗