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PubMed2005

RPBS: a web resource for structural bioinformatics.

RPBS (Ressource Parisienne en Bioinformatique Structurale) is a resource dedicated primarily to structural bioinformatics. It is the result of a joint effort by several teams to set up an interface that offers original and powerful methods in the field. As an illustration, we focus here on three such methods uniquely available at RPBS: AUTOMAT for sequence databank scanning, YAKUSA for structure databank scanning and WLOOP for homology loop modelling. The RPBS server can be accessed at http://bioserv.rpbs.jussieu.fr/ and the specific services at http://bioserv.rpbs.jussieu.fr/SpecificServices.html.

Computational Biology↗
PubMed2004

RAG: RNA-As-Graphs web resource.

BACKGROUND: The proliferation of structural and functional studies of RNA has revealed an increasing range of RNA's structural repertoire. Toward the objective of systematic cataloguing of RNA's structural repertoire, we have recently described the basis of a graphical approach for organizing RNA secondary structures, including existing and hypothetical motifs. DESCRIPTION: We now present an RNA motif database based on graph theory, termed RAG for RNA-As-Graphs, to catalogue and rank all theoretically possible, including existing, candidate and hypothetical, RNA secondary motifs. The candidate motifs are predicted using a clustering algorithm that classifies RNA graphs into RNA-like and non-RNA groups. All RNA motifs are filed according to their graph vertex number (RNA length) and ranked by topological complexity. CONCLUSIONS: RAG's quantitative cataloguing allows facile retrieval of all classes of RNA secondary motifs, assists identification of structural and functional properties of user-supplied RNA sequences, and helps stimulate the search for novel RNAs based on predicted candidate motifs.

Computational Biology↗
PubMed2006

Palliative care and end-of-life care World Wide Web resources for geriatrics.

As the average life span of Americans increases, there is a tremendous need for geriatric- specific information and resources, especially for those older adults with life-limiting illnesses. Emerging literature underscores the differences in palliative and end-of-life approaches between younger and older adults in treating symptoms, understanding issues related to psychosocial and spiritual well-being, and alleviating caregiver burden. Hundreds of internet sites currently exist that pertain to geriatrics, and health professionals now have access to evidence-based clinical care guidelines, guides for education and training, and networks to support patients and their families. Even consumer-oriented organizations have assumed responsibility for informing patients and families and outlining supportive care services for patients and families. This paper reports the results of a systematic evaluation and critique of 15 websites, and summarizes their unique contributions clinical care guidelines, teaching materials and training opportunities, effective models of care, and advice on dealing with the complex emotional, social and financial issues facing older adults at the end-of-life.

Aged↗