Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Software Design”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed1992

[Use of a computer-controlled servo system to produce "ephysiological" contraction of isolated rat papillary muscle].

A computer-controlled servo system consisting of an ergometer with a force-displacement dual mode transducer, a Z-80 single-board microcomputer and a designed software was constructed. This servo system can be used to generate physiological contraction in isolated rat papillary muscle, in which the muscle went through a complete 4-phase cycle of force and length changes, similar to those undergone by muscle fibers in the beating heart during the cardiac cycle. This system is being used to investigate the tension-length relation and the network of isolated myocardium as well as the end-systolic tension-length relation and the force-velocity relation simultaneously.

Animals↗
PubMed1999

[Software package for self-constructed CCD-ICP-OES. 1. Software system and design idealogy].

A software package and its design idealogy for the self-constructed CCD-ICP-OES are described. The MS Windows 95TR was used as the operating platform. The Software package written in MS Visual C + + TR V 4.2 included the control of grating and CCD, the dynamic monitoring, the treatment of spectral signal, the fixing of wavelength position, the automatic fixing of spectral line, the quantitative analysis, the stripping method, the Kalman filter and the artificial neural network.

English Abstract↗
PubMed2003

Experiences with a generator tool for building clinical application modules.

OBJECTIVES: To elaborate main system characteristics and relevant deployment experiences for the health information system (HIS) Orbis/OpenMed, which is in widespread use in Germany, Austria, and Switzerland. METHODS: In a deployment phase of 3 years in a 1.200 bed university hospital, where the system underwent significant improvements, the system's functionality and its software design have been analyzed in detail. We focus on an integrated CASE tool for generating embedded clinical applications and for incremental system evolution. We present a participatory and iterative software engineering process developed for efficient utilization of such a tool. RESULTS: The system's functionality is comparable to other commercial products' functionality; its components are embedded in a vendor-specific application framework, and standard interfaces are being used for connecting subsystems. The integrated generator tool is a remarkable feature; it became a key factor of our project. Tool generated applications are workflow enabled and embedded into the overall data base schema. Rapid prototyping and iterative refinement are supported, so application modules can be adapted to the users' work practice. CONCLUSIONS: We consider tools supporting an iterative and participatory software engineering process highly relevant for health information system architects. The potential of a system to continuously evolve and to be effectively adapted to changing needs may be more important than sophisticated but hard-coded HIS functionality. More work will focus on HIS software design and on software engineering. Methods and tools are needed for quick and robust adaptation of systems to health care processes and changing requirements.

Computer Systems↗
PubMed2003

A case study of object-oriented bio-chemistry: a unified specification of the coagulation cascade.

We propose a case study where a familiar but very complex and intrinsically woven bio-computing system--the blood clotting cascade--is specified using methods from software design known as object-oriented design (OOD). The specifications involve definition and inheritance of classes and methods and use design techniques from the most widely used OOD-language: the Unified Modeling Language (UML), as well as its Real-Time-UML extension. First, we emphasize the needs for a unified methodology to specify complex enough biological and biochemical processes. Then, using the blood clotting cascade as a example, we define the class diagrams which exhibit the static structure of procoagulant factors of proenzyme-enzyme conversions, and finally we give a dynamic model involving events, collaboration, synchronization and sequencing. We thus show that OOD can be used in fields very much beyond software design, gives the benefit of unified and sharable descriptions and, as a side effect, automatic generation of simulation software.

Biochemistry↗
PubMed2004

GenoFrag: software to design primers optimized for whole genome scanning by long-range PCR amplification.

Genome sequence data can be used to analyze genome plasticity by whole genome PCR scanning. Small sized chromosomes can indeed be fully amplified by long-range PCR with a set of primers designed using a reference strain and applied to several other strains. Analysis of the resulting patterns can reveal the genome plasticity. To facilitate such analysis, we have developed GenoFrag, a software package for the design of primers optimized for whole genome scanning by long-range PCR. GenoFrag was developed for the analysis of Staphylococcus aureus genome plasticity by whole genome amplification in approximately 10 kb-long fragments. A set of primers was generated from the genome sequence of S.aureus N315, employed here as a reference strain. Two subsets of primers were successfully used to amplify two portions of the N315 chromosome. This experimental validation demonstrates that GenoFrag is a robust and reliable tool for primer design and that whole genome PCR scanning can be envisaged for the analysis of genome diversity in S.aureus, one of the major public health concerns worldwide.

Base Pairing↗
PubMed1991

Optimization of a trileaflet valve design.

This study investigates the fundamental principles that should govern the basic design of an optimal trileaflet valve. The geometry of the leaflets is described in terms of radius of the base (Rb), radius of the commissures (Rc), height of the valve (H), height of the commissures (Hs), and angle of the open leaflet to vertical (beta). Using computer-aided design software and these design parameters, a computer model of the valve was constructed. Choosing the parameters empirically did not produce an optimal valve. The four criteria for optimal performance were defined as: (1) a certain minimum coaptation height, (2) no folds in the leaflet, (3) minimum valve height, and (4) minimum leaflet flexion. Mathematical relationships were established between the design parameters and the performance parameters. These relationships indicated that the parameters Rc, Hs, and beta could be used to minimize valve height; however, a reduction in valve height must be balanced against the accompanying increase in leaflet flexion. For an optimal valve, the design parameters were Rb = 10 mm, then Rc = 8 to 10 mm, H = 11.5 mm, Hs = 2.4 to 2.6 mm, and beta = 4 degrees to 11 degrees . The optimal valve of any radius can be designed by scaling Rc, H, and Hs with respect to Rb. These design parameters were similar to those of the natural aortic valve. Trileaflet bioprosthetic valves designed on these principles are expected to have enhanced efficiency and longevity.

Bioprosthesis↗
PubMed1992

VA's Integrated Imaging System on three platforms.

The DHCP Integrated Imaging System provides users with integrated patient data including text, image and graphics data. This system has been transferred from its original two screen DOS-based MUMPS platform to an X window workstation and a Microsoft Windows-based workstation. There are differences between these various platforms that impact on software design and on software development strategy. Data structures and conventions were used to isolate hardware, operating system, imaging software, and user-interface differences between platforms in the implementation of functionality for text and image display and interaction. The use of an object-oriented approach greatly increased system portability.

Computer Graphics↗
PubMed1998

[Investigation and manufacture of intellectualized tonometer bassed on the principle of linearly measuring the applanation area diameter of ocular cornea].

The design principle of intellectualized tonometer based theory of linearly measuring the applanation area diameter of ocular cornea has been mainly introduced, which inclueds optics and construction design principle, principle of hardware and software design of intellectualized instrument and the calculation method of ocular pressure etc. The method and result of calibration of the tonometer are also included.

Cornea↗
PubMed1996

Testing and validation of computerized decision support systems.

Systematic, through testing of decision support systems (DSSs) prior to release to general users is a critical aspect of high quality software design. Omission of this step may lead to the dangerous, and potentially fatal, condition of relying on a system with outputs of uncertain quality. Thorough testing requires a great deal of effort and is a difficult job because tools necessary to facilitate testing are not well developed. Testing is a job ill-suited to humans because it requires tireless attention to a large number of details. For these reasons, the majority of DSSs available are probably not well tested prior to release. We have successfully implemented a software design and testing plan which has helped us meet our goal of continuously improving the quality of our DSS software prior to release. While requiring large amounts of effort, we feel that the process of documenting and standardizing our testing methods are important steps toward meeting recognized national and international quality standards. Our testing methodology includes both functional and structural testing and requires input from all levels of development. Our system does not focus solely on meeting design requirements but also addresses the robustness of the system and the completeness of testing.

Artificial Intelligence↗
PubMed2001

Software sensor design for COD estimation in an anaerobic fluidized bed reactor.

In this paper, a method for unknown input estimation in stochastic system is presented. A key problem in bioprocess systems is the absence, in some cases, of reliable on-line measurements for real time monitoring applications. In this paper, a software sensor for an anaerobic digester is presented. Unmeasured components of the influent are estimated from available on-line measurements. Unknown input Kalman filter is discussed to estimate the state and unknown input of the process. First, the theory of unknown inputs optimal filtering in the stochastic case is exposed and a design procedure is proposed. The observer is applied to an anaerobic fluidized bed reactor to estimate the variations in Chemical Oxygen Demand (COD) concentration and experimental results are presented.

Anaerobiosis↗
PubMed2003

Chairside multi-unit restoration of a quadrant using the new Cerec 3D software.

The new Cerec 3D design software for inlays and partial and full crowns simplifies work when producing several restorations in one session. Quite significant progress has been achieved, in that the entire row of teeth of a quadrant can be acquired completely and displayed by successively overlapping optical impressions. The digital working model of a quadrant in which all preparations are acquired is the result. The restorations can be designed individually and inserted virtually. Thanks to virtual insertion, the proximal contacts to neighboring restorations can be designed perfectly and all restorations finally designed, milled, and inserted in one sitting. This method provides a significant rationalization effect.

Adult↗