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[The problem of cyclic basic structure of neurotic disorders].

The working hypothesis could be confirmed that a nuclear syndrome (Basis-syndrom) consisting of alterations in drive and mood as well as in autonomic activation, possibly contributing to neurotic disorders, is independent of such factors as sex, education, premorbid personality, duration of illness, age at onset of the illness, social mobility during the illness, number of pregnancies, family history, occupation, marital state, social class compared with that of parents, social contacts, or past physical illnesses. It was shown in a sample of 50 neurotic outpatients that the factor 'past illnesses' influenced the number of vegetative sumptoms prior to therapy. The effect of psychotherapy on psychic and vegetative disturbances was greater in women with children, i.e., not in occupations. In patients whose social class was not changed during the illness, the number of vegetative symptoms diminished more than in the others. In all the other cases, improvement was not related to the factors mentioned. This can be interpreted as supporting the hypothesis.

Adolescent↗

[Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders].

The paper presents a complex psychophysiological analysis of the effect of a combined administration of pantogam and potassium orotate (kalii orotas) on the dynamics of cognitive function in patients with neurotic disorders. The investigation was conducted in an 8-stage consecutive cycle and employed computer-aided diagnostic system. It was established that the combined use of pantogam and potassium orotate produces a positive effect upon the dynamics of restoration of the attention and memory mechanisms in neurotic patients.

Attention↗

The Nottingham study of neurotic disorder. Effect of personality status on response to drug treatment, cognitive therapy and self-help over two years.

Repeated assessments of psychopathology, together with personality status, were made over two years on 181 psychiatric out-patients with generalised anxiety disorder (59), panic disorder (66), or dysthymic disorder (56) diagnosed using an interview schedule for DSM-III. Patients were randomly allocated to drug treatment, cognitive and behaviour therapy, or a self-help treatment programme. Although there were no overall differences in compliance rate and efficacy between the three modes of treatment, the psychological treatment methods, particularly self-help, were more effective in patients without personality disorder, and those with personality disorder responded better to drug treatment, primarily antidepressants. The findings suggest that assessment of personality status could be a valuable aid to selection of treatment in neurotic disorders and that self-help approaches are particularly valuable once personality disorder has been excluded.

Adult↗

Common personality features in neurotic disorder.

The personality characteristics of 77 patients seen in general practice with a Catego diagnosis of anxiety state (including phobic state) or depressive neurosis derived from the Present State Examination were compared with those in 77 normal subjects chosen at random from the list of the same general practitioner. Each patient was matched with a normal subject of the same age and sex. The personality characteristics were rated using the Personality Assessment Schedule, an interview schedule designed to elicit the premorbid personality of the subject. The neurotic patients had significantly higher scores for the personality charcteristics of anxiousness, vulnerability, resourcelessness, hypochondriasis and other features commonly described as oral and hysterical. Schizoid features were absent in the neurotic group. The results suggest that there are common personality attributes in neurotic disorder and that these have clinical significance.

Adolescent↗

[Comparative electroencephalographic studies of stutterers on the basis of neurotic disorders and on the basis of organic lesions of the central nervous system].

The paper contains information regarding EEG registration in stuttering patients from 20-35 years of age. In 55 cases stuttering was found against the background of neurotic disorders, in 39--accompanied by residual signs of organic brain lesions. In the first group there was a tendency towards an acceleration of the rhythms and desynchronization of the EEG activity which reached normal levels during the treatment period. The patients of the second group demonstrated a stable tendency towards a synchronization of activity, slower rhythms with pathological activity of a bilateral--synchronous character and theta-rhythm in the central parietal areas.

Brain↗

[Neurotic disorders in monkeys during increased stress on analytic-synthetic processes].

It has been shown in experiments on three rhesus monkeys that an enhanced stress of analytical-synthetic processes consisting in learning to differentiate a sequence of tones, leads to neurotic disorders of monkeys higher nervous activity. They are manifested individually and consist in disturbances of general behaviour, in forced movements, breakdowns of differentiations, the missing of positive responses in the previously elaborated conditioned stereotype and in typical dynamics of the formation of positive and negative conditioned reflexes to a chain of tones (2000 + + 4000 c/s; 2000 + 2000 c/s; 4000 + 2000 c/s; 4000 + 4000 c/s).

Animals↗

Change in personality status in neurotic disorders.

Personality disorders are generally thought not to change by much over time. We assessed the personality status of 202 patients who had a defined diagnostic and statistical manual (DSM)-III neurotic disorder, dysthymia, panic disorder, or generalised anxiety. All patients had had drug and psychological treatment in a randomised controlled trial. 12 years after entry to the study, we reassessed the personality status of 178 (88%) of these patients using the same test (personality assessment schedule). The personality traits of patients in the cluster B flamboyant group (antisocial, histrionic) became significantly less pronounced over 12 years, but those in the cluster A odd, eccentric group (schizoid, schizotypal, paranoid), and the cluster C anxious, fearful group (obsessional, avoidant) became more pronounced. The measure of agreement between baseline and 12-year personality clusters was poor or slight (kappa=0.14, 95% CI 0.04-0.23). Our results suggest that the assumption that personality characteristics do not change with time is incorrect.

Adult↗

Are social deprivation and psychiatric service utilisation associated in neurotic disorders? A case register study in south Verona.

Measures of service utilisation from the South Verona psychiatric case register in North-East Italy for the years 1983, 1986 and 1989 were used to identify possible associations with sociodemographic variables from the 1981 census for neurotic disorders. There were no consistent patterns of associations between local social and demographic predictors and rates of psychiatric service utilisation. This contrasts markedly with the associations found previously in England (for all psychiatric admissions) and in Italy (for various measures of service utilisation concerning contacts both in and outside hospital for schizophrenic as well as for all psychiatric patients) where social deprivation factors proved to be strong predictors of service use.

Community Mental Health Centers↗

[Principles of changes of structural organization of cell membranes and functional properties of erythrocytes in neurotic disorders].

Investigation into structural, metabolic, and functional conditions of red blood cells was performed in 24 patients with a neurosis (neurasthenia, disturbance of asaptation) with the aid of electrophoretic division of proteins of the erythrocyte membrane, thin-layer chromatography, fluorescent probing of membranes, evaluation of peroxidative oxidation process, scanning and transmission electron microscopy, laser diphractometry, photometry. The patients with neurotic disorders at the early period after the influence of psychogenic factors (up to 3 months) revealed disorganization of lipid and protein composition of the red cell membrane, increase in microviscosity of its lipid phase, impairment of surface architectonics and ultrastructure of red cells, decrease of a deformation ability and increase of aggregate properties of erythrocytes. The authors treat stability of erythrocytes' homeostasis under the long-term influence of psychogenic factors from a viewpoint of adaptive changes in organism under the influence of neurogenic factors.

Adult↗

The outcome of neurotic disorders after out-patient and day hospital care.

New psychiatric out-patients with depressive, phobic, and anxiety neurosis were randomly allocated to out-patient care or to one of two types of day hospital treatment, one specialising in psychotherapy and the other offering all forms of day care. Of 106 patients who entered the study, 78 had assessments of psychiatric symptomatology and social adjustment both before treatment and after 4, 8 and 24 months. There was no significant difference in outcome between depressive, phobic, and anxiety neurosis, and no overall difference in response to treatment between the three types of care. Suicidal symptoms were significantly less common in out-patients. In many respects, neurotic disorder can be regarded as a single syndrome.

Ambulatory Care↗

[Clinical picture and features of the dynamics of vegetative crises in patients with neurotic disorders].

The author studied 115 patients with principal clinical forms of neuroses and neurotic developments of personality, with the clinical picture characterized by vegetative crises. Using clinical follow-up examinations of patients and specially designed questionnaires, the characteristic features of the clinical picture and the time-course of vegetative crises were investigated. The findings showed the dependence of the crisis structure on the character of the main neurotic syndrome and the relationship between the structure of crises and permanent vegetative disorders in patients. The time-course and regularities of the manifestations of the major components of the crisis were studied in relation to the stage of neurotic disorders--neurosis and neurotic development of the personality.

Adrenal Medulla↗