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At least 73 records · Page 4Linked to original sources
PubMed2006

Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets.

BACKGROUND: Genetic modification of non-human islets before transplantation may provide means by which they can escape immunity and, thus, be used in a human host. To accomplish this, efficient gene transfer methods are needed. Lentiviral vectors are transgene vehicles capable of stably transducing a variety of primary, post-mitotic cells including islets. METHODS: We investigated whether lentiviral transduction impaired rat pancreatic islet function long term. Following transduction, the gross morphology, viability and in vitro functionality of islets were evaluated by microscopy, adenylate nucleotide and insulin secretion assays, respectively. Further, in vivo functionality of transduced islets was assessed by transplanting the islets under the kidney capsule of diabetic nude mice. RESULTS: All transduced islets contained green fluorescent protein (GFP)-positive cells. In single cell suspensions prepared from transduced islets, 33+/-8% (n = 3) of dispersed islet cells were GFP-positive. The ADP/ATP ratio was 0.07+/-0.01 for transduced islets and 0.06+/-0.01 for controls (normal range <0.11). No morphological changes were observed in transduced islets. Further, basal insulin secretion was comparable between the two islet groups. When transduced and non-transduced islets were challenged with insulin secretagogues, they showed similar increases in insulin release. Transduced and non-transduced islets were equally effective in normalizing blood glucose when transplanted into diabetic nude mice. Euglycemia was maintained for 8 weeks until the graft-bearing kidney was removed. Intense green fluorescence was seen in removed islet grafts. Histology revealed preserved islet morphology, with abundant insulin-producing cells, few apoptotic cells and infiltrating leukocytes in both transduced and non-transduced grafts. CONCLUSIONS: Lentivirus transduction does not affect islet morphology or function. Lentiviral vectors will allow genetic modifications to be performed in islets before transplantation--modifications that can improve engraftment and/or prevent xenograft rejection.

Animals↗
PubMed2003

Equivalence of Gaussian and piston ultrasonic transducer voltages.

A plane-wave decomposition of collimated beams and electromechanical reciprocity relations are used to demonstrate fundamental differences and unusual similarities about transducer fields and transducer voltages at ultrasonic frequencies under various conditions. It is shown that the voltage induced by a transmitting acoustic piston transducer (constant particle velocity over the transducer surface) radiating into an ideal fluid medium on a second identical piston transducer, operating as a receiver, is nearly identical to the voltage observed when the two transducers have instead a Gaussian radial surface velocity distribution. The strong similarity in induced voltage begins when the two devices are separated by only several acoustic wavelengths, still well within the nearfield of both transducers, and the similarity increases with separation. Cases of transducer velocity distributions different from piston, such as Lorentzian or triangular, yield results nearly identical to the piston case. Transducers of differing size are also treated. It is further shown that an "equivalent transducer" can be derived for any combination of radiators, whose field is identical to the voltage measured using the pair. Moreover, with this concept the calculation of voltage in two-probe experiments is as simple as well-known approximations to the Rayleigh integral for a single transducer. These results have substantial consequences for calculations, either analytical or numerical, that predict the voltage measured in two-transducer experiments.

Journal Article↗
PubMed1996

Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors.

BACKGROUND: The effects of regulating endothelial cell (EC) plasminogen activator production on thrombus accumulation in vivo are incompletely understood. By overexpressing plasminogen activators in ECs via gene transfer, the hypothesis was tested that increased levels of plasminogen activators inhibit the accumulation of thrombus in vivo. METHODS AND RESULTS: Cultured baboon ECs transduced with human cDNAs for wild-type tissue plasminogen activator (TPA) or for glycosylphosphatidylinositol-anchored urokinase-type plasminogen activator (a-UPA) were seeded onto collagen-coated segments of vascular graft (collagen segments) and exposed overnight to flow using an in vitro perfusion circuit. The antigenic levels of TPA and UPA each increased 10-fold in the media perfusing the corresponding transduced ECs compared with untransduced ECs (P < or = .05 in both cases). In baboons the antithrombotic effects of TPA-transduced or a-UPA-transduced ECs were measured as 111In-platelet deposition and 125I-fibrin accumulation on collagen segments bearing sparsely attached ECs (tarnsduced versus untransduced) interposed in exteriorized arteriovenous femoral shunts. Platelet-rich thrombus formed on the collagen segments with fibrin-rich thrombus propagated distally. The presence of TPA-transduced or a-UPA-transduced ECs on collagen segments at a density of 25,000 ECs/cm2 decreased 111AIn-platelet deposition and 125I-fibrin accumulation on collagen surfaces compared with untransduced ECs present at equivalent density (P < .05 for platelet deposition with TPA-transduced ECs and P < .05 for platelet deposition on the propagated tail, as well as fibrin accumulation on the graft with a-UPA-transduced ECs). The systemic levels of fibrinopeptide A, thrombin-antithrombin complex, D-dimer, and both local and systemic levels of TPA and UPA were not increased by transduced ECs compared with untransduced ECs. The focal antithrombotic effects of transduced ECs appear to be due to local enhancement of thrombolysis. CONCLUSIONS: ECs transduced with recombinant TPA and a-UPA enhance local antithrombotic activity in vivo. This strategy of attaching transduced ECs overexpressing plasminogen activators may be therapeutically useful by preventing thrombo-occlusive failure of implanted cardiovascular devices or mechanically denuded vessels.

Animals↗
PubMed2003

Use of a curved-array transducer to reduce interobserver variation in sonographic measurement of thyroid volume in healthy adults.

PURPOSE: Sonographic calculation of thyroid volume is used in the diagnosis and follow-up of thyroid diseases. Since the calculated volume of thyroid lobes is highly influenced by the longest (ie, craniocaudal) diameter, we examined whether using a curved-array transducer as opposed to a linear-array transducer to measure the craniocaudal diameter would reduce interobserver variation. METHODS: Three sonographers with different levels of expertise each used a 5-12-MHz linear-array transducer and a 2-5-MHz curved-array transducer to measure the craniocaudal diameter of both thyroid lobes of 25 healthy volunteers. On the basis of these measurements, thyroid lobe volumes were calculated. Single-factor analysis of variance was used to evaluate the interobserver variations between the measurements made by all 3 observers as well as between measurements taken by pairs of observers. A p value of less than 0.05 was considered significant. RESULTS: Using the linear-array transducer to measure the craniocaudal diameter resulted in significant interobserver variation in thyroid volume calculation (p = 0.02), whereas using the convex-array transducer did not. Using either transducer resulted in a highly significant interobserver variation in measurements of the craniocaudal diameter, although the variation was far more pronounced for measurements made with the linear-array transducer (p = 0.0005) than for those made with the curved-array transducer (p = 0.04). For both transducers, the interobserver variations were most pronounced between the most and the least experienced sonographers. CONCLUSIONS: To avoid significant interobserver variation in calculating thyroid lobe volume, we recommend using a curved-array transducer to measure the craniocaudal diameter of the thyroid lobes.

Adult↗
PubMed1991

Pulse-echo imaging using a nondiffracting beam transducer.

Conventional ultrasonic transducers generate beams that diffract as they travel. This phenomenon causes images produced in B-mode to be degraded in the far-field of the transducers. Focused transducers are used to improve image quality. Unfortunately, focused transducers have short depth of field. Although multiple pulse transmissions focused at several depths are used to increase the effective depth of field, imaging frame rate is reduced dramatically leading to blurred images of moving objects such as the heart. We present a family of transducers that produce nondiffracting beams of large depth of field. Therefore, uniformly high resolution throughout the imaging area can be obtained without sacrificing the imaging frame rate. In addition, the nondiffracting property of these beams makes the correction for beam diffraction negligible in tissue characterization. This paper reports the results of computer simulations as well as in vitro and in vivo pulse-echo imaging experiments with a nondiffracting transducer. Images are compared to those obtained by conventional focused Gaussian shaded beam transducers and a commercial ACUSON 128 B-scanner. The new transducer has much longer depth of field with higher sidelobes than conventional transducers of the same aperture. Sidelobes can be reduced using the new transducer to transmit and the dynamically focused transducer to receive.

Calibration↗
PubMed2001

Evaluation of a 1 MHz transducer for transcranial Doppler ultrasound including embolic signal detection.

A 1 MHz transducer for use with transcranial Doppler ultrasound may improve the intensity and therefore the detection of embolic signals (ES) and may also reduce the number of absent acoustic windows. A series of studies was performed to investigate its potential benefits. Firstly, ES were detected using a 1 MHz and a 2 MHz transducer both in vitro and in vivo. Secondly, the time taken to identify 100 middle cerebral arteries (MCA) was recorded for both transducers and the best Doppler signal obtained was reviewed off-line and graded for quality. ES were more intense when detected with the 1 MHz compared with the 2 MHz transducer, both in vitro (p <.0001) and in vivo (p <.0001). Of the 100 MCAs studied, 81 had acoustic windows identified with both transducers. The number of acoustic windows detected with one transducer but not the other was the same for both transducers (n = 3). The time taken to identify the MCA was longer with the 1 MHz transducer (p <.0001) and the quality of the signal achieved was poorer (p <.0001). In conclusion, the 1 MHz transducer improved embolic signal intensity but the overall quality of the flow spectrum obtained was poorer with the 1 MHz than with the 2 MHz transducer. A lower frequency transducer of 1 MHz or possibly 1.5 MHz with transcranial Doppler ultrasound may improve the application of embolic signal detection but may not improve the signal for routine measurement of flow velocities.

Endarterectomy, Carotid↗
PubMed2006

Determination of the baculovirus transducing titer in mammalian cells.

Baculovirus has emerged as a promising vector for in vivo or ex vivo gene therapy. To date, the infectious titer and multiplicity of infection (MOI) based on the ability of baculovirus to infect insect cells are commonly adopted to indicate the virus dosage. However, the infectious titer and MOI do not reliably represent the baculovirus transducing ability, making the comparison of baculovirus-mediated gene transfer difficult. To determine the baculovirus transducing ability more rapidly and reliably, we developed a protocol to evaluate the transducing titers of baculovirus stocks. The virus was diluted twofold serially and used to transduce HeLa cells. The resultant transduction efficiencies were measured by flow cytometry for the calculation of transducing titers. Compared to the infectious titer, the determination of transducing titer is more reproducible as the standard deviations among measurements are smaller. Also, the transducing titers can be obtained in 24 h, which is significantly faster as opposed to 4-7 days to obtain the infectious titer. More importantly, we demonstrated that baculoviruses with higher transducing titers could transduce cells at higher efficiency and yield stronger and longer transgene expression, confirming that the transducing titer was representative of the baculovirus transducing ability. This finding is particularly significant for ex vivo gene delivery whereby unconcentrated viruses are used for transduction and long-term transgene expression is desired. In this regard, our titration protocol provides a simple, fast, and reliable measure to evaluate the quality of virus stocks during virus production and purification, and is helpful to predict the performance of vector supernatants and ensure reproducible gene delivery experiments.

Baculoviridae↗
PubMed1978

Bacteriophage P22-mediated specialized transduction in Salmonella typhimurium: identification of different types of specialized transducing particles.

The temperate bacteriophage P22 mediates both generalized and specialized transduction in Salmonella typhimurium. Specialized transduction by phage P22 is different from, and less restricted than, the well characterized specialized transduction by phage lambda, due to differences in the phage DNA packaging mechanism. Phage lysates produced by induction of lysogenic strains contain very high frequencies of supQ newD- and proA,B-specialized transducing particles (10(-2)/PFU and 10(-3)/PFU, respectively), most of which are produced by independent aberrant excision events of various types. In a model, 12 different modes of transduction mechanisms were characterized by: (i) the structure of the specialized transducing genomes after injection into a new host cell, i.e., linear or circular, and (ii) the requirements for the transduction process, i.e., host recombination functions, phage integration functions, or presence of a prophage. By using different recipient strains and phage helper strains, it was possible to show that most specialized transducing particles (ca. 99%) contain linear genomes that cannot circularize upon injection into a new host cell and that require the presence of an integrated prophage as a site for a recombinational event to give rise to a transductant. Only 0.1% of all specialized transducing particles were shown to transduce by integration, suggesting that transducing genomes containing terminally redundant ends represent only a minor fraction of all transducing particles that are produced. However, it should be pointed out that the frequency (approximately 10(-5)/PFU) of these specialized transducing genomes that can circularize upon injection into a new host cell is as high as or even higher than the frequency of specialized transducing particles of phage lambda. The remaining approximately 1% of all specialized transducing particles can transduce by any one of the other mechanisms described.

Adsorption↗
PubMed1985

70% alcohol disinfection of transducer heads: experimental trials.

We investigated the feasibility of transducer head disinfection with 70% alcohol wipes. In the initial trial, nine gas-sterilized transducers were inoculated with an estimated 5 X 10(6) organisms of a clinical isolate of Enterobacter cloacae, mimicking a contaminated fluid couple. A sterile disposable transducer dome was attached to each transducer. The units were allowed to sit for 24 hours at room temperature; the domes were then removed. Three transducer heads were cultured prior to disinfection to ensure that viable organisms remained. Each transducer head was wiped clean with a single alcohol wipe, allowed to dry, and then cultured. All nine cultures showed growth of E. cloacae. A second series of trials with 54 transducers employed an identical protocol, except that each transducer head received not one, but two, applications of alcohol. In addition to E. cloacae (26 runs), Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans were employed in nine, nine and ten runs, respectively. Cultures of 53 of 54 transducer heads showed no growth; the single positive culture was attributed to an error in technique. These preliminary results suggest that the double-alcohol-wipe technique may be an easy, cost-effective, alternative or supplemental method of transducer head disinfection. However, we do not advocate routine implementation of this technique in patient care settings until clinical trials confirm its safety and efficacy.

1-Propanol↗
PubMed1987

Zero stability of disposable and reusable pressure transducers.

Zero stability tests were performed on contrasting, commercially available, blood pressure-transducer systems. One system was based on a brand of disposable transducer. The others employed one brand of reusable transducer with and without samples of two different brands of compatible disposable domes. Drift was measured at atmospheric pressure over 3-hr periods. Drifts with the disposable transducers and with the bare reusable transducers were small, ranging from -2 to +2 mm Hg over 3 hr. However, the drifts of the reusable transducers with domes were significantly greater, ranging from -11 mm to +5 mm Hg. The disposable transducers did not drift significantly after the first half hour, although the reusable transducers with domes continued to drift. In addition, one brand of disposable dome produced inaccurate calibrations with the reusable transducer. The methodology of drift measurement and analysis should be practical and useful in other settings and with other brands of transducers. In general, the results indicate that periodic zeroing is still a clinically important procedure, and it is a worthwhile effort prior to treatment decisions based on pressure readings.

Blood Pressure Determination↗
PubMed1996

Evaluation of the implantable force transducer for chronic tendon-force recordings.

In vivo force measurements from tendons and ligaments have become an important technique to determine internal forces, joint loading, and mechanisms of neuromotor control. The most frequently used transducers for such force recordings were placed external to the target tissue. Because of space restrictions and the associated impingement artifacts, these external transducers cannot be used for force measurements in all tendons and ligaments. In these situations, transducers placed inside the target tissue have been used recently; however, the suitability and performance characteristics of these internal transducers have not been assessed systematically. The purpose of this study was to assess the suitability and performance characteristics of an internally placed force transducer which has been used previously. The results indicated that small angular displacements of the transducer within the target tissue, as well as small relative rotations of the corresponding bones, resulted in substantially changed transducer output for given externally applied loads. Also, the transducer output was found to depend on the rate of load application. It was concluded that, although the internal force transducer gave reliable signals within a given experiment, and thus, could be used to assess relative changes in tissue forces pre- and post-interventions, it would be difficult to use the transducer for the accurate determination of the actual tissue forces during unrestrained animal locomotion.

Animals↗
PubMed1999

Diagnostic yield of a 1-MHz transducer in evaluation of the basal cerebral arteries.

The authors examined the efficacy of a 1-MHz transducer in routine ultrasound monitoring. Fifty outpatients (34 women, 16 men; mean age, 65 +/- 2) with inadequate temporal bone window for examination with 2-MHz transducers were re-examined with a 1-MHz transducer. Additionally, 50 controls (34 men, 16 women; mean age 49 +/- 2) with adequate temporal bone window were examined with both the 1- and 2-MHz transducers. Signal quality was classified as good (GQ), adequate (AQ), or poor (PQ). Finally, 30 normal controls were examined with both transducers under standardized conditions, to evaluate potential differences in velocity measurements. A total of 90 temporal windows were lacking in the 50 patients. Use of the 1-MHz transducer resulted in identification of the middle cerebral artery in 68 cases (76%; PQ, n = 13; AQ, n = 29; GQ, n = 26), the anterior cerebral artery in 51 cases (57%; PQ, n = 23; AQ, n = 17; GQ, n = 11) and the posterior cerebral artery in 46 cases (51%; PQ, n = 12; AQ, n = 21; GQ, n = 13). Examination was feasible with both transducers in the 50 controls, with minimal differences in signal quality between the two transducers. Correlation between velocity values acquired with the 1- and 2-MHz transducers was significant for all vessels examined. Best values were measured for the middle cerebral artery, followed by the anterior cerebral artery and posterior cerebral artery. The authors conclude that the use of the 1-MHz transducer increases the yield of transcranial Doppler sonography.

Aged↗
PubMed1998

Specific absorption rate ratio patterns of cylindrical ultrasound transducers for breast tumors.

The purpose of this paper is to examine the optimal driving frequency and to configure the ultrasound energy deposition schema for a various size and location of breast tissues when a portion or the entire cylindrical ultrasound transducer is employed for breast hyperthermia treatments. This work employs a computer simulation program based on an ideal ultrasound power deposition from a cylindrical transducer. The ultrasound power within the breast is assumed to be exponentially attenuated according to the penetration depth of the ultrasound beam and a uniform absorption for the entire breast is also assumed. The distribution of the specific absorption rate (SAR) ratio is employed to determine the heating pattern of a set of given parameters. The control parameters considered are the ultrasound frequency in the breast tissue, the active portion of cylindrical transducer, and the shifting distance between the central axes of the breast and the transducer. The effect of the breast size on the SAR ratio is also considered. Simulation results demonstrate that the breast size, the ultrasound frequency in breast tissue, the shifting distance, and the active portion of the cylindrical transducer are the potential parameters for influencing the distribution of the SAR ratio. High frequencies should be used for the superficial heating treatments and the active portion of the transducer can be changed to obtain a region with an appropriate SAR ratio to cover the treatment region. Low frequencies are used for deep heating treatments and the region of the high SAR ratio can be moved by shifting the transducer and its pattern is varied with the transducer's active portion. The distribution of the SAR ratio indicates the domain of treatable tumor size and tumor depth for a given set of parameters (driving frequency, shifting distance and active portion of the transducer, as well as breast diameter). Findings of this study can be used to know whether or not the tumor is treatable as well as to select the optimal driving frequency and the appropriate active portion of the cylindrical transducer for a treatment, and hopefully to design an appropriate cylindrical ultrasound heating system for breast tumors.

Biophysical Phenomena↗
PubMed1999

Effect of ultrasound transducer frequency on the appearance of the fetal bowel.

We evaluated how ultrasound transducer frequency affected the appearance of the fetal bowel. One hundred women with singleton pregnancies, who were undergoing routine ultrasonographic examination, were assessed at a single institution. Patients with known fetal anomalies, abnormal biochemical screening results, or a history of cystic fibrosis were excluded. Images of the fetal abdomen were obtained in all patients using a single multi-Hertz transducer, with transducer frequencies set at 5 MHz and 8 MHz. Images were read separately by two radiologists, blinded to patient name and transducer frequency. Observers rated the presence or absence of echogenic bowel, defined as bowel with echogenicity greater than or equal to that of adjacent bone. Using the 8 MHz frequency, the radiologists interpreted 31% of the cases as having echogenic bowel, whereas using the 5 MHz frequency, the radiologists interpreted only 3% of the cases as having echogenic bowel (P<0.0001). A fetus was 10 times as likely to be given a diagnosis of echogenic bowel by both observers when the 8 MHz transducer was used than when the 5 MHz transducer was used by one observer (relative risk 10, 95% CI 3-11). Furthermore, using the 8 MHz frequency transducer, at least one of the radiologists interpreted echogenic bowel in 62% of the cases. We concluded that echogenic fetal bowel is a very common observation when imaging is performed with an 8 MHz transducer, and thus echogenic bowel diagnosed with an 8 MHz transducer is unlikely to reflect underlying abnormality. Identification of echogenic bowel with an 8 MHz transducer should not prompt further testing.

Female↗
PubMed1997

Human gastric carcinoma transduced with the IL-2 gene: increased sensitivity to immune effector cells in vitro and in vivo.

We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quantitatively different in the parental and IL-2 gene-transduced cells, although the former did not secrete IL-2. Surface expression of IL-2 receptors was comparable in the parental and transduced cells at the mRNA or protein levels. Nevertheless, in vitro proliferation of IL-2 gene-transduced HR cells was significantly more rapid than that of parental cells. Both parental and IL-2 gene-transduced HR cells were equally sensitive to lysis by IL-2-activated natural killer (A-NK) cells, as measured in 4 hr 51Cr-release assasys or to apoptosis induced by NK or A-NK cells, assessed in 1 hr 3H-TdR-release assays. In 24 hr MTT assays, however, the IL-2 gene-transduced cells were significantly more sensitive to these effector cells than were parental cells. Upon intrasplenic injection of 5 x 10(6) parental or transduced HR cells into nude mice, liver metastases developed. Metastases of parental HR cells killed the animals in 24 days. In contrast, metastases of the IL-2 gene-transduced HR cells became necrotic by day 14 and were found to be surrounded by murine NK cells and macrophages. Survival of nude mice injected with IL-2 gene-transduced HR cells was significantly prolonged (>50 days) relative to that of mice injected with parental HR. Thus, IL-2 gene-transduced HR cells produced sufficient amounts of functional IL-2 in vivo to be able to recruit to the tumor site and support functions of endogenous cytotoxic immune effector cells, which were responsible for regression of hepatic metastases and significant improvement of survival in these mice.

Animals↗
PubMed2005

Load characteristics of high power sandwich piezoelectric ultrasonic transducers.

Based on the equivalent circuit theory, the load characteristics of high power piezoelectric ultrasonic sandwich transducers are studied. Two types of loads are studied. One is liquid load as in ultrasonic cleaning, and the other is solid load as in ultrasonic drilling and machining. The effect of load and structure of the transducer on the resonance frequency of the transducer is analyzed. It is shown that the effect of load on the resonance frequency of sandwich transducers with different structures is different. For liquid load as in ultrasonic cleaning, the effect of the load on the resonance frequency of the sandwich transducer with symmetrical structure is the largest. It is the smallest for the transducer with its displacement node in the back metal cylinder. For solid load as in ultrasonic drilling and machining, the effect of the load on the resonance frequency of the sandwich transducer with its displacement node in the front metal cylinder is the largest. It is also the smallest for the transducer with its displacement node in the back metal cylinder. On the other hand, for some applications, such as ultrasonic drilling, when the lateral dimension of the tool is much less than that of the transducer, its effect on the resonance frequency of the transducer is small. The conclusions are useful in designing vibrating systems for different ultrasonic applications.

Journal Article↗
PubMed2006

Cymbal piezoelectric composite underwater acoustic transducer.

The working principle of Cymbal piezoelectric composite underwater acoustic transducer was studied in this paper. PZT-5A piezoelectric ceramic disk was used as piezoelectric phase and brass foil was used as end cap electrode of the Cymbal transducer. The silicon rubber was used as the insulated proof layer of the underwater acoustic transducer. The properties of this transducer used as hydrophone, such as operation frequency, free-field voltage receiving sensitivity and directivity, were investigated. Several kinds of prototype of this transducer were fabricated and the properties of this transducer used as hydrophone were tested. The results show that the properties of this transducer used as hydrophone depend on the dimensions of Cymbal transducer because the piezoelectric properties of this transducer are dependent on the dimensions of Cymbal transducer's end caps. The appropriate dimensions for getting higher free-field voltage receiving sensitivity with -184.7 dB were obtained.

Journal Article↗
PubMed2000

Micromachined ultrasound transducers with improved coupling factors from a CMOS compatible process

For medical high frequency acoustic imaging purposes the reduction in size of a single transducer element for one-dimensional and even more for two-dimensional arrays is more and more limited by fabrication and cabling technology. In the fields of industrial distance measurement and simple object recognition low cost phased arrays are lacking. Both problems can be solved with micromachined ultrasound transducers (MUTs). A single transducer is made of a large number of microscopic elements. Because of the array structure of these transducers, groups of elements can be built up and used as a phased array. By integrating parts of the sensor electronics on chip, the cabling effort for arrays can be reduced markedly. In contrast to standard ultrasonic technology, which is based on massive thickness resonators, vibrating membranes are the radiating elements of the MUTs. New micromachining technologies have emerged, allowing a highly reproducible fabrication of electrostatically driven membranes with gap heights below 500 nm. A microelectronic BiCMOS process was extended for surface micromechanics (T. Scheiter et al., Proceedings 11th European Conference on Solid-State Transducers, Warsaw, Vol. 3, 1997, pp. 1595-1598). Additional process steps were included for the realization of the membranes which form sealed cavities with the underlying substrate. Membrane and substrate are the opposite electrodes of a capacitive transducer. The transducers can be integrated monolithically on one chip together with the driving, preamplifying and multiplexing circuitry, thus reducing parasitic capacities and noise level significantly. Owing to their low mass the transducers are very well matched to fluid loads, resulting in a very high bandwidth of 50-100% (C. Eccardt et al., Proceedings Ultrasonics Symposium, San Antonio, Vol. 2, 1996, pp. 959-962; P.C. Eccardt et al., Proceedings of the 1997 Ultrasonics Symposium, Toronto, Vol. 2, 1997, pp. 1609-1618). In the following it is shown how the BiCMOS process has been modified to meet the demands for ultrasound generation and reception. Bias and driving voltages have been reduced down to the 10 V range. The electromechanical coupling is now almost comparable with that for piezoelectric transducers. The measurements exhibit sound pressures and bandwidths that are at least comparable with those of conventional piezoelectric transducer arrays.

Journal Article↗