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PubMedDate not supplied

In vitro elution of gentamicin from Plaster of Paris beads.

OBJECTIVE: To determine the in vitro elution characteristics of gentamicin from Plaster of Paris-gentamicin (POP-gent) beads. STUDY DESIGN: In vitro, controlled, experimental study. METHODS: The POP-gent beads were made using a bead mold from 20 g calcium sulfate hemihydrate, 5 mL (500 mg) gentamicin solution, and 3 mL of phosphate buffered saline (PBS). Control beads were made similarly, using 30 g of dried powder and 8 mL of PBS. Beads were left in the mold overnight, gas-sterilized with ethylene oxide, and stored at room temperature for 5 months before testing. Bead chains were placed in sterile tubes containing porcine serum, and tubes were placed in a 37 degrees C incubator on a rocker. Serum was removed at intervals over 14 days and the concentration of gentamicin determined by fluorescent polarization immunoassay. Serum antibacterial activity was determined against an equine origin Escherichia coli. RESULTS: POP-gent beads released gentamicin for the 14-day sampling period. Eighty percent of the gentamicin incorporated in the beads was released over the first 48 hours. Eluent from POP-gent beads inhibited the growth of E coli at all time periods. No gentamicin was eluted from control beads and control eluent did not inhibit growth of E coli. CONCLUSIONS: In this experimental model, POP-gent beads released bactericidal drug for 14 days. Eighty percent of the gentamicin incorporated into the beads was released during the first 48 hours. The drug retains its bactericidal activity after ethylene oxide sterilization and storage at room temperature for up to 5 months. CLINICAL RELEVANCE: Pop-gent beads may be a useful repository device to deliver gentamicin locally in tissues.

Animals↗
PubMed1995

Effect of dentin preparation and acid etching on the sealing ability of glass ionomer and composite resin when used to repair furcation perforations over plaster of Paris barriers.

Access openings and furcation perforations were prepared in 60 human extracted teeth and randomly divided into four equal groups. Plaster of Paris barriers were created in all perforations. The defects were obturated using either glass ionomer or composite resin with or without acid etching of the dentin. The pulp chambers and access openings were filled with composite resin. After immersion in 2% methylene blue solution for 2 weeks, the teeth were sectioned longitudinally and dye penetration was measured under a stereomicroscope using the NIH Image 1.47 Macintosh program. The results indicated that light-cured glass ionomer provided a significantly better seal than did the light-cured composite resin with or without dentin preparation and acid etching. The glass ionomer allowed significantly less dye penetration when used on etched dentin than it did on nonetched dentin.

Acid Etching, Dental↗
PubMed1990

[Treatment of bone infection by plaster of Paris pellets impregnated with antibiotics].

In two prospective clinical trials, the authors treated 83 chronic osteomyelitis from various origins by sequestrectomy completed with insertion of Plaster of Paris pellets impregnated with antibiotics. After a review of the experimental and clinical reports on the subjects, the authors give their results: 61.5% of healings and 38.5% of failures. Because of the small number of cases, it was not possible to find out an explanation for this fair results. However wide extension of the lesions, which is frequent in chronic haematogenous osteomyelitis, seems to be a contraindication to the technics. The authors conclude to the necessity of carrying up new experiments with new antibiotics and large series of patients in order to point out the righted indications of the method.

Adolescent↗
PubMed1993

Diffusion of fibroblast growth factor from a plaster of Paris carrier.

Fibroblast growth factor (FGF) is a polypeptide that has been shown to have a stimulatory effect on osseous tissues in vitro. This study characterized the release of FGF from plaster of Paris (PLP) and measured the dissolution of PLP in various solutions with the aim of developing a reliable carrier system for the release of FGF in vivo. The study consisted of five experiments: (I) FGF diffusion from PLP pellets, (II) FGF diffusion from PLP discs, (III) PLP dissolution in saline, (IV) PLP dissolution in serum, and (V) FGF adsorption by commercially pure titanium. FGF was observed to be released at a rate directly proportional to the rate of dissolution of the PLP carrier, suggesting that either the FGF binds to the PLP; or, alternatively, the FGF may be entrapped by the PLP. Dissolution rate, and thus release rate, could be varied by varying the mass of the carrier. Greater diffusion of FGF was observed in larger, more slowly dissolving PLP carriers. Dissolution of PLP was observed to be slower in serum than in saline, apparently due to stabilization by factors in the serum but not due to a concentration gradient effect. Titanium coupons did not adsorb significant amounts of FGF. These results indicate that PLP, which has been shown in the past neither to aggravate inflammatory response nor to interfere with bone ingrowth, may serve as delivery vehicle for FGF to osseous tissues in vivo.

Adsorption↗
PubMed2002

Evaluation of fiberglass versus plaster of Paris for immobilization of fractures of the arm and leg.

We conducted a prospective randomized study comparing the costs, comfort, and effects on activities of daily living of fractures managed in plaster of Paris (POP) vs. fiberglass (FG) for at least 4 weeks. A total of 183 patients with short arm and short leg casts were evaluated. Twenty-seven patients were excluded, leaving 156 patients in the study. The average cost per fracture immobilized in a short arm cast was $12.90 for POP and $15.45 for FG. For short leg casts, the average cost of immobilization was $49.06 for POP and $47.85 for FG. FG had a significantly lower breakdown rate in short leg casts (17% vs. 66%) but not in short arm casts. In 21 measures of activities of daily living and comfort, FG short arm casts were significantly better than POP in only the weight of the cast (p = 0.01). FG short leg casts were superior to POP in getting dressed, odor, sweating under the cast, work/school accomplishments, and overall fewer restrictions and comfort.

Arm Injuries↗
PubMed1985

A combination of plastic and plaster of Paris (Kombigips) in fracture treatment.

A new model of plaster bandage with combination of gypsum and plastics is presented and its economic use is compared with traditional technics. "Kombigips" in 12 patients was more efficient in staging of fracture healing than traditional plaster bandages, because the X-ray properties of "Kombigips" are more profitable. "Kombigips" is much more cheaper than use of pure plastic bandages and nearly as cheap as use of traditional plaster bandages.

Adolescent↗
PubMedDate not supplied

Plaster of Paris mould for stereotactic frame fixation.

Stereotactic procedures have been prevalent in neurosurgical practice for a prolonged time period. With the advent of new custom-made frames designed for morphologic and functional neurosurgical procedures, its extended use in the pediatric population is becoming increasingly popular. However, there is still a need for sophistication in design and instrumentation. We describe a novel method of a plaster of Paris mould for stereotactic frame fixation, which can be a useful adjunct during frame fixation. It primarily accounts for a remarkable variation in skull shapes and sizes seen in the pediatric population undergoing stereotaxy besides many other advantages.

Adolescent↗
PubMed1996

Ultrasound assessment and conservative management of inversion injuries of the ankle in children: plaster of Paris versus Tubigrip.

We studied 45 children who presented with an inversion injury of the ankle. The clinical signs suggested injury to the distal growth plate of the fibula, but the plain radiographs appeared normal. Ultrasound examination of the joint in 40 patients showed a subperiosteal haematoma consistent with a growth-plate injury in 23 (57.5%). Children who had been treated with a tubular bandage and crutches by random selection had a mean time to return of normal activity of 14.22 days compared with 21.60 days for those treated with a plaster-of-Paris cast (t=3.60, p=0.0032; d=7.38, 95% CI 3.0 to 11.8). We conclude that children with inversion ankle injuries who have clinical signs of injury to the distal fibular growth plate but a normal radiological appearance, should be treated with a tubular bandage and crutches.

Activities of Daily Living↗
PubMed1976

A five-year assessment of controlled trials of in-patient and out-patient treatment and of plaster-of-Paris jackets for tuberculosis of the spine in children on standard chemotherapy. Studies in Masan and Pusan, Korea. Fifth report of the Medical Research Council Working Party on tuberculosis of the spine.

In two centres in Korea 350 patients with a diagnosis of tuberculosis of the thoracic and/or lumbar spine were allocated at random: in Masan to in-patient rest in bed (IP) for six months followed by out-patient treatment or to ambulatory out-patient treatment (OP) from the start; in Pusan to out-patient treatment with a plaster-of-Paris jacket (J) for nine months or to ambulatory treatment without any support (No J). All patients recieved chemotherapy with PAS with isoniazid for eighteen months, either supplemented with streptomycin for the first three months (SPH) or without this supplement (PH), by random allocation. The main analysis of this report concerns 299 patients (eighty-three IP, eighty-three OP, sixty-three J, seventy No J; 143 SPH, 156 PH). Pre-treatment factors were similar in both centres except that the patients in Pusan had, on average, less extensive lesions although in a greater proportion the disease was radiographically active. One patient (J/SPH) died with active spinal disease and three (all No J/SPH) with paraplegia. A fifth patient (IP/PH) who died from cardio respiratory failure also had pulmonary tuberculosis. Twenty-three patients required operation and/or additional chemotherapy for the spinal lesion. A sinus or clinically evident abscess was either present initially or developed during treatment in 41 per cent of patients. Residual lesions persisted in ten patients (four IP, two OP, one J, three No J; six SPH, four PH) at five years. Thirty-two patients had paraparesis on admission or developing later. Complete resolution occurred in twenty on the allocated regimen and in eight after operation or additional chemotherapy or both. Of the remaining four atients, all of whom had operation and additional chemotherapy, three died and one still had paraparesis at five years. Of 295 patients assessed at five years 89 per cent had a favourable status. The proportions of the patients responding favourably were similar in the IP (91 per cent) and OP (89 per cent) series, in the J (90 per cent) and No J (84 per cent) series and in the SPH (86 per cent) and PH (92 per cent) series.

Abscess↗