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At least 73 records · Page 4Linked to original sources
PubMed1997

Set- and Element-Level Stimulus-Response Compatibility Effects for Different Manual Response Sets.

In a previous study of two-choice reactions, pairings of spatial stimuli with bimanual presses made on a keyboard and verbal stimuli with unimanual aimed movements made on a display screen showed higher set-level compatibility than the opposite pairings; element-level compatibility (i.e., mapping) effects were also larger for the conditions with high set-level compatibility than for those whose set-level compatibility was low. In the 4 experiments described here, the relevant factors were isolated, allowing the determinants of those compatibility differences to be evaluated in more detail. Forty-eight students participated in Experiment 1, and 24 each in Experiments 2, 3, and 4. The primary determinant of the set-level compatibility variation was whether the response alternatives involved 1 or 2 effectors, but the differences in element-level compatibility effects were determined primarily by the distinction between responding on the screen as opposed to on the keyboard. Implications for models of stimulus-response compatibility are examined.

perceptual-motor interactions↗
PubMed1993

Executive function in Parkinson's disease: set-shifting or set-maintenance?

In order to distinguish impairment in set-shifting in Parkinson's disease (PD) from inability to inhibit distraction by stimuli that compete for attention, 18 nondemented patients with idiopathic PD and 13 normal controls equated for age and education, were administered the Odd-Man Out (OMO) test and the Stroop Color-Word Test. PD patients were significantly impaired on the OMO test but showed no evidence of interference during the Stroop test. Analysis of error patterns during the OMO test indicated that the requirement to repeatedly switch rules, rather than the requirement to maintain steady responding between rule switches, was responsible for impaired OMO performance. It is concluded that the OMO test is fundamentally a test of set shifting, rather than a test of set maintenance in PD. In addition, analysis of a larger sample of PD patients revealed a significant positive relationship between number and severity of extrapyramidal signs and error production on the OMO, and between the latter and global mental function. These relationships were independent of each other, suggesting that impairment in set-shifting function in PD may arise from pathology of the fronto-striatal system independently of changes in cognitive ability.

Aged↗
PubMed2006

A comparison between integrating clinical practice setting and randomized controlled trial setting into economic evaluation models of therapeutics.

BACKGROUND: Cost-effectiveness analyses generated from randomized controlled trials (RCTs) represent results obtained under ideal experimental conditions (efficacy) and the applicability of these data to real-world settings (effectiveness) may be questionable. OBJECTIVE: To compare cost-effectiveness results obtained from a RCT setting with the results derived from community-based clinical practice. METHODS: Using data from a community-based cohort study and from a RCT, two cost-effectiveness analyses were performed and the incremental cost-effectiveness ratios (ICERs) were calculated for the use of etanercept in the treatment of patients with rheumatoid arthritis. RESULTS: Using an effectiveness-based analysis, the mean quality-adjusted life years (QALYs) gained during the 12-month monitoring period were 0.45 and 0.35 for the treatment and control groups respectively. The ICER for etanercept treatment was 174,200 dollars (CDN) per QALY (95% confidence limits between 119,500 dollars and 285,000 dollars). Incorporating efficacy data obtained from the RCT into the analysis, the mean QALYs gained were 0.56 and 0.35 for the treatment and control groups respectively. This resulted in a substantially lower ICER for etanercept treatment of 82,952 dollars per QALY (95% confidence limits between 66,500 dollars and 103,430 dollars). CONCLUSION: Depending on the type of clinical setting used for the analysis, the resulting ICER for etanercept treatment was very different. These results help to explain the difference in cost-effectiveness reported in previous modeling studies, some based on RCT assumptions and some based on effectiveness setting.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2003

Transmission of alien chromosomes from selfed progenies of a complete set of Allium monosomic additions: the development of a reliable method for the maintenance of a monosomic addition set.

Selfed progeny of a complete set of Allium fistulosum - Allium cepa monosomic addition lines (2n = 2x + 1 = 17, FF+1A-FF+8A) were produced to examine the transmission rates of respective alien chromosomes. All eight types of the selfed monosomic additions set germinable seeds. The numbers of chromosomes (2n) in the seedlings were 16, 17, or 18. The eight extra chromosomes varied in transmission rate (%) from 9 (FF+2A) to 49 (FF+8A). The complete set of monosomic additions was reproduced successfully by self-pollination. A reliable way to maintain a set of Allium monosomic additions was developed using a combination of two crossing methods, selfing and female transmission. FF+8A produced two seedlings with 18 chromosomes. Cytogenetical analyses, including GISH, showed that the seedlings were disomic addition plants carrying two entire homologous chromosomes from A. cepa in an integral diploid background of A. fistulosum. Flow cytometry analysis showed that a double dose of the alien 8A chromosome caused fluorescence intensity values spurring in DNA content, and isozyme analysis showed increased glutamate dehydrogenase activity at the gene locus Gdh-1.

Allium↗
PubMed2003

Matrix method to find a new set of Zernike coefficients from an original set when the aperture radius is changed.

A matrix method is developed that allows a new set of Zernike coefficients that describe a surface or wave front appropriate for a new aperture size to be found from an original set of Zernike coefficients that describe the same surface or wave front but use a different aperture size. The new set of coefficients, arranged as elements of a vector, is formed by multiplying the original set of coefficients, also arranged as elements of a vector, by a conversion matrix formed from powers of the ratio of the new to the original aperture and elements of a matrix that forms the weighting coefficients of the radial Zernike polynomial functions. In developing the method, a new matrix method for expressing Zernike polynomial functions is introduced and used. An algorithm is given for creating the conversion matrix along with computer code to implement the algorithm.

Journal Article↗
PubMed2003

A comparison of buprenorphine treatment in clinic and primary care settings: a randomised trial.

OBJECTIVE: To compare outcomes, costs and incremental cost-effectiveness of heroin detoxification performed in a specialist clinic and in general practice. DESIGN AND SETTING: Randomised controlled trial set in a specialist outpatient drug treatment centre and six office-based general practices in inner city Sydney, Australia. PARTICIPANTS: 115 people seeking treatment for heroin dependence, of whom 97 (84%) were reinterviewed at Day 8, and 78 (68%) at Day 91. INTERVENTIONS: Participants were randomly allocated to primary care or a specialist clinic, and received buprenorphine for 5 days for detoxification, then were offered either maintenance therapy with methadone or buprenorphine, relapse prevention with naltrexone, or counselling alone. MAIN OUTCOME MEASURES: Completion of detoxification, engagement in post-detoxification treatment, and heroin use assessed at Days 8 and 91. Costs relevant to providing treatment, including staff time, medication use and diagnostic procedures, with abstinence from heroin use on Day 8 as the primary outcome measure. RESULTS: There were no significant differences in the proportions completing detoxification (40/56 [71%] primary care v 46/59 [78%] clinic), participating in postwithdrawal treatment (28/56 [50%] primary care v 36/59 [61%] clinic), reporting no opiate use during the withdrawal period (13/56 [23%] primary care v 13/59 [22%] clinic), and in duration of postwithdrawal treatment by survival analysis. Most participants in both groups entered postwithdrawal buprenorphine maintenance. On an intention-to-treat basis, self-reported heroin use in the month before the Day 91 interview was significantly lower than at baseline (27 days/month at baseline, 14 days/month at Day 91; P < 0.001) and did not differ between groups. Buprenorphine detoxification in primary care was estimated to be $24 more expensive per patient than treatment at the clinic. The incremental cost-effectiveness ratio reveals that, in this context, it costs $20 to achieve a 1% improvement in outcome in primary care. CONCLUSIONS: Buprenorphine-assisted detoxification from heroin in specialist clinic and primary care settings had similar efficacy and cost-effectiveness. Buprenorphine treatment can be initiated safely in primary care settings by trained GPs.

Adolescent↗
PubMedDate not supplied

Toward collecting a standardized nursing data set across the continuum: case of adult care nurse practitioner setting.

Viable strategies are needed to move toward collection of a standardized nursing data set across settings for eventual use in examining nursing effectiveness. One strategy is to introduce potential nurse adopters to subsets of valid setting-specific standardized terms and measures to support adoption and initial implementation. The present study was designed to identify the "most clinically useful" NANDA (North American Nursing Diagnoses Association) diagnoses, NOC (Nursing Outcomes Classifications) outcomes, and NIC (Nursing Intervention Classifications) interventions pertinent to the adult care nurse practitioner setting. Ultimately, clinicians must recognize, however, that they will need to use additional terms and measures outside the subsets to more fully describe the nursing care provided.

Adult↗
PubMed2006

Supporting continuity of information in the patient transfer process should there be a minimum data set across care settings?

Existing clinical information systems do not facilitate the easy transfer of relevant clinical information; hence there are significant disparities in both the type and timeliness of information that accompanies a patient transfer between care settings. Patient data is commonly fragmented between various health care settings and providers, further contributing to a reduction in the quality of information that is shared. Delineating a transfer minimum data set would provide the basis for communicating consistent information between care settings.

Continuity of Patient Care↗
PubMed1990

Effect of single setting versus multiple setting training on learning to shop in a department store.

The effects of single versus multiple setting training on the generalization of shopping skills to untrained department stores were analyzed. One group received training in a single department store and the other, in three different stores. Measures were taken on operational behaviors, social behaviors, number of settings in which criterion performance was achieved, and number of sessions required to achieve criterion within the training settings. No differences between groups were found as a result of training condition. We concluded that for some individuals with mental retardation, training in either single or multiple settings may be sufficient for generalization.

Adolescent↗
PubMed1989

Freedom Set II--a Y-set CAPD system with a novel design.

The Freedom Set II is designed with a three-way valve to control the direction of dialysate flow thus simplifying the procedure and decreasing training time. Twenty-four patients from two centers were trained on the Freedom Set II and were observed for ninety patient months. Five patients who had been on other bagless systems expressed their preference for the Freedom Set II. The peritonitis rate for the observation period was one episode every 21 patient months. We conclude that the Freedom Set II provides safe, cost-effective dialysis and simplifies the CAPD procedure.

Consumer Behavior↗
PubMed1981

[Studies on the setting reaction of the zinc phosphate dental cement (3)--quantitative analysis for consumed zinc oxide through setting reaction of the cement (author's transl)].

Zinc oxide powder of zinc phosphate cement for dental use was mixed with various phosphoric acid for cement liquid contained Al3+ and not, and zinc oxide in each cement after setting was determined quantitatively Then, consumed zinc oxide through setting reaction was calculated. When zinc oxide powder was mixed with cement liquid contained Al3+, consumed zinc oxide through setting reaction was approximate half quantity of it mixed with liquid contained no Al3+. This result show that setting reaction of zinc phosphate dental cement is the interaction Al3+ and H2PO4- in cement liquid rather than simple neutralizing reaction, ZnO+H3PO4 or ZnO+H2PO4-.

Aluminum↗
PubMed1994

Goal setting and performance in sport and exercise settings: a synthesis and critique.

Although goal setting research in industrial and organizational settings has been proliferating rapidly over the past 20 yr, it is only recently that sport psychologists begun to systematically test its effects in sport and exercise settings. However, the recent empirical literature in sport and exercise examining the relationship between goals and performance has been equivocal. Thus, the purposes of the present review are fourfold: (a) briefly review the industrial/organizational literatures concerning the relationship between goals and task performance; (b) review the literature testing the relationship between goals and performance in sport and exercise settings; (c) discuss methodological and interpretive limitations including the impact of mediating variables; (d) offer future directions for research.

Attitude↗
PubMed2002

Urine testing and urinary tract infections in febrile infants seen in office settings: the Pediatric Research in Office Settings' Febrile Infant Study.

OBJECTIVE: To determine the predictors and results of urine testing of young febrile infants seen in office settings. DESIGN: Prospective cohort study. SETTING: Offices of 573 pediatric practitioners from 219 practices in the American Academy of Pediatrics Pediatric Research in Office Settings' research network. SUBJECTS: A total of 3066 infants 3 months or younger with temperatures of 38 degrees C or higher were evaluated and treated according to the judgment of their practitioners. MAIN OUTCOME MEASURES: Urine testing results, early and late urinary tract infections (UTIs), and UTIs with bacteremia. RESULTS: Fifty-four percent of the infants initially had urine tested, of whom 10% had a UTI. The height of the fever was associated with urine testing and a UTI among those tested (adjusted odds ratio per degree Celsius, 2.2 for both). Younger age, ill appearance, and lack of a fever source were associated with urine testing but not with a UTI, whereas lack of circumcision (adjusted odds ratio, 11.6), female sex (adjusted odds ratio, 5.4), and longer duration of fever (adjusted odds ratio, 1.8 for fever lasting > or = 24 hours) were not associated with urine testing but were associated with a UTI. Bacteremia accompanied the UTI in 10% of the patients, including 17% of those younger than 1 month. Among 807 infants not initially tested or treated with antibiotics, only 2 had a subsequent documented UTI; both did well. CONCLUSIONS: Practitioners order urine tests selectively, focusing on younger and more ill-appearing infants and on those without an apparent fever source. Such selective urine testing, with close follow-up, was associated with few late UTIs in this large study. Urine testing should focus particularly on uncircumcised boys, girls, the youngest and sickest infants, and those with persistent fever.

Adult↗
PubMed1991

Effects of changes in articulator settings on generated occlusal tracings. Part II: Immediate side shift, intercondylar distance, and rear and top wall settings.

An occlusal scribing device attached to a fully adjustable articulator was used to generate occlusal tracings. The tracings were analyzed to determine the effect changes in immediate side shift, intercondylar distance, and rear and top wall settings had on molar occlusal morphology. When ranked from greatest to least effect, a 0.2 mm change in the immediate side shift setting had the greatest effect on the occlusion, whereas a 5-degree change in the rear and top wall settings had the least effect.

Centric Relation↗
PubMed2000

Management of HIV-infected children in the home and institutional settings. Care of children and infections control in schools, day care, hospital settings, home, foster care, and adoption.

The likelihood of high-risk pediatric exposure to HIV infection, other than perinatal exposure, has been shown to be low in most cases, and HIV PEP should be considered on a case-by-case basis. Generic considerations in the management of children who have become HIV infected emphasizes the principles of inclusion, maintaining confidentiality of a child's HIV status, and notifying those who need to know about the HIV status to care properly for the child or adolescent. Although appropriate infection-control precautions are applicable for all children and for many pathogens, children especially HIV-infected children, exposed to such pathogens, must be managed in a timely fashion. In many cases, recommendations that are applicable in one setting are applicable in others. Some exceptions apply, including infection-control precautions in hospitals versus other settings. A few additional considerations have been made for special settings and activities, including adoption, foster care, athletics, summer camp, and other recreational activities.

Bites, Human↗
PubMed2000

Training radial basis function neural networks: effects of training set size and imbalanced training sets.

Obtaining training data for constructing artificial neural networks (ANNs) to identify microbiological taxa is not always easy. Often, only small data sets with different numbers of observations per taxon are available. Here, the effect of both size of the training data set and of an imbalanced number of training patterns for different taxa is investigated using radial basis function ANNs to identify up to 60 species of marine microalgae. The best networks trained to discriminate 20, 40 and 60 species respectively gave overall percentage correct identification of 92, 84 and 77%. From 100 to 200 patterns per species was sufficient in networks trained to discriminate 20, 40 or 60 species. For 40 and 60 species data sets an imbalance in the number of training patterns per species always affected training success, the greater the imbalance the greater the effect. However, this could be largely compensated for by adjusting the networks using a posteriori probabilities, estimated as network output values.

Neural Networks, Computer↗
PubMedDate not supplied

Transformation of a set of slices rotated on a common axis to a set of Z-slices: application to three-dimensional visualization of the in vivo human lens.

A technique that transforms a set of images acquired as a rotating frame about an axis (Z axis) into a set of images along the Z axis in presented. This technique is applied to the three-dimensional visualization of the in vivo human lens. A Scheimpfling slit camera acquired 60 optical images through the in vivo human lens. Between each image acquisition the plane containing the slit beam of light was sequentially rotated. This set of 60 images was transformed into a new stack of images on the Z axis. The transformed stack of Z images was visualized with volume rendering software.

Aged↗
PubMed1996

Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets.

We describe a novel approach to design a set of primers selective for large groups of genes. This method is based on the distribution frequency of all nucleotide combinations (octa- to decanucleotides), and the combined ability of primer pairs, based on these oligonucleotides, to detect genes. By analyzing 1000 human mRNAs, we found that a surprisingly small subset of octanucleotides is shared by a high proportion of human protein-coding region sense strands. By computer simulation of polymerase chain reactions, a set based on only 30 primers was able to detect approximately 75% of known (and presumably unknown) human protein-coding regions. To validate the method and provide experimental support for the feasibility of the more ambitious goal of targeting human protein-coding regions, we sought to apply the technique to a large protein family: G-protein coupled receptors (GPCRs). Our results indicate that there is sufficient low level homology among human coding regions to allow design of a limited set of primer pairs that can selectively target coding regions in general, as well as genomic subsets (e.g., GPCRs). The approach should be generally applicable to human coding regions, and thus provide an efficient method for analyzing much of the transcriptionally active human genome.

Animals↗