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At least 73 records · Page 4Linked to original sources

X-ray intensifying screen visible light detection meter.

A light meter has been designed and built for the purpose of measuring the light emitted from an intensifying screen during x-ray irradiation. The meter uses a photodiode detector with a minimal drift amplification system. The meter repeatability was better than 0.5% and was found to be linear. A significant x-ray induced signal was recorded during measurement which needed to be subtracted from readings to deduce the intensification screen light output. The energy response of four screen types was subsequently measured.

Radiometry↗

Comprehensive combinatory standard correction: a calibration method for handling instrumental drifts of gas chromatography-mass spectrometry systems.

The current work describes a new method, the comprehensive combinatory standard correction (CCSC), for the correction of instrumental signal drifts in GC-MS systems. The method consists in analyzing together with the products of interest a mixture of n selected internal standards, and in normalizing the peak area of each analyte by the sum of standard areas and then, select among the summation operator sigma(p = 1)(n)C(n)p possible sums, the sum that enables the best product discrimination. The CCSC method was compared with classical techniques of data pre-processing like internal normalization (IN) or single standard correction (SSC) on their ability to correct raw data from the main drifts occurring in a dynamic headspace-gas chromatography-mass spectrometry system. Three edible oils with closely similar compositions in volatile compounds were analysed using a device which performance was modulated by using new or used dynamic headspace traps and GC-columns, and by modifying the tuning of the mass spectrometer. According to one-way ANOVA, the CCSC method increased the number of analytes discriminating the products (31 after CCSC versus 25 with raw data or after IN and 26 after SSC). Moreover, CCSC enabled a satisfactory discrimination of the products irrespective of the drifts. In a factorial discriminant analysis, 100% of the samples (n = 121) were well-classified after CCSC versus 45% for raw data, 90 and 93%, respectively after IN and SSC.

Analysis of Variance↗

Sniffing out the truth: clinical diagnosis using the electronic nose.

Recently the use of smell in clinical diagnosis has been rediscovered due to major advances in odour sensing technology and artificial intelligence (AI). It was well known in the past that a number of infectious or metabolic diseases could liberate specific odours characteristic of the disease stage. Later chromatographic techniques identified an enormous number of volatiles in human clinical specimens that might serve as potential disease markers. "Artificial nose" technology has been employed in several areas of medical diagnosis, including rapid detection of tuberculosis (TB), Helicobacter pylori (HP) and urinary tract infections (UTI). Preliminary results have demonstrated the possibility of identifying and characterising microbial pathogens in clinical specimens. A hybrid intelligent model of four interdependent "tools", odour generation "kits", rapid volatile delivery and recovery systems, consistent low drift sensor performance and a hybrid intelligent system of parallel neural networks (NN) and expert systems, have been applied in gastric, pulmonary and urine diagnosis. Initial clinical tests have shown that it may be possible in the near future to use electronic nose technology not only for the rapid detection of diseases such as peptic ulceration, UTI, and TB but also for the continuous dynamic monitoring of disease stages. Major advances in information and gas sensor technology could enhance the diagnostic power of future bio-electronic noses and facilitate global surveillance models of disease control and management.

Biomarkers↗

Role of random genetic drift in the evolution of interactive systems.

Through comparative studies of DNA sequences it has become possible to test the neutral and the selection theories of molecular evolution. The separate estimation of the numbers of synonymous and non-synonymous substitutions is one of the most powerful tools for detecting selection. The patterns on the average and variance of these two types of substitutions of mammalian genes turned out to be in accord with the slightly deleterious or the nearly neutral mutation theory for non-synonymous changes. Interactive systems at the amino acid level were suggested to be responsible for such nearly neutral or very weak selection. An attractive model is the NK model of Kauffman, which assumes that each amino acid makes a fitness contribution that depends upon the amino acid and upon K other amino acids among the N that make the protein. It is known that the fitness landscape is very rugged for K > or = 2. Population genetic analysis of this model suggest that protein evolution obeys the nearly neutral theory and that random genetic drift is important. In other words, evolution becomes rapid in small populations because proportion of near-neutrality increases among new mutations, and proteins as interactive systems evolve by shifting through random genetic drift on the multipeaked fitness landscape.

Animals↗

Voltammetric and drift spectroscopy investigation in dithiophosphinate-chalcopyrite system.

The mechanism of dithiophosphinate (DTPI) adsorption on chalcopyrite was investigated by diffuse reflectance Fourier transformation (DRIFT) spectroscopy and by cyclic voltammetry (CV) at various pHs. CV experiments showed that the redox reactions occurred at a certain degree of irreversibility on the chalcopyrite surface in the absence of a collector due to preferential dissolution of iron ions in slightly acid solution and irreversible surface coverage by iron oxyhydroxides in neutral and alkaline solutions. In the presence of DTPI, CV experiments failed to identify the type of the adsorbed DTPI species and electrochemical processes occurring on chalcopyrite due to formation of an electrochemically passive surface layer preventing electron transfer. However, DRIFT spectroscopy tests showed this passive layer to be mainly CuDTPI + (DTPI)2. Both CV and DRIFT spectroscopy established that the activity of collector species decreased with increasing pH due to formation of stable hydrophilic metal oxyhydroxides on the chalcopyrite surface.

Adsorption↗

Rate-distortion analysis of motion-compensated rate scalable video.

Generally speaking, rate scalable video systems today are evaluated operationally, meaning that the algorithm is implemented and the rate-distortion performance is evaluated for an example set of inputs. However, in these cases it is difficult to separate the artifacts caused by the compression algorithm and data set with general trends associated with scalability. In this paper, we derive and evaluate theoretical rate-distortion performance bounds for both layered and continuously rate scalable video compression algorithms which use a single motion-compensated prediction (MCP) loop. These bounds are derived using rate-distortion theory based on an optimum mean-square error (MSE) quantizer, and are thus applicable to all methods of intraframe encoding which use MSE as a distortion measure. By specifying translatory motion and using an approximation of the predicted error frame power spectral density, it is possible to derive parametric versions of the rate-distortion functions which are based solely on the input power spectral density and the accuracy of the motion-compensated prediction. The theory is applicable to systems which allow prediction drift, such as the data-partitioning and SNR-scalability schemes in MPEG-2, as well as those with zero prediction drift such as fine granularity scalability MPEG-4. For systems which allow prediction drift we show that optimum motion compensation is a sufficient condition for stability of the decoding system.

Algorithms↗

Experiences with continuous intra-arterial blood gas monitoring: precision and drift of a pure optode-system.

OBJECTIVE: The utility of continuous intra-arterial blood gas analysis (CBGA) with combined electrochemical and optode sensors has been demonstrated. More recently, a pure optode sensor with a changed sensing element architecture has become available. The aim was to determine the measurement accuracy and long-term stability of the new sensor. DESIGN: A prospective explorative study was performed. Simultaneous measurements of intermittent blood gas analyses (IBGA) (ABL 610, Radiometer, Copenhagen) and CBGA (Diametrics Medical, High Wycombe, Bucks., UK) were compared using Bland-Altman analysis. PATIENTS: Twenty-five patients admitted to the ICU and requiring mechanical ventilation for an expected minimum of about 96 h were included. RESULTS: Mean monitoring time was 106.1 (range 15-231) hours. Bias and precision for PO(2 )were -0.2 kPa (1%)+/-1.8 kPa (9.5%); PCO(2): 0.03 kPa (0.6%)+/-0.44 kPa (9.3%); pH: -0.001 (0.01%)+/-0.04 (0.45%). The sensor showed no change of measurement characteristics during 4 days of measurement. However, in 69 cases continuous monitoring was interrupted (reversible sudden drops of PO(2) measurement) possibly caused by thrombotic deposition and/or sensor bending and accidental sensor retraction. CONCLUSIONS: The precision and bias of the PCO(2)- and pH-sensing elements were in line with the findings of the older sensor technology. The possibility that the PO(2) optode could offer greater accuracy than the older technology is suggested by comparisons with results reported in previous studies. No sensor drift occurred during long-term measurement over more than 4 days.

Adult↗

Observation of toroidal flow antiparallel to the drift direction in the hot electron mode plasmas in the compact helical system.

A toroidal flow antiparallel to the drift direction is observed in the hot electron mode plasmas when a large positive electric field and a sharp electron temperature gradient are sustained inside the internal transport barrier in the Compact Helical System. This toroidal flow reaches up to 5x10(4) m/s at the plasma center, and it is large enough to reverse the toroidal flow driven by a tangentially injected neutral beam. These observations clearly show the plasma favors flow in the minimum nablaB direction at the transport barrier.

Journal Article↗

Morphology of the drifting osteon.

Drifting osteons were followed longitudinally through the cortex of human and baboon long bones using serial sections. Direction of transverse drift was recorded at different cross-sectional levels of the same systems, and maximum angular change in drift direction was measured for each system. Most drifting osteons exhibit: (1) substantial ( approximately 90 degrees ) variation in the direction of transverse drift along their longitudinal axes, (2) intermittent regions of concentric (type I) morphology, and (3) change in drift direction over time, evident at single cross-sectional levels. Additionally, 3-dimensional reconstruction reveals that the basic multicellular units (BMUs) responsible for creating drifting osteons are morphologically distinct from the cutting-cone-closing-cone model BMUs that produce other types of osteons. The stimulus involved in the activation and guidance of drifting BMUs is unclear, but it is likely that the complex strain environment experienced by long bone cortices exerts a significant influence on their morphology.

Adolescent↗

Irreversible evolution of quantum chaos.

The pendulum is the simplest system having all the basic properties inherent in dynamic stochastic systems. In the present paper we investigate the pendulum with the aim to reveal the properties of a quantum analogue of dynamic stochasticity or, in other words, to obtain the basic properties of quantum chaos. It is shown that a periodic perturbation of the quantum pendulum (similarly to the classical one) in the neighborhood of the separatrix can bring about irreversible phenomena. As a result of recurrent passages between degenerate states, the system gets self-chaotized and passes from the pure state to the mixed one. Chaotization involves the states, the branch points of whose levels participate in a slow "drift" of the system along the Mathieu characteristics this "drift" being caused by a slowly changing variable field. Recurrent relations are obtained for populations of levels participating in the irreversible evolution process. It is shown that the entropy of the system first grows and, after reaching the equilibrium state, acquires a constant value.

Journal Article↗

The PB3300 intraarterial blood gas monitoring system.

Continuous intraarterial blood gas (IABG) monitoring is in clinical use both in the operating room and intensive care unit. This technology uses miniature, optically-based sensors that can be placed into a patient's artery. The arterial blood gas values are transduced into an optical signal that is measured by a bedside monitor on which the values are displayed. In this paper, we describe the operating principles of the PB3300 Intra-Arterial Blood Gas Monitoring System (Puritan-Bennett Corporation, FOxS Division, Carlsbad, CA). Topics include the principles of fluorescent determinations of pH, PCO2, and PO2; the optical path of the PB3300; system calibration; dye layer geometry; and clinical operation. The accuracy, precision, and drift of the system measuring tonometered aqueous standards are reported. The following values were noted for eight sensors sending data to eight monitors: system bias and precisions of 0.00 +/- 0.02 pH at a pH of 7.40, -2.5 +/- 1.5 mm Hg PCO2 at a PCO2 of 40 mm Hg, and 3.3 +/- 1.3 mm Hg PO2 at a PO2 of 80 mm Hg.

Blood Gas Analysis↗

An in vivo comparison of a catheter mounted pressure transducer system with conventional balloon catheters.

In the assessment of respiratory muscle function balloon catheters have been widely used for pressure measurements. However, this type of investigation is poorly tolerated by acutely ill patients. This study assessed the performance of a possible alternative, a catheter-mounted miniature pressure transducer (CMT). The assessment consisted of a laboratory study of the linearity, frequency response, and stability of gain and baseline of the CMT system, and an in vivo study directly comparing the CMT and balloon catheter systems in seven normal subjects for a range of respiratory manoeuvres. These were: 1) maximal inspiratory and expiratory pressures against a closed airway, 2) twitch transdiaphragmatic pressure elicited by cervical magnetic phrenic nerve stimulation, and 3) tidal breathing, sniffs and coughs in five body positions. The agreement of the two systems was analysed for measurements of 1) absolute pressures, 2) magnitude of changes in pressure, and 3) rate of change of pressure (maximum relaxation rate after sniff manoeuvres). The CMT system was linear, with a high frequency response and stable gain, but showed baseline drift. The two systems agreed well for measurements of change and rate of change of pressure, but less well for measurements of absolute pressure. The CMT system tested is potentially useful for studies of acute changes in respiratory pressures, or studies of respiratory muscle strength, but would be less useful where accurate measurements of absolute pressures are required.

Catheterization↗

Long-term testing of an intracranial pressure monitoring device.

OBJECT: Long-term monitoring of intracranial pressure (ICP) is limited by the lack of an implantable sensor with low drift. The goal of this study was to demonstrate that a new capacitive transducer system will produce accurate and stable ICP records over extended periods. METHODS: Intracranial pressure sensors were implanted into the frontal white matter of four dogs. In addition, a fluid-filled catheter was placed in the cisterna magna (CM) to measure cerebrospinal fluid (CSF) pressure. The animals were tested using standard physiological maneuvers such as jugular vein compression, head elevation, and CSF withdrawal from and saline injection into the CM to verify that the ICP sensor precisely matched CSF pressure changes. The mean ICP pressure and CM pressure were compared for months to demonstrate that the transducer system produced minimal drift over time. The change in the ICP sensor record closely duplicated that of the CSF waveform in the CM in response to well-known physiological stimuli. More important, mean ICP pressure remained within 3 mm Hg of CM pressure for months, with a mean difference of less than 0.3 mm Hg. Histological examination of the dog brains revealed only minimal tissue reaction to the presence of the sensor. CONCLUSIONS: The authors demonstrate a new implantable solid-state sensor that reliably measures ICP for months, with minimal drift. The clinical application of this sensor and its telemetry is for long-term monitoring of patients with head injury, mass lesions, and hydrocephalus.

Animals↗

Mating system and the evolution of quantitative traits: an experimental study of Mimulus guttatus.

The mating system of a population profoundly influences its evolution. Inbreeding alters the balance of evolutionary forces that determine the amount of genetic variation within a population. It redistributes that variation among individuals, altering heritabilities and genetic correlations. Inbreeding even changes the basic relationships between these genetic statistics and response to selection. If populations differing only in mating system are exposed to the same selection pressures, will they respond in qualitatively different ways? Here, we address this question by imposing selection on an index of two negatively correlated traits (flower size and development rate) within experimental populations that reproduce entirely by outcrossing, entirely by self-fertilizing, or by a mixture of outcrossing and selfing. Entirely selfing populations responded mainly by evolving larger flowers whereas outcrossing populations also evolved more rapid development. Divergence occurred despite an equivalent selection regime and no direct effect of mating system on fitness. The study provides an experimental demonstration of how the interaction of selection, genetic drift, and mating system can produce dramatic short-term changes in trait means, variances, and covariances.

Crosses, Genetic↗

Noise-covered drift bifurcation of dissipative solitons in a planar gas-discharge system.

The trajectories of propagating self-organized, well-localized solitary patterns (dissipative solitons) in the form of electrical current filaments are experimentally investigated in a planar quasi-two-dimensional dc gas-discharge system with high Ohmic semiconductor barrier. Earlier phenomenological models qualitatively describing the experimental observations in terms of a particle model predict a transition from stationary filaments to filaments traveling with constant finite speed due to an appropriate change of the system parameters. This prediction motivates a search for a drift bifurcation in the experimental system, but a direct comparison of experimentally recorded trajectories with theoretical predictions is impossible due to the strong influence of noise. To solve this problem, the filament dynamics is modeled using an appropriate Langevin equation, allowing for the application of a stochastic data analysis technique to separate deterministic and stochastic parts of the dynamics. Simulations carried out with the particle model demonstrate the efficiency of the method. Applying the technique to the experimentally recorded trajectories yields good agreement with the predictions of the model equations. Finally, the predicted drift bifurcation is found using the semiconductor resistivity as control parameter. In the resulting bifurcation diagram, the square of the equilibrium velocity scales linearly with the control parameter.

Journal Article↗

Histological evaluation of the effect of transseptal fibre resection on the rate of physiological migration of rat molar teeth.

Twenty-seven female Sprague-Dawley rats were given lead acetate as a vital stain, and rates of alveolar bone formation, representative of drift, were measured histologically. Teeth around which the transseptal fibre system had been destroyed drifted less quickly on both functioning (p less than 0.01) and non-functioning (p less than 0.001) sides than those with intact transseptal fibres. Both horizontal and vertical components of physiological drift were equally affected by destruction of the transseptal fibre system. It was felt that the transseptal fibres probably exerted their primary effect on the tooth, with bone remodelling around the drifting tooth being affected secondarily.

Animals↗