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72 records · Page 4Linked to original sources
PubMed2000

[Thrombosis diseases and lung cancer].

OBJECTIVE: To increase the awareness of lung cancer complicating thrombosis disease(TD). METHODS: 20 cases of lung cancer with TD which were from 1,050 cases of lung cancer confirmed by pathology and cytology in 80's and 90's from a teaching hospital were retrospectively reviewed. RESULTS: Of the 20 cases, there were 8 cases complicated with deep venous thrombosis(DVT); 4 cases with pulmonary thromboembolism (PTE); 4 cases with DVT and PTE, and 4 cases with nonbacterial thrombotic endocarditis (NBTE). 6 cases of DVT/PTE occurred 2-6 months before detection of lung cancer, 3 cases of NBTE had brain and peripheral artery embolism 2-7 months before detection of lung cancer. The pathology of 12 cases of lung cancer with TD was adenocarcinoma. CONCLUSIONS: TD complicating lung cancer was not unusual and could be warning sign indicating occult lung cancer. Physician ought to alert to lung cancer or other cancers when facing aged healthy subjects of sudden TD under unknown origin. The most common physiologic type of lung cancer complicating TD was adenocarcinoma. Hypercoagulation state was the most important cause of TD complicating lung cancer.

Adult↗
PubMedDate not supplied

Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome.

Interleukin-6 (IL-6) is reportedly increased in serum and CSF from acute stroke patients. However, the cellular origin and possible role of IL-6 in CNS after stroke are unclear. We describe a woman with recurrent stroke, disseminated intravascular coagulation (DIC) and non-bacterial thrombotic endocarditis (NBTE) caused by ovarian cancer (Trousseau syndrome). The patient died 50 days after the final episode of cerebral embolism. The immunohistochemical study revealed IL-6 protein to have been expressed both in cerebral neurons spared from ischemic insult and in epithelial cells of the ovarian tumor. We speculate that IL-6 produced in ovarian cancer may be associated with the hypercoagulable state and the development of NBTE in this patient. In contrast, IL-6 induction in cerebral neurons may contribute to the survival of these neurons after a stroke.

Coronary Thrombosis↗
PubMed1979

Neonatal nonbacterial thrombotic endocarditis.

Neonatal nonbacterial thrombotic endocarditis (NBTE), a rare disorder yet to be diagnosed antemortem, is described in two infants. The first infant was postmature and suffered from polycythemia and meconium aspiration. The meconium-stained placenta manifested evidence of ischemia and disseminated intravascular coagulation (DIC). The second patient was delivered near term by cesarean section, and hyaline membrane disease developed. The pathogenesis of NBTE may relate to perinatal hypoxia with transient tricuspid insufficiency, polycythemia, and DIC.

Disseminated Intravascular Coagulation↗
PubMed1980

[Valve lesions of the right heart associated with use of indwelling pulmonary artery catheters (author's transl)].

Pulmonary artery chatheterisation by means of flow-directed balloon-tipped catheters has proved a valuable aid in assessing haemodynamic parameters of critically ill patients. Serious complications are reported to be uncommon. On postmortem examination of 8 patients, in whom flow-directed balloon-tipped catheters were employed, and whose catheters were dissected in situ, there were 5 instances of non-bacterial thrombotic endocarditis (NBTE) and 4 of focal valvular bleeding. This is a much more frequent incidence of valvular lesions than has been reported previously. The pathogensis of NBTE is briefly disicussed, and attention is drawn to potential long-term complications. We suppose that valvular diseases of the right side of the heart will gain in significance due to the increasing use of flow-directed balloon-tipped pulmonary artery catheters.

Adolescent↗
PubMed1997

[Nonbacterial thrombotic endocarditis: a review of a necropsy series].

Nonbacterial thrombotic endocarditis (NBTE) is characterized by the deposition of thrombi on undamaged heart valves and by the increased frequency of associated arterial embolic events in patients with chronic debilitating diseases. Fifteen subjects diagnosed by necropsy of nonbacterial thrombotic endocarditis (NBTE) were studied to evaluate the general features, associated diseases, arterial embolic events, distribution and characteristics of histologic lesions. The most common underlying disease was neoplasm, which was present in 10 cases. Of these, 6 were adenocarcinomas, 3 hematological, and the remaining case was a bladder carcinoma. Other associated diseases included amyloidosis, MELAS syndrome, and sepsis. In most cases peripheral arterial embolic events were detected (9 cases). The central nervous system and the lung were involved in 7 cases (78%), heart and kidneys in 5 cases (56%), and spleen in 4 cases (44%). Other involved organs included pancreas, thyroid gland, testicles, meninges, liver and adrenal glands. The left valves were predominantly involved. The mitral valve in eight cases and the aortic valve in six cases. All cases with right involvement had the antecedent of central venous catheterization. Subendothelial fibrosis was a common histological finding which revealed the chronicity of the disease.

Adolescent↗
PubMed1985

Cerebrovascular complications in patients with cancer.

In an autopsy study of patients with cancer, 14.6% had pathologic evidence of cerebrovascular disease (CVD), and in 7.4% clinical symptoms of CVD had been present in life. The usual risk factors for CVD were overshadowed by pathophysiologic abnormalities related to the neoplasm, including direct effects of the tumor, coagulation disorders, infections and diagnostic or therapeutic procedures. In patients with leukemia, hemorrhages (72.4%) were much more common than ischemic infarcts. In lymphoma patients, the incidence of cerebral bleeding was lower (36.3%). In both groups, the leading causes of ischemic infarction were septic thrombi and intravascular coagulation. In patients with carcinoma, cerebral infarctions (54.1%) were more frequent than hemorrhages. NBTE (18.5%) and intravascular coagulation (9.6%) were the most common etiologies. Hemorrhages other than intratumoral bleeding in patients with melanoma or germ cell tumors were unusual. The clinical presentation of CVD in patients with cancer is more often a diffuse encephalopathy, with or without localizing signs, than the typical acute onset of a focal deficit. This was particularly true with intravascular coagulation, septic infarction and subdural hematoma. Our study suggests that by knowing the clinical setting, neurologic features and laboratory findings, one can, in many instances, make an accurate clinical diagnosis that, in some cases, leads to effective treatment.

Arteriosclerosis↗
PubMed1999

Systematic prediction of new inorganic ferroelectrics in point group 4.

The latest release of the Inorganic Crystal Structure Database contains a total of 87 entries corresponding to 70 different materials in point group 4. The structures reported for 11 materials in space group P4 satisfy the criteria for ferroelectricity, as do four in P4(1), one each in P4(2) and P4(3), 12 in I4, including seven that form three families, and another three in I4(1). Three previously known ferroelectrics were also listed in I4 and one in I4(1). In addition, the listing for point group 4 contains 22 entries for nonferroelectric materials and three with misassigned space groups. Among the newly predicted ferroelectrics in point group 4, assuming the validity of the underlying structural reports, are Ce(5)B(2)C(6), modulated NbTe(4), Na(3)Nb(12)O(31)F, Ca(2)FeO(3)Cl, K(4)CuV(5)O(15)Cl, TlBO(2), CrOF(3), PbTeO(3), VO(HPO(3))(H(2)O).3H(2)O, MgB(2)O(OH)(6), beta-tetragonal boron, CuBi(2)O(4), WOBr(4), Na(8)PtO(6), SbF(2)Cl(3), Ba(1.2)Ti(8)O(16), Ni[SC(NH(2))(2)](4)Cl(2), Ca(2)SiO(3)Cl(2), the mineral caratiite, NbAs, beta-NbO(2) and Ag(3)BiO(3).

Journal Article↗
PubMed2004

Trousseau's syndrome related to adenocarcinoma of the colon and cholangiocarcinoma.

Malignancy-related thromboembolism, so-called Trousseau's syndrome, can present as acute cerebral infarction, non-bacterial thrombotic endocarditis (NBTE) and migratory thrombophlebitis. It is usually attributed to a cancer-related hypercoagulable state, chronic disseminated intravascular coagulopathy (DIC), or tumour embolism. We report on two patients with adenocarcinoma of the colon and cholangiocarcinoma who developed widespread thromboembolism during disease progression. Both did poorly despite aggressive institution of anticoagulation therapy. These cases emphasize that cerebral infarction or refractory thromboembolism in cancer-treated patients should prompt investigation for recurrent or metastatic disease or progression of the underlying malignancy. Optimal treatment remains to be established.

Adenocarcinoma↗
PubMed1994

Focal cerebral ischemia and antiphospholipid antibodies: a case for cardiac embolism.

We report clinical, neuroimaging and immunological findings in seven women with antiphospholipid antibodies (APLA) and cerebral ischemia. Two patients had systemic lupus erythematosus (SLE) and five had the antiphospholipid syndrome (APS). Autopsies were done in 3 women who died acutely with focal neurological deficits. Evidence for cerebral embolism was found in all patients: a) pathology demonstrated multiple cerebral infarctions and cerebral emboli from underlying non-bacterial thrombotic endocarditis (NBTE) in the patients who died. b) Three patients had thickened mitral valves and embolic cerebral occlusions were identified with cerebral angiography. c) In one patient, echocardiography detected a thrombus on the posterior leaflet of a prolapsing mitral valve at the time of ictus. Our data provide further evidence to implicate valvular endothelium in the genesis of cerebral ischemia in some patients with APLA.

Adult↗
PubMedDate not supplied

Infective endocarditis in a patient with Hodgkin's lymphoma: a case report.

A common sequela of certain malignancies is nonbacterial thrombotic endocarditis (NBTE), a phenomenon in which sterile fibrin/platelet aggregates are deposited onto normal cardiac valves. These verrucae represent a predisposing factor for the initiation of infective endocarditis following a bacteremia. This paper presents a case history which is highly suggestive of infective endocarditis which occurred as a result of multiple odontogenic abscesses in a patient with Hodgkin's lymphoma. The case illustrates the important role that the dentist can play in the management of cancer patients and emphasizes a wholistic concept of medical care in which the dentist is an integral member of the health-care team.

Adult↗
PubMed1992

[Cerebral infarctions in elderly patients with anemia].

The authors investigated the cause of cerebral infarctions in elderly patients with anemia. Among 411 patients with acute cerebral infarctions, eight patients showed anemia (Hb < 10 g/dl) at the time of stroke. Only 2 patients had strokes during hospitalization were aware of their anemias before stroke. They were classified into two groups. One was the sudden onset group (4 patients) of whom 3 had malignant tumors, and 2 showed disseminated intravascular coagulations (DIC). There were no patients with atrial fibrillation or cardiac disease. All patients showed cortical infarction, and two died soon after stroke. Autopsy revealed verruca formation of the mitral valve in one patient and thrombus in the right ventricle in another. We thought that non-bacterial thrombotic endocarditis (NBTE) was the major cause of cerebral infarctions in this group. The other group consisted of 4 cases of thrombotic stroke. Their neurological symptoms appeared to be progressive. They also showed cortical infarctions except for one case of pontine infarction. Severe stenosis of the cerebral arteries was revealed by angiography in two patients and by autopsy in one. We concluded that cerebral infarctions in elderly patients with anemia can be important signs of underlying malignant tumors in sudden onset strokes or cases of severe cerebral artery stenosis with thrombotic strokes.

Aged↗
PubMed2001

Right-sided non-bacterial thrombotic endocarditis in a chronic hemodialysis patient with Muir-Torre syndrome.

Endocarditis is a recognised complication ofhemodialysis. This is generally only thought of in terms of infective vegetations. We present a case of right-sided NBTE in a patient with an indwelling venous catheter who also had advanced pelvic malignancy. The unusual side of this patient's endocarditic lesions implicates a role for the venous catheter in determining the site of non-bacterial thrombus formation. It is also a reminder that endocarditis is always a risk when using central venous catheters, even after appropriate sterile precautions have been taken.

Adult↗
PubMedDate not supplied

[Nonbacterial thrombotic endocarditis related to hepatocarcinoma].

A case of a woman with nonbacterial thrombotic endocarditis (NBTE) associated with hepatocarcinoma is here presented. Epidemiologic and clinicopathologic aspects are reviewed, early clinical suspicion may prevent embolization. it represents the first case reported in the national literature.

Aged↗
PubMed1991

Cerebrovascular complications in cancer patients.

The clinician should be alert to the possibility of cerebrovascular disease in cancer patients who develop signs of diffuse or focal cerebral dysfunction. The cause of cerebrovascular disease can usually be determined by knowing the primary tumor type, extent of metastatic disease, and type of antineoplastic treatment. Symptomatic infarctions are more common than hemorrhages in patients with carcinoma, and NBTE and cerebral intravascular coagulation are the most common causes of infarction. Brain hemorrhages in patients with carcinoma are usually from hemorrhage into metastatic tumor. Symptomatic hemorrhages are much more common than infarction in patients with leukemia, and hemorrhages may be caused by coagulopathy or central nervous system infiltration. Infarction in leukemia is usually due to septic embolism or intravascular coagulation. By determining the cause of cerebrovascular disease in the cancer patient, the clinician can often recommend appropriate treatment and predict the clinical outcome.

Brain Neoplasms↗
PubMed1991

[Pathological and etiological studies on cerebral infarction in the vertebrobasilar arterial system].

25 cases of cerebral infarcts in vertebrobasilar arterial system are reported. Those were divided into 4 groups: 1. Embolism (10), the causes were NBTE, pulmonary infarct, rheumatic or congenital heart disease, coronary artery disease, respectively, and 2 unknown. 2. Thrombosis (5), the causes were arteriosclerosis, vascular malformations in the basal part of cerebrum. 3. Inflammatory infarcts (3), those were verified from tuberculosis, syphilis and aspergillosis respectively. 4. Lacunar infarcts (7), the causes were considered from hypertension. Pathologically, it was noticed that the location of embolism often situated at the terminal of basilar artery, and that if the embolism was completely obliterated, often a hemorrhagic infarction would follow. But the thrombosis in basilar artery, even the lumen was completely obliterated, any infarct would not follow, if the related collateral circulation was satisfactory. Clinically, the embolism in basilar artery often showed sudden onset, and that the symptoms of brain stem would aggravate quickly, but the thrombosis in basilar artery, if the collateral circulation was satisfactory, and symptom of brain stem might not follow.

Adult↗
PubMed1982

Bronchogenic carcinoma, leukemoid reaction, marantic endocarditis, and consumptive thrombocytopathy.

This paper details the simultaneous occurrence of a severe leukemoid reaction, non-bacterial thrombotic endocarditis (NBTE) (marantic endocarditis), and a consumptive thrombocytopathy without signs of micro-angiopathic hemolysis on peripheral blood smear in a patient with terminal metastatic, undifferentiated, large cell bronchogenic carcinoma. The case is presented and the condition is discussed in detail.

Blood Platelet Disorders↗
PubMed1995

Autopsy-identified infections among bone marrow transplant recipients: a clinico-pathologic study of 56 patients. Bone Marrow Transplantation Team.

We reviewed the autopsy records of 56 patients who had undergone BMT at the Detroit Medical Center during 1988-1992. Most patients (43 of 56) had died within 2 months of BMT. One or more infections were identified at autopsy in 25 of 40 (63%) allogeneic and four of 16 (25%) autologous BMT recipients. Microorganisms isolated at autopsy were cytomegalovirus (CMV) (14 patients), yeasts (13 patients), molds (aspergillus six patients, mucor one patient) and bacteria (seven patients). Presence of infection was not identified or proven prior to death in nine of 14 patients (65%) with CMV, six of 13 patients (46%) with yeasts and four of six patients (67%) with aspergillus. Most bacterial infections (five of seven patients) were identified ante-mortem. Lungs and the gastrointestinal tract were the organ systems mostly involved in patients with or without autopsy-identified infections. Pathologic findings in the lungs were diffuse alveolar damage, interstitial pneumonia and bronchopneumonia and, in the gastrointestinal tract, were ulcerations and hemorrhages of esophagus, stomach, small and large intestines. Examination of the heart showed non-bacterial thrombotic endocarditis (NBTE) in five patients, four with right-sided involvement only. Failure to identify non-bacterial pathogens ante-mortem and their frequent association with mortality in bone marrow transplant patients are high-lighted in the present study.

Adolescent↗