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PubMed1995

The portrait of Robert Kerr (d. 1824).

The importance of Dr. Robert Kerr in Canadian history is not large, but he played a significant role in the early years of what is now Ontario. Though his Canadian years were spent largely in active military service and, after his discharge, at Kingston and in the Niagara peninsula, nevertheless, in the compact and sparse settlements and posts of the times he was widely known and influential. Moreover, Kerr had a significant connection with one of the founders of Toronto. As this discussion will show, a fateful conjunction of art and medicine lies behind a portrait of Robert Kerr.

Canada↗
PubMed2000

Portraits of people with mental disorders in English Canadian history.

This paper will discuss the ways in which academic and non-academic historians in English Canada have portrayed people with mental disorders. The phrase "people with mental disorders" refers to individuals who were considered mentally disturbed by their contemporaries and/or by historians. This includes discussion of people who were in mental institutions as well as people who were never confined. Citations are from both detailed studies and fleeting references on this topic. Areas considered include portraits of people with mental disorders as being anonymous, passive, active, named, dangerous, untrustworthy; they also include the problem of stereotypes in the writing of this history.

Canada↗
PubMedDate not supplied

Further medals with the portrait of Gregor Mendel.

Four new medals with Mendel's portrait were issued after 1985. Two of them were issued by the Mendelianum in Brno, one comes from the Federal Republic of Germany, and one from Spain.

Genetics↗
PubMed2005

[Portrait of an alien enemy].

Official documents and photographs are forms of alienation yet they carry imprints of the inner life of their subjects. An identity paper and photograph of the eighteen-year-old Anna Freud (August 1914) serves as the basis for an investigation of various aspects of her identity at the time - firstly her position in England as an "alien enemy"; secondly her emotional and sexual predicament, brought to light primarily through her father's response to Ernest Jones' supposed advances; and finally her own sense of self as deduced from the expression in the portrait, backed up by the evidence of her poetry.

Austria↗
PubMed1977

A medical history of the Spanish Habsburgs. As traced in portraits.

From the 13th century untill well into the 20th, the Habsburgs were one of the great powers in Europe--for most of this time, the leading dynasty. To preserve the purity of the line, marriages between uncles and nieces, aunts and nephews, and cousins were commonplace. As a consequence, genetic complexities developed, and the famous prognathic "Habsburg jaw," among other noticeable traits, was passed down to succeeding generations. Never has a dynasty been so well documented in paintings, and their portraits provide an unusually complete series of medical illustrations that show the facial characteristics that marked the family in general. The observations are confirmed and extended by information from modern medical sources as well as from the medical records that date to the Habsburgs' own times.

Austria↗
PubMed2005

The "portrait" of hereditary breast cancer.

Five to ten per cent of all breast carcinomas are of hereditary origin. Many of them have been associated to mutations in the BRCA1 and BRCA2 susceptibility genes. No "BRCA3" gene has been found to account for the non-BRCA1/BRCA2 breast cancer (BRCAx) families, and BRCAx tumors are increasingly believed to originate from multiple distinct genetic events. Phenotype studies have questioned the existence of specific "portraits" among hereditary breast carcinomas (HBC). They have shown that most BRCA1 tumors have a "basal (epithelial)-like" aspect, while BRCA2 and BRCAx HBC are more heterogeneous. HBC have also been submitted to genetic analyses, notably with the objective of resolving the heterogeneity of BRCAx lesions. The present review aims to summarize recent data on BRCA1, BRCA2, and BRCAx HBC, including hypotheses on the origin of BRCA1 tumors and their paradoxical relations to estrogen-sensitivity.

Breast Neoplasms↗
PubMed2005

Care of the self and patient participation in genetic discourse: a Foucauldian reading of the surgeon general's "my family health portrait" program.

Critics of genetic discourse are concerned that deterministic and discriminatory views of genetics are increasingly becoming adopted. These views argue that current genetic discourse becomes a source of power whereby powerful institutions harm people with so-called "bad" genes. This essay argues that current analyses of the power of genetics discourse are grounded in an improper reading that disempowers patients. Deploying Michel Foucault's concept "care of the self," this essay claims that genetics discourse is better understood as a way that patients take on power through rhetoric rather than a force that has power over patients. Through a close reading of the "My Family Health Portrait" program, this paper argues that patients experience a process of "subjection" wherein they become agents of and objects of genetics discourse both. This alternative mode of analyzing the power of genetics discourse has implications for our collective understanding of the operations of the care of the self and the uses of genetic information that we propose.

Awareness↗
PubMed2006

Gabor filters and phase portraits for the detection of architectural distortion in mammograms.

Architectural distortion is a subtle abnormality in mammograms, and a source of overlooking errors by radiologists. Computer-aided diagnosis (CAD) techniques can improve the performance of radiologists in detecting masses and calcifications; however, most CAD systems have not been designed to detect architectural distortion. We present a new method to detect and localise architectural distortion by analysing the oriented texture in mammograms. A bank of Gabor filters is used to obtain the orientation field of the given mammogram. The curvilinear structures (CLS) of interest (spicules and fibrous tissue) are separated from confounding structures (pectoral muscle edge, parenchymal tissue edges, breast boundary, and noise). The selected core CLS pixels and the orientation field are filtered and downsampled, to reduce noise and also to reduce the computational effort required by the subsequent methods. The downsampled orientation field is analysed to produce three phase portrait maps: node, saddle, and spiral. The node map is further analysed in order to detect the sites of architectural distortion. The method was tested with 19 mammograms containing architectural distortion. In a preliminary experiment, a sensitivity of 84% was obtained at 7.8 false positives per image.

Breast Neoplasms↗
PubMed2004

Magical food and health beliefs: a portrait of believers and functions of the beliefs.

The aims of the present two studies were to delineate a portrait of people who are attracted to magical beliefs about food and health and to study the self-reported functions for the beliefs. Participants were Finnish men and women ranging in age from 15 to 66 years (N=3261 in study 1 and N=189 in study 2), and they filled in either an Internet-based or a paper questionnaire. The believers were more often women than men, vegetarians than omnivores, and they relied more on alternative medicine, thought in a more intuitive way, and demonstrated more eating-disordered thinking than the nonbelievers. Additionally, the believers had experienced slightly more negative life events than the nonbelievers in study 1 but contrary to our hypothesis, they did not differ in their desire for control. The believers reported value-expressive function as the most important one served by their beliefs, followed by the control and utilitarian functions. The emotional, intuitive nature of food beliefs and their connection to values and identity are discussed.

Adolescent↗
PubMed2004

Antisense protein kinase A RI alpha-induced tumor reversion: portrait of a microarray.

Antisense oligonucleotides can selectively block disease-causing genes due to the specificity of the Watson-Crick base-pairing mechanism of action. A genome-wide view of antisense technology is illustrated via protein kinase A RI alpha antisense. Complementary DNA microarray analysis of the RI alpha antisense-induced expression profile shows the up- and down-regulation of clusters of coordinately expressed genes that define the molecular portrait of a reverted tumor cell phenotype. This global view broadens the horizons of antisense technology; it advances the promise of antisense beyond a single target gene to the whole cell and the whole organism. Along with recent rapid advances in oligonucleotide technologies-including new chemical and biological understanding of more sophisticated nucleic acid drugs-oligonucleotide-based gene silencing offers not only an exquisitely specific genetic tool for exploring basic science but also an exciting possibility for treating and preventing cancer and other diseases.

Animals↗
PubMed2004

A portrait of locomotor behaviour in Drosophila determined by a video-tracking paradigm.

This paper presents a detailed characterisation of locomotor behaviour of a single Drosophila fly freely walking in a small square arena. Locomotor activity is monitored by a video-tracking paradigm. Multiple parameters are extracted to construct the portrait of locomotor activity: the total distance moved, the number of episodes of activity and inactivity, the duration of activity, and the mean walking speed. To initiate a quantification of the fly's spatial walking movements, the number of passages in a virtual centre zone has also been determined. Moreover, to reveal the trajectory, as an index of fly's navigation ability, the turning angle, the angular velocity and the meander have been measured. Finally, we show that the number of episodes of inactivity as function of their duration follows a power law, while its counterpart, the episodes of activity does not, suggesting that the overall pattern of locomotor activity adheres to a fractal-like structure. Remarkably, the majority of these parameters are sexually dimorphic. This fine description of locomotor activity represents a new tool which will facilitate the study of the role of the different brain structures in the organisation of locomotor activity and the localisation of the fly's central pattern generator for locomotion and its motivational control.

Animals↗
PubMed2004

Portraits of some founders of the German Society of Legal Medicine.

In the preceding paper by W. Krauland the foundation of the German Society of Legal Medicine, which took place at the 76th meeting of the German Naturalists and Physicians in Breslau, 1904, was described in detail. Carl Ipsen, Julius Kratter, Adolf Lesser, Georg Puppe, Emil Ungar and Fritz Strassmann were chosen as the preliminary board of the Society. They were respected scientists in their field, working at different universities in Germany and Austria. Life and scientific work of these founders of the German Society of Legal Medicine shall be described in short portraits.

Europe↗
PubMed2006

Victimization and health among indigent young women in the transition to adulthood: a portrait of need.

PURPOSE: To understand victimization by physical and sexual violence and its association with physical and behavioral health in a probability sample of sheltered homeless and low-income-housed young women in the transition to adulthood (ages 18 through 25). METHODS: Participants were 224 women ages 18 through 25 who were selected by means of a stratified random sample from 51 temporary shelter facilities (N = 94) and 66 Section 8 private project-based Housing and Urban Development (HUD)-subsidized apartment buildings (N = 130) in Los Angeles County, California. Women completed structured interviews. RESULTS: Forty-one percent of the sample had been physically or sexually victimized as children and 51% had been victimized since turning 18. Young women who experienced victimization were significantly (p < .05) more likely than non-victimized women to have a sexually-transmitted disease (STD) other than HIV/AIDS or Hepatitis B or C, vaginal discharge or bleeding and pelvic pain in the past 6 months, and past-12 month screening diagnoses of drug abuse/dependence and depression. Victimized women were also significantly more likely to use alcohol to intoxication and drugs, including crack and amphetamines, during the past 6 months, and to have experienced psychological distress and poor self-esteem. CONCLUSIONS: This study highlights striking rates of victimization and its association with physical and behavioral health problems among indigent young women during the period of emerging adulthood. This portrait of need communicates an urgency to develop multifaceted programs for such women to help them successfully navigate the transition to adulthood and realize their full potential as adults.

Adolescent↗
PubMed2006

Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells.

An understanding of the regulatory mechanisms responsible for pluripotency in embryonic stem cells (ESCs) is critical for realizing their potential in medicine and science. Significant similarities exist among ESCs harvested from different species, yet major differences have also been observed. Here, by cross-species analysis of a large set of functional categories and all transcription factors and growth factors, we reveal conserved and divergent functional landscapes underlining fundamental and species-specific mechanisms that regulate ESC development. Global transcriptional trends derived from all expressed genes, instead of differentially expressed genes alone, were examined, allowing for a higher discriminating power in the functional portrait. We demonstrate that cross-species correlation of transcriptional changes that occur upon ESC differentiation is a powerful predictor of ESC-important biological pathways and functional cores within a pathway. Hundreds of functional modules, as defined by Gene Ontology, were associated with conserved expression patterns but bear no overt relationship to ESC development, suggestive of new mechanisms critical to ESC pluripotency. Yet other functional modules were not conserved; instead, they were significantly up-regulated in ESCs of either species, suggestive of species-specific regulation. The comparisons of ESCs across species and between human ESCs and embryonal carcinoma stem cells suggest that while pluripotency as an essential function in multicellular organisms is conserved throughout evolution, mechanisms primed for differentiation are less conserved and contribute substantially to the differences among stem cells derived from different tissues or species. Our findings establish a basis for defining the "stemness" properties of ESCs from the perspective of functional conservation and variation. The data and analyses resulting from this study provide a framework for new hypotheses and research directions and a public resource for functional genomics of ESCs.

Animals↗
PubMed1996

Serial self-portrait: a technique to monitor changes in self-concept.

Recovery work for adult survivors of childhood sexual abuse can be difficult because survivors have endured traumas and events that marred and disrupted the development of their sense of self. Serial portrait drawing, an expressive technique, can be useful for clients and therapists to monitor changes and progress. These changes can lead to increased awareness, insight development, and motivation for continuing the often grueling work of recovery. Recognizing and exploring self-concept issues are necessary for healing to occur.

Adult↗
PubMed1990

Standardized portrait photography for dental patients.

Photography is becoming an increasingly important tool in the dental profession. But documentation of orthodontic or orthognathic treatment with pretreatment and posttreatment photographs can be misleading if features on one or both photographs are distorted. The dental photographer must be constantly aware of the importance of standardizing photographic variables when documentation of change is important. Although total reproducibility may not be practical, the photographer can establish a reasonably standardized approach to photographing patients. In this article the authors present the major considerations for frontal and profile facial photographs. Lens selection, camera position, subject distance, and position are all variables to be understood and controlled if accurate reproduction is desired. Numerous frontal and lateral photographs were made with head position, camera position, jaw position, and lens focal length changed to allow assessment of their contribution to the final picture. Using easily recognized facial landmarks, dental photographers can standardize frontal and lateral portraits for more consistent comparison.

Dental Records↗
PubMed2000

Molecular portraits of human breast tumours.

Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce information from the cell's identity to its environmental status, thereby controlling the level of expression of every gene in the genome. Here we have characterized variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals, using complementary DNA microarrays representing 8,102 human genes. These patterns provided a distinctive molecular portrait of each tumour. Twenty of the tumours were sampled twice, before and after a 16-week course of doxorubicin chemotherapy, and two tumours were paired with a lymph node metastasis from the same patient. Gene expression patterns in two tumour samples from the same individual were almost always more similar to each other than either was to any other sample. Sets of co-expressed genes were identified for which variation in messenger RNA levels could be related to specific features of physiological variation. The tumours could be classified into subtypes distinguished by pervasive differences in their gene expression patterns.

Breast Neoplasms↗
PubMed2002

Molecular portraits and the family tree of cancer.

The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide expression patterns in complex biological systems. Although the potential of microarrays is yet to be fully realized, these tools have shown great promise in deciphering complex diseases such as cancer. The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns.

DNA, Neoplasm↗