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At least 73 records · Page 4Linked to original sources
PubMed2004

[The pathomechanism and the direction of therapy development in view of cDNA microarray].

We recently developed a new cDNA microarray encompassing more than 5,000 genes expressed in human skeletal muscle. We successfully identified the differences at the gene expression profiles among Duchenne muscular dystrophy patients. Using our microarray, we catalogued gene expression during myogenic differentiation. The resultant expression patterns were classified into eight groups by hierarchical cluster analysis. Among them, clusters 6, 7, and 8 contain genes which show high expression level at the later differentiation stage and encode mainly sarocmere and extracellular matrix proteins. We used genes in these clusters as markers for regeneration. We identified that these regeneration-associated genes were not necessarily upregulated in Fukuyama congenital muscular dystrophy (FCMD) even though necrosis-associated genes were highly upregulated, suggesting the insufficient regenerating capability in FCMD. We have also characterized genes regulated by IGF-I simulation. We subject cascade specific inhibitors and IGF-I to human myotubes and performed gene expression profiling using our cDNA microarray. We found that PI3K/Akt-1 cascade first activates transcriptional factors such as MyoD, myogenin, and MEF2C, and then genes in clusters 6, 7, and 8, which have E-box and MEF-box where these transcriptional factors associate. We expect to develop a new therapeutic method by elucidating the molecular mechanism of muscular dystrophy and the effect of IGF-I and anti-myostatin treatments.

Animals↗
PubMed1989

[New radiopharmaceuticals for oncologic diagnosis and therapy: developments in radioimmunoscintigraphy and radioimmunotherapy].

131I labeled monoclonal antibodies are at a disadvantage for radioimmunoscintigraphy due to the in-vivo cleavage of radioiodine by deiodases. Alternative labeling with 99mTc was not very successful because of the lack of suitable ligands for stable technetium complexes. New developments in this field will be presented using stable 99mTc-N2S2 complexes. Some comments on radioimmunotherapy have also been added.

Antibodies, Monoclonal↗
PubMed1993

Critical assessment of combination therapy development.

Although antihypertensive treatment has been found to reduce cardiovascular morbidity and mortality, hypertensive patients are still at a significantly increased risk compared with normotensive controls. One of the reasons is that blood pressure control is often suboptimal. In fact, less than 40% of patients reach the target set by the treating physician. The development of wisely chosen fixed combinations could be one means, among others, to improve blood pressure control without compromising tolerability. The prescription, in a single pill, of two antihypertensive agents has the potential advantage of improving compliance by reducing the number of pills that need to be taken per day. There should be a pharmacological rationale, with the two agents having different and complementary modes of actions to reduce blood pressure: for example, a vascular selective calcium antagonist lowers total peripheral resistance and a beta-blocker lowers heart rate and, thus, cardiac output. These drugs can also mutually neutralise some of each others' side-effects, such as the initial heart rate increases which may occur with dihydropyridine calcium antagonists, and the rise in peripheral resistance elicited by some beta-blockers. The creation of a fixed-dose combination for effective and safe treatment of hypertension requires a complex programme of development. An example is the formulation of a combination tablet of felodipine and metoprolol in which extended-release techniques were applied to ensure that blood pressure control was maintained throughout the 24-h dosing interval. Evaluation included pharmacokinetic studies of the formulation, interaction studies and clinical trials of crossover and parallel-group designs to establish the 24-h efficacy and safety of the product.(ABSTRACT TRUNCATED AT 250 WORDS)

Antihypertensive Agents↗
PubMed1997

[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others].

Pancreatic cancer is extremely resistant to various cancer therapies, however, variety of new therapies for pancreatic cancer have been investigated: (1) immunotherapy including cytokines like TNF, adoptive immunotherapy with lymphokine-activated killer cells or cytotoxic T-lymphocytes, and tumor vaccines using mutated Ki-ras oncoprotein or irradiated tumor cells which were transfected by cytokine genes; (2) gene therapy including transfer of cytokine genes or antisense Ki-ras oncogene, and a combination of gene transfer of herpes simplex virus thymidine kinase and subsequent administration of ganciclovir; (3) differentiation therapy including a quinolinone derivative, vesnarinone; (4) endocrine therapy including cholecystokinin-receptor antagonist, CR1505 or L364,718; (5) heavy water, and etc. All of these therapies will be applied for the treatment of pancreatic cancer in the near future.

Animals↗
PubMedDate not supplied

Developing a rural therapy with big city approaches.

Both rural communities and urban communities experience problems associated with drug use and drug dependence. However, existing treatment interventions are not tailored for rural settings. This article describes a project which will modify an existing social skills behavioral therapy for rural populations, refine the therapy, develop a manual, train and supervise therapists, and pilot test the structured behavioral outpatient rural therapy to treat rural drug users and drug dependents as Stage I Research for NIDA's Behavioral Therapies Development Program.

Behavior Therapy↗