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A behavioral approach to obesity.

For many individuals, the practice of overeating is crucial in the development and maintenance of the obese state. Behavior theory views excessive eating leading to obesity as an overlearned habit, strongly conditioned to numerous internal and external cues. A number of studies are reviewed that assess the relationship between emotional arousal and food consumption. Obese persons who successfully lost and maintained a weight loss appeared able to reduce the number of inappropriate stimuli they previously responded to with food intake. The specific behavior modification techniques employed to change eating patterns are discussed, and weight loss maintenance follow-up statistics using these procedures are presented.

Arousal

Abnormalities of the nervous system in Lyme disease: response to antimicrobial therapy.

Objective measures of neurologic function were used to assess response to treatment in patients with late Lyme borreliosis. Neurophysiologic evidence of peripheral neuropathy was present in 64 of 137 patients tested. Measures of distal axon function (sensory amplitude and conduction velocity, motor terminal latency) were most affected. Repeat studies following 60 patients receiving antimicrobial therapy demonstrated significant improvement in these values. Before and after therapy 17 patients with late Lyme borreliosis and prominent subjective cognitive dysfunction underwent neuropsychologic tests of memory, conceptual ability, concentration, psychomotor function, overlearned intellectual abilities, and mood. Significant abnormalities were evident before treatment; all reversed with antimicrobial therapy. Many patients with this encephalopathy had specific abnormalities revealed by magnetic resonance imaging of the brain and had evidence of intrathecal synthesis of antibody to Borrelia. These findings indicate that late Lyme borreliosis commonly causes nervous system abnormalities that are reversible with appropriate antibiotic therapy.

Anti-Bacterial Agents

A comparative analysis of functional status among Spanish- and English-speaking patients with dementia.

The assessment of functional capacity is regarded as an important part of a comprehensive diagnostic work-up for dementia. However, there is a paucity of data regarding comparative functional performance among different ethnic/cultural groups. In this study, we compared Spanish- and English-speaking dementia patients and normal controls on a comprehensive functional assessment battery administered within the clinical setting. Despite equivalent levels of cognitive impairment, Spanish-speaking dementia patients evidenced more difficulties on certain functional tasks relative to their English-speaking counterparts. On the other hand, Spanish- and English-speaking controls did not differ with regards to their functional performance. Results suggest that the extent of deterioration in specific functional subskills may be related to the degree to which they have been overlearned and practiced. Further, they indicate the potential utility of direct functional assessment in both Spanish- and English-speaking populations.

Activities of Daily Living

Left hemisphere preponderance in trajectorial learning.

The present study examines the organisational principle of a trajectorial storage mechanism for isochronically controlled overlearned movements. 48 right-handed subjects were trained on new ideograms at five different sizes. After the trajectory had been overtrained with one hand, learning transfer to the contralateral hand was analysed. Results indicate a significant transfer of trajectorial information after training with the right hand towards the left hand which points to a preponderance of the dominant left hemisphere in generalizing storage of learned trajectories to either upper extremity. The trajectorial storage system has clear geometrical restraints.

Female

Disability and intellectual function in multiple sclerosis patients.

Forty-eight multiple sclerosis patients were rated on the Kurtzke Disability Status Examination and tested on the Wechsler Adult Intelligence Scale. Their disability status scores, ranging from 1 to 9, with a mean of 3.98, correlated significantly only with duration of illness (r = .33, significant at the.05 level). Severity of disability was not significantly correlated with age of patient, age at onset of multiple sclerosis symptoms, Verbal IQ, Performance IQ, or Full Scale IQ. Wechsler Adult Intelligence Scale mean subtest scores ranged from average to bright normal. Scores on Performance subtests with a large motor component were lower than on Verbal subtests measuring verbal overlearned information, abstract reasoning, and vocabulary.

Adolescent

Do older people know how good they are?

Information and procedures that have been overlearned during a lifetime form a body of 'crystallized' intelligence that is relatively unaffected by ageing. Thus in spite of marked decrements in their 'fluid' memory abilities it is possible that older people may retain knowledge about the limitations and characteristics of their own memory ('metamemory'). To test whether efficiency of metamemory is, indeed, independent of age-related decline in fluid intelligence, 320 people aged from 50 to 79 years were asked to predict their probable performance on four simple memory tasks which had been carefully explained to them. They then experienced the tasks and their predictions were compared with their actual performances. Actual task performance was modestly predicted by chronological age and by AH 4 and Mill Hill IQ test scores but not by subjective self-ratings of everyday memory and cognitive efficiency (the Broadbent CFQ, and the Sunderland & Harris MQ). The data suggest that absolute levels of prediction of performance were associated with self-confidence and were best predicted by scores on the Beck depression scale and by fluid IQ test scores. There was also evidence that individuals with higher test scores gave more accurate as well as more optimistic predictions of their own abilities. Taken together these results suggest that the accuracy of individuals' assessments of their own abilities does alter with age-related changes in fluid IQ, but probably more radically by age-related changes in self-regard and in life-style.

Activities of Daily Living

Retrieval of information from long-term memory.

Information is represented in long-term memory as a network of associations among concepts. Information is retrieved by spreading activation from concepts in working memory through the network structure. The time required to retrieve information is a function of the level of activation that it achieves. Fanning of multiple paths from a node dissipates the activation the node sends down any path and increases retrieval time. Fan effects are reduced as subjects overlearn the material or when they can change their task from a recognition judgment to a consistency judgment.

Face

Lateral asymmetry in perceptual judgments of reading disabled, hyperactive and control children.

Three groups of 11 year old boys, classified as reading-disabled/hyperactive, hyperactive, and normal controls, made same-different judgments to pairs of verbal or visuospatial stimuli presented simultaneously to the right or left side of a fixation point. Two experimental paradigms were used, one emphasizing comparison judgments from memory, the other, new comparison judgments. Reading-disabled boys made more errors of judgment than did controls. All subjects exhibited faster reaction times for different judgments of pairs appearing in the left visual field. Reaction times were longer and errors more numerous for judgments made when two stimuli were presented simultaneously, one to each visual field. Differences in performance for the two halves of the visual field are attributed to memory storage effects for overlearned stimuli. The deficiency in interhemispheric comparisons is attributed to immaturity of the cerebral commissures. The reading-disabled group appears to encompass two subgroups with differing modes of information processing.

Child

The lateralization of arithmetic and number processing: a review.

Calculation and number processing require ideographic and semantic operations which may involve the right as well as the left hemisphere. There is often also present a spatial component, whether overt as with column-addition or multiplication procedures, or covert if numbers are recoded into continuously varying analog quantities or magnitudes of a psychophysical or imaginal nature, to facilitate numerical comparison. Again right hemisphere mechanisms may be partly responsible. Evidence for such a minor hemisphere contribution is reviewed in the light of studies with clinical and commissurotomy cases, and normal subjects. Calculation itself is hard to define, as it often seems to reduce to the operation of overlearn, associative, tabular look-up functions and algorithms. Indeed alphabetic comparisons analogous to numerical tasks should generate similar laterality effects in clinical and normal populations.

Brain Damage, Chronic

[Attention deficits and schizophrenia. Multidisciplinary approaches and the Stroop's test].

Since McGhie & Chapman's (1961) pioneering work, there have been continual attempts to clarify the link between attentional disturbances observable in schizophrenics and their schizophrenic symptoms. Venables (1964, 1977) claims that this diminution is a consequence of a badly controlled arousal, resulting in an inadequate filtering at the level of sensory input. Although the notion of a faulty sensory filter is simple and intellectually satisfying, this idea rapidly met with articulate opposition. Broadbent himself, in 1971, revised his model to take into account the way in which semantic aspects influence selective attention, and proposed the existence of a second stage of information processing, coming after the sensory filter. It became increasingly clear that progress in understanding selective attention would depend upon more centrally-directed approaches. In 1935, Stroop developed an ingenious way of studying selective attention. In his task, an "automatic", overlearned task (reading short words aloud) is put into conflict with a slightly more difficult task (colour-naming): the subject has to name the colour of the ink in which a word is printed, but the word itself is the name of a different colour. For instance, when the word "blue" is written in red ink, the correct response is "red". Typically, subjects find it difficult to inhibit the reading response, and take significantly more time to name a colour that forms an incompatible word than take to name the colour of a row of letters "x". This increased reaction time for the incompatible condition is attributed to an "interference" caused by the verbal information contained in the double stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)

Attention

Syndromes in developmental dysphasia and adult aphasia.

We have attempted to draw some parallels between syndromes of adult acquired aphasia and of childhood developmental dysphasia. There appear to be two syndromes that are almost exact duplicates in the adults and the children: (a) pure word deafness and verbal auditory agnosia, and (b) aphemia and verbal dyspraxia. Two other syndromes seem to have rather close but not exact counterparts: Broca's aphasia and the phonologic-syntactic deficit syndrome, and transcortical sensory aphasia and the semantic-pragmatic deficit syndrome. There are two dysphasic syndromes, the phonologic production deficit syndrome and the lexical-syntactic deficit syndrome, that do not seem to have close adult counterparts. Neither of these dysphasic syndromes has been defined in adequate linguistic detail, and it is possible that their description may have to be modified when more data become available. Whether these comparisons between dysphasias and aphasias have heuristic value for guiding external validation studies of the clinically defined dysphasic syndromes of preschool children remains to be determined. Our purpose was to formulate hypotheses as to which cerebral systems are likely to be dysfunctional in children with clinically defined dysphasic syndromes. We recognize that the disorders of language acquisition and those of overlearned adult language have fundamental differences, and that plasticity of the child's developing brain introduces further complexities. Nevertheless, it seems reasonable to think that there are constants in brain organization that span all ages. Looking for language deficits common to aphasic adults (whose lesions can usually be delineated with contemporary neuroimaging techniques) and to dysphasic children (in whom there are rarely any neurologic clues) may be a fruitful way to begin to define the cerebral correlates of the children's deficits.

Adult

Cognitive deficits in adolescents who developed diabetes early in life.

A comprehensive battery of neuropsychological tests was administered to 125 adolescents with a history of insulin-dependent diabetes, and to 83 demographically similar nondiabetic control subjects. To test the hypothesis that developing this disease early in life greatly increases the risk of manifesting significant cognitive impairments, diabetic subjects were assigned to an "early-onset" (diagnosis before age 5 years) or a "later-onset" subgroup. Results showed that subjects with early onset of diabetes performed more poorly than either subjects with later onset of diabetes or nondiabetic control subjects on virtually all tests, including measures of intelligence, school achievement, visuospatial ability, memory, motor speed, and eye-hand coordination. Moreover, multiple regression analyses demonstrated that the age at onset and the duration of diabetes seem to affect neuropsychological functioning in very different ways. The duration of the disease best predicted performance on those tests requiring highly overlearned, primarily verbal, skills whereas the age at onset best predicted scores on tests requiring the ability to process relatively unfamiliar, typically nonverbal, information in novel ways. Although the etiology of these deficits remains unclear, there is a possibility that they are secondary to mild brain damage that develops as a consequence of multiple episodes of serious hypoglycemia early in life.

Adolescent

The role of tone height, melodic contour, and tone chroma in melody recognition.

The present experiments assessed the contribution of tone height, melodic contour, and tone chroma to melody recognition. Rather than using highly familiar folk songs as in earlier studies, subjects were taught new melodies. Novel melodies were used to (a) more precisely control potential cues (e.g., rhythm) that are not of present interest, (b) eliminate unison intervals that cannot be transformed appropriately, (c) provide a direct analysis of the nature of confusion errors, (d) test whether recently learned melodies are recognized differently than highly overlearned melodies, and (e) evaluate the extent to which practice in the experimental task alters the process of recognition. The results replicate previous studies using familiar folk songs. Transformations of the original melodies were accurately recognized when tone height was violated, but both melodic contour and tone chroma were maintained. Violating both tone height and contour while maintaining chroma produced extremely poor recognition. Performance was intermediate when just melodic contour was preserved. There is now good evidence to support the idea that melodic contour and tone chroma, in addition to tone height, contribute to recognition of both highly familiar and recently learned melodies.

Humans

The effect of visual deprivation in the rat on transfer effects after form discrimination training.

In 3 experiments the performances of light-reared (LR) and dark-reared (DR) 90-day-old rats were compared on a variety of transfer tests following acquisition of 3 discriminations involving patterns of small squares (dots). Though no significant difference due to rearing condition was found in acquisition of those discriminations consisting of single lines of dots in various orientations, transfer tests did reveal subtle differences in the way LR and DR rats analyze contour information. Significant differences due to rearing were also observed on the acquisition of a complex dot pattern (gradient vs X) and, in spite of overtraining, on subsequent stimulus equivalence tests. Anomalous transfer effects were not observed in any of these test situations.

Animals

Associative recall and formation of stable modes of activity in neural network models.

Models of neural networks with recurrent inhibition are studied, as well as one model which also includes recurrent excitation. The models are intended as possible descriptions of the cerebral cortex. Each network model is composed of neuron models called pyramidal cells and stellate cells in accordance with the names of two types of cells in the cortex. Inputs and outputs of the network are connected to the pyramidal cells while feedback is provided by the stellate cells. Connections within the network are random. During a learning phase the pyramidal cell excitatory synapses become facilitated according to a two-conditional facilitation rule. This is the basis of the model's ability for associative learning. The associative retrieval of information can be studied during a subsequent association phase. This has been done by simulation on a digital computer. It was shown that all of the models considered can be designed to perform a so-called decision-making function. This means that if the associating input pattern is similar to several patterns which occurred during learning the model can decide which similarity is greatest by responding with the appropriate associated pattern. The model also including recurrent excitation differs from the simpler models in that it can become stabilized in so-called stable modes of activity which are self-sustaining and remain even after the input has been turned off. Normally, only one stable mode can be active at a time. However, through careful choice of construction parameters it was possible to obtain a model in which a maximum of two stable modes could be activated independently of each other. Physiological and psychological interpretations are discussed and so are the limitations of the models, which are evident in certain situations.

Cerebral Cortex