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Results for “Retrocochlear Diseases”

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At least 73 records · Page 4Linked to original sources
PubMed2003

[Phanerogenetic retrocochlear low frequency hearing loss].

OBJECTIVE: To study the pathogenisis of retrocochlear low frequency hearing loss. METHODS: Clinical and audiologic findings [auditory brainstem response (ABR), evoked otoacoustic emission (EOAE), et al] of 29 cases with retrocochlear low frequency hearing loss were studied. RESULTS: The head injury, acoustic neuroma, peripheral neurophathy, hereditary hear loss, multiple sclerosis and brainstem disease can cause retrocochlear low frequency hearing loss. The typical clinical manifestations of retrocochlear low frequency hearing loss were normal EOAE which cannot be suppressed by contralateral white noise, but with abnormal ABR as well as with no acoustic reflex and -SP/AP > 0.44. CONCLUSIONS: The results suggest that phanerogenetic retrocochlear low frequency hearing loss should be a syndrome rather than a disease called "auditory neuropathy". The main lesions of the disease are brainstem, cochlear nuclei and auditory nerve.

Adolescent↗
PubMed1978

Auditory brain stem responses in patients with acoustic neuromas.

In the continuing search for methods to diagnose acoustic neuromas at an early stage, we have applied the auditory brain stem response examination to 27 patients with surgically verified acoustic neuromas. It is confirmed that the main indicator of retrocochlear versus cochlear disease is the interaural latency difference of the Jewett5 wave, the IT5. Women exhibit significantly lower latency values to J5 than men, approximately 0.25 msec. Age also has some influence, so that the J5 latency tends to increase with age, but in this investigation the trend did not reach statistical significance. We were unable to find a correlation between tumour size and IT5. Even if the audiogram shows a considerable hearing impairment at 2 kHz this technique can be used without any correction factors, when the stimulus is a 2 kHz filtered tone-pip. In the presence of an acoustic neuroma there will often be adaptation of the response and it is preferable to arrange the mode of stimulus presentation so that this phenomenon eventually becomes prominent. One patient came out with a false-negative result. We believe this to have been due to our lack of experience at that time and that today we would have recognized the presence of a tumour. If this correction is accepted, the series contains no false-negatives. Regardless of this it can be concluded that for the time being, out of the functional audiological tests, the auditory brain stem response examination is the most reliable indicator for the presence of retrocochlear lesions.

Adolescent↗
PubMed1990

[Trimetazidine versus betahistine in vestibular vertigo. A double blind study].

The efficacy of trimetazidine (60 mg/day) in vertigo was compared with that of betahistine (24 mg/day) in a three-month double-blind study. Included in the study were only patients with peripheral vertigo associated or not with tinnitus or hearing loss, and excluded were those presenting with symptoms related to retrocochlear or central disease. Out of the 40 patients enrolled, 20 suffered from Meniere's disease; 4 patients either dropped out of the study or were non-compliant to therapy and could not be taken into account in the final analysis, which bore on 36 patients (18 treated by trimetazidine and 18 with betahistine). There were no dropouts in the Meniere's disease subgroup (10 receiving trimetazidine and 10 receiving betahistine). Results revealed a better response to therapy with trimetazidine in patients suffering from vertigo, and this was particularly true of the Meniere's disease subgroup (p less than 0.025). Moreover, in the latter subgroup, all patients treated with trimetazidine fully recovered from vertigo spells, while these disappeared completely only in 4 of the patients administered betahistine (p less than 0.005). There was no noticeable difference between the two treatment groups as regards the evolution of the accompanying symptoms and the audiometric or vestibular test results. Clinical acceptability was equally excellent in both treatment groups. Overall, this study allowed to confirm the therapeutical efficacy of trimetazidine in the management of vertigo, as well as establishing the clinical advantage of trimetazidine over betahistine in patients suffering from Meniere's disease.

Adult↗
PubMed1996

[Clinical application of enzyme linked immunosorbent assay in testing antibodies against cochlear tissues and nerve tissues].

Fifty-two patients with idiopathic sensorineural hearing loss and 20 controls were examined by enzyme linked immunosorbent assay (ELISA) with cow cochlear antigen (CCAg) and cow cochlear nerve antigen (CCNAg). The antibody level against CCAg was 0.3811 +/- 0.743 in the control group and 0.9241 +/- 0.2408 in the experimental group (OD, x +/- 2s, P < 0.01). Compared with the x +/- 2s antibody level of the control group, the antibody level of 24 of 52 (46%) patients of the experimental group was positive. The antibody level against CCNAg was 0.2254 +/- 0.382 in the control group and 0.2331 +/- 0.656 in the experimental group (P > 0.05). Compared with the x +/- 2s antibody level of the control group, the antibody level of 6 of 52 patients (11.5%) of the experimental group was elevated. It is suggested that ELISA method can be used as quantitatively in the diagnosis of autoimmune inner ear diseases. Moreover, the serum antibodies against CCNAg detected in this experiment suggest that some of autoimmune inner diseases might be retrocochlear.

Adolescent↗
PubMed1986

Noninvasive recordings of cochlear evoked potentials in Meniere's disease.

Noninvasive meatal electrocochleography simultaneously recorded with brain stem auditory evoked potentials were performed on 24 adult patients with unilateral Meniere's disease. Data from the affected ear were compared with those of the nonaffected ear and with those of ten healthy normally hearing adults. The most striking finding was the significant deviation from the norm of the nonaffected ears' action potential duration. The combination of simultaneously recorded surface meatal electrocochleography and brain stem auditory evoked potentials complement the diagnostic battery of Meniere's disease in ruling out retrocochlear involvement, indicating cochlear involvement of the affected ear, and revealing subclinical changes in the contralateral ears.

Adult↗