Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Polygonum”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4Linked to original sources
PubMed2003

Micropropagation of Polygonum multiflorum THUNB and quantitative analysis of the anthraquinones emodin and physcion formed in in vitro propagated shoots and plants.

An efficient and rapid protocol for in vitro induction and complete plant regeneration of Polygonum multiflorum THUNB has been developed. Nodal explants were grown in vitro on Murashige and Skoog's (MS) basal medium containing different concentrations of alpha-naphthaleneacetic acid (NAA) and benzyladenine (BA). The nodal explants (97%) produced multiple shoots (4.7 shoots per explant) on MS basal medium supplemented with 0.2 mg/l NAA and 2.0 mg/l BA after 6 weeks of culture. Eighty-eight percent to 100% of the shoots (1.0 cm in length) elongated (about 3.02-4.28 cm) and rooted on MS basal medium supplemented with NAA or indole-3-butyric acid (IBA). All the rooted shoots were transferred to pots containing autoclaved soil, vermiculite, and peat moss (1 : 1 : 1). The plantlets were successfully acclimatized under greenhouse conditions with high humidity before transferring to the field. The anthraquinone contents were determined using HPLC. Analysis revealed that the contents of the major medicinal compounds-emodin and physcion in the 6 weeks old in vitro grown shoots and three month old in vitro propagated plants grown in greenhouse were higher than those of the marketed crude drug (processed underground or stem parts of P. multiflorum).

Anthraquinones↗
PubMed2002

Constituents from Polygonum cuspidatum.

Two lignan sulfates, a stilbene derivative and a phenol sulfate, together with 10 known compounds, were isolated from an aqueous extract of the root of Polygonum cuspidatum. The new compounds were elucidated based on chemical evidence and spectroscopic techniques including two-dimensional NMR methods. They exhibited no inhibition of lipid peroxidation and no cytotoxic and DNA cleavage activities.

Antineoplastic Agents, Phytogenic↗
PubMedDate not supplied

Antimicrobial substances from rhizomes of the giant knotweed Polygonum sachalinense against the fish pathogen Photobacterium damselae subsp. piscicida.

The antimicrobial compounds against the fish pathogen Photobacterium damselae subsp. piscicida were isolated from Polygonum sachalinense rhizomes. The structures of the antimicrobial compounds 1 and 2 were determined by 1H and 13C NMR, 2D-NMR (COSY, HSQC, HMBC and ROESY) and FAB-MS to be phenylpropanoid glycosides, vanicoside A and B, respectively. Both compounds have feruloyl and p-coumaroyl groups bonded to a sucrose moiety in their structures. Vanicoside A also has an acetyl group in the sucrose moiety. The MIC values for vanicoside A and B against Ph. damselae subsp. piscicida DPp-1 were 32 and 64 microg/ml, respectively. The antimicrobial activities of these vanicosides were modest, in contrast to higher activities (MICs at < 4 microg/ml) of antibiotics, florphenicol, ampicillin and amoxicillin, which have been generally used for treating pasteurellosis. The activities of the vanicosides, however, were higher than those (MICs at 256 microg/ml) of ferulic acid and p-coumaric acid. It was suggested that the structure of phenylpropanoids esterified with sucrose was essential for higher antimicrobial activity of vanicosides and also acetylation of sucrose might affect the activity against the bacterium.

Animals↗
PubMedDate not supplied

Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans.

AIM OF STUDY: Search for plant compounds possessing anti-leukemic properties. RESULTS: We have shown that 5-hydroxy-7-methoxy flavanone (pinostrobin) isolated from Polygonum lapathifolium ssp. nodosum quickly penetrates through cytoplasm to the cellular nucleus of the cultured cells, and gives intensive apoptotic response in stimulating leukemic cells in vitro. The number of apoptotic cells increased with the concentration of pinostrobin: 10 nM - 25% and 60%; 100 nM - 45% and 76%; 1 microm - 70% and 88% for Jurkat and HL60 cell lines, respectively CONCLUSION: Pinostrobin may be considered as a good candidate for a leukemia chemopreventic agent.

Antineoplastic Agents↗
PubMed2001

Polygodial, the fungitoxic component from the Brazilian medicinal plant Polygonum punctatum.

Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay with the fungus Cladosporium sphaerospermum. The bioassay-guided chemical fractionation of this extract afforded the sesquiterpene dialdehyde polygodial as the active constituent. The presence of this compound with antibiotic, anti-inflammatory and anti-hyperalgesic properties in "erva-de-bicho" may account for the effects attributed by folk medicine to this plant species.

Antifungal Agents↗
PubMed2006

An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin.

Over the last decades, the incidence of ultraviolet B (UVB)-related skin problems has been increasing. Damages induced by UVB radiation are related to mutations that occur as a result of direct DNA damage and/or the production of reactive oxygen species. We investigated the anti-oxidant effects of a Polygonum multiflorum thumb extract against skin damage induced by UVB irradiation. Female SKH-1 hairless mice were divided into three groups: control (N = 7), distilled water- (N = 10), and P. multiflorum extract-treated (PM, N = 10) groups. The PM (10 g) was extracted with 100 mL distilled water, cryo-dried and 9.8 g was obtained. The animals received a topical application of 500 microL distilled water or PM extract (1, 2, 4, 8, and 16%, w/v, dissolved in distilled water) for 30 min after UVB irradiation (wavelength 280-320 nm, 300 mJ/cm(2); 3 min) of the dorsal kin for 14 days, and skin immunohistochemistry and Cu,Zn-superoxide dismutase (SOD1) activity were determined. SOD1 immunoreactivity, its protein levels and activities in the skin were significantly reduced by 70% in the distilled water-treated group after UVB irradiation compared to control. However, in the PM extract-treated groups, SOD1 immunoreactivity and its protein and activity levels increased in a dose-dependent manner (1-16%, w/v, PM extract) compared to the distilled water-treated group. SOD1 protein levels and activities in the groups treated with 8 and 16%, w/v, PM extract recovered to 80-90% of the control group levels after UVB. These results suggest that PM extract strongly inhibits the destruction of SOD1 by UV radiation and probably contains anti-skin photoaging agents.

Administration, Topical↗
PubMed2002

Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology.

Four groups of 1-mo-old male senescence-accelerated mice (SAMP8) were fed Polygonum multiflorum Thunb. (PM) extract for 18 wk to determine the effect of PM on memory ability and histopathological changes in mice. The baseline diet consisted of a casein diet group, and the three test diets were supplemented with 50% ethanol, 95% ethanol, or water extracts of PM. It was found that the mice fed with PM extracts had better active shuttle avoidance response, fewer vacuole numbers, less lipofuscin in the hippocampus, and lower MDA concentrations in the brain. Our data showed that the ethanol PM extract groups (both 50% and 95% groups) had lower lipofuscin percentages and MDA concentrations, and higher total thiol concentrations than the water PM extract group. The 50% ethanol PM extract group showed significantly lower total cholesterol and triglyceride values than the other groups, but the HDL cholesterol level was the same. These results suggest that dietary supplementation with either ethanol or water extracts can reduce brain pathological changes and promote learning and memory ability. The performance of PM extracts depended on the extraction method, with ethanol extraction tending to obtain better results.

Age Factors↗
PubMedDate not supplied

Rediscovery of Alnicola cholea (Cortinariaceae): taxonomic revision and description of its mycorrhiza with Polygonum viviparum (Polygonaceae).

Alnicola cholea, a little-known species so far reported only from the two original localities in the French Alps, is redefined here based on revision of herbarium materials and studies of recent field collections. A detailed morphological and anatomical description of fruit bodies of Alnicola cholea, including a discussion on its taxonomic status and distribution data is provided. Due to the unique combination of characters of Alnicola cholea within the genus, a new monospecific section is introduced for this species: Alnicola sect. Cholea, sect. nov. Mycorrhizal symbiosis of A. cholea with an arcticalpine plant Polygonum viviparum was observed in the Tatra Mountains (Poland). A description of these mycorrhizae is given, providing first detailed data on an identified herbaceous plant mycorrhiza.

Agaricales↗
PubMedDate not supplied

Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L.

The flavonoid aglycones were studied in the herbs of the following taxons of the Polygonum L. genus: P. hydropiper L, P. bistorta L., P. aviculare L., P. persicaria L., P. lapathifolium ssp. tomentosum (Schrank) Dans, P. lapathifolium ssp. nodosum (Pers.) Dans, P. amphibium L., P. mite Schrank, P. conolvulus L. (Bilderdykia convolvulus L.) by means of the RP-HPLC method. The content of taxifolin, quercetin, quercetin-3-methyl ether, kaempferol, myritcetin, luteolin, isorhamnetin and rhamnetin were determined.

Flavonoids↗
PubMed2001

[Histochemical localization and quantitative analysis of anthraquinones in rhizome of Polygonum cuspidatum].

Anthraquinones were histochemically locayed and content were determined in rhizome of Polygonum cuspidatum. Anthraquinones were located in the parenchyma cells of rhizome, including vascular ray, part of parenchyma cell in phloem, cortex and pith. Phelloderm and ray initial also accumulated a small amount anthraquinones. The content of total anthraquinones was highest in pith that consisted of parenchyma cells, and higher in bark (including phloem, cortex and periderm) than in xylem. The content of total anthraquinones was highest in three-year-old rhizome, and higher in biennial rhizome than in annual rhizome. It suggests that correlation exist between accumulation of anthraquinones and the growth age of rhizome.

Anthraquinones↗
PubMed2000

[Quantitative analysis of 4(3)-quinazolinedione in 4 "daqingye", leave of Isatis indigotica, Baphicacanthus cusia, Polygonum tinctorium and Clerodendron cyrtophyllum].

Using 4(3)-quinazolinedione, the active constituent of "Daqingye", as the quality control criteria, 4 samples of the herbal drug collected from Isatis indigotica, Baphicacanthus cusia, Polygonum tinctorium and Clerodendron cyrtophyllum were comparetively analyzed by RP-HPLC. The results showed that the average 4(3)-quinazolinedione contents (microgram/g) were 30.7, 7.2, 4.4 and 27.5 respectively. This method was proved to be quick, simple and reproducible, and provided a reliable basis for the quality control and evaluation of Chinese Traditional Drug "Daqingye".

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2002

[Study on the determination of manganese in the Polygonum multiflorum by flame atomic absorption spectrometry].

This paper presents a method for the determination of manganese in the organism of the Chinese herbal medicine of the Polygonum multiflorum. Manganese was complexes, extracted and determined by FAAS. The opimum condition of experiment was studied. The accuracy and the detection limit were 7.6 and 8.4 ng.mL-1 respectively. The Mn was determined in range of 0.00-2.00 micrograms.mL-1. The relative standard deviation was 1.77%.

Drugs, Chinese Herbal↗
PubMed2003

[Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats].

OBJECTIVE: To observe the number and morphological changes of cholinergic neurofibers in rats under the destruction of kainic acid, and to investigate the protective effect and the mechanism of polygonum multiflorum thunb (PMT) on acetyl-chorine esterase (AChE) neurofibers. METHODS: Excitative neurotoxin kainic acid was injected into the basal forebrain, Meynert neucleus, medial septal neucleus and the Broca neucleus to establish the destruction model. Then the destructive experimental group was fed with PMT, and the histochemical method was used to display the changes of AChE fibers, the protection and activation of PMT. RESULTS: The number of projecting AChE fibers to the cortex and the hippocampus in PMT group was larger than that in the control group, and no morphological destruction was seen in the experimental group (P < 0.01). CONCLUSION: PMT has a protective effect on AchE projecting fibers in rats.

Alzheimer Disease↗
PubMed1999

Antimutagenic property of an herbal medicine, Polygonum multiftorum Thunb. detected by the Tradescantia micronucleus assay.

The root extracts of a Chinese herb, Polygonum multiflorum Thunb., have been used for centuries as an internal medicine to improve liver and kidney functions. In this study, we evaluated the antimutagenic property of this drug with the Tradescantia micronucleus (Trad-MCN) assay. The Trad-MCN bioassay is a well-established test for chromosome damage induced by physical or chemical agents in terms of micronuclei (MCN) frequency. Inflorescences of the Tradescantia plant cuttings were first exposed to 0.35 Gy soft X-rays (80 kV, 5 mA, 1 mm Al filter, dose rate around 0.50 Gy/min), followed by drug treatments at 1, 3, and 6% concentrations of the aqueous solution for a total recovery period of 24 hours. The positive (X-rays), negative (nutrient solution), and drug control (3% drug solution) groups were maintained in each of the three series of repeated experiments. Flower buds of the treated and control groups were fixed in aceto-alcohol (1:3 ratio) in preparation for slides to score MCN frequencies in the early tetrads of the meiotic pollen mother cells. The mean MCN frequencies (MCN/100 tetrads +/- SE) of the positive control (irradiated) was 26.68 +/- 2.49; the negative control was 2.93 +/- 0.50; the PM solution control was 2.06 +/- 0.39, and the 0.35 Gy X-ray plus 6% PM drug treated was 18.76 +/- 1.69. A 45% reduction in chromosome damage was observed. Antimutagenic effects were relatively decreased at lower concentrations of PM. This antimutagenic effect could be attributed to the antioxidant action of PM, enhancement of DNA repair, or the radical elimination from the irradiated plant cells.

Antimutagenic Agents↗
PubMed2004

[Studies on chemical constituents from Polygonum macrophyllum].

OBJECTIVE: To study the chemical structures from Polygonum macrophyllum D. Don. METHODS: To isolate the constituents by reverse phase chromatography and characterize their structures by the analysis of chemical property and spectral data. RESULT: Six compounds were isolated from the 70% acetone extract from the complete herb of P. macrophyllum. Their structures were elucidated as (-)-epicatechin-5-O-beta-D-glucopyranoside (I), (+)-catechin-7-O-beta-D-glucopyranoside (II), 1-(3-O-beta-D-glucopyranosyl 4,5-dihydroxy-phenyl)-ethanone (III) (-)-epicatechin (IV), chlorogenic acid (V) and gallic acid (VI). CONCLUSION: Compounds I-VI were isolated from the plant for the first time.

Catechin↗
PubMed2005

[Studies on chemical constituents in herb of Polygonum orientale].

OBJECTIVE: To study the chemical constituents of the essential substance from Polygonum oriental. METHOD: Compounds were isolated with silica gel and polyamide chromatography and their structures were determined by spectral analysis and chemical evidence. RESULT: Six compounds were obtained and identified as myricitrin, luteolin, gallic acid, catechin, protocatechuic acid, p-hydroxycinnamic acid. CONCLUSION: Six compounds were isolated from P. oriental for the first time.

Flavonoids↗
PubMed2005

[Progress of study on brain protective effect and mechanism of Polygonum multiflorum].

This paper reviews the brain protective effect and mechanism of Polygonum multiflorum (PM), its extracts and active component, tetrahydroxystilbene-glucoside (2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside) published in recent decade. They have major effects as calcium channel antagonists, antioxidant, cholinomimetic drugs and cholinesterase inhibitors, as well as actions in regulating cell apoptosis and prolonging the ageing. The brain protective mechanism of PM is multi-target, multi-link and multi-way. Therefore, PM has great applicative value in prevention and treatment of senile neuropathies, such as Alzheimer's disease, Parkinson's disease and vascular dementia, etc.

Animals↗