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At least 721 records · Page 40Linked to original sources
PubMed1978

Primary adenoid cystic carcinoma of skin.

Two primary adenoid cystic carcinomas of skin were studied histologically and histochemically. Histologically, they closely resemble adenoid cystic carcinoma found in other tissues but in the skin must be distinguished from aggressive basal cell carcinomas. The natural history of these tumors and of those collected from the literature suggest a long indolent and progressive course. Local excision with meticulous histologic control of the surgical margins appears to be an appropriate therapeutic strategy. Thus far lymph node metastases have not been observed.

Adult↗
PubMed1978

Adenoid cystic carcinoma (cylindroma) and mucoepidermoid carcinoma of the bronchus. Factors affecting survival.

A review was made of the presentation, treatment, and follow-up of 20 patients with adenoid cystic carcinoma and 12 patients with mucoepidermoid carcinoma of the bronchus who were seen at the Mayo Clinic during the 50 year period 1927 through 1977. Three forms of therapy were employed: complete surgical resection, radiation therapy alone, and radiation therapy after endoscopic removal of tumor tissue. Superior results were obtained in the group with adenoid cystic carcinoma, when complete resection was possible. Significant survival and palliation of sepsis was achieved with subtotal resection. The mucoepidermoid carcinomas in this series were classified on the basis of histologic differentiation. Mucoepidermoid carcinoma of Grade 1 was managed by conservative pulmonary resection. Mucoepidermoid carcinoma of Grades 2 and 3 showed a greater propensity for malignancy. Widespread dissemination caused death with unresectable high-grade mucoepidermoid carcinomas of Grades 2 and 3.

Adolescent↗
PubMed1978

Adenoid cystic carcinoma of the Cervix. Report of 9 cases and a reappraisal.

The clinical and pathologic findings of 9 patients with adenoid cystic carcinoma of the cervix are presented. A review of the literature identified an additional 29 cases. The tumor was usually associated with adenocarcinoma or squamous cell carcinoma of the cervix. Adenoid cystic carcinoma of the cervix appears to be an aggressive type of tumor; of the 38 cases reported in the literature lung metastases have occurred in 18 (47.4%), and of these, 14 patients are known to have died of the cancer.

Aged↗
PubMed1990

Early adenoid cystic carcinoma of the upper oesophagus.

A 70-year-old male patient with an early stage primary adenoid cystic carcinoma of the oesophagus is reported. The 1.5 cm protuberant tumour, located in the upper oesophagus and found during examination for heartburn, was radically resected. It was restricted to the submucosa, which strongly suggests that it originated from the oesophageal glands. Microscopically, the tumour showed sparse S100 cells. This finding is in contrast with that in adenoid cystic carcinomas of the salivary glands.

Aged↗
PubMedDate not supplied

Adenoid cystic carcinoma of the uterine cervix. Cytologic features.

A case of primary cervical adenoid cystic carcinoma in a 75-year-old woman is reported. Two cervical smears taken at the time of initial presentation for vaginal spotting were negative; a third smear, taken a year later prior to laparotomy, was diagnosed as positive. The cytologic findings in the positive cervical smear are described and illustrated. The differential diagnosis of the cytologic findings is discussed, and the literature on this lesion is briefly reviewed. The results in this case and others suggest that the diagnosis of cervical adenoid cystic carcinoma in an asymptomatic patient may be missed by routine smear examination.

Aged↗
PubMed1990

[Establishment of a human cancer cell line from adenoid cystic carcinoma of the minor salivary gland].

This paper reports the establishment of a human cancer cell line from adenoid cystic carcinoma of the minor salivary gland and the study of its biological behaviours. The cells of the cell line (SACC-83) are polygonal in shape, with a mosaic arrangement. Ultrastructural study reveals that many secretory granules are present in the cytoplasm. The mitosis index, growth curve, chromosome analysis and transplantation into nude mice were performed and discussed. The results prove that this cell line possesses the morphological and biological features of adenoid cystic carcinoma.

Adult↗
PubMed1990

Induction of bone formation in an adenoid cystic carcinoma of the maxillary sinus by adoptive immunotherapy involving intra-arterial injection of lymphokine-activated killer cells and recombinant interleukin-2 in combination with radiotherapy.

A patient with an adenoid cystic carcinoma of the maxillary sinus was treated by adoptive immunotherapy involving intra-arterial injection of lymphokine-activated killer cells (a total number of 7 x 10(7) cells) and recombinant interleukin-2 (a total dose of 2.75 x 10(7) units) in combination with radiotherapy (60Co; total irradiation dose of 5,000 rads). Consequently, it was found that bone formation was induced in the treated tumor, which was then replaced completely by lamellar bone tissue with myxomatous stroma. This finding indicates that the tumor cells composing certain adenoid cystic carcinoma can be converted into normal-appearing, bone-forming cells by current therapy and this differentiation phenomenon leads to cure of the tumor.

Biopsy↗
PubMed1990

Adenoid cystic carcinoma of the trachea--a cause of pseudo-angina pectoris.

Primary tracheal tumors are rare. Typically slow growing, they present late in the course of disease, with obstructive respiratory symptoms. A 25-year-old man developed external substernal chest pain and pressure with dyspnea that were relieved with rest. Noninvasive evaluation identified a tracheal tumor, adenoid cystic carcinoma by biopsy, which was previously undescribed as a cause of pseudo-angina pectoris. The patient's evaluation, management, and 20-month follow-up are presented. A mechanism for the patient's noncardiac exertional chest pain is proposed. Previous experience with adenoid cystic carcinomas of the trachea is reviewed.

Adult↗
PubMed1990

Adenoid cystic carcinoma of the external auditory canal.

Adenoid cystic carcinoma of the external auditory canal is much less common than squamous cell carcinoma and basal cell carcinoma. Signs and symptoms of the case presented here consisted of a longstanding discharging ear, a progressive hearing loss, and the presence of a circumferential subcutaneous induration in the distal third of the external auditory canal. No dizziness, tinnitus, or facial weakness was present. Computed tomography showed a soft tissue mass in the external auditory canal and middle ear with no lytic areas of the mastoid or the temporal region. A biopsy specimen was interpreted as an adenoid cystic carcinoma. Treatment consisted of radical excision of the external auditory canal via a modified temporal bone resection. This radical approach resulted in the local eradication of the lesion.

Carcinoma, Adenoid Cystic↗
PubMed1986

An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen.

A neoplastic epithelial cell line, TYS, was isolated from a well-differentiated squamous cell carcinoma expressing carcinoembryonic antigen (CEA) that arose in human oral mucosa. Expressions of CEA and amylase as well as ample tonofilaments were detected in cultured TYS cells. Transplantation of the cells into athymic nude mice resulted in production of adenoid squamous cell carcinoma containing CEA and amylase. Cultivation of TYS cells in the presence of sodium butyrate resulted in suppression of cell growth and production of secretory granules with amylase in the cytoplasm of the cells. When the sodium butyrate-treated cells were transplanted into nude mice, a small mass developed transiently at the inoculation site and then disappeared. This mass was histopathologically interpreted as acinic cell carcinoma with squamoid lesion. These findings suggest that we have established a human adenoid squamous carcinoma cell line presumably derived from a minor salivary gland present in oral mucosa.

Adenoids↗
PubMed1988

Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli.

We have compared the ability of anti-IgE, calcium ionophore A23187, substance P, compound 48/80, poly-L-lysine, and morphine to release histamine from mast cells of human skin, lung, adenoids, tonsils, and colon. Use of a single collagenase/hyaluronidase dispersion technique for all tissues has allowed comparisons of reactivity to be made that are free from methodological variations. Mast cells from all tissues examined secreted histamine in response to anti-IgE and calcium ionophore A23187. However, only skin mast cells were responsive to substance P, compound 48/80, poly-L-lysine, and morphine. Activation of human skin mast cells by these nonimmunologic stimuli clearly distinguishes them from the mast cells of human lung, adenoids, tonsils, and colon and is indicative of functional heterogeneity within the human mast cells population. We propose that the presence of functional receptor sites for neuropeptides and basic compounds on skin mast cells that are not present in mast cell populations from mucosal or lymphoid sources reflects a specialized role for these cells in vascular homeostasis.

Adenoids↗
PubMed1988

Adenoid cystic carcinoma of the trachea and main-stem bronchus. A clinical, histopathologic, and immunohistochemical study.

Twelve cases of adenoid cystic carcinoma of the trachea and main-stem bronchus were histologically analyzed, and the results were examined with reference to the growth pattern of the tumor and the prognosis. The tumors were histologically classified into tubular, cribriform, and solid subtypes. Three histologic grades were established: grade I, tumors with tubular and cribriform subtypes but without solid subtype; grade II, tumors with tubular and cribriform subtypes in which the solid subtype comprised less than 20% of the area; grade III, tumors in which the solid subtype comprised more than 20% of the area. Three gross infiltrating types were established: type I, entirely intraluminal; type II, predominantly intraluminal; type III, predominantly extraluminal. In most cases histologic grade correlated with gross tumor type; that is, grades, I, II, and III were grossly types I, II, and III, respectively. The tumors infiltrating along the tracheobronchial wall were of the tubular or cribriform subtype, but not of the solid subtype. In two patients who died of distant metastasis, the histologic studies revealed the solid subtype. Immunohistochemical analysis demonstrated that the tubular subtype was the most differentiated form and the solid subtype, the most undifferentiated form. The histologic subtype of adenoid cystic carcinoma of the tracheobronchial tree was an important factor in the growth pattern of the tumor and the prognosis.

Adult↗
PubMed1989

Results of fast neutron therapy of adenoid-cystic carcinomas of the head and neck at the neutron therapy facility Hamburg-Eppendorf.

Between 1977 and 1987, 30 patients with adenoid-cystic carcinomas of the head and neck region were treated, at the Hamburg-Eppendorf neutron therapy facility, with a 14 MeV-DT-generator. The present review deals with 15 patients treated before October 1986 e.g. with follow up longer than one year. These results, although preliminary, tend to confirm that fast neutrons is the best irradiation modality of adenoid-cystic carcinomas of the head and neck region, especially when surgery is not possible, or cannot be radical.

Adult↗
PubMed1989

[Association of an adenoid cystic epithelioma with a clear cell carcinoma of the palate].

An infrequent polymorphous minor salivary gland tumor is described. It involved the palate and later invaded the upper jaw. The morphologic features are those of both adenoid cystic carcinoma and clear cell carcinoma. The clinical course, the cellular admixture of tumour components, and the immunohistologic results allow us to propose that clear cell carcinoma originating from adenoid cystic carcinoma offers the worst prognosis.

Adenocarcinoma↗
PubMed1989

[Measurement of adenoid tissue in the lateral plate of the nasopharynx. Clinico-radiologic correlation].

172 children were studied, being 113 hypertrophy symptomatic adenoid (AH) and 59 of control group. Clinical findings were compiled of such entity in a direct way; without knowing the results, measurings of the diameter of the adenoid tissue were taken, at the trachea and preadenoid aerial column (PAAC). It was shown that their involvement is a forecaster of undoubtful value in the prognosis of AH, specially if it is considered that other procedures are hard to carry out such as in the case of the child affected by posterior rhinoscopy.

Adenoids↗
PubMed1988

Primary adenoid cystic carcinoma of the Bartholin's gland: a clinical, histological and immunocytochemical study of a case.

Adenoid cystic carcinoma of the Bartholin's gland is a rare tumor. Only 41 cases, to our knowledge, have been described in literature. It is impossible, at present, to determine the best management of this disease. Local recurrence and distant metastases (mainly of the lung) frequently occur. A case of adenoid cystic carcinoma of the Bartholin's gland is looked into with respect to clinical and immunohistochemical characteristics. Radiation therapy is suggested as effective together with surgery. The efficacy of routine lymphadenectomy has not been demonstrated. The case reported is the first described with nodal metastasis as single mode of recurrences presentation.

Adult↗
PubMedDate not supplied

[Cystic adenoid cancer of the esophagus. Report of a case and review of the literature].

A 59-year-old man had adenoid cystic carcinoma of the esophagus. The tumor, in the lower third of the esophagus, was resected; the patient died 7 months after surgery from widespread distant metastases. The initial diagnostic was epidermoid carcinoma on the biopsy. In the literature adenoid cystic carcinoma are frequently associated with epithelial abnormalities. Also of interest within the literature was the fact that radiotherapy and combination chemotherapy may be an effective treatment modality for this cancer.

Carcinoma, Adenoid Cystic↗
PubMed1988

[Adenoid cystic carcinomas of the head and neck. Results of treatment with high-dosage radiotherapy].

Different opinions exist about the role of radiotherapy in the treatment of adenoid cystic carcinoma of the head and neck. In this paper the results of 14 patients with high-dosage irradiation are reported. Radiotherapy with local curative intent was performed in all patients. 10/14 patients were irradiated post-operatively. 4/14 patients received radiation therapy alone. By percutaneous irradiation (n = 13) focal doses of 80 Gy were applied, by interstitial irradiation (n = 1) 70 Gy. Despite the less favourable patient group - 8/14 patients had either a T3- or T4-tumour; 5/14 patients were referred because of recurrent disease - local tumour control could be achieved in all cases after a mean observation time of 3.5 years. Together with newer reports of literature we consider adenoid cystic carcinomas of salivary gland origin as locally curable by postoperative high-dosage radiotherapy.

Adult↗