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PubMed2005

Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986-2000).

OBJECTIVE: To determine survival times in dogs with right atrial hemangiosarcoma treated by means of pericardectomy and tumor resection, with or without adjuvant chemotherapy, and identify complications associated with treatment. DESIGN: Retrospective study. ANIMALS: 23 dogs. PROCEDURE: Dogs were included only if the diagnosis was confirmed histologically. RESULTS: The most common initial complaints included acute collapse (8 [35%] dogs), anorexia or inappetence (8 [35%]), and lethargy (8 [35%]). The most common physical examination abnormalities included muffled heart sounds (12 [52%] dogs), tachycardia (7 [30%]), and weak pulses (7 [30%]). Postoperative complications developed in 12 (52%) dogs; however, most complications were minor. Twenty (87%) dogs were discharged from the hospital. Survival time was significantly longer in the 8 dogs that received adjuvant chemotherapy (mean, 164 days; median, 175 days) than in the 15 dogs that did not receive chemotherapy (mean, 46 days; median, 42 days). Dogs that received chemotherapy were significantly younger and had significantly lower WBC counts than did dogs that did not receive chemotherapy. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that in dogs with right atrial hemangiosarcoma, surgical resection of the tumor was associated with a low complication rate and complications that did arise typically were minor. In addition, use of adjuvant chemotherapy following resection was associated with significantly longer survival times, compared with resection alone.

Animals↗
PubMedDate not supplied

Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991-1993).

A retrospective analysis was performed on the case records of 32 dogs with Stage I or II splenic hemangiosarcoma that were treated by splenectomy alone and that survived the seven-day postoperative period. Median survival time for these 32 cases was 86 days (mean, 116 days; range, 14 to 470 days), and the one-year survival rate was estimated to be 6.25%. Survival was not influenced by signalment, presenting signs, stage of disease, or clinicopathological findings. The data provides a basis from which to evaluate adjuvant chemotherapy for splenic hemangiosarcoma that is confined to the spleen macroscopically.

Animals↗
PubMedDate not supplied

Primary hemangiosarcoma of the iliopsoas muscle eliciting a peripheral neuropathy.

An eight-year-old, male castrated bullmastiff presented to the Kansas State University Veterinary Medical Teaching Hospital with left hind-limb paralysis. A mass was identified in the left paralumbar soft tissue adjacent to the fourth (L4) to sixth (L6) lumbar vertebrae by magnetic resonance imaging. The iliopsoas muscle contained the mass which was identified as a hemangiosarcoma on histopathological examination. Hemangiosarcoma is rarely reported as a primary tumor arising from muscle vascular endothelium.

Animals↗
PubMed1975

Hemangiosarcoma of the liver. Spectrum of morphologic changes and clinical findings.

Analysis of four cases of hemangiosarcoma of the liver and review of the literature indicate that these tumors are either predominantly cystic and fairly well differentiated or are more solid and poorly differentiated. Well-differentiated hemangiosarcomas may resemble peliosis hepatis or other benign conditions. The tumor was associated disseminated intravascular coagulation and fibrinolysis syndrome in one of our cases. One of our patients had received thorium dioxide (Thorotrast) but none seemed to have been exposed to arsenicals or to vinyl chloride.

Adult↗
PubMed2000

Hemangiosarcoma of the spleen: helical computed tomography features.

Hemangiosarcoma of the spleen is a rare malignant tumor. Prognosis is poor and is usually related to splenic rupture. Clinical symptoms include abdominal pain and left upper quadrant mass. Many clinical conditions have similar presenting symptoms and make diagnosis difficult. However, in this case report, we describe characteristic contrast enhancement pattern with spiral CT imaging of hemangiosarcoma of the spleen. Such imaging features with the previously described clinical symptoms will help in making the diagnosis early. Early splenectomy will improve prognosis and survival.

Abdominal Pain↗
PubMed1989

[Hepato-splenic hemangiosarcoma: presentation of a clinical case].

A 65-year-old farmer who had used arsenic as a plaguicide for many years developed a hepatosplenic hemangiosarcoma with metastasis in the colonic serosa, mesentery and omental. The tumor was complicated with intraabdominal hemorrhage originated by spontaneous intraperitoneal rupture. The echographic and post-mortem findings are presented. This is the first case of hepatic hemangiosarcoma reported in Uruguay.

Aged↗
PubMed1989

Primary vertebral hemangiosarcoma in a dog.

A 7-year-old spayed Cocker Spaniel was evaluated for recurrent hind limb paraplegia. Radiography and myelography revealed a compression fracture of T-9 secondary to a lytic process. Findings at necropsy and histologic and immunohistochemical examinations revealed 3 sites of hemangiosarcoma in each of the bodies of T-9 to T-11. Primary vertebral hemangiosarcoma is rare, and in this dog may have represented a multicentric occurrence or a primary neoplasm with adjacent metastatic foci.

Animals↗
PubMed1988

Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985).

Data on age, sex, and breed were obtained from surgical pathologic records of 92 dogs with splenic hemangiosarcoma (SHS) and for 125 dogs with splenic hematoma (SHA) diagnosed in 1985 at the University of Pennsylvania School of Veterinary Medicine. Further information on body weight, clinical and surgical findings, and survival time was obtained for 59 dogs (64.1%) with SHS and 91 dogs (72.8%) with SHA. Splenic hemangiosarcoma was markedly more common in dogs 8 to 13 years old, and SHA was appreciably more common in dogs greater than or equal to 8 years old, compared with dogs 1 to 7 years old. Compared with sexually intact females, only spayed females were at significantly (odds ratio [or], 2.2; 95% confidence interval [CI], 1.2 to 4.1) increased risk for developing SHS; sex predisposition was not found for dogs with SHA. The German Shepherd Dog was the only breed with increased risk for development of either SHS (OR, 4.7; 95% CI, 2.7 to 7.8) or SHA (OR, 2.8; 95% CI, 1.7 to 4.9), compared with all other purebred dogs. Association of tumor type for 7 commonly reported clinical signs with observance of hemoperitoneum at surgery was determined; anorexia (P = 0.01), collapse (P = 0.01), and hemoperitoneum (P less than 0.001) were significantly more common in dogs with SHS. The median survival time for dogs with SHS was 19 days, compared with 338 days for dogs with SHA (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMed1988

Disseminated hemangiosarcoma in a horse.

A 6.5-year-old horse with a history of exercise-induced pulmonary hemorrhage was admitted because of acute onset of epistaxis, dyspnea, high respiratory rate, pale mucous membranes, and dark feces. There was no clinical or laboratory evidence of a bleeding disorder, and the horse's anemia was considered to be secondary to pulmonary hemorrhage. The cause of the hemorrhage was not found on thoracic sonograms or from cytologic examination of transtracheal aspirates. Despite supportive care, the horse's health deteriorated, and it was euthanatized. Necropsy revealed blood in the thoracic and peritoneal cavities and reddish black masses in many tissues. Histologic examination confirmed a diagnosis of hemangiosarcoma. Hemangiosarcoma is a rare tumor in horses; however, as this case demonstrates, it can cause pulmonary hemorrhage and respiratory distress and may be difficult to diagnose before death.

Animals↗
PubMed1985

Canine hemangiosarcoma: retrospective analysis of 104 cases.

Hemangiosarcoma was diagnosed in 104 dogs. The mean age was 10 years. Twenty-two breeds were represented. The most common were the German Shepherd Dog and Poodle. Most tumors were in the spleen (65/104). Other primary sites included the soft tissues of the trunk and extremities (18), liver (6), heart (3), and lung (2). Sixty of the dogs were examined because of rupture of the primary tumor or metastatic disease. Of the 104 dogs, 4 are alive and 100 are dead: 35 were euthanatized at the time of diagnosis, and the remaining 65 had a mean survival time of 123 days. The mean survival time of the 4 living dogs was 360 days. Forty-seven of the 65 dogs with splenic hemangiosarcoma were treated with surgery alone, surgery and immunotherapy, or surgery, immunotherapy, and combination chemotherapy. The same 47 dogs were clinically staged. There was no difference in survival time according to therapy or stage of disease.

Animals↗
PubMedDate not supplied

[Splenic hemangiosarcoma].

The authors present a case of splenic hemangiosarcoma which was encounter-a group including some 600 splenectomies. Hemangiosarcomas represent only 3% of all malignant splenic tumours. This clinical observation is of particular interest because of the extreme rarity of such cases. It is also interesting because of the conditions which have determined the intervention, as well as by the prolonged survival of the patient.

Hemangiosarcoma↗
PubMed1981

A retrospective study of canine hemangiosarcoma and its association with acanthocytosis.

A retrospective study was conducted on cases of canine hemangiosarcoma diagnosed at the Western College of Veterinary Medicine between 1969 and 1979. A total of 33 dogs were assessed with respect to breed, age, sex and site of neoplasia. Hemangiosarcoma was most common in older dogs and there was no sex predilection. Incidence was highest in German Shepherds. The primary sites in order of most frequent occurrence were spleen, right atrium and liver. Acanthocytes were found in six of 12 dogs examined. There was no association between acanthocytosis and such factors as breed, primary site of the neoplasm and splenic or hepatic involvement.

Acanthocytes↗
PubMed1993

[A case of primary cardiac hemangiosarcoma].

A case of primary hemangiosarcoma of right atrium was reported. The patient was 43 years old female. She had the symptoms of tamponade due to massive bloody pericardial effusion. Echocardiography, computed tomography, NMR imaging and angiography revealed the precise delineation and extension of tumor, and also allowed diagnosis of hemangiosarcoma. Extirpation of tumor was performed under the cardiopulmonary bypass. The patient was died 3 months later after the operation for liver metastasis. The bloody pericardial effusion seems to be an important symptom of the primary malignant cardiac tumor, and early and precise diagnosis may allow successful operation and long survival of the patients.

Adult↗
PubMed1995

Hemangiomas and hemangiosarcomas in inbred laboratory mice.

Hemangiomas and hemangiosarcomas are rare, naturally developing tumors of blood vessels. In a retrospective study covering a period of 57 contiguous months between 1986 and 1991, four cavernous hemangiomas, eight capillary hemangiomas, and three hemangiosarcomas developed spontaneously in A/J, BALB/cJ, BALB/cByJ, C57BL/6J, NU/J, and 129/SvJ inbred mouse strains. When data were correlated to actual numbers of each sex in the colony, no sexual dimorphism was determined. At the time of submission, mice ranged in age from 100 to 434 days, with a mean of 217 days. Tumors principally affected the skin but were also diagnosed in the seminal vesicles, liver, muscle tissue, and cerebellum. Immunohistochemistry, with antisera directed against human von Willebrand factor (factor VIII-related antigen) as an endothelial cell marker, labeled mouse endothelial cells inconsistently. A monoclonal antibody directed against the smooth muscle actin isoform, but not the sarcomeric muscle actin isoform, outlined vascular structures in tumors and normal vascular smooth muscle in adjacent normal tissues.

Actins↗
PubMed1996

Hemangiosarcoma of the spleen. Report of a case.

A case of hemangiosarcoma of the spleen in a 59-year-old man is presented. The diagnosis was made on the surgical specimen after the patient had undergone emergency splenectomy for spontaneous rupture. In the post-operative course endoperitoneal chemotherapy with dexorubicin was performed. Six months later a liver biopsy showed metastatic tumor. The patient died nine months after the onset of the symptoms. Autopsy was not performed. Pathological aspects of splenic hemangiosarcoma and differences of prognosis between splenectomy performed before and after rupture are described.

Fatal Outcome↗
PubMed1999

Establishment of a human hemangiosarcoma cell line (ISO-HAS).

A cell line (ISO-HAS) has been established from tumor tissue of a human hemangiosarcoma arising on the scalp by the use of conditioned medium from a murine-phenotypic angiosarcoma cell line (ISOS-1). Cells have been cultured for more than 2 years with up to 100 passages. The cells retained endothelial-cell properties, such as a characteristic cobblestone appearance at confluency, contact-inhibited growth, active uptake of acetylated low-density lipoprotein labeled with 1,1-dioctadecyl 1,3,3,3,3-tetramethyl-indocarbocyanine perchlorate (DiI-Ac-LDL) and CD31 expression. However, they were weakly positive for von-Willebrand-factor (vWf) antigen and for binding of Ulex europaeus agglutinin-I (UEA-I) lectin, and lacked tube-formation activity. These findings indicate that ISO-HAS is a poorly differentiated endothelial cell line. ISO-HAS cells showed accumulation of p53 protein in the nuclei, and a new-typed p53-gene point mutation was found in exon 7 at codon 240. When inoculated s.c. into severe-combined-immunodeficiency (SCID) mice, the cells showed solid-tumor growth that caused death. These properties suggest that ISO-HAS is a malignant endothelial cell line with high tumorigenicity.

Animals↗
PubMed1976

Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy.

Hepatic artery ligation is useful as a palliation of irressectable hepatic tumors, but does not always produce a satisfactory result. Hepatic tumor with high vascularity is expected to respond more favorably. In this context, primary liver cell carcinoma and carcinoid tumor or leiomyosarcoma of the liver have been satistfactorily treated by hepatic artery ligation. A case is presented of hemangiosarcoma of theliver and spleen treated effectively by hepatic artery ligation, splenectomy, and postoperative intraportal infusion of 5-fluorouracil, as indicated by the regression of hepatic tumors on postoperative scanning and arteriograpms.

Adult↗
PubMed1993

Diagnosis of brain metastases from a primary hemangiosarcoma of the spleen with magnetic resonance imaging.

BACKGROUND: Primary malignant splenic neoplasms are rare tumors. Apart from involvement of the spleen by malignant lymphoma, hemangiosarcoma is the most common form of primary malignant neoplasm in the spleen. The diagnosis often is made at autopsy or after spontaneous splenic rupture. The prognosis is usually poor, and widespread metastases soon occur. METHOD: Currently, no case of metastasis to the brain has been reported to the authors' knowledge. RESULTS: This case report describes a patient who, as the first sign of metastatic disease, had symptoms from brain metastases 3 months after splenectomy. CONCLUSION: Magnetic resonance imaging was diagnostic.

Aged↗