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At least 73 records · Page 4Linked to original sources

A neurodevelopmental model for anorexia nervosa.

This paper integrates genetic and biological data on aetiological risk for anorexia nervosa (AN) with cognitive and psychosocial explanatory models. We have reviewed clinical and basic science data from each of these domains and then used a developmental perspective to formulate a multifactorial threshold model. By positioning interpersonal stress as a central component of this model, psychological, social and biological conceptualisations of AN can be used to generate a data driven, neurodevelopmental hypothesis for the aetiology of this complex disorder.

Adaptation, Psychological↗

Nursing decision making and the science of the concrete.

Information systems are going to change our understanding of nursing as a discipline and as a practice. The act of decision making will be the focus of the impact of information systems on nursing. The article models types of nursing knowledge, organizing them into concrete and abstract knowledge. Information systems will allow the inclusion of concrete science data, which has not been possible previously. Role performance is seen as a mechanism for the integration of the two sciences, and a new understanding for nursing decision making is proposed.

Decision Making↗

Animal models of intervertebral disc degeneration: lessons learned.

STUDY DESIGN: A literature review of intervertebral disc degeneration animal models. OBJECTIVES: Focus is placed on those models that suggest degeneration mechanisms relevant to human. SUMMARY OF BACKGROUND DATA: Medical knowledge from observational epidemiology and intervention studies suggest many etiologic causal factors in humans. Animal models can provide basic science data that support biologic plausibility as well as temporality, specificity, and dose-response relationships. METHODS: Studies are classified as either experimentally induced or spontaneous, where experimentally induced models are subdivided as mechanical (alteration of the magnitude or distribution of forces on the normal joint) or structural (injury or chemical alteration). Spontaneous models include those animals that naturally develop degenerative disc disease. RESULTS: Mechanobiologic relationships are apparent as stress redistribution secondary to nuclear depressurization (by injury or chemical means) can cause cellular metaplasia, tissue remodeling, and pro-inflammatory factor production. Moderate perturbations can be compensated for by cell proliferation and matrix synthesis, whereas severe perturbations cause architectural changes consistent with human disc degeneration. CONCLUSIONS: These models suggest that two stages of architectural remodeling exist in humans: early adaptation to gravity loading, followed by healing meant to reestablish biomechanical stability that is slowed by tissue avascularity. Current animal models are limited by an incomplete set of initiators and outcomes that are only indirectly related to important clinical factors (pain and disability).

Animals↗

Physician-patient interaction in reproductive counseling.

OBJECTIVE: To review the scientific and clinical bases for effective patient counseling in contraceptive care. DATA SOURCES: All articles and chapters in the Annotated Bibliography of Doctor Patient Communication of the Task Force on Doctor and Patient of the American Academy on Physician and Patient were searched and included. This is an expert-derived data base based on MEDLINE review from 1969 to 1994 and including expert-selected additions from PsychLit and a variety of other social science data bases, books, and reviews. METHODS OF STUDY SELECTION: Expert consensus was used from the Committee on Bibliography of the American Academy on Physician and Patient. TABULATION, INTEGRATION, AND RESULTS: The doctor-patient interaction is the main determinant of the accuracy and completeness of patient data, diagnostic accuracy, efficiency in the encounter, compliance, patient understanding of problems, and patient and physician satisfaction. Yet this critical skill is inadequately taught and practiced, with serious consequences for patient care and physician job satisfaction. Use of the 14 structural elements (preparing the environment, preparing oneself, observation, greeting, introduction, detecting and overcoming barriers to communication, surveying problems, negotiating a priority problem, developing a narrative thread, establishing the life context of the patient, establishing a safety net, presenting findings and options, negotiating plans, and closing) and three functions (gathering information, developing a therapeutic relationship, and patient education) and their associated behaviors improves encounter results significantly. Other helpful activities are patient activation, facilitating partnership, review of findings and plans, eliciting and responding to patients' attitudes and emotions about contraception and fertility, and use of empathy and positive regard. CONCLUSIONS: The use of scientifically derived, empirically validated interview skills substantially improves outcomes in contraceptive and other patient education and counseling. Use of appropriate structure and functions of the encounter, patient participation and partnership, review of patient understanding and reactions, and relating to the patients' attitudes and emotions about the subject each improve the outcomes of contraceptive care.

Contraception↗

Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem.

Emerging spatial multiomics technologies provide an increasingly large amount of information content at multiple scales. However, it remains challenging to efficiently represent and harmonize diverse spatial datasets. Here we present Giotto Suite, a suite of modular packages that provides scalable and extensible end-to-end solutions for multiscale and multiomic data analysis, integration and visualization. At its core, Giotto Suite is centered around an innovative data framework, allowing the representation and integration of spatial omics data in a technology-agnostic manner. Giotto Suite integrates molecular, morphology, spatial and annotated feature information to create a responsive and flexible workflow, as demonstrated by applications to several state-of-the-art spatial technologies. Furthermore, Giotto Suite builds upon interoperable interfaces and data structures that bridge the established fields of genomics and spatial data science in R, thereby enabling independent developers to create custom-engineered pipelines. As such, Giotto Suite creates an immersive and multiscale ecosystem for spatial multiomic data analysis.

Genomics↗

A challenge to the metabolic approach to myocardial ischaemia.

The negative results of glucose-insulin-potassium (GIK) in the very large CREATE-ECLA trial that studied 20,201 patients with ST-elevation acute myocardial infarction (AMI), are disappointing and warrant thorough evaluation. We attempt to put the new data into perspective and uncover the serious flaws in the trial design, otherwise the whole metabolic concept will be disparaged. The crucial issue, developed from basic science data, is that GIK should be initiated very early, before, or at the time of reperfusion. Another problem with CREATE-ECLA is that the mortality in Killip class 1 reperfused patients was 7.1%, much higher than that of a recent Dutch study in which mortality was only 1.2%. Nonetheless, there was a strong trend towards a lower mortality in the sub-groups that received the best reperfusion therapy in CREATE-ECLA, as well as in the first of two rather small Dutch GIK trials. In the future, the ideal protocol to test would be if GIK were given in the ambulance as the patient is being transported to a specialized centre of percutaneous coronary intervention (PCI), with the aim of expanding the time window between pain onset and actual PCI.

Cardiotonic Agents↗

The application of signal detection theory to decision-making in forensic science.

Signal Detection Theory (SDT) has come to be used in a wide variety of fields where noise and imperfect signals present challenges to the task of separating hits and correct rejections from misses and false alarms. The application of SDT helps illuminate and improve the quality of decision-making in those fields in a number of ways. The present article is designed to make SDT more accessible to forensic scientists by: (a) explaining what SDT is and how it works, (b) explicating the potential usefulness of SDT to forensic science, (c) illustrating SDT analysis using forensic science data, and (d) suggesting ways to gain the benefits of SDT analyses in the course of carrying out existing programs of quality assessment and other research on forensic science examinations.

Decision Making↗

The Data Distillery: A Graph Framework for Semantic Integration and Querying of Biomedical Data.

The Data Distillery Knowledge Graph (DDKG) is a framework for semantic integration and querying of biomedical data across domains. Built for the NIH Common Fund Data Ecosystem, it supports translational research by linking clinical and experimental datasets in a unified graph model. Clinical standards such as ICD-10, SNOMED, and DrugBank are integrated through UMLS, while genomics and basic science data are structured using ontologies and standards such as HPO, GENCODE, Ensembl, STRING, and ClinVar. The DDKG uses a property graph architecture based on the UBKG infrastructure and supports ontology-based ingestion, identifier normalization, and graph-native querying. The system is modular and can be extended with new datasets or schema modules. We demonstrate its utility for informatics queries across eight use cases, including regulatory variant analysis, tissue-specific expression, biomarker discovery, and cross-species variant prioritization. The DDKG is accessible via a public interface, a programmatic API, and downloadable builds for local use.

Journal Article↗

Pupils' liking for school: ability grouping, self-concept and perceptions of teaching.

BACKGROUND: Research indicates that affective aspects of development provide a basis for autonomous learning. Pupils' liking for school may be a useful indicator of their relationships with teachers and the school. AIMS: The aim of the research reported in this paper is to establish the properties of a measure of pupils' liking for school and to examine associations between this measure, pupils' experiences in lessons, their self-concepts and the amount of setting implemented in school. SAMPLE: A stratified sample of 45 mixed secondary comprehensive schools was selected for the research. Schools represented a variety of ability-grouping practices in the lower school (Years 7-9), from completely mixed-ability to setting in all academic subjects. All Year 9 pupils were included in the sample. METHODS: Pupils completed a questionnaire containing items on their self-concept, liking for school, and their perceptions of teaching in English, mathematics, and science. Data on pupils' gender, ethnic origin, social disadvantage and attainment was also collected. RESULTS AND CONCLUSIONS: The properties and correlates of scales indicating pupils' liking for school and their perceptions of teaching in English, mathematics, and science are established. Liking for school is greater among girls, pupils with higher academic self-concepts, and those with more positive perceptions of teaching. Pupils are more positive about teaching they experience in English than in mathematics or science. When other variables are statistically controlled, there is no significant effect of the extent of ability grouping in the school as a whole. Affective aspects of learning should not be neglected in the drive to raise standards.

Achievement↗

W(h)ither the deaf community? Population, genetics, and the future of Australian sign language.

According to enrollments in schools for the deaf and data from the national census and neonatal hearing screening programs, the incidence of severe and profound childhood deafness in Australia is, and has been, less than commonly assumed. Factors implicated include improved medical care, mainstreaming, cochlear implants, and genetic science. Data for the United States, Britain, and other developed countries seem consistent with those for Australia. Declining prevalence and incidence rates have immediate implications for sign-based education, teacher-of-the-deaf training programs, and educational interpreting. There are also serious consequences for research, documentation, and teaching regarding Australian Sign Language (Auslan), and for the future viability of Auslan. Prompt action is essential if a credible corpus of Auslan is to be collected as the basis for a valid and verifiable description of one of the few native sign languages in the world with significant attested historical depth.

Australia↗

Data archiving in animal experimentation: merits, challenges, and a case study.

Electronic data archives may supplement the traditional peer-reviewed journal article. The merits of data archiving include public service, a more complete research project, overcoming barriers to limited-access research resources, and increasing the impact of a scientific project. A case study of chimpanzee timing performance in space is derived from the NASA Life Sciences Data Archive (http://lsdajsc. nasagov). An analysis of the archived data suggests that the scalar property (a form of Weber's law) applies to timed performance of a chimpanzee in orbit of the earth. Challenges associated with data archives are discussed. Although significant challenges are associated with archiving electronic data, these difficulties are outweighed by its merits.

Animal Experimentation↗

Health promotion for older Americans in the 21st century.

OBJECTIVES: To provide a broad overview of the role of the individual, the physical environment, and the social environment on health and functioning in older adults (65 and older), and to highlight interventions and recommendations for action on each of these levels. DATA SOURCES: Published studies and government reports on health and functioning in older Americans and on the individual, social, and physical environmental contributors to health were identified through journal and government documents review and computer library searches of medical and social science data bases for 1980-1999. STUDY SELECTION: Preference was given to published studies and government reports that focused specifically on behavioral and environmental contributors and barriers to health promotion in Americans 65 and older and/or that highlighted creative interventions with relevance to this population. Both review articles and presentations of original research were included, with the latter selected based on soundness of design and execution and/or creativity of intervention described. DATA EXTRACTION: Studies were examined and their findings organized under three major headings: (1) behavioral risk factors and risk reduction, including current government standards for prevention and screening; (2) the role of the physical environment; and (3) the role of the social environment in relation to health promotion of older adults. DATA SYNTHESIS: Although most attention has been paid to the role of behavioral factors in health promotion for older adults, a substantial body of evidence suggests that physical and social environmental factors also play a key role. Similarly, interventions that promote individual behavioral risk reduction and interventions targeting the broader social or physical environment all may contribute to health in the later years. CONCLUSIONS: With the rapid aging of America's population, increased attention must be focused on health promotion for those who are or will soon be older adults. Promising intervention strategies addressing the individual, the physical environment, and the social environment should be identified and tested, and their potential for replication explored, as we work toward a more comprehensive approach to improving the health of older Americans in the 21st century.

Aged↗

Factor analytic study of the personality of female methadone outpatients.

Several researchers have examined the personality of chemical abusers by employing a multivariate clustering strategy. All of these studies focused on hospitalized inpatient addicts. Only one included females in the study. The purpose of this study is to examine the transposed data factor analytically derived profiles of female methadone maintained outpatients. All clients were given the Mini-Mult short form version of the Minnesota Multiphasic Personality Inventory. Seventy profiles were randomly selected from 130 female profiles. Program Factor of the Analyses of Behavioral Sciences Data program series was employed in statistically processing this data. Descriptions of the five factors are provided. Most of the profile types seem to fall into the normal or personality disordered categories. Forth-two percent of the profiles were normal, 24% were Personality Disorders, 6% were Neurotic, and 28% were unclassified using five factors.

Adult↗

The pathophysiology of thoracic disc disease.

Nucleus pulposus herniations are far less common in the thoracic spine than at the cervical and lumbar regions. Traditionally, diagnosis of thoracic disc herniations has been challenging because the signs and symptoms are often subtle early in their course. As a result, delays in diagnoses are common. Because they are uncommon as well as difficult to diagnosis, the neurosurgical community has sparse data on which to base good clinical decision making for the treatment of these herniations. In this review the authors seek to place the phenomenon of thoracic disc disease into the context of its pathophysiology. After a careful evaluation of the available clinical, pathological, and basic science data, a case is made that the cause of nucleus pulposus herniations in the thoracic spine is similar to those occurring in the lumbar and cervical regions. The lower incidence of herniations is ascribed primarily to the reduced allowable flexion at the thoracic level compared with the lumbar and cervical levels. To a lesser extent, the contribution of the ribs to weight-bearing may also play a role. Further review of clinical data suggests that thoracic disc herniations, like herniated cervical and lumbar discs, may be asymptomatic and may respond to conservative therapy. Similarly, good surgery-related results have been reported for herniated thoracic discs, despite the more challenging nature of the surgical procedure. The authors conclude that treatment strategies for thoracic disc herniations may logically and appropriately follow those commonly used for the cervical and lumbar levels.

Back Pain↗

Case based reasoning in criminal intelligence using forensic case data.

A model that is based on the knowledge of experienced investigators in the analysis of serial crime is suggested to bridge a gap between technology and methodology. Its purpose is to provide a solid methodology for the analysis of serial crimes that supports decision making in the deployment of resources, either by guiding proactive policing operations or helping the investigative process. Formalisation has helped to derive a computerised system that efficiently supports the reasoning processes in the analysis of serial crime. This novel approach fully integrates forensic science data.

Crime↗

Application of a radiotelemetry system for chronic measurement of blood pressure, heart rate, EEG, and activity in the chicken.

This paper reports the first successful chronic monitoring (for 30 days) of blood pressure, heart rate, EEG, and physical activity in a freely moving bird, following (described) implantation of a commercially available (Data Sciences International) radiotelemetry device in a 1.6-kg broiler chicken. The tip of the device's pressure sensing catheter was introduced into the descending aorta via a leg (ischiadic) artery and, although the catheter was tied in place, circulation in the leg was maintained and leg function was not impaired. EEG was recorded from the device's paired sensing electrodes positioned on the surface of the telencephalon. Physiological and activity data collected by the radiotelemetry system over 2 complete 24-h periods, 1 and 4 weeks after implantation of the device, were analyzed with the system's own (Dataquest LabPRO) analysis software. The results presented are discussed mainly in terms of variation between light and dark periods.

Animals↗

Translational studies in neurorehabilitation: from bench to bedside.

Stroke is the leading cause of adult disability in the western world. Consensus has built over the last few years regarding the usefulness of training to improve motor disability resulting from stroke. Until recently, there were no accepted strategies to enhance the beneficial effects of training. However, the combination of basic and clinical science data over the last few years is changing this picture, and is highly relevant to the field of neurorehabilitation. Human studies in both healthy individuals and patients after brain damage demonstrate as a proof of principle that somatosensory input, cortical stimulation, interhemispheric interactions, and pharmacologic interventions can modulate cortical plasticity in neurorehabilitation after stroke. These findings strongly suggest directions in the development of novel strategies to enhance training effects on motor recovery. The intent of this review is to describe these strategies, the basic science principles on which they are based, and the clinical applications that have emerged so far.

Brain Damage, Chronic↗