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PubMed2003

[A case of lung silicosis associated with plasmocytoma: the diagnosis and certification difficulties].

Silicosis is a chronic, progressing disease of the respiratory system. The aim of this paper was to describe a case of silicosis coexisting with not typical plasmocytoma. Silicosis was diagnosed in a 62-year old woman, after an 8-year employment as a grinder. The patient has suffered from progressing weakness, fatigue, and dyspnea for 2 years. The increased leucocytosis (18-20,000) and moderate lymphocytosis were found in laboratory tests. The patient was admitted to the hospital in a very serious condition, with fever and progressing insufficiency of the respiratory and circulatory systems. Following computed tomography (CT), tumorous silicosis was diagnosed in the Department of Internal and Occupational Diseases. After three months, the increased level of the whole number of serum proteins (until 90 g/l) was found for the first time together with few places of osteolysis in the x-ray cranium picture. The plasmocytoma infiltrations were found in the post-mortem lung examination. The described case seems to be interesting in view of a possible induction of monoclonal gammopathy by silicosis.

Diagnosis, Differential↗
PubMed1990

[Solitary intra and extracranial plasmocytoma. Apropos of a case and review of the literature].

The authors use data drawn from a wide review of literature with an exhaustive bibliography to confirm the rarity of single plasmocytoma in the cranial vault in comparison to other localizations for this tumour. The case observed well illustrates this conclusion and shows how the patients could survive for a long time because solitary plasmocytoma are so sensitive to radiology.

Combined Modality Therapy↗
PubMed1990

Studies on the cell phenotype characteristics of hybrid cells crossed between rat nucleated erythroblasts and mouse plasmocytoma (SP2/O) cell line.

The present study is designed to investigate the regulatory effect of mammalian erythroblasts, prior to naturally-occurring denucleation, on malignancy of mouse plasmocytoma cells and the possibility of reactivation of the pyknotic late erythroblast nuclei in hybrid cells crossed between rat intermediate or late erythroblasts of 15-day Wistar rat embryonic livers, and mouse plasmocytoma (SP2/O) cell lines. Results indicated that: (i) Suppression of tumorigenicity and reversion of the malignant phenotype were observed in hybrid cells in a similar way as those of cybrid cells crossed between reticulocytes and myeloma cells as we reported previously, thus providing further evidence to support the hypothesis that some regulatory substances already existed in mammalian intermediate and late erythroblasts long before nuclear extrusion. (ii) Appearance of positive histochemical reaction for hemoglobins in cytoplasm and electrophoretic bands of rat and mouse globin chains in hybrid cell lysate were identified. The transcripts of mouse globin genes could be readily detected by nucleic acid hybridization technique with mouse beta-globin gene probes. (iii) Reassuming of rat chromosome and globin gene products synthesis in hybrid cell indicates that the originally pyknotic nuclei of late erythroblasts could be reactivated to assume functional activity after cell hybridization. The mechanism of regulatory effect and its possible relation to naturally occurring denucleation in developing mammalian red blood cells were discussed.

Animals↗
PubMed1981

[Polyradiculoneuritis associated with plasmocytoma. Recovery following radiotherapy (author's transl)].

A new case of extensive subacute polyradiculoneuritis associated with a costal plasmocytoma secreting IgG lambda is reported. Radiotherapy of the rib, resulted in remarkable neurological improvement and haematological cure, which have now persisted for more than 5 years, though treatment was discontinued 3 years ago. By its distinctive haematological features, this case illustrates the lack of clear-cut distinction between "solitary" plasmocytoma and multiple myeloma. It also emphasizes the need for systematic testing for plasma cell proliferation when confronted with a subacute or chronic neuropathy of obscure origin.

Adult↗
PubMed1995

Solitary extramedullary plasmocytoma of the breast with kappa monoclonal gammopathy.

We report a case of solitary extramedullary plasmocytoma of the breast in a 85 year old woman. This is the third case of solitary breast plasmocytoma in the world's literature. This disorder is very rare and it was associated with a serum monoclonal protein. A similar case is presented and its clinical presentation and pathology discussed.

Aged↗
PubMed1978

[Cerebellopontile angle symptomology in plasmocytoma: a case report].

The author reports on a patient with cerebellopontile angular symptomatology in the case of a plasmocytoma. The diagnosis of plasmocytoma was established from the pathological results of gamma globulin subfractionation and immune electrophoresis. Also commented in this discussion is the problem of essential cryptogenetic paraproteinosis.

Cerebellar Neoplasms↗
PubMedDate not supplied

Solitary plasmocytoma of bone in an adolescent.

PURPOSE: To describe an adolescent with solitary plasmocytoma of bone and compare the pathologic and radiographic findings with osteomyelitis. PATIENT AND METHODS: A 17-year-old girl had a 3-year history of swelling of the right tibia, local pain, and hyperemia. RESULTS: Initial biopsy was interpreted as osteomyelitis. The lesion was rebiopsied 3 years later and showed a plasma cell neoplasm. A review of the first biopsy confirmed a similar histologic picture. CONCLUSION: Although solitary plasmocytoma of bone is a rare neoplasm in adolescence, it must be considered in the differential diagnosis of chronic osteomyelitis.

Adolescent↗
PubMed1983

Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.

The expression of the H2 Ia-associated invariant chain (Ii) has been determined by pulse labeling cells with [35S]methionine and resolving the proteins. Expression is maximal in noncycling peripheral B lymphocytes and is reduced upon maturation of B lymphocytes to plasma cells. B cell-derived cell lines behave correspondingly: IgM+ non-secretor cell lines synthesize Ii while plasmocytoma cells do not. Pre-B cell lines are also negative. In all Ii-negative cell lines, the synthesis of Ii is selectively induced by treating the cells with inhibitors of replication.

Animals↗
PubMed2006

[Rare types of vasculitis as markers of plasmocytoma].

We report on two female patients who presented with painful recurrent palpable purpura, ulcers and necroses on the extremities. The results of all examinations and laboratory tests considered together suggested a diagnosis of necrotizing leukocytoclastic vasculitis. Leukocytoclastic vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, presenting with variable clinical symptoms. In most cases it becomes manifest as palpable purpura, but hemorrhagic-necrotizing, bullous, nodular and urticarial presentations also occur. Common etiological factors include bacterial, viral or drug antigens, chronic infections (hepatitis B and C), non-Hodgkin lymphomas (monoclonal gammopathy, multiple myeloma), leukemia (hairy cell leukemia), and tumors (bronchial, breast, and gastric cancer) and also connective tissue disorders. In the course of the work-up, a plasmocytoma was discovered as the cause of the leukocytoclastic vasculitis, presenting in a similar way to livedo reticularis in one case and to pyoderma gangraenosum in the other.

Aged↗
PubMed1992

Early disappearance of murine plasmocytoma stem cells in long-term bone marrow culture.

Long-term bone marrow culture (LTBMC) was evaluated as a purging procedure in the murine plasmocytoma MOPC-315s system. MOPC-315s cells injected in Balb-c mice rapidly proliferate both in marrow and spleen, where macroscopic tumor colonies develop. A linear relationship between the number of injected cells and spleen colonies was observed, consistent with the presence of 1 clonogenic myeloma stem cell out of 1800 cells. In vitro, MOPC-315s cells are easily identifiable as rosette-forming cells (RFC+) with trinitrophenil acid (TNP) coated sheep red blood cells. When bone marrow (BM) cells containing 20-40% RFC+ were seeded in LTBMC, RFC+ rapidly decreased and were no longer detectable by day 14 of culture. Clonal Ig gene rearrangement was evident at time 0, but it was no more detectable later on. In addition, cells taken at days 14 and 21 of culture were no more tumorigenic when injected in vivo. The results suggest the efficacy of the LTBMC for the in vitro elimination of myeloma cells, including the neoplastic stem cells.

Animals↗
PubMed1986

Near-haploidy in a case of plasmocytoma.

Chromosome studies of a solitary plasmocytoma in the femoral bone revealed a near-haploid chromosome number of 31-32 with a loss of one homolog of each chromosome pair except #1, #7, #9, #15, #19-21, and the sex chromosomes (XY). The cytogenetic findings have been compared with 16 cases of near-haploid neoplasms from the literature studied using banding techniques. A common feature present in 13 of the 16 cases reported was found to be disomy 21; the only chromosomes consistently present in one copy in all neoplasms were #2, #3, #4, and #5.

Chromosome Aberrations↗
PubMed2006

Solitary plasmocytoma of the distal humerus.

A patient presented with chronic shoulder pain from a rare plasmocytoma in the distal humerus that resolved following a pathologic fracture. Staged reconstruction of the elbow after resection of the tumor in the distal humerus resulted in resolution of the patient's elbow and shoulder symptoms.

Arthroplasty, Replacement↗
PubMed1980

Manganese and magnesium dependent properties and inner plasma membrane surface localization of guanylate cyclase from murine plasmocytoma cells.

The particulate fraction from murine plasmocytoma cells contained 90 per cent of the total guanylate cyclase activity. Triton X-100 produced a 6 fold stimulation of guanylate cyclase activity in plasma membrane enriched fractions obtained by zonal centrifugation. Isolated inside out (10) vesicles contained 9 times more activity than rightside out (RSO) vesicles. This difference was abolished by Triton X-100 treatment of the vesicles indicating that the catalytic site of guanylate cyclase is located on the inner face of the plasma membrane. Kinetic studies of membranous guanylate cyclase showed that optimal activity was found with manganese. Only 20 per cent of this activity was obtained with magnesium. The Km for GTP with magnesium (1.4 mM) was about 7 fold greater than with manganese (0.2 mM). Positive cooperativity was obtained in both cases and the Hill coefficients were 1.8 for manganese and 1.6 for magnesium. Physiological concentrations of ATP were found to inhibit both manganese and magnesium supported activities indicating a possible regulatory mechanism for this nucleotide in vivo.

Animals↗
PubMed1997

Solitary plasmocytoma of the mandible--a combined approach for treatment and reconstruction.

A 44-year-old man presented with a solitary plasmocytoma in the left mandible. After neoadjuvant radiation therapy and chemotherapy, a bone marrow biopsy was taken for cryopreservation. In simulation surgery, tumour resection and primary reconstruction were planned on an individual stereolithographic 3-D skull model. Radical tumour resection and primary reconstruction using a microvascular iliac crest bone graft was performed. In case of extensive osteolysis and/or mandibular asymmetry due to tumourous bone enlargement, preoperative model planning has proved to be a useful tool for primary reconstruction. In the three-year follow up, the patient showed no recurrence of disease.

Adult↗
PubMed1994

[Generalized IgG-lambda plasmocytoma and stenosis of a Cimino shunt caused by plasma cell infiltration].

A 56-year-old apparently healthy man was on routine examination found to have a paraproteinaemia, classified as an IgG-lambda plasmocytoma in stage 1 on the basis of a raised IgG level (1950 mg/dl) and partly binuclear plasma cells in bone marrow. When 5 months later the IgG concentration had increased to 2980 mg/dl and the proportion of plasma cells in bone marrow to 15%, treatment was begun with melphalan (0.25 mg/kg) and prednisolone (2 mg/kg), both on 4 successive days every 6 weeks. The patient's general condition rapidly worsened after 6 months. The extent of osteolysis increased, necessitating radiotherapy of the vertebrae as well as a change in treatment to vincristine, cyclophosphamide, doxorubicin and prednisolone. At that time renal failure set in. But the prophylactically placed Cimino shunt had become infiltrated with plasma cells causing shunt stenosis and soft-tissue swelling. The infiltration was reduced by irradiation with 18 Gy. Numerous bluish skin discolorations now appeared and plasma cell infiltrates were shown in lung and pleura, as well as in the abdomen. The patient died 15 months after the diagnosis had been made.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1974

Correlation between the mobility of inner plasma membrane structure and agglutination by concanavalin A in two cell lines of MOPC 173 plasmocytoma cells.

Both the distribution of the concanavalin A-binding sites and the rearrangement of the intramembranous particles revealed by the freeze-etching technique, have been studied by means of two variants of the same cell line issued from MOPC 173 murine plasmocytoma. One variant does not agglutinate even in presence of high lectin concentration. It has been shown that the number of binding sites and affinity are almost the same in the two variants. The clustered distribution of intramembranous particles is induced by the interaction of the concanavalin A and the cell surface only in the variant which is agglutinable. From these results it became apparent that the clustered distribution of the membrane particulate components is an acquired feature of the plasma membrane accompanying cell agglutination.

Agglutination↗