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Bioconversion of waste office paper to L(+)-lactic acid by the filamentous fungus Rhizopus oryzae.

L(+)-lactic acid production was investigated using an enzymatic hydrolysate of waste office automation (OA) paper in a culture of the filamentous fungus Rhizopus oryzae. In 4 d culture, 82.8 g/l glucose, 7 g/l xylose, and 3.4 g/l cellobiose contained in the hydrolysate were consumed to produce 49.1 g/l of lactic acid. The lactic acid yield and production rate were only 0.59 g/g and 16.3 g/l/d, respectively, only 75% and 61% of the results from the glucose medium. The low production rate from waste OA hydrolysate was elucidated by trials using xylose as the sole carbon source; in those trials, the lactic acid production rate was 7.3 g/l/d, only 28% that of glucose or cellobiose. The low lactic acid yield from waste OA hydrolysate was clarified by trials using artificial hydrolysates comprised of 7:2:1 or 7:1:2 ratios of glucose:cellobiose:xylose. For both, the lactic acid production rate of 17.4 g/l/d matched that of waste OA paper, while the lactic acid yield was similar to that of the glucose medium. This indicates that the production rate may be inhibited by xylose derived from hemicellulose, and the yield may be inhibited by unknown compounds derived from paper pulp.

Acremonium↗

Bioconversion of waste office paper to gluconic acid in a turbine blade reactor by the filamentous fungus Aspergillus niger.

Gluconic acid production was investigated using an enzymatic hydrolysate of waste office automation paper in a culture of Aspergillus niger. In repeated batch cultures using flasks, saccharified solution medium (SM) did not show any inhibitory effects on gluconic acid production compared to glucose medium (GM). The average gluconic acid yields were 92% (SM) and 80% (GM). In repeated batch cultures using SM in a turbine blade reactor (TBR), the gluconic acid yields were 60% (SM) and 67% (GM) with 80-100 g/l of gluconic acid. When pure oxygen was supplied the production rate increased to four times higher than when supplying air. Remarkable differences in the morphology of A. niger and dry cell weight between SM and GM were observed. The difference in morphology may have caused a reduction of oxygen transfer, resulting in a decrease in gluconic acid production rate in SM.

Air↗

Computerizing the cancer centre.

This article describes a PC-based computer network that caters for the clinical information needs of a cancer centre, crossing specialty boundaries and involving all members of the multidisciplinary team. Data are captured at all stages of patients' progress, from diagnosis through to treatment and follow-up. Office automation is integral to the system, which produces work-load and process audit information as well as clinical outcomes. Data are entered prospectively at the point of care by health care professionals, ensuring a high degree of clinical confidence. It incorporates internationally recognized datasets and its modular structure facilitates implementation and development.

Computer Communication Networks↗

[Use of computers in radiology. Word processing, office technology and documentation--continuing the past or using newer technology?].

The use of computers can result in drastic rationalisation in radiology with regard to text processing, office automation and documentation. The staff can be streamlined and work can be processed more rapidly, easier and more reliably, thus essentially improving effective productivity levels. Basing on the experience collected in handling the COMRAD system. Where the textrail is the most important software component, the article explains by means of the example of three different types of reports how the radiologist is assisted in his work by the computer.

Hospital Departments↗

Optical disk technology and information.

The optical video disk, spawned by the home entertainment industry, and its counterpart, the optical digital disk, both hold great promise for information storage and retrieval and the scientific enterprise. Optical digital disks for computer mass storage are currently under development by many firms. In addition, efforts are under way to allow encoding of digital information on video disks. This is desirable as an inexpensive publication medium for machine-readable data as well as a means of obtaining both video and digital information on one disk. Potential applications of this technology include inexpensive on-line storage, random access graphics to complement on-line information systems, hybrid network architectures, office automation systems, and archival storage.

Computers↗

The leading edge. Data systems can provide the tools needed to meet goals.

Management information systems--essential for strategic planning and management in today's complex healthcare environment--must be designed in concert with goals and strategies developed at the executive or corporate level. Healthcare organizations need management information to support four major functions: strategic planning and marketing, resource allocation, performance assessment, and evaluation of products and services. Computer systems fall into three general categories--administrative, clinical, and decision support (management information systems). Management information systems are the least advanced of the three. The need for strategic planning and managerial control in the face of complexity and competition, however, will result in rapid advances. The chief executive officer must be responsible for the following areas to ensure the effective use of information systems: strategic planning, information systems planning, user-driven focus, systems integration, and monitoring of results. Many larger healthcare organizations have established the position of chief information officer (CIO) to assist in these tasks. The CIO coordinates information systems, telecommunications, management engineering, and office automation.

Decision Support Systems, Management↗

The information archipelago--plotting a course.

Information systems applications in some aspects resemble those of a decade ago--they cost a lot, are technically complex, and take a long time to develop. Moreover, as the technology continues to change rapidly, managers find themselves continually squeezed by a shortage of the technical staff and financial resources they need to keep up. A company can use knowledge of its particular strengths and weaknesses in regard to IS to steer its way onto a safe course, say these authors in the second article of a series dealing with the "islands" of information: computers, telecommunications, and office automation (see "The Information Archipelago--Maps and Bridges," HBR September-October 1982). Setting a safe course requires a new planning approach, for which the guideposts are the company's familiarity with any one technology, the importance of the technology to corporate strategy, and certain business characteristics such as size, complexity of product lines, and the general approach to corporate planning.

Information Systems↗

Small computers: the directions of the future in mental health.

Small computers will have a significant impact on mental health centers during the 1980's. The continued advances in computer technology, together with price decreases, will provide affordable hardware even at the smallest centers. The challenges will be to provide the systems and the programs that will make this hardware adaptable to the needs of the centers. Center staff will need to become more cognizant of the problems and solutions toward implementing automated offices.

Community Mental Health Centers↗

Practice strategies. The paperless office: are we there yet?

The technology is here. Why aren't ODs jumping on board? Building a truly "paperless practice" isn't simply a matter of buying a few computers. Its cost can be measured in money, space, training time, and aggravation. And sometimes the doctors who need it most are the least able to implement it. This author discusses the pros and cons of the paperless practice and shows us how some "paperless" optometrists have done it in their offices.

Humans↗

Analyzing process variation in chart review using a networked spreadsheet application in the Walter Reed Army Medical Center Nephrology Clinic.

The role of reviewer variation in interpreting outcomes of outpatient clinic chart reviews has been poorly studied. The present study used results collected from a network-based spreadsheet application (Microsoft Excel), which is widely available throughout the Army Medical Department, for chart reviews. Data were collected from January 1998 to August 2000, and 2,308 charts of 1,127 patients were reviewed. Results showed a significant improvement in documentation of contact with the referring provider from 1998 to 2000 (55.9% in 1998, 81.6% in 1999, and 80.6% in 2000; p < 0.01 by chi 2 for both). The percentage of charts for new consultations with inadequately controlled blood pressure managed appropriately improved from 73.7% in 1999 to 89.2% in 2000 (p < 0.01 by chi 2). These results persisted in logistic regression analysis controlling for different reviewers. In conclusion, widely available office automation tools allow the systematic analysis of chart review data with the potential to improve practice patterns.

Chi-Square Distribution↗