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PubMedDate not supplied

Pharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens.

We report that the classical guanylate cyclase inhibitor methylene blue (MB, 1 microM or 10 microM), but not the selective guanylate cyclase inhibitor 1H-[1,2,4]oxidazolo[4,3-a]quinoxalin-1-one (1 microM) or nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (100 microM), causes a shift to the left in the concentration-response curve for noradrenaline in the isolated rat vas deferens preparations. The main objective of our study was to investigate the pharmacological mechanism by which MB increases the sensitivity of the rat vas deferens to noradrenaline. According to the presented results, MB did not change rat vas deferens sensitivity to methoxamine or noradrenaline in the presence of desipramine (0.1 microM). The pre-contracted rat vas deferens relaxation induced by isoproterenol was also not significantly changed by MB (1 microM). Thus, we suggest that MB increases rat vas deferens sensitivity through neuronal uptake inhibition without interfering in either the nitrergic mechanism or guanylate cyclase activity.

Animals↗
PubMed2003

Barium toxicity after exposure to contaminated contrast solution--Goias State, Brazil, 2003.

Barium-containing contrast solutions are commonly used in radiologic studies. On May 22, 2003, three patients at radiology clinics in Goias State, Brazil, were hospitalized after ingesting such solutions; two persons died within 24 hours of hospitalization. Exposure occurred during radiologic examination of the upper or lower gastrointestinal tract. An investigation was conducted by municipal and state public health authorities with assistance from the Ministry of Health's National Agency for Sanitary Surveillance (ANVISA) and Brazil's Field Epidemiology Training Program (FETP), known locally as EPISUS. This report summarizes the results of that investigation, which found that 44 persons had suspected barium toxicity, nine of whom died. Eight of the nine deaths were linked to a single lot of brand A contrast solution. A national recall was announced on May 23, and the manufacturing facility was inspected and closed. Clinicians should be alert for signs of barium toxicity in patients in the hours after administration of contrast solutions during radiologic studies.

Barium Compounds↗
PubMed2003

Effect of reinforcement methods on the retention of resin-bonded fixed partial dentures using a composite denture tooth as a pontic: in vitro evaluation.

PURPOSE: The incorporation of composite denture teeth as pontics in resin-bonded fixed partial dentures has been deemed to be short-lived. This study investigated whether pre- or posttreatments could improve the bonding of denture tooth pontics. MATERIALS AND METHODS: A model fixed partial denture was fabricated that included composite denture teeth (Endura) bonded with 1 of 2 resin systems (C&B-Metabond or Aeliteflo). The bonding surface of the pontic was pretreated with one of three methods (air-particle abrasion [AA], AA plus silanization, or cavity preparation plus AA). The bonding areas between pontic and abutments were posttreated with 1 of 2 methods (reinforcement with fiber or metal post). Five bonded specimens for each treatment group were subjected to 20,000 thermocycles (40 degrees C to 60 degrees C; dwell time 60 s) before retentive forces (N) were determined. All data were analyzed with two-way ANOVA and Bonferroni's test (p = 0.05). RESULTS: All specimens that underwent the pre- and posttreatment outperformed untreated specimens. For the specimens bonded with C&B-Metabond and posttreated with a polyethylene fiber (Ribbond) or a metal post (DC Post), the mean retentive forces were 316 N and 301 N for mandibular specimens, and 354 N and 380 N for maxillary specimens, respectively. These values were significantly higher than those obtained with other pretreatment methods (p < or = 0.0003). For mandibular specimens bonded with Aeliteflo, specimens posttreated with Ribbond exhibited significantly higher retentive forces (332 N) compared to other specimens (p < or = 0.0001). CONCLUSION: Within the limitations of this study, the bond strength of a resin-bonded fixed partial denture incorporating a composite denture tooth as the pontic was improved by reinforcement with either a polyethylene fiber or a metal post.

Analysis of Variance↗
PubMedDate not supplied

Shear bond strength between composite resin and denture teeth: effect of tooth type and surface treatments.

PURPOSE: The purpose of this study was to investigate the strength of the composite resin-denture tooth bond as affected by different tooth surface treatments. MATERIALS AND METHODS: Spectrum TPH was condensed on 112 mandibular first molar acrylic resin and composite resin denture teeth, which received seven different treatments: Four groups were treated with Prime & Bond NT adhesive, and three groups were treated with One Step adhesive. Four groups (two of each adhesive category) were treated with Composite Activator and air abrasion. In one group, AeliteFlo was used just before the condensation of Spectrum TPH. Bond strength was evaluated with a shear test device on a Monsanto testing machine. The results were evaluated statistically with two-way ANOVA and the Scheffé method. RESULTS: There was a significant interaction between denture tooth type and surface treatments. Bond strength of composite resin was greater to composite than to acrylic resin teeth when the bond was mediated only with adhesives. One Step adhesive and AeliteFlo resulted in a higher bond of composite resin to both types of teeth. Wetting tooth surfaces with Composite Activator did not increase the bond. CONCLUSION: When repairing denture teeth with composite resin and adhesives, the bond strength was higher with composite than with acrylic resin teeth, and there were differences between the adhesives used.

Acid Etching, Dental↗
PubMedDate not supplied

[New capacities of roentgen diagnosis in detecting small intestinal pathology].

The paper based on the data of more than 200 studies of the small bowel with the new agent Entero-VU specially designed for X-ray study of the bowel gives an objective evaluation of this agent. The authors of the paper analyze the capacities of Entero-VU in diagnosing 38 cases of Crohn's disease, tuberculosis and tumors of the small bowel. Moreover, as a separate section the paper provides an assessment of the agent in mapping the X-ray standards of the small bowel. In the authors' opinion, the use of this agent as though fills the existing gap in the X-ray study of the small bowel.

Barium Compounds↗
PubMed2003

Effect of different polymerization methods on composite microleakage.

PURPOSE: To evaluate the microleakage of a condensable resin composite using a microhybrid flowable composite as a liner, cured with four different methods of polymerization. METHODS: 40 freshly extracted caries-free human premolars and molars were used. MO/DO Class II standardized preparations were performed with the gingival margin placed 1 mm above the CEJ. Teeth were randomly divided into four groups. Group 1 (control group): conventional mode (Elipar Highlight), Group 2: step mode (Elipar Highlight), Group 3: ramp mode (Elipar Trilight) and Group 4: pulse mode (VIP). Preparations were etched with 32% phosphoric acid (Uni-Etch) and an adhesive system (One-Step) was used according to the manufacturer's instructions. Teeth were then restored using a 1 mm layer of flowable composite (A2 AEliteflo LV) on the gingival and pulpal floor and condensable composite (Pyramid A2 Dentin and A1 Enamel) in 2 mm increments. Teeth were thermocycled x500 between 5 degrees C and 55 degrees C with a dwell of 30 seconds and then placed in a 0.5% methylene blue dye solution for 24 hours at 37 degrees C. Samples were sectioned longitudinally and evaluated for microleakage at the gingival margin under a stereomicroscope at x30 magnification. Dye penetration was scored using an ordinal scoring system as 0: no penetration; 1: enamel penetration; 2: dentin penetration. RESULTS: A Mann-Whitney U Test revealed a statistically significant difference between Group 1 with Groups 2, 3 and 4 (P < 0.001). Group 1 yielded the most microleakage. No statistically significant difference was noted between Groups 2, 3 and 4.

Acid Etching, Dental↗
PubMed2003

Single-visit, adjacent composite onlays--a dual-catalyst, inert gas-processed chairside technique.

Considerable research has been conducted on laboratory-processed composite resins in the last two decades. Substantial long-term studies support the theory that physical properties improve greatly if these composites are processed under high-pressure inert gas. In addition, the use of dual catalysts (light and heat) will generate higher conversion rates in the composite. This article describes a clinical technique for fabricating adjacent onlays or three-quarter crowns in a single visit that capitalizes on the inert gas and dual-catalyst research.

Acid Etching, Dental↗