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The biological availability was investigated of diphenhydramine and fomocaine, two of the active principles of the new formulation "Herit" used as a jelly against burns and small wounds. Fomocaine and diphenhydramine penetrate deeply into stratum corneum. The addition of fomocaine guarantees a quick pain relieving effect on the damaged skin. The jelly does not retain diphenhydramine and fomocaine.