Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Telangiectasis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed2006

Photodynamic therapy for subretinal neovascularization in type 2A idiopathic juxtafoveolar telangiectasis.

BACKGROUND: Photodynamic therapy (PDT) with verteporfin is now the standard of care worldwide for the treatment of choroidal neovascularization, but has been used only rarely in those with subretinal neovascular membranes (SRNVM) due to type 2A idiopathic juxtafoveolar retinal telangiectasis (IJT). We performed a retrospective study to examine the outcome of patients treated with PDT for SRNVM secondary to IJT. METHODS: Retrospective interventional case series of 7 eyes of 6 IJT patients with SRNVMs treated with PDT. Ophthalmic examination and fluorescein angiography were performed before treatment, with retreatment every 3 months as needed. The main outcome was the proportion of patients avoiding vision loss (change of +/- 4 letters, or better). RESULTS: Baseline Snellen acuity ranged from 20/40 to 20/400 (median 20/80). Mean follow-up was 21 months. Patients received 2.4 treatments on average. Five of 7 patients avoided vision loss; acuity improved in 3 eyes (> or = 1 line improvement), stayed the same in 2 eyes (+/- 4 letters) and decreased in 2 eyes (> or = 1 line decrease) over time. Median final acuity was 20/80. Five of 7 eyes had final acuities of > or = 20/200. No leakage was observed in any eyes following cessation of treatment.

Adult↗
PubMed1997

Grid laser photocoagulation for macular edema in bilateral juxtafoveal telangiectasis.

OBJECTIVE: The purpose of the study is to report the efficacy of laser photocoagulation treatment for macular edema in bilateral juxtafoveal telangiectasis (BJT). DESIGN: The study design was a retrospective, clinical study. PARTICIPANTS: The authors observed 14 patients with BJT, studying the visual acuities and retinal changes of treated and untreated eyes. MAIN OUTCOME MEASURES: Visual acuity, presence of macular edema, and associated retinal findings were measured. RESULTS: Of 28 eyes, 10 (8 patients) received 15 laser photocoagulation treatments for macular edema. Neither treated nor untreated eyes had visual improvement of two or more lines. After treatment, five eyes (50%) had increased retinal vascular distortion develop, three (30%) had new draining retinal venules, five (50%) had intraretinal fibrovascular tissues, and four (40%) had retinal and preretinal hemorrhages develop. CONCLUSIONS: Grid laser photocoagulation therapy for macular edema in patients with BJT appears to neither improve nor stabilize long-term visual acuity. In addition, treatment is associated with retinal pigment epithelial changes, increased postoperative retinal vascular distortion, postoperative vascularized retinal scars, and postoperative retinal hemorrhages. These changes, however, do not appear to cause a further loss of vision.

Aged↗
PubMed1999

Radiation exposure: a new risk factor for idiopathic perifoveal telangiectasis.

OBJECTIVE: To examine the association between previous radiation exposure and idiopathic perifoveal telangiectasis (IPT). DESIGN: A multicentered, individually matched, case-control study design was used. PARTICIPANTS/CONTROLS: Sixty-five case subjects were matched with 175 control subjects. Individuals with unequivocal evidence of angiographically confirmed IPT were included as cases. Control subjects were matched for center, age, and gender. MAIN OUTCOME MEASURE: The main exposures of interest were a history of therapeutic head or neck irradiation and environmental radiation exposure. METHODS: A standardized questionnaire was administered to case and control subjects. Data were collected for the main exposures of interest as well as pertinent covariates. Conditional logistic regression was used to evaluate therapeutic and environmental radiation as risks for IPT. RESULTS: On univariate analysis, head or neck irradiation was associated with IPT (odds ratios [OR] = 4.15, 95% confidence interval [CI] = 1.30-13.24). While controlling for diabetes and family history of diabetes, IPT was found to be associated with both head or neck irradiation (OR = 4.06, 95% CI = 1.20-13.76) and with environmental irradiation (OR = 6.73, 95% CI = 1.06-42.74). CONCLUSIONS: This study presents a previously unreported association between prior radiation exposure and IPT.

Aged↗
PubMedDate not supplied

Atypical retinitis proliferans, retinal telangiectasis, and vitreous hemorrhage in a patient with tuberous sclerosis.

This report describes an unusual case of recurrent vitreous hemorrhage and atypical retinal neovascularization in a patient with tuberous sclerosis. During three years of observation, the patient also developed retinal telangiectasis with macular edema and lipid exudation. Although the patient did not have an obvious astrocytic hamartoma, a diffuse, flat retinal hamartoma within the nerve fiber layer was suspected.

Adult↗
PubMed2007

Optical coherence tomography findings in nonproliferative group 2a idiopathic juxtafoveal retinal telangiectasis.

PURPOSE: To determine the optical coherence tomography (OCT) findings in eyes with group 2a idiopathic juxtafoveal retinal telangiectasis (IJRT). METHODS: Forty-one eyes of 22 patients with nonproliferative group 2a IJRT were examined. OCT testing including retinal topographic mapping and analysis, and horizontal and vertical line scans, was obtained on each eye. RESULTS: None of the 41 eyes had a thickened foveal center. The average center foveal thickness was 166 microm (31-264 microm). Stage 1 eyes (n = 2) were normal fellow eyes in patients with contralateral group 2a IJRT. Stage 2 eyes (n = 11) all had parafoveolar temporal graying and intraretinal temporal fluorescein leakage, but rarely had photoreceptor disruption (18%) on OCT testing. Stage 3 eyes (n = 14) all had clinical and fluorescein findings similar to or more pronounced than stage 2 eyes. All stage 3 eyes also had one or more foveal cysts at various retinal depths on OCT. Most of these eyes (86%) had photoreceptor disruption and outer retinal atrophy on OCT. Stage 4 eyes (n = 14) all had a black foveal or parafoveolar pigment plaque and intraretinal temporal fluorescein leakage. All stage 4 eyes had a hyper-reflective plaque with shadowing on OCT corresponding to the pigment plaque. Most of these eyes had one or more foveal cysts (64%) and all of these eyes had photoreceptor disruption and outer retinal atrophy. CONCLUSION: OCT helps in the staging of group 2a IJRT and reveals multiple retinal structural abnormalities.

Aged↗
PubMed2005

Use of intravitreal triamcinolone acetonide injection in unilateral idiopathic juxtafoveal telangiectasis.

Idiopathic juxtafoveal telangiectasis (IJT) is one of the primary retinal telangiectasia that can result in visual impairment attributed to resultant cystoid macular oedema and rarely, choroidal neovascularization. The authors herein report successful treatment using intravitreal triamcinolone acetonide in a case of unilateral IJT that did not respond to prior laser photocoagulation. Serial optical coherence tomography was used to monitor the effectiveness of intravitreal triamcinolone acetonide in the treatment of IJT.

Fovea Centralis↗
PubMed1982

Giant cerebral capillary telangiectasis in an infant.

The authors describe an unusual and unique case of a giant capillary telangiectasis of the right frontal lobe encountered in a 10-month-old child. The patient presented with progressive neurologic symptoms mimicking a brain tumor. The lesions was resected in toto with good clinical results.

Brain Neoplasms↗
PubMed2002

Idiopathic juxtafoveolar retinal telangiectasis: case report and literature review.

BACKGROUND: Idiopathic Juxtafoveolar Retinal Telangiectasis (IJRT) is a retinal vascular anomaly, characterized by irregular dilation and incompetence of retinal vessels. Although the etiology of the condition is unknown, its various presentations have been characterized into three groups. Treatment includes laser photocoagulation and observation and is based on disease classification. CASE REPORT: The case report presents a patient with Group 2A, Stage 3 IJRT. The clinical appearance, differential diagnosis, and management of IJRT and its subgroups are discussed. CONCLUSION: Appropriate classification of IJRT is essential to the successful management of this condition.

Diagnosis, Differential↗
PubMed1992

[Parafoveal retinal telangiectasis and changes of the capillary free zone in non-diabetic patients].

Microaneurysms, hard exudates, hemorrhages and/or edema in the macular region were observed in 10 eyes of 10 non-diabetic patients. By fluorescein angiography, parafoveal retinal telangiectasis was found in all cases. Deformation, enlargement and boundary disruption of the foveolar avascular zone were discernible in most cases, as were unevenness of capillary spacing, small areas of non-perfusion and leakage of dye in some cases. Analysis and calculations of the foveolar avascular zone were done with the Model-970 Quantmet computerized image analysis system. The data showed that the values of circumference, vertical diameter and roundness of the avascular zone differed significantly from those of the 10 normal control eyes.

Adult↗
PubMed1991

Cystoid macular edema secondary to juxtafoveolar telangiectasis in Coats' disease.

A 28-year-old man with unilateral Coats' disease and cystoid macular edema secondary to juxtafoveolar telangiectasis underwent successful juxtafoveolar argon green laser photocoagulation therapy with resolution of the edema and improvement in metamorphopsia and visual acuity. Despite this success, the effect of laser therapy in these patients remains uncertain. It should be considered only after detailed discussion with the patient about the possibility of posttreatment paracentral scotomata and the alternative of a reasonable period of observation for possible spontaneous resolution of the edema.

Adult↗
PubMed1989

[Asteroid hyalitis: an uncommon complication of retinal telangiectasis].

The authors report a case of asteroid hyalosis which required a vitrectomy because of the decreased vision. The vitrectomy places in a prominent position an epi-macular membrane which has been peeling during the procedure and retinal vascular malformations like "telangiectasies" which are the starting point of other complications.

Adult↗
PubMed1983

An unusual brainstem capillary telangiectasis in a child.

This case report concerns a brainstem telangiectasis that mimicked a tumor causing progressive neurologic symptoms over a period of 6 years prior to death. Intravascular coagulation within the malformation leading to localized ischemia is proposed as the mechanism for the apparent growth of the lesion.

Brain Neoplasms↗
PubMed1993

Subretinal hemorrhage after grid laser photocoagulation for idiopathic juxtafoveolar retinal telangiectasis.

A 56-year-old man had decreased vision secondary to bilateral idiopathic juxtafoveolar retinal telangiectasis. One month after grid laser photocoagulation for macular edema in the right eye, a subretinal hemorrhage developed. Over the next 2 months, the hemorrhage spontaneously resorbed and vision improved to 20/50. At 2-year follow up, without further treatment, vision was still 20/50.

Fluorescein Angiography↗
PubMed2003

Hereditary hemorrhagic telangiectasis treated by the harmonic scalpel.

BACKGROUND: Hereditary hemorrhagic telangiectasis (HTT) is a familial autosomal dominant genetic disorder that causes abnormalities of the wall of peripheral blood vessels. Severe nosebleed often is the dominant symptom. A variety of therapies have been proposed for epistaxis control in HHT but with limited success. METHODS: We report two cases of HHT in which recurrent nasal bleeding was successfully controlled using the Harmonic Scalpel. RESULTS: Use of the Harmonic Scalpel avoids the carbonization and incrustation of the nasal mucosa that commonly results from electrocautery and laser irradiation. Even during active bleeding, hemostasis can be achieved by repeated applications of the scalpel blade. CONCLUSION: This method can be performed quick and reliably on an outpatient basis. The Harmonic Scalpel may be the treatment of choice for recurrent epistaxis in HHT.

Blood Coagulation↗
PubMed1981

DNA-repair synthesis in ataxia telangiectasis lymphoblastoid cells.

The ability of a number of Epstein-Barr virus-transformed lymphoblastoid cells from ataxia telangiectasis (AT) patients to repair gamma-radiation damage to DNA was determined. All of these AT cells were previously shown to be hypersensitive to gamma-radiation. Two methods were used to determine DNA-repair synthesis: isopycnic gradient analysis and a method employing hydroxyurea to inhibit semiconservative DNA synthesis. Control, AT heterozygote and AT homozygote cells were demonstrated to have similar capacities for repair of radiation damage to DNA. In addition at high radiation doses (10-40 krad) the extent of inhibition of DNA synthesis was similar in the different cell types.

Ataxia Telangiectasia↗
PubMed1989

[A case report of pulmonary arterio-venous fistula complicated with hereditary hemorrhagic telangiectasis].

A 5-year-old girl with multiple pulmonary arterio-venous fistulae was reported. Both her mother and grandmother have been diagnosed as the same disease previously. Her grandmother was treated with resection of the right basal segment for arterio-venous fistulae. Her mother is well with fistulae for more than 20 years. The patient was operated upon to enucleate two larger fistulae in segments 3 and 6 of right lung. Her postoperative course was uneventful. She was discharged from the hospital on the 22nd postoperative day. Pulmonary arteriovenous fistulae are thought to be a part of the hereditary hemorrhagic telangiectasis. Enucleation of the larger fistulae of the lung are preferable even for multiple lesions.

Arteriovenous Fistula↗