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[Morphological manifestations of the intracellular toxic effect of microorganisms of the ornithosis-lymphogranuloma-trachoma group].

Interactions of the causative agents of meningopneumonia and ovine abortion with pulmonary macrophages in experimental infection in white mice were studied by histological, immunofluorescent and electron microscopic methods. The causative agent of meningopneumonia did not multiply in colonies and caused toxic lesions in the cells and formed cytoplasmic oxiphilic inclusion bodies. Being the product of cell degeneration, these oxiphilic inclusion bodies were conducive to long-term survival of the cell and slow release from them of elementary bodies of meningopneumonia agent. The agent of ovine abortion multiplied in colonies without toxic affection of the cells or formation of oxiphilic inclusion bodies. It is suggested that oxiphilic inclusion bodies represent morphological manifestation of the intracellular toxic effect of rickettsial and ornithosis-like agents possessing dissociated (non-colonial) mode of multiplication.

Abortion, Veterinary↗

[Pigeon coryza--ornithosis--pigeon breeder's lung].

The published informations on the entities pigeon coryza and ornithosis are reviewed. On the basis of own experiences and experimental data obtained in the Landesveterinäruntersuchungsamt Koblenz, pigeon coryza apparently is a symptom rather than a clearly defined disease. Finally pigeon breeder's lung is discussed in front of the background of own observations and recommendations to be of allergic origin.

Animals↗

[An outbreak of ornithosis at a textile factory].

For the first time an outbreak of ornithosis at a textile factory is described. The data on the specific epidemiological features of the outbreak, the specific clinical features of the disease, the results of catamnestic observations and the study of the titers of specific antibodies in the complement fixation test are presented.

Adolescent↗

Complement-fixation and hemagglutination antigens from a Chlamydial (ornithosis) agent grown in cell cultures.

Methods are described for the preparation of complement-fixation (CF) and hemagglutination (HA) antigens from the Texas turkey ornithosis agent grown in McCoy cell culture monolayers. The particulate antigens prepared for this study were satisfactory for testing mammalian sera by direct CF tests and avian sera by indirect CF or modified direct CF tests. Comparison of titers were made on human, bovine and ovine sera using direct CF tests employing antigen prepared for this study, 6 BC yolk sac antigen, and a commercially available antigen. The HA antigen agglutinated mouse erythrocytes, but it was not of value in hemagglutination inhibition tests because of "nonspecific" inhibitors in both mammalian and avian sera.

Animals↗

[Importance and distribution of serological findings of ornithosis-psittacosis in semi-domestic pigeons].

Ornithosis-psittacosis is a widely distributed disease in birds throughout the world. A serological study by the complement-fixation test and a few isolation of Chlamyqia were performed on feral pigeon population of Antwerpen city. The incidence of positive cases in Antwerpen averages 58.51 %. For each serum, a serological index (S. I.) was calculated with regard to the intensity of immunological response in different dilutions: S. I. seems to suggest an endemic status of the disease in Antwerpen. Evolution in time of the prevalence and the serological response shows the presence of two peaks: the first one in spring and the last one in summer. This might be explained by some factors influencing the transmission of the infection: between them, one must emphasize the pigeons habits and the ectoparasites.

Animals↗

[Mechanism of the negative action of a bacterial lipopolysaccharide (pyrogenal) on the course of experimental ornithosis infection].

The intravenous injection of pyrogenal into mice following their intravenous infection aggravates the course of ornithosis infection and leads to more intensive multiplication of the infective agent. After the injection of pyrogenal is discontinued a change in the course of the infectious process occurs and the infective agent is quickly eliminated from the body. This is accompanied by increased formation of specific antibodies. The negative effect of pyrogenal is due to its high toxicity for macrophages containing the colonies of the infective agent, the suppression of the reaction of neutrophil leukocytes at the sites of the destruction of infected cells and the suppression of the general reaction of the mononuclear phagocytic system. Pyrogenal does not damage lymphoid tissue and even produces an immunostimulant effect on it, but the increased immune response can be completely realized only after pyrogenal injections are stopped and the reaction of mononuclear phagocytes is restored.

Animals↗

[Nosocomial ornithosis].

Ornithosis is an occupational hazard to workers in the poultry industry, zoonosis. Own sporadic unusual case is appearing under the hospital circumstances as a nosocomial atypical pneumonia.

Aged↗

[Severe pneumonia with a pneumococcal aspect during an ornithosis outbreak].

OBJECTIVES: To describe the clinical, radiological and biological features of Chlamydia psittaci pneumonia. METHODS: A pneumonia outbreak occurred in a healthy middle-aged population working in a poultry slaughterhouse. Systematic serology (2 samples at 5 weeks intervals) provided the diagnosis of Chlamydia psittaci pneumonia in 6 patients. Patient files were analyzed retrospectively. RESULTS: The clinical presentations in this series of pneumonia were particularly homogeneous with a pneumococcal profile in all 6 cases: sudden onset, temperature above 39 degrees C, lobar alveolar involvement, hypoxemia, hyperleukocytosis and liver dysfunction. One case of hallucinatory delirium was observed. The patients were given spiramycin (9 million units per day for 3 weeks) and all recovered rapidly with no complications. CONCLUSION: The unusual virulence of the Chlamydia psittaci and very important inoculum were probably involved in this outbreak because of the severity of the pulmonary features and the short exposure of some patients to the bacteria. These cases suggest that the prevention of ornithosis in poultry slaughterhouses should be reinforced.

Abattoirs↗

ORNITHOSIS.

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Psittacosis↗