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Analogue computer system for the evaluation of hip joint moments during normal walking.

Hip joint moments were determined by analogue computer techniques, using as inputs the angles formed by body segments during normal walking. The control algorithm was based on the division of the walking cycle into six stages; each activated by contact of heel, mid-foot and fore-foot. The problem of the accuracy of double differentiation was overcome by means of two filters which amplify the gain at the basic frequency of the walking cycle, while reducing it above 10 Hz. The analogue model gave reasonable results, suggesting that it could be used as an input to a real time microcomputer-based adaptive control system for the maintenance of hip joint balance in an amputee during walking.

Computer Simulation↗

Introduction to computer systems in diagnostic radiology.

Diagnostic radiology is immensely complex. It involves a consultation process, patient handling to produce images, and advanced technology. Computers have been applied extensively to these processes, and examples are given of some of these applications. Fully integrated computerized radiology systems have been an elusive goal. Integrity of patient data is probably the key to integration. Progress in the field continues.

Appointments and Schedules↗

A computer system for clinical microbiology.

The Department of Clinical Microbiology at St Thomas' Hospital has been producing bacteriological reports on a computer for more than three years and is now producing some 2300 reports per week. The system is operated entirely by laboratory staff without special training, and involves the use of optical mark reader (OMR) forms as worksheets, automatic validation and release of most reports, the use of local terminals, and scrutiny of reports by pathologists using a visual display unit. The OMR worksheet records not only the final result but also most of the tests and observations made on the samples; it is the only working document used by technicians. One specialist clinic submits its laboratory requests on an OMR form, which is subsequently used to record the results. The reports are printed and also filed in the computer to produce analyses for hospital, laboratory, and clinical management.

Computers↗

A computer system for transcribing radiology reports.

A minicomputer system has been developed to assist in the transcription, distribution, and long-term storage of radiology reports. Reports are dictated in the traditional manner by a radiologist and then entered into specially programmed computer terminals by a transcriptionist. Completed reports are electronically distributed throughout the department and the hospital. Inactive reports are stored by the computer on microfiche. At one institution, the system is used to produce all of the reports in the radiology department, a total of approximately 200,000 reports per year.

Computers↗

Theoretical and experimental study of an immobilized bienzyme system. Computer calculations and electron microscopy visualization of local concentration profiles.

A cytochemical method was used in order to visualize the existence of local concentrations of metabolites within an immobilized bienzyme system. Glucose oxidase (EC 1.1.3.4) and peroxidase (EC 1.11.1.7) were immobilized together into an artificial proteic membrane obtained by a previously described co-cross-linking process using a bifunctional agent, glutaraldehyde. The cytochemical reagent 3,3'-diaminobenzidine was used as a hydrogen donor substrate and kinetic studies were performed with both free and immobilized forms of the enzymes; in the latter case, a new direct method was introduced which allowed kinetic studies on the visualization system itself. From experimental kinetic parameters, theoretical concentrations profiles were calculated by computer using numerical analysis methods. These results were discussed with special attention to the electron microscopic observations. Computer simulations were in good agreement with electron micrographs. No geometrical similarity was seen in our system between poly(3,3'-diaminobenzidine) precipitate distribution and peroxidase molecule homogeneous location.

Computers↗

Use of a neural net computer system for analysis of flow cytometric data of phytoplankton populations.

Flow cytometry has been used over the past 5 years to begin detailed exploration of the distribution and abundance of picoplankton in the oceans. Light scattering and fluorescence measurements on individual plankton cells in seawater samples allow construction of population signatures from size and pigment characteristics. The use of "list mode" data has made these studies possible, but on-shore analysis of copious data does not permit on-site reexamination of important or unexpected observations, and overall effort is greatly handicapped by data analysis time. Here we describe the application of neural net computer technology to the analysis of flow cytometry data. Although the data used in this study are from oceanographic research, the results are general and should be directly applicable to flow cytometry data of any sort. Neural net computers are ideally suited to perform the pattern recognition required for the quantitative analysis of flow cytometry data. Rather than being programmed to perform analysis, the neural net computer is "taught" how to analyze the cell populations by presenting examples of inputs and correct results. Once the system is "trained," similar data sets can be analyzed rapidly and objectively, minimizing the need for laborious user interaction. The neural network described here offers the advantages of 1) adaptability to changing conditions and 2) potential real-time analysis. High accuracy and processing speed near that required for real-time classification have been achieved in a software simulation of the neural network on a Macintosh SE personal computer.

Computer Systems↗